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1. A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials

Author

European Commission, Slovenian Research Agency, Norwegian Research Council, Jeliazkova, Nina [0000-0002-4322-6179], Longhin, Eleonora [0000-0002-3939-7135], El Yamani, Naouale [0000-0001-5456-8230], Rundén-Pran, Elise [0000-0002-5541-4513], Moschini, Elisa [0000-0001-9825-6263], Serchi, Tommaso [0000-0003-2386-3514], Vrček, Ivana Vinković [0000-0003-1382-5581], Burgum, Michael J. [0000-0002-3123-8914], Doak, Shareen H. [0000-0002-6753-1987], Cimpan, Mihaela Roxana [0000-0003-2029-3173], Battistelli, Chiara [0000-0003-2386-0727], Bossa, Cecilia [0000-0003-2084-2902], Tsekovska, Rositsa [0000-0001-5431-5743], Drobne, Damjana [0000-0002-5970-7460], Novak, Sara [0000-0003-0026-456X], Repar, Neža [0000-0003-4310-0362], Ammar, Ammar [0000-0002-8399-8990], Nymark, Penny [0000-0002-3435-7775], Di Battista, Veronica [0000-0002-6491-9185], Sosnowska, Anita [0000-0003-3288-4309], Puzyn, Tomasz [0000-0003-0449-8339], Kochev, Nikolay [0000-0001-6547-3675], Iliev, Luchesar [0000-0001-7000-8890], Jeliazkov, Vedrin [0000-0002-1520-5995], Reilly, Katie [0000-0002-6054-0645], Lynch, Iseult [0000-0003-4250-4584], Bakker, Martine [0000-0001-8379-7016], Delpivo, Camila [0000-0002-4413-7602], Sánchez-Jiménez, A. [0000-0002-2625-9155], Fonseca, Ana Sofia [0000-0002-1424-6365], Manier, Nicolas [0000-0003-3873-6657], Fernández-Cruz, M. L. [0000-0001-5988-1939], Rashid, Shahzad [0009-0002-3525-6607], Willighagen, Egon L. [0000-0001-7542-0286], Apostolova, Margarita D. [0000-0001-7188-506X], Dusinska, Maria [0000-0003-1358-1652], Jeliazkova, Nina, Longhin, Eleonora, El Yamani, Naouale, Rundén-Pran, Elise, Moschini, Elisa, Serchi, Tommaso, Vrček, Ivana Vinković, Burgum, Michael J., Doak, Shareen H., Cimpan, Mihaela Roxana, Rios-Mondragon, Ivan, Cimpan, Emil, Battistelli, Chiara, Bossa, Cecilia, Tsekovska, Rositsa, Drobne, Damjana, Novak, Sara, Repar, Neža, Ammar, Ammar, Nymark, Penny, Di Battista, Veronica, Sosnowska, Anita, Puzyn, Tomasz, Kochev, Nikolay, Iliev, Luchesar, Jeliazkov, Vedrin, Reilly, Katie, Lynch, Iseult, Bakker, Martine, Delpivo, Camila, Sánchez-Jiménez, A., Fonseca, Ana Sofia, Manier, Nicolas, Fernández-Cruz, M. L., Rashid, Shahzad, Willighagen, Egon L., Apostolova, Margarita D., Dusinska, Maria, European Commission, Slovenian Research Agency, Norwegian Research Council, Jeliazkova, Nina [0000-0002-4322-6179], Longhin, Eleonora [0000-0002-3939-7135], El Yamani, Naouale [0000-0001-5456-8230], Rundén-Pran, Elise [0000-0002-5541-4513], Moschini, Elisa [0000-0001-9825-6263], Serchi, Tommaso [0000-0003-2386-3514], Vrček, Ivana Vinković [0000-0003-1382-5581], Burgum, Michael J. [0000-0002-3123-8914], Doak, Shareen H. [0000-0002-6753-1987], Cimpan, Mihaela Roxana [0000-0003-2029-3173], Battistelli, Chiara [0000-0003-2386-0727], Bossa, Cecilia [0000-0003-2084-2902], Tsekovska, Rositsa [0000-0001-5431-5743], Drobne, Damjana [0000-0002-5970-7460], Novak, Sara [0000-0003-0026-456X], Repar, Neža [0000-0003-4310-0362], Ammar, Ammar [0000-0002-8399-8990], Nymark, Penny [0000-0002-3435-7775], Di Battista, Veronica [0000-0002-6491-9185], Sosnowska, Anita [0000-0003-3288-4309], Puzyn, Tomasz [0000-0003-0449-8339], Kochev, Nikolay [0000-0001-6547-3675], Iliev, Luchesar [0000-0001-7000-8890], Jeliazkov, Vedrin [0000-0002-1520-5995], Reilly, Katie [0000-0002-6054-0645], Lynch, Iseult [0000-0003-4250-4584], Bakker, Martine [0000-0001-8379-7016], Delpivo, Camila [0000-0002-4413-7602], Sánchez-Jiménez, A. [0000-0002-2625-9155], Fonseca, Ana Sofia [0000-0002-1424-6365], Manier, Nicolas [0000-0003-3873-6657], Fernández-Cruz, M. L. [0000-0001-5988-1939], Rashid, Shahzad [0009-0002-3525-6607], Willighagen, Egon L. [0000-0001-7542-0286], Apostolova, Margarita D. [0000-0001-7188-506X], Dusinska, Maria [0000-0003-1358-1652], Jeliazkova, Nina, Longhin, Eleonora, El Yamani, Naouale, Rundén-Pran, Elise, Moschini, Elisa, Serchi, Tommaso, Vrček, Ivana Vinković, Burgum, Michael J., Doak, Shareen H., Cimpan, Mihaela Roxana, Rios-Mondragon, Ivan, Cimpan, Emil, Battistelli, Chiara, Bossa, Cecilia, Tsekovska, Rositsa, Drobne, Damjana, Novak, Sara, Repar, Neža, Ammar, Ammar, Nymark, Penny, Di Battista, Veronica, Sosnowska, Anita, Puzyn, Tomasz, Kochev, Nikolay, Iliev, Luchesar, Jeliazkov, Vedrin, Reilly, Katie, Lynch, Iseult, Bakker, Martine, Delpivo, Camila, Sánchez-Jiménez, A., Fonseca, Ana Sofia, Manier, Nicolas, Fernández-Cruz, M. L., Rashid, Shahzad, Willighagen, Egon L., Apostolova, Margarita D., and Dusinska, Maria

