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© 2019 by the authors., Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially better option co-therapy for cisplatin, but there are strong limitations due to the difficulty of accessing the inner ear. The use of nanocarriers for the efficient delivery of drugs to auditory cells is a novel approach for this problem. Solid lipid nanoparticles (SLNs) are biodegradable and biocompatible nanocarriers with low solubility in aqueous media. We show here that stearic acid-based SLNs have the adequate particle size, polydispersity index and ζ-potential, to be considered optimal nanocarriers for drug delivery. Stearic acid-based SLNs were loaded with the fluorescent probe rhodamine to show that they are efficiently incorporated by auditory HEI-OC1 (House Ear Institute-Organ of Corti 1) cells. SLNs were not ototoxic over a wide dose range. Glucocorticoids are used to decrease cisplatin-induced ototoxicity. Therefore, to test SLNs’ drug delivery efficiency, dexamethasone and hydrocortisone were tested either alone or loaded into SLNs and tested in a cisplatin-induced ototoxicity in vitro assay. Our results indicate that the encapsulation in SLNs increases the protective effect of low doses of hydrocortisone and lengthens the survival of HEI-OC1 cells treated with cisplatin., B.C. was supported by an MSC postdoctoral contract, FP7-PEOPLE2013-IAPP TARGEAR. This work was supported by grants MINECO/FEDER (SAF2017-86107-R) and Comunidad de Madrid/FEDER MULTITARGET&VIEW-CM (B2017/BMD-3688) to I.V.N. and ELKARTEK (2017 KK-2017/00008) to I.A.

Diffuse large B-cell lymphoma (DLBCL) is a group of clinically aggressive and heterogeneous malignancies, of which approximately 60% can be cured with anthracycline-based chemoimmunotherapy. Based on gene expression profiling, DLBCL can be classified into two molecularly distinct subgroups showing

In 2012, the county of Uppland in Sweden launched a service granting patients online access to their electronic medical record (EMR), including the list of staff who have logged into the record (the “log list”). Patients seem predominantly positive to this service whereas many professionals, physicians specifically, have expressed concerns about, for example, increased risks of threats and violence towards healthcare staff. One year after launch the present study was conducted to examine whether staff whose patients had gained access to online EMRs experienced greater risks of threats and violence, and were exposed to more threats and violence, than those whose patients had not yet gained access. The extent to which professional role, gender, work experience and staff attitudes to the service were important factors was also examined. A total of 174 professionals at Uppsala University Hospital responded to a web survey (35% response rate). 83 represented the emergency department, whose patients had online EMR access, and 91 represented the psychiatric department, whose patients had not. 40% of all participating professionals, emergency physicians and psychiatric staff specifically, believed that risks of threats and violence increase after launch. The results did not, however, support a correlation between patient access to online EMRs and more incidents of threats and violence, and only one respondent reported that patient access had played any significant negative role in relation to an incident. These and other results may prove useful as the online EMR service is now being launched in other Swedish counties as well. År 2012 infördes inom Uppsala läns landsting en tjänst som ger patienter tillgång till sin journal via nätet, inklusive listan över personal som loggat in i journalen. Patienter har visat sig vara övervägande positiva till tjänsten, medan många vårdgivare, speciellt läkare, har uttryckt farhågor gällandes, till exempel, ökad risk för hot och våld mot vårdpersonal. Ett år efter införandet genomfördes denna enkätstudie med syfte att undersöka om sjukvårdspersonal vars patienter fått tillgång till journal via nätet upplever högre grad av risk för hot och våld samt om de i realiteten är mer utsatta för hot och våld än dem vars patienter inte fått denna tillgång. Även betydelsen av yrke, kön, arbetserfarenhet samt generell attityd till journal via nätet undersöktes i relation till hot och våldsrisker respektive utsatthet för våld. En webundersökning besvarades av 174 anställda vid Akademiska sjukhuset i Uppsala (svarsfrekvens 35 %). 83 representerade den öppna akutvårdsmottagningen, vars patienter hade tillgång till journal via nätet, och 91 representerade de slutenvårdspsykiatriska avdelningarna, vars patienter inte hade denna tillgång. 40 % av respondenterna, speciellt akutvårdsläkare och psykiatrivårdspersonal, trodde att riskerna för hot och våld ökar vid införande av journal via nätet. Resultaten påvisade dock inte någon korrelation mellan patienttillgång till journal via nätet och förekomst av hot- och våldsincidenter och endast en respondent svarade att patienttillgång spelat en betydande negativ roll i relation till en incident. Dessa och andra resultat i studien kan vara av betydelse nu när införanden av journal via nätet sprids även till andra landsting i Sverige.

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