50 results on '"Saba, Raya"'
Search Results
2. An international analysis evaluating frontline bendamustine with rituximab in extranodal marginal zone lymphoma
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Alderuccio, Juan Pablo, Arcaini, Luca, Watkins, Marcus P., Beaven, Anne W., Shouse, Geoffrey, Epperla, Narendranath, Spina, Michele, Stefanovic, Alexandra, Sandoval-Sus, Jose, Torka, Pallawi, Alpert, Ash B., Olszewski, Adam J., Kim, Seo-Hyun, Hess, Brian, Gaballa, Sameh, Ayyappan, Sabarish, Castillo, Jorge J., Argnani, Lisa, Voorhees, Timothy J., Saba, Raya, Chowdhury, Sayan Mullick, Vargas, Fernando, Reis, Isildinha M., Kwon, Deukwoo, Alexander, Jonathan S., Zhao, Wei, Edwards, Dali, Martin, Peter, Cencini, Emanuele, Kamdar, Manali, Link, Brian K., Logothetis, Constantine N., Herrera, Alex F., Friedberg, Jonathan W., Kahl, Brad S., Luminari, Stefano, Zinzani, Pier Luigi, and Lossos, Izidore S.
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- 2022
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3. Multicenter Analysis of Advanced Stage Grade 3A Follicular Lymphoma Outcomes by Frontline Treatment Regimen
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Shah, Nirav N., Szabo, Aniko, Saba, Raya, Strelec, Lauren, Kodali, Dheeraj, Vaughn, John L., Esan, Olukemi, Yang, David T., Mato, Anthony R., Kanate, Abraham S., Olteanu, Horatiu, Hamadani, Mehdi, Fenske, Timothy S., Kenkre, Vaishalee P., Svoboda, Jakub, Cashen, Amanda F., and Epperla, Narendranath
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- 2019
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4. Overall survival of cHL patients who progress after autologous stem cell transplant: results in novel agent era.
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Desai, Sanjal H., primary, Spinner, Michael A., additional, Evens, Andrew M, additional, Sýkorová, Alice, additional, Bachanova, Veronika, additional, Goyal, Gaurav, additional, Kahl, Brad S, additional, Dorritie, Kathleen A, additional, Azzi, Jacques, additional, Kenkre, Vaishalee P., additional, Chang, Cheryl, additional, Michalka, Jozef, additional, Ansell, Stephen M., additional, Fusco, Brendon, additional, Sumransub, Nuttavut, additional, Hatic, Haris, additional, Saba, Raya, additional, Ibrahim, Uroosa, additional, Harris, Elyse I., additional, Shah, Harsh R., additional, Wagner-Johnston, Nina D., additional, Arai, Sally, additional, Nowakowski, Grzegorz S., additional, Mocikova, Heidi, additional, Jagadeesh, Deepa, additional, Blum, Kristie, additional, Diefenbach, Catherine, additional, Iyengar, Siddharth, additional, Rappazzo, Katherine Cynthia, additional, Baidoun, Firas, additional, Choi, Yun, additional, Prochazka, Vit, additional, Advani, Ranjana H, additional, and Micallef, Ivana N., additional
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- 2023
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5. Mycobacterium kansasii Infection in a Patient Receiving Biologic Therapy—Not All Reactive Interferon Gamma Release Assays Are Tuberculosis
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Saleem, Nasir, Saba, Raya, Maddika, Srikanth, and Weinstein, Mitchell
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- 2017
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6. Supplementary Table from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
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Menssen, Andrew J., primary, Khanna, Ajay, primary, Miller, Christopher A., primary, Nonavinkere Srivatsan, Sridhar, primary, Chang, Gue Su, primary, Shao, Jin, primary, Robinson, Joshua, primary, O'Laughlin, Michele, primary, Fronick, Catrina C., primary, Fulton, Robert S., primary, Brendel, Kimberly, primary, Heath, Sharon E., primary, Saba, Raya, primary, Welch, John S., primary, Spencer, David H., primary, Payton, Jacqueline E., primary, Westervelt, Peter, primary, DiPersio, John F., primary, Link, Daniel C., primary, Schuelke, Matthew J., primary, Jacoby, Meagan A., primary, Duncavage, Eric J., primary, Ley, Timothy J., primary, and Walter, Matthew J., primary
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- 2023
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7. Supplementary Figure from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
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Menssen, Andrew J., primary, Khanna, Ajay, primary, Miller, Christopher A., primary, Nonavinkere Srivatsan, Sridhar, primary, Chang, Gue Su, primary, Shao, Jin, primary, Robinson, Joshua, primary, O'Laughlin, Michele, primary, Fronick, Catrina C., primary, Fulton, Robert S., primary, Brendel, Kimberly, primary, Heath, Sharon E., primary, Saba, Raya, primary, Welch, John S., primary, Spencer, David H., primary, Payton, Jacqueline E., primary, Westervelt, Peter, primary, DiPersio, John F., primary, Link, Daniel C., primary, Schuelke, Matthew J., primary, Jacoby, Meagan A., primary, Duncavage, Eric J., primary, Ley, Timothy J., primary, and Walter, Matthew J., primary
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- 2023
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8. Data from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