Abstract

Making research data findable, accessible, interoperable and reusable (FAIR) is typically hampered by a lack of skills in technical aspects of data management by data generators and a lack of resources. We developed a Template Wizard for researchers to easily create templates suitable for consistently capturing data and metadata from their experiments. The templates are easy to use and enable the compilation of machine-readable metadata to accompany data generation and align them to existing community standards and databases, such as eNanoMapper, streamlining the adoption of the FAIR principles. These templates are citable objects and are available as online tools. The Template Wizard is designed to be user friendly and facilitates using and reusing existing templates for new projects or project extensions. The wizard is accompanied by an online template validator, which allows self-evaluation of the template (to ensure mapping to the data schema and machine readability of the captured data) and transformation by an open-source parser into machine-readable formats, compliant with the FAIR principles. The templates are based on extensive collective experience in nanosafety data collection and include over 60 harmonized data entry templates for physicochemical characterization and hazard assessment (cell viability, genotoxicity, environmental organism dose-response tests, omics), as well as exposure and release studies. The templates are generalizable across fields and have already been extended and adapted for microplastics and advanced materials research. The harmonized templates improve the reliability of interlaboratory comparisons, data reuse and meta-analyses and can facilitate the safety evaluation and regulation process for (nano) materials.

Published
2024

2. Safe(r) by design implementation in the nanotechnology industry

Author

European Commission, Sánchez-Jiménez, A. [0000-0002-2625-9155], Puelles, Raquel [0000-0002-7185-2177], Pérez-Fernández, Marta [0000-0002-8522-6679], Gómez-Fernández, Paloma [0000-0002-2086-0652], Barruetabeña, Leire [0000-0003-4648-9959], Jacobsen, Nicklas Raun [0000-0002-2504-2229], Suarez-Merino, Blanca [0000-0002-0201-265X], Manier, Nicolas [0000-0003-3873-6657], Trouiller, Bénédicte [0000-0003-4367-2870], Navas Antón, José María [0000-0002-7644-8499], Kalman, Judit [0000-0002-3610-1968], Salieri, Beatrice [0000-0002-8338-6206], Hischier, Roland [0000-0002-1084-7665], Handzhiyski, Yordan [0000-0002-8248-0524], Apostolova, Margarita D [0000-0001-7188-506X], Hadrup, Niels [0000-0002-1188-445X], Oudart, Yohan [0000-0001-9790-0766], Merino, Cesar [0000-0002-1414-2208], Liguori, Biase [0000-0001-9531-7796], Sabella, Stefania [0000-0003-3353-3607], Rose, Jerome [0000-0003-3071-8147], Galea, Karen S. [0000-0002-9540-8513], Stepankova, Sandra [0000-0002-9730-7302], Mouneyrac, Catherine [0000-0003-3769-0386], Barrick, Andrew [0000-0002-2653-2780], Châtel, Amélie [0000-0003-2245-0216], Dusinska, Maria [0000-0003-1358-1652], Rundén-Pran, Elise [0000-0002-5541-4513], Mariussen, Espen [0000-0001-5150-942X], Bressot, Christophe [0000-0002-3649-0596], Aguerre-Chariol, Olivier [0000-0001-9488-9530], Shandilya, Neeraj [0000-0003-3328-8517], Gomez-Cordon, Julio [0000-0002-6749-4354], Simar, Sophie [0000-0002-9144-5149], Nesslany, Fabrice [0000-0003-2846-1442], Jensen, Keld Alstrup [0000-0002-2764-3634], van