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152 results on '"Saarela, Seppo"'

4. Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides)

Author

Niiranen, Laura, primary, Mäkelä, Kari A., additional, Mutt, Shivaprakash J., additional, Viitanen, Riikka, additional, Kaisanlahti, Anna, additional, Vicente, David, additional, Noponen, Tommi, additional, Autio, Anu, additional, Roivainen, Anne, additional, Nuutila, Pirjo, additional, Saarela, Seppo, additional, and Herzig, Karl-Heinz, additional

Published
2021
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6. Seasonal Regulation of Metabolism: The Effect of Wintertime Fasting and Autumnal Fattening on Key Central Regulators of Metabolism and the Metabolic Profile of the Raccoon Dog (Nyctereutes Procyonoides)

Author

Niiranen, Laura, primary, Mäkelä, Kari A., additional, Dona, Anthony, additional, Krumsiek, Jan, additional, Karhu, Toni, additional, Mäkinen, Markus J., additional, Thalmann, Olaf, additional, Saarela, Seppo, additional, and Herzig, Karl-Heinz, additional

Published
2021
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15. Melatonin prevents the suppression of cardiac Ca(super 2+) stimulated ATPase activity induced by alloxan

Author

Chen, Li-Dun, Kumar, Pramod, Reiter, Russel J., Tan, Dun-Xian, Manchester, Lucien C., Chambers, James P., Poeggeler, Burkhard, and Saarela, Seppo

Subjects
Melatonin -- Research, Adenosine triphosphatase -- Research, Calcium channels -- Research, Biological sciences
Abstract

Melatonin disrupts the alloxan-initiated inhibition of cardiac calcium ion-stimulated ATPase activity. Alloxan-induced toxicity of cardiac sarcolemma causes Ca2+-pump activity repression but increases the voltage-sensitive calcium channel density. The anti-oxidant ability of melatonin promotes a protective influence on heart sarcolemmal membrane activity in alloxan-infused rats.

Published
1994

19. The distribution of melanopsin (OPN4) protein in the human brain

Author

Nissilä, Juuso S., primary, Mänttäri, Satu K., additional, Särkioja, Terttu T., additional, Tuominen, Hannu J., additional, Takala, Timo E., additional, Kiviniemi, Vesa J., additional, Sormunen, Raija T., additional, Saarela, Seppo Y. O., additional, and Timonen, Markku J., additional

Published
2016
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20. Shivering and digestion-related thermogenesis in pigeons during dark phase

Author

RASHOTTE, MICHAEL E., SAARELA, SEPPO, HENDERSON, ROSS P., and HOHTOLA, ESA

Subjects
Physiology -- Research, Thermogenesis -- Physiological aspects, Fasting -- Physiological aspects, Birds -- Physiological aspects, Biological sciences
Abstract

Rashotte, Michael E., Seppo Saarela, Ross P. Henderson, and Esa Hohtola. Shivering and digestion-related thermogenesis in pigeons during dark phase. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1579-R1587, 1999.--The pigeon's main source of regulated heat production, shivering, is especially likely to be used for thermoregulation during the dark phase of the day when there is little heat from locomotor activity. However, food stored in the pigeon's crop is digested during the night, and digestion-related thermogenesis (DRT) will provide heat that should decrease the need for shivering to maintain body temperature (Tb). We investigated the conditions under which DRT alters the occurrence of nocturnal shivering thermogenesis in pigeons. In fasting experiments, in which DRT was minimal, variations in pectoral shivering were closely related to the kinetics of nocturnal Tb when the ambient temperature (Ta) was moderate (21 [degrees] C). In that case, shivering was low while Tb fell at the beginning of the night, moderate during the nocturnal plateau in Tb, and strong during the prelight increase in Tb. Similar kinetics of nocturnal Tb occurred when Ta = 28 [degrees] C, but shivering was negligible throughout the dark phase. In restricted feeding experiments, nocturnal DRT was varied by providing different amounts of food late in the light phase. When Ta = 21 [degrees] C, 11 [degrees] C, and 1 [degrees] C, nocturnal Tb and [O.sub.2] consumption were directly related to the amount of food ingested. However, nocturnal shivering tended to decrease as the food load increased and was significantly reduced at the higher loads. Because nocturnal shivering did not become more efficient in producing heat as the size of the food load increased, we conclude that nocturnal DRT decreased the need for shivering thermogenesis. fasting; restricted feeding; body temperature; energy reserves; birds; circadian