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Menssen, Andrew J., primary, Khanna, Ajay, primary, Miller, Christopher A., primary, Nonavinkere Srivatsan, Sridhar, primary, Chang, Gue Su, primary, Shao, Jin, primary, Robinson, Joshua, primary, O'Laughlin, Michele, primary, Fronick, Catrina C., primary, Fulton, Robert S., primary, Brendel, Kimberly, primary, Heath, Sharon E., primary, Saba, Raya, primary, Welch, John S., primary, Spencer, David H., primary, Payton, Jacqueline E., primary, Westervelt, Peter, primary, DiPersio, John F., primary, Link, Daniel C., primary, Schuelke, Matthew J., primary, Jacoby, Meagan A., primary, Duncavage, Eric J., primary, Ley, Timothy J., primary, and Walter, Matthew J., primary
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- 2023
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9. Supplementary Data from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
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Menssen, Andrew J., primary, Khanna, Ajay, primary, Miller, Christopher A., primary, Nonavinkere Srivatsan, Sridhar, primary, Chang, Gue Su, primary, Shao, Jin, primary, Robinson, Joshua, primary, O'Laughlin, Michele, primary, Fronick, Catrina C., primary, Fulton, Robert S., primary, Brendel, Kimberly, primary, Heath, Sharon E., primary, Saba, Raya, primary, Welch, John S., primary, Spencer, David H., primary, Payton, Jacqueline E., primary, Westervelt, Peter, primary, DiPersio, John F., primary, Link, Daniel C., primary, Schuelke, Matthew J., primary, Jacoby, Meagan A., primary, Duncavage, Eric J., primary, Ley, Timothy J., primary, and Walter, Matthew J., primary
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- 2023
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10. Checkpoint Inhibitors Based Salvage Regimens Lead to Higher Survival in Relapsed Refractory Classic Hodgkin Lymphoma Undergoing Autologous Stem Cell Transplant
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Desai, Sanjal H, primary, Spinner, Michael A, additional, David, Kevin, additional, Bachanova, Veronika, additional, Goyal, Gaurav, additional, Kahl, Brad S., additional, Dorritie, Kathleen, additional, Azzi, Jacques, additional, Kenkre, Vaishalee P, additional, Arai, Sally, additional, Chang, Cheryl, additional, Fusco, Brendon, additional, Sumransub, Nuttavut, additional, Hactic, Haris, additional, Saba, Raya, additional, Ibrahim, Uroosa, additional, Harris, Elyse I, additional, Maurer, Matthew J, additional, Shah, Harsh, additional, Wagner-Johnston, Nina, additional, Jagadeesh, Deepa, additional, Orellana-Noia, Victor, additional, Diefenbach, Catherine, additional, Iyengar, Siddharth, additional, Rappazzo, KC, additional, Mishra, Rahul, additional, Choi, Yun, additional, Nowakowski, Grzegorz S, additional, Advani, Ranjana, additional, and Micallef, Ivana N, additional
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- 2023
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11. Checkpoint inhibitor‐based salvage regimens prior to autologous stem cell transplant improve event‐free survival in relapsed/refractory classic Hodgkin lymphoma
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Desai, Sanjal H., primary, Spinner, Michael A., additional, David, Kevin, additional, Bachanova, Veronika, additional, Goyal, Gaurav, additional, Kahl, Brad, additional, Dorritie, Kathleen, additional, Azzi, Jacques, additional, Kenkre, Vaishalee P., additional, Arai, Sally, additional, Chang, Cheryl, additional, Fusco, Brendon, additional, Sumransub, Nuttavut, additional, Hatic, Haris, additional, Saba, Raya, additional, Ibrahim, Uroosa, additional, Harris, Elyse I., additional, Shah, Harsh, additional, Murphy, Jacob, additional, Ansell, Stephen, additional, Jagadish, Deepa, additional, Orellana‐noia, Victor, additional, Diefenbach, Catherine, additional, Iyenger, Siddharth, additional, Rappazzo, K. C., additional, Mishra, Rahul, additional, Choi, Yun, additional, Nowakowski, Grzegorz S., additional, Advani, Ranjana H., additional, and Micallef, Ivana N., additional
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- 2023
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12. Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression
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Menssen, Andrew J., primary, Khanna, Ajay, additional, Miller, Christopher A., additional, Nonavinkere Srivatsan, Sridhar, additional, Chang, Gue Su, additional, Shao, Jin, additional, Robinson, Joshua, additional, O'Laughlin, Michele, additional, Fronick, Catrina C., additional, Fulton, Robert S., additional, Brendel, Kimberly, additional, Heath, Sharon E., additional, Saba, Raya, additional, Welch, John S., additional, Spencer, David H., additional, Payton, Jacqueline E., additional, Westervelt, Peter, additional, DiPersio, John F., additional, Link, Daniel C., additional, Schuelke, Matthew J., additional, Jacoby, Meagan A., additional, Duncavage, Eric J., additional, Ley, Timothy J., additional, and Walter, Matthew J., additional
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- 2022
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13. Outcomes of classic Hodgkin lymphoma, relapsed within one year of diagnosis, in the era of novel agents.