Tongeren, Martie [0000-0002-1205-1898], Rodríguez Llopis, Isabel [0000-0003-1514-4800], Sánchez-Jiménez, A., Puelles, Raquel, Pérez-Fernández, Marta, Gómez-Fernández, Paloma, Barruetabeña, Leire, Jacobsen, Nicklas Raun, Suarez-Merino, Blanca, Micheletti, Christian, Manier, Nicolas, Trouiller, Bénédicte, Navas Antón, José María, Kalman, Judit, Salieri, Beatrice, Hischier, Roland, Handzhiyski, Yordan, Apostolova, Margarita D, Hadrup, Niels, Bouillard, Jacques, Oudart, Yohan, Merino, Cesar, Garcia, Erika, Liguori, Biase, Sabella, Stefania, Rose, Jerome, Masion, Armand, Galea, Karen S., Kelly, Sean, Stepankova, Sandra, Mouneyrac, Catherine, Barrick, Andrew, Châtel, Amélie, Dusinska, Maria, Rundén-Pran, Elise, Mariussen, Espen, Bressot, Christophe, Aguerre-Chariol, Olivier, Shandilya, Neeraj, Goede, Henk, Gomez-Cordon, Julio, Simar, Sophie, Nesslany, Fabrice, Jensen, Keld Alstrup, van Tongeren, Martie, Rodríguez Llopis, Isabel, European Commission, Sánchez-Jiménez, A. [0000-0002-2625-9155], Puelles, Raquel [0000-0002-7185-2177], Pérez-Fernández, Marta [0000-0002-8522-6679], Gómez-Fernández, Paloma [0000-0002-2086-0652], Barruetabeña, Leire [0000-0003-4648-9959], Jacobsen, Nicklas Raun [0000-0002-2504-2229], Suarez-Merino, Blanca [0000-0002-0201-265X], Manier, Nicolas [0000-0003-3873-6657], Trouiller, Bénédicte [0000-0003-4367-2870], Navas Antón, José María [0000-0002-7644-8499], Kalman, Judit [0000-0002-3610-1968], Salieri, Beatrice [0000-0002-8338-6206], Hischier, Roland [0000-0002-1084-7665], Handzhiyski, Yordan [0000-0002-8248-0524], Apostolova, Margarita D [0000-0001-7188-506X], Hadrup, Niels [0000-0002-1188-445X], Oudart, Yohan [0000-0001-9790-0766], Merino, Cesar [0000-0002-1414-2208], Liguori, Biase [0000-0001-9531-7796], Sabella, Stefania [0000-0003-3353-3607], Rose, Jerome [0000-0003-3071-8147], Galea, Karen S. [0000-0002-9540-8513], Stepankova, Sandra [0000-0002-9730-7302], Mouneyrac, Catherine [0000-0003-3769-0386], Barrick, Andrew [0000-0002-2653-2780], Châtel, Amélie [0000-0003-2245-0216], Dusinska, Maria [0000-0003-1358-1652], Rundén-Pran, Elise [0000-0002-5541-4513], Mariussen, Espen [0000-0001-5150-942X], Bressot, Christophe [0000-0002-3649-0596], Aguerre-Chariol, Olivier [0000-0001-9488-9530], Shandilya, Neeraj [0000-0003-3328-8517], Gomez-Cordon, Julio [0000-0002-6749-4354], Simar, Sophie [0000-0002-9144-5149], Nesslany, Fabrice [0000-0003-2846-1442], Jensen, Keld Alstrup [0000-0002-2764-3634], van Tongeren, Martie [0000-0002-1205-1898], Rodríguez Llopis, Isabel [0000-0003-1514-4800], Sánchez-Jiménez, A., Puelles, Raquel, Pérez-Fernández, Marta, Gómez-Fernández, Paloma, Barruetabeña, Leire, Jacobsen, Nicklas Raun, Suarez-Merino, Blanca, Micheletti, Christian, Manier, Nicolas, Trouiller, Bénédicte, Navas Antón, José María, Kalman, Judit, Salieri, Beatrice, Hischier, Roland, Handzhiyski, Yordan, Apostolova, Margarita D, Hadrup, Niels, Bouillard, Jacques, Oudart, Yohan, Merino, Cesar, Garcia, Erika, Liguori, Biase, Sabella, Stefania, Rose, Jerome, Masion, Armand, Galea, Karen S., Kelly, Sean, Stepankova, Sandra, Mouneyrac, Catherine, Barrick, Andrew, Châtel, Amélie, Dusinska, Maria, Rundén-Pran, Elise, Mariussen, Espen, Bressot, Christophe, Aguerre-Chariol, Olivier, Shandilya, Neeraj, Goede, Henk, Gomez-Cordon, Julio, Simar, Sophie, Nesslany, Fabrice, Jensen, Keld Alstrup, van Tongeren, Martie, and Rodríguez Llopis, Isabel