Published
1999

24. The distribution of melanopsin (OPN4) protein in the human brain.

Author

Nissilä, Juuso S., Mänttäri, Satu K., Särkioja, Terttu T., Tuominen, Hannu J., Takala, Timo E., Kiviniemi, Vesa J., Sormunen, Raija T., Saarela, Seppo Y. O., and Timonen, Markku J.

Subjects
MELANOPSIN, RETINAL ganglion cells, BRAIN, MESSENGER RNA, IMMUNOELECTRON microscopy, WESTERN immunoblotting
Abstract

Until now, melanopsin (OPN4) – a specialized photopigment being responsive especially to blue light wavelengths – has not been found in the human brain at protein level outside the retina. More specifically, OPN4 has only been found in about 2% of retinal ganglion cells (i.e. in intrinsically photosensitive retinal ganglion cells), and in a subtype of retinal cone-cells. Given that Allen Institute for Brain Science has described a wide distribution of OPN4 mRNA in two human brains, we aimed to investigate whether OPN4 is present in the human brain also at protein level. Western blotting and immunohistochemistry, as well as immunoelectron microscopy, were used to analyse the existence and distribution of OPN4 protein in 18 investigated areas of the human brain in samples obtained in forensic autopsies from 10 male subjects (54 ± 3.5 years). OPN4 protein expression was found in all subjects, and, furthermore, in 5 out of 10 subjects in all investigated brain areas localized in membranous compartments and cytoplasmic vesicles of neurons. To our opinion, the wide distribution of OPN4 in central areas of the human brain evokes a question whether ambient light has important straight targets in the human brain outside the retinohypothalamic tract (RHT). Further studies are, however, needed to investigate the putative physiological phototransductive actions of inborn OPN4 protein outside the RHT in the human brain. [ABSTRACT FROM AUTHOR]

Published
2017
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28. Rapid Development of Fasting-Induced Hepatic Lipidosis in the American Mink (Neovison vison): Effects of Food Deprivation and Re-Alimentation on Body Fat Depots, Tissue Fatty Acid Profiles, Hematology and Endocrinology

Author

Rouvinen-Watt, Kirsti, primary, Mustonen, Anne-Mari, additional, Conway, Rebecca, additional, Pal, Catherine, additional, Harris, Lora, additional, Saarela, Seppo, additional, Strandberg, Ursula, additional, and Nieminen, Petteri, additional

Published
2009
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33. Transcranial light affects plasma monoamine levels and expression of brain encephalopsin in the mouse.

Author

Flyktman, Antti, Mänttäri, Satu, Nissilä, Juuso, Timonen, Markku, and Saarela, Seppo

Subjects
OPSINS, BRAIN physiology, RETINA, PHYSIOLOGICAL effects of light, CIRCADIAN rhythms, AMINES, LABORATORY mice, WESTERN immunoblotting
Abstract

Encephalopsin (OPN3) belongs to the light-sensitive transmembrane receptor family mainly expressed in the brain and retina. It is believed that light affects mammalian circadian rhythmicity only through the retinohypothalamic tract, which transmits light information to the suprachiasmatic nucleus in the hypothalamus. However, it has been shown that light penetrates the skull. Here, we present the effect of transcranial light treatment on OPN3 expression and monoamine concentrations in mouse brain and other tissues. Mice were randomly assigned to control group, morning-light group and evening-light group, and animals were illuminated transcranially five times a week for 8 min for a total of 4 weeks. The concentrations of OPN3 and monoamines were analysed using western blotting and HPLC, respectively. We report that transcranial light treatment affects OPN3 expression in different brain areas and plasma/adrenal gland monoamine concentrations. In addition, when light was administered at a different time of the day, the response varied in different tissues. These results provide new information on the effects of light on transmittersmediating mammalian rhythmicity. [ABSTRACT FROM AUTHOR]

Published
2015
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