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Desai, Sanjal, primary, Spinner, Michael Alexander, additional, David, Kevin A., additional, Bachanova, Veronika, additional, Goyal, Gaurav, additional, Saba, Raya, additional, Dorritie, Kathleen Anne, additional, Azzi, Jacques Mario, additional, Harris, Elyse, additional, Fusco, Brendon, additional, Sumransub, Nuttavut, additional, Hatic, Haris, additional, Ibrahim, Uroosa, additional, Iyengar, Siddharth, additional, Rappazzo, Katherine Cynthia, additional, Baidoun, Firas, additional, Orellana-Noia, Victor Manuel, additional, Magid Diefenbach, Catherine S., additional, Advani, Ranjana H., additional, and Micallef, Ivana N. M., additional
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- 2022
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14. Long-term survival consequent on the abscopal effect in a patient with multiple myeloma
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Saba, Raya, Saleem, Nasir, and Peace, David
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- 2016
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15. Kaposi sarcoma: an unusual cause of gastrointestinal bleeding
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Akanbi, Olalekan, Saleem, Nasir, Maddika, Srikanth, and Saba, Raya
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- 2016
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16. Isolated case of left ventricular diverticulum; other aneurysmal structures of the left ventricle
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Khreis, Mahmoud, Saleem, Nasir, and Saba, Raya
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- 2016
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17. Engraftment Syndrome in Patients with Relapsed Refractory Classical Hodgkin Lymphoma Who Received PD-1 Blockade Containing Salvage Therapy Followed By Autologous Stem Cell Transplantation
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Saba, Raya, primary, Augustin, Kristan, additional, Ryan, Meaghan, additional, Bartlett, Nancy L., additional, and Cashen, Amanda, additional
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- 2022
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18. Sinus pericranii in a young adult with chronic headache
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Saba, Raya, Senussi, Mourad H, Alwakkaf, Ahmad, and Brown, Harry
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- 2013
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19. Predictors of Relapse and Survival Following Autologous Stem Cell Transplant in Patients with Diffuse Large B-Cell Lymphoma
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Todd A. Fehniger, Marie Hu, Marcus Watkins, David A. Russler-Germain, Qing Cao, Saba Raya, Veronika Bachanova, and Daniel J. Weisdorf
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Pathology ,medicine.medical_specialty ,business.industry ,Immunology ,medicine ,In patient ,Cell Biology ,Hematology ,Stem cell ,business ,medicine.disease ,Biochemistry ,Diffuse large B-cell lymphoma - Abstract
Background: Although the majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured with intensive chemotherapy and rituximab, 30-40% of patients will be refractory to or relapse after first line treatment. For these patients, the current standard of care is salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation (ASCT). Prior studies have largely examined clinical risk factors associated with higher risk of relapse after ASCT; however, there is limited data integrating both pathologic and molecular features. Thus, we aimed to identify high-risk features associated with relapse and survival after ASCT using a combination of clinical, molecular, pathologic, and transplant characteristics. Methods: We retrospectively analyzed the medical records of all adult patients with DLBCL who underwent ASCT at our two institutions from 2010 to 2020. Patients with primary CNS lymphoma, primary mediastinal B-cell lymphoma, or Burkitt lymphoma were excluded. We analyzed demographics, clinical characteristics, cell of origin (COO) by immunohistochemistry (IHC), fluorescence in-situ hybridization (FISH) testing, and treatment/transplant characteristics. The primary endpoints were 3-year progression-free survival (PFS) and overall survival (OS) from ASCT. The Kaplan-Meier method was used to estimate survival with univariate and multivariate Cox proportional hazards regression performed to identify factors associating with PFS and OS, summarized using hazard ratios (HR) with 95% confidence intervals (CI). Results: A total of 235 DLBCL patients underwent ASCT from 2010 to 2020. Median age at ASCT was 61 years (range: 25-75) and 63% were male. At DLBCL diagnosis, 80% had advanced stage disease, 74% had extranodal involvement, 13% had poor performance status, and 65% had elevated lactate dehydrogenase (LDH). 