Abstract

The implementation of Safe(r) by Design (SbD) in industrial innovations requires an integrated approach where the human, environmental and economic impact of the SbD measures is evaluated across and throughout the nanomaterial (NM) life cycle. SbD was implemented in six industrial companies where SbD measures were applied to NMs, nano-enabled products (NEPs) and NM/NEP manufacturing processes. The approach considers human and environmental risks, functionality of the NM/NEP and costs as early as possible in the innovation process, continuing throughout the innovation progresses. Based on the results of the evaluation, a decision has to be made on whether to continue, stop or re-design the NM/NEP/process or to carry out further tests/obtain further data in cases where the uncertainty of the human and environmental risks is too large. However, SbD can also be implemented at later stages when there is already a prototype product or process available, as demonstrated in some of the cases. The SbD measures implemented in some of the case studies did not result in a viable solution. For example the coating of silicon nanoparticles with amorphous carbon increased the conductivity, the stability and reduced the dustiness of the particles and therefore the risk of explosion and the exposure to workers. However the socioeconomic assessment for their use in lithium-ion batteries for cars, when compared to the use of graphite, showed that the increase in performance did not overcome the higher production costs. This work illustrates the complexities of selecting the most appropriate SbD measures and highlights that SbD cannot be solely based on a hazard and exposure assessment but must include other impacts that any SbD measures may have on sustainability including energy consumption and waste generation as well as all associated monetary costs.

Published
2020

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