71 patients (30%) had a prior or concurrent indolent lymphoma diagnosis indicating transformed disease. Of the patients with available COO and molecular data, 115 (60%) had germinal center B-cell (GCB) phenotype by IHC, 10 (6%) had a single MYC rearrangement by FISH, and 35 (22%) had MYC plus BCL2 and/or BCL6 rearrangements (DHL/THL). After first-line treatment, 12% remained refractory and 62% later relapsed at a median of 13 months (range: 1-240). Patients received a median of 2 (range: 1-5) lines of treatment pre-ASCT. At time of ASCT, 66% were in complete response (CR) and 32% were in partial response (PR) by standard of care imaging and response criteria. With median follow-up of 5.2 years from time of ASCT, 98 patients (42%) relapsed and 78 (33%) died. 3-year PFS and OS were 58% (95% CI 51-64%) and 74% (95% CI 67-79%), respectively. In univariate analysis, factors associated with worse PFS and worse OS included 3 or more lines of treatment pre-ASCT (p60 at ASCT (HR 1.92, 95% CI 1.06-3.47, p=0.03) (Figure 1C). Stratifying by COO and disease status at transplant, 3-year OS was best in the GCB/CR group (84%, 95% CI 73-90%), while worse but similar in the GCB/non-CR and non-GCB/CR groups (68%, 95% CI 51-80% and 71%, 95% CI 56-83%, respectively) (Figure 1D). The non-GCB/non-CR group had the worst 3-year OS (48%, 95% CI 27-67%). No individual factors beyond CR/non-CR at ASCT were associated with worse 3-year PFS. Notably, DHL/THL patients (77% of whom were in CR at time of ASCT) had similar PFS (p=0.08) and OS (p=0.30) to non-DHL/THL patients, suggesting that response to therapy may be more prognostic than high-risk molecular features alone. Conclusions: This analysis indicated that factors associated with OS after ASCT were disease status at time of transplant and COO, with non-GCB patients not in CR having the poorest outcomes. GCB patients not in CR were still able to be cured by ASCT at a high rate. Molecular rearrangements including DHL/THL were not prognostic, although interpretation may be limited by the modest number of DHL/THL patients. These findings may inform which patients should undergo ASCT, while the highest risk group may be better treated with alternatives including novel targeted agents or chimeric antigen receptor cell therapy. Figure 1 Figure 1. Disclosures Bachanova: FATE: Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Research Funding; KaryoPharma: Membership on an entity's Board of Directors or advisory committees; Gamida Cell: Membership on an entity's Board of Directors or advisory committees, Research Funding. Fehniger: Compass Therapeutics: Research Funding; Affimed: Research Funding; ImmunityBio: Research Funding; Wugen: Consultancy, Current equity holder in publicly-traded company, Patents & Royalties: related to memory like NK cells, Research Funding; OrcaBio: Other; Kiadis: Other; HCW Biologics: Research Funding; Indapta: Other. Weisdorf: Fate Therapeutics: Research Funding; Incyte: Research Funding.
- Published
- 2021
20. Novel Salvage Regimens Lead to Better Response and Survival in Relapsed Refractory Classic Hodgkin Lymphoma after Autologous Stem Cell Transplant
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Saba Raya, Catherine Diefenbach, Nuttavut Sumransub, Jacques Azzi, Sanjal Desai, Grzegorz S. Nowakowski, Sally Arai, Michael A. Spinner, Gaurav Goyal, Vaishalee P. Kenkre, Haris Hactic, Victor M. Orellana-Noia, Ranjana H. Advani, Ivana N. Micallef, Matthew J. Maurer, Elyse I. Harris, Veronika Bachanova, Uroosa Ibrahim, Kevin A. David, Cheryl H. Chang, KC Rappazzo, Brendon Fusco, and Kathleen A. Dorritie
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Oncology ,medicine.medical_specialty ,business.industry ,Immunology ,Cell Biology ,Hematology ,Biochemistry ,Internal medicine ,Relapsed refractory ,medicine ,Hodgkin lymphoma ,Stem cell ,Lead (electronics) ,business - Abstract
Introduction: Clinical trials of novel salvage therapies (ST) have encouraging outcomes for relapsed/refractory classic Hodgkin lymphoma (R/R cHL) after autologous stem cell transplant (ASCT); yet studies comparing novel ST with conventional salvage chemotherapy are lacking. In a single center cohort, we demonstrated that bendamustine/brentuximab (BBV) had higher overall response rates (ORR) and complete response (CR) rates in ASCT-eligible R/R cHL (Desai et al JCO, 2021). Herein we report comparative outcomes of novel and conventional ST in R/R cHL who undergo ASCT, in a large multicenter retrospective cohort. Methods: Consecutive R/R cHL pts who underwent ASCT at 12 institutions across United States were included. Demographics and clinical variables at relapse including age, sex, B symptoms, stage, bulky disease (BD, single mass > 6 cm) extra nodal disease (END), primary refractory disease (PRD) and early relapse (ER, within 1 year) were recorded by electronic health records review. Study objectives were ORR, CR to first ST, post-ASCT PFS and OS by final ST. Time to event endpoints were defined from date of ASCT. Results: From 12 participating institutions, 853 pts of R/R cHL who underwent ASCT were eligible for this study. Median age was 33 (14-72) years, 457 (54%) were male, 446 (52%) had BD, 257 (30%) had advanced stage, 271 (32%) had END, 369 (43%) had B symptoms, 142 (17%) had PRD and 307 (36%) had ER. All 853 received at least 1 ST, 245 received 2 ST, 71 received 3 ST and 26 received 4 ST. Seven groups of ST were identified: 1. Conventional platinum-based chemotherapy (PBC) group including ICE, DHAP and ESHAP 2. BBV 3. Brentuximab Vedotin and nivolumab (BV/Nivo) 4. BV alone (BV) 5. gemcitabine-based chemotherapy (Gem) 6. checkpoint inhibitors (CPI) and 7. other miscellaneous agents (Misc). 1st ST was as follows: 553 had PBC; 69 had BBV; 48 had BV/Nivo; 65 had BV; 49 had Gem; 4 had CPI and 63 had Misc. There was no significant difference in the baseline characteristics by type of 1 st ST (data not shown). BBV had significantly higher ORR (92% vs 79%, p Final ST prior to ASCT was PBC in 451, BBV in 76, BV/Nivo in 48, BV in 87, CPI in 24, Gem in 90 and Misc in 64. Table 1 lists K-M estimates of 2-year survival probabilities for different Final ST groups. Median follow up was 3 (range 0.1-13) years. BV/Nivo group had significantly higher proportion of patients with PRD and BD than PBC, no other differences in baseline characteristics were identified amongst ST groups (data not shown). BV/Nivo (HR: 0.1 (CI 95:0.02-0.4), p 536 pts underwent ASCT in CR, 273 underwent ASCT in partial response (PR) and 31 underwent ASCT with progressive disease (PD). Pre-ASCT PR (HR 1.6 (CI 95:1.3-2.6), p In pts with pre-ASCT CR, all 36 who had pre-ASCT CR after BV/Nivo were alive and relapse free for follow up of 0.1-5 yrs. BV/Nivo was associated with significantly higher PFS (HR 0.1 (CI 95: 0.01-0.7), p Conclusions: BV/Nivo has a higher CR rate and better post-ASCT PFS compared to conventional chemotherapy and can lead to durable remissions in pts with pre-ASCT CR. BBV had a higher response rate and similar post-ASCT survival to conventional chemotherapy. BV had lower response rates compared to chemotherapy. Novel ST such as BV/Nivo and BBV may be preferable to conventional chemotherapy in R/R cHL. Figure 1 Figure 1. Disclosures Spinner: Notable Labs: Honoraria. Bachanova: FATE: Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte: Research Funding; KaryoPharma: Membership on an entity's Board of Directors or advisory committees; Gamida Cell: Membership on an entity's Board of Directors or advisory committees, Research Funding. Dorritie: SITC presentation: Honoraria; Genmab: Research Funding; University of Pittsburgh/UPMC Hillman Cancer Center: Current Employment; Janssen: Research Funding; F. Hoffman-La Roche Ltd: Research Funding; Juno/BMS: Research Funding; Kite, a Gilead Company: Research Funding; OncLive/Institutional Perspectives on Cancer presentation: Honoraria. Arai: Magenta Therapeutics: Research Funding. Maurer: Nanostring: Research Funding; Morphosys: Membership on an entity's Board of Directors or advisory committees, Research Funding; Kite Pharma: Membership on an entity's Board of Directors or advisory committees; Genentech: Research Funding; Celgene: Research Funding; Pfizer: Consultancy, Membership on an entity's Board of Directors or advisory committees. Diefenbach: Genentech, Inc./ F. Hoffmann-La Roche Ltd: Consultancy, Honoraria, Research Funding; Seattle Genetics: Consultancy, Honoraria, Research Funding; Janssen: Consultancy, Honoraria, Research Funding; Celgene: Research Funding; IMab: Research Funding; Morphosys: Consultancy, Honoraria, Research Funding; Bristol-Myers Squibb: Consultancy, Honoraria, Research Funding; Merck Sharp & Dohme: Consultancy, Honoraria, Research Funding; Perlmutter Cancer Center at NYU Langone Health: Current Employment; AbbVie: Research Funding; IGM Biosciences: Research Funding; Incyte: Research Funding; Trillium: Research Funding; Gilead: Current equity holder in publicly-traded company; MEI: Consultancy, Research Funding. Nowakowski: Kyte Pharma: Consultancy; Ryvu Therapeutics: Consultancy; Selvita: Consultancy; Curis: Consultancy; Karyopharm Therapeutics: Consultancy; Celgene/Bristol Myers Squibb: Consultancy, Research Funding; Roche: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; MorphoSys: Consultancy; Bantham Pharmaceutical: Consultancy; Daiichi Sankyo: Consultancy; Zai Labolatory: Consultancy; Incyte: Consultancy; Kymera Therapeutics: Consultancy; TG Therapeutics: Consultancy; Blueprint Medicines: Consultancy; Nanostrings: Research Funding. Advani: Astellas/Agensys: Research Funding; AstraZeneca: Membership on an entity's Board of Directors or advisory committees; Bayer: Membership on an entity's Board of Directors or advisory committees; Bristol Myer Squibb: Membership on an entity's Board of Directors or advisory committees; Cell Medica: Membership on an entity's Board of Directors or advisory committees; Forty Seven: Membership on an entity's Board of Directors or advisory committees, Research Funding; Genetech Inc.: Membership on an entity's Board of Directors or advisory committees, Research Funding; Gilead: Membership on an entity's Board of Directors or advisory committees; Janssen Pharmaceutical: Research Funding; Juno: Membership on an entity's Board of Directors or advisory committees; Kite Pharma: Membership on an entity's Board of Directors or advisory committees; Kura: Research Funding; Kyowa: Membership on an entity's Board of Directors or advisory committees; Merck: Research Funding; Millenium: Research Funding; Pharmacyclics: Consultancy, Research Funding; Portola Pharmaceuticals: Consultancy; Regeneron: Research Funding; Roche: Membership on an entity's Board of Directors or advisory committees; Sanofi: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Research Funding; Takeda: Membership on an entity's Board of Directors or advisory committees.
- Published
- 2021
21. 39 - Checkpoint Inhibitors Based Salvage Regimens Lead to Higher Survival in Relapsed Refractory Classic Hodgkin Lymphoma Undergoing Autologous Stem Cell Transplant
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Desai, Sanjal H, Spinner, Michael A, David, Kevin, Bachanova, Veronika, Goyal, Gaurav, Kahl, Brad S., Dorritie, Kathleen, Azzi, Jacques, Kenkre, Vaishalee P, Arai, Sally, Chang, Cheryl, Fusco, Brendon, Sumransub, Nuttavut, Hactic, Haris, Saba, Raya, Ibrahim, Uroosa, Harris, Elyse I, Maurer, Matthew J, Shah, Harsh, Wagner-Johnston, Nina, Jagadeesh, Deepa, Orellana-Noia, Victor, Diefenbach, Catherine, Iyengar, Siddharth, Rappazzo, KC, Mishra, Rahul, Choi, Yun, Nowakowski, Grzegorz S, Advani, Ranjana, and Micallef, Ivana N
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- 2023
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22. 520 - Engraftment Syndrome in Patients with Relapsed Refractory Classical Hodgkin Lymphoma Who Received PD-1 Blockade Containing Salvage Therapy Followed By Autologous Stem Cell Transplantation
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Saba, Raya, Augustin, Kristan, Ryan, Meaghan, Bartlett, Nancy L., and Cashen, Amanda
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- 2022
- Full Text
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23. Comparative Outcomes of Relapsed Follicular Lymphoma Patients Treated with Novel Agents: A Multi-Center Analysis
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Wei Wei, Luke D. Zurbriggen, Kami J. Maddocks, Mohammad K. Khan, Chaitra S. Ujjani, Loretta J. Nastoupil, Nilanjan Ghosh, Boyu Hu, Daniel J. Landsburg, Amy A. Ayers, Adam Kittai, Brad S. Kahl, Alexey V. Danilov, Melody R. Becnel, Sheenu Sheela, Saba Raya, Deborah M. Stephens, Andrew H. Rogers, Vaishalee P. Kenkre, Brian T. Hill, Allison M. Winter, Ryan C. Lynch, Emily C. Ayers, and Jonathon B. Cohen
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Oncology ,medicine.medical_specialty ,business.industry ,Immunology ,Follicular lymphoma ,Cell Biology ,Hematology ,medicine.disease ,Biochemistry ,Duvelisib ,Lymphoma ,Log-rank test ,chemistry.chemical_compound ,chemistry ,Internal medicine ,medicine ,Rituximab ,business ,Idelalisib ,health care economics and organizations ,Lenalidomide ,medicine.drug ,Copanlisib - Abstract
Background: Follicular lymphoma (FL) is the most common indolent lymphoma and is generally characterized by prolonged survival with multiple relapses throughout the disease course. There is no standard of care as to the initial choice or sequencing of treatments for relapsed disease. Novel agents approved in the relapsed setting include lenalidomide in combination with rituximab (R2) and PI3K inhibitors (PI3Ki) including idelalisib, duvelisib, and copanlisib. However, there are no prospective data comparing the safety/efficacy of these novel agents to guide treatment selection. We aimed to examine the characteristics and outcomes of patients with relapsed follicular lymphoma treated with these novel agents. Methods: We conducted a retrospective analysis of adult patients with FL treated with commercially-available novel agents at 10 US academic cancer centers. Patients were excluded if they received one of these therapies as first line therapy or for the treatment of transformed disease. Treatment with lenalidomide or PI3Ki was determined by the treating physician, as was the decision to incorporate monoclonal antibody (mAb). For patients who received both classes of novel agent, baseline and treatment characteristics were grouped by first novel class used. The Fisher's Exact test was used to compare categorical variables and the Mann Whitney U test for continuous variables. Progression-free survival (PFS) was defined as time from the initiation of the first novel agent to progression of disease (POD), either FL or transformed disease, or death from any cause. Overall survival (OS) was defined as time from the initiation of the first novel agent to death from any cause. Outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test. Results: 98 patients were included. Available baseline characteristics at diagnosis are described in Table 1. The median time from the end of the last FL treatment to the start of the first novel agent was 12 months (range 0-79). The first novel agent was lenalidomide +/-mAb in 49% (n=48) of the patients and a PI3Ki +/- mAb in 51% (n=50) of patients. Idelalisib was the most commonly used PI3Ki (n=47) followed by copanlisib (n=2) and duvelisib (n=1). The median number of therapies prior to the first novel agent was 2 (range 1-8) and not significantly different between treatment classes. Reason for discontinuation of novel agent was significantly different between groups with greater discontinuations due to toxicity (40% vs 28%) and transformed disease (15% vs. 3%) for the PI3Ki ± mAb group vs. lenalidomide ± mAb group, respectively (p = 0.02). The median PFS and OS for the entire cohort was 10 months (95% CI 7.6-14) and 120 months (95% CI, 49-NA), respectively (Figure A). When comparing outcomes to current FDA approvals-lenalidomide + mAb (n=43) versus PI3Ki monotherapy (PI3Ki, n=38), the median PFS was significantly longer in the lenalidamide + mAb group compared to the PI3Ki group (15 vs. 6 months, p=0.016), as was the OS (120 vs. 37 months, p=0.002, respectively, Figure B). Conclusions: In this multi-center analysis, despite multiple relapses, the median survival for FL patients treated with novel agents was 120 months from the initiation of the first novel therapy. With the caveat of retrospective comparison, lenalidomide + mAb (i.e. R2) appears superior to PI3Ki as first novel agent in the relapsed setting with the recognition that a high proportion of patients discontinued PI3Ki due to toxicity. Because the majority of the patients received idelalisib conclusions cannot be drawn about alternative PI3Ki which may have lower toxicity profiles or intermittent dosing strategies, allowing for safer and more prolonged treatment. Future prospective studies are needed to directly compare these agents and determine optimal sequencing of therapies. Disclosures Landsburg: Takeda: Research Funding; Triphase: Research Funding; Triphase: Research Funding; Takeda: Research Funding; Curis, INC: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Speakers Bureau; Seattle Genetics: Speakers Bureau; Curis, INC: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding. Kahl:AbbVie Inc, Acerta Pharma - A member of the AstraZeneca Group, AstraZeneca Pharmaceuticals LP, BeiGene, Celgene Corporation, Genentech, Pharmacyclics LLC, an AbbVie Company, Roche Laboratories Inc.: Consultancy. Maddocks:Merck: Research Funding; Pharmacyclics: Membership on an entity's Board of Directors or advisory committees, Research Funding; Teva: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; BMS: Research Funding; Novartis: Research Funding. Danilov:TG Therapeutics: Consultancy; Bayer Oncology: Consultancy, Research Funding; Celgene: Consultancy; Curis: Consultancy; Seattle Genetics: Consultancy; Aptose Biosciences: Research Funding; Takeda Oncology: Research Funding; Bristol-Meyers Squibb: Research Funding; MEI: Research Funding; Janssen: Consultancy; Abbvie: Consultancy; Pharmacyclics: Consultancy; Gilead Sciences: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; AstraZeneca: Consultancy, Research Funding; Verastem Oncology: Consultancy, Other: Travel Reimbursement , Research Funding. Ujjani:Pharmacyclics: Honoraria; PCYC: Research Funding; Atara: Consultancy; Atara: Consultancy; Genentech: Honoraria; AbbVie: Honoraria, Research Funding; Gilead: Consultancy; Pharmacyclics: Honoraria; PCYC: Research Funding; Astrazeneca: Consultancy; Genentech: Honoraria; AbbVie: Honoraria, Research Funding. Lynch:Juno Therapeutics: Research Funding; Rhizen Pharmaceuticals S.A: Research Funding; T.G. Therapeutics: Research Funding; Incyte Corporation: Research Funding; Takeda Pharmaceuticals: Research Funding; Johnson Graffe Keay Moniz & Wick LLP: Consultancy. Nastoupil:Gilead: Honoraria; Bayer: Honoraria; Celgene: Honoraria, Research Funding; Spectrum: Honoraria; TG Therapeutics: Honoraria, Research Funding; Novartis: Honoraria; Janssen: Honoraria, Research Funding; Genentech, Inc.: Honoraria, Research Funding. Ghosh:Forty Seven Inc: Research Funding; Celgene: Consultancy, Research Funding, Speakers Bureau; Genentech: Research Funding; T G Therapeutics: Consultancy, Research Funding; Gilead/Kite: Consultancy, Speakers Bureau; Pharmacyclics: Consultancy, Research Funding, Speakers Bureau; AbbVie: Consultancy, Speakers Bureau; Seattle Genetics: Consultancy, Speakers Bureau; Spectrum: Consultancy, Speakers Bureau; Astra Zeneca: Speakers Bureau. Stephens:Karyopharm: Research Funding; Gilead: Research Funding; Acerta: Research Funding. Cohen:ASH: Research Funding; Lymphoma Research Foundation: Research Funding; Astra Zeneca: Research Funding; Seattle Genetics, Inc.: Consultancy, Research Funding; Bristol-Meyers Squibb Company: Research Funding; Takeda Pharmaceuticals North America, Inc.: Research Funding; Gilead/Kite: Consultancy; LAM Therapeutics: Research Funding; UNUM: Research Funding; Hutchison: Research Funding; Genentech, Inc.: Consultancy, Research Funding; Janssen Pharmaceuticals: Consultancy. Hill:Gilead: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen: Research Funding; Takeda: Research Funding; Genentech: Consultancy, Research Funding; Celegene: Consultancy, Honoraria, Research Funding; Seattle Genetics: Consultancy, Honoraria; TG therapeutics: Research Funding; AstraZeneca: Consultancy, Honoraria; Pharmacyclics: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Abbvie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Kite: Consultancy, Honoraria.
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- 2019
24. Impact of Novel Agents on Outcomes of Patients with Classical Hodgkin Lymphoma and Primary Treatment Failure
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Mehdi Hamadani, Martha Glenn, Stefan K. Barta, Lukas Emery, Narendranath Epperla, Yang Liu, Jakub Svoboda, Nishitha Reddy, Luciano J. Costa, Paolo Caimi, Ana C. Xavier, Tarsheen K. Sethi, Madelyn Burkart, Celeste M. Bello, Julio C. Chavez, Shalin Kothari, Frederick Lansigan, Amanda F. Cashen, Walter Hanel, Caryn E. Sorge, John L Vaughn, Jonathon B. Cohen, Saba Raya, Hatcher J. Ballard, Rehan Sarmad, Michael C. Churnetski, Talha Badar, Francisco J. Hernandez-Ilizaliturri, and Reem Karmali
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Oncology ,medicine.medical_specialty ,Chlorambucil ,business.industry ,medicine.medical_treatment ,Immunology ,Salvage therapy ,Cell Biology ,Hematology ,Hematopoietic stem cell transplantation ,medicine.disease ,Biochemistry ,Chemotherapy regimen ,Lymphoma ,Novel agents ,Internal medicine ,medicine ,Primary treatment ,business ,Brentuximab vedotin ,health care economics and organizations ,medicine.drug - Abstract
Introduction: The majority of patients with classical Hodgkin lymphoma (cHL) will be cured with anthracycline-containing chemotherapy regimens. However, 10-20% of patients with early-stage disease and 30-40% of patients with advanced-stage cHL will relapse. The standard treatment for patients with relapsed cHL is salvage chemoimmunotherapy followed by high-dose chemotherapy (HDT) and autologous hematopoietic cell transplantation (auto-HCT) in chemotherapy-sensitive patients. Patients with primary treatment failure (PTF), i.e. patients who have progressive disease while on therapy or who fail to achieve complete remission (CR) at the end of initial therapy, or experience early relapse after CR1 are expected to have a worse prognosis than patients with late relapse. Since 2011 newer treatments, namely Brentuximab vedotin and PD1/PDL1 blockers have been introduced for the treatment of relapsed and refractory cHL. It is unknown whether changes in disease monitoring and management, including the availability of new agents, impacted survival of patients with cHL and PTF. Methods: Fifteen US academic medical centers contributed cases to the ECLIPSE study (Evaluation of Classical Hodgkin Lymphoma patients wIth Primary treatment failure and analySis of outcomEs). ECLIPSE retrospectively captured patient, disease and treatment characteristics and treatment response as assessed by treating physicians. Eligible patients were ≥ 15 years diagnosed with cHL on or after 2005, who received treatment with curative intent with anthracycline-containing chemotherapy regimens, and developed one of the 3 patterns of PTF: detection of progressive disease during or within 6 weeks of completion of chemotherapy (PP cohort, primary progression), partial response (PR) or stable disease (SD) by functional imaging at completion of chemotherapy (PR/SD cohort), or disease progression detected within 12 months of completion of chemotherapy after prior documentation of CR (ER cohort, early relapse). Patients were divided into two "eras" based on year of diagnosis, 2005-2010 (era1) and 2011-2018 (era2), with the latter expected to reflect changes in salvage therapy for cHL. Results: Patient characteristics for the 553 cases are summarized in Table. Median follow up of survivors was 58.7 and 31.2 months for patients diagnosed in era1 and era2, respectively. ABVD was the upfront treatment for 97.6% of cases. Nearly all patients (98.5%) received salvage therapy after PTF and 60.9% underwent auto-HCT. Patients who relapsed or progressed post auto-HCT received a median of 1 (range 0 to 3) salvage regimens. Five-year overall survival (OS) from time of PTF was 70.3% (95% CI=63.4-77.2%) for patients diagnosed in era1, and 77.6% (95% CI=70.3-84.8%, p = 0.018) for patients diagnosed in era2 (Figure A). While there was no difference in OS among the PP, PR/SD and ER cohorts in the era1 (Figure B), the PR/SD and ER cohorts had better OS than PP cohort in era2 (Figure C). On comparing the OS for each of the 3 cohorts between era1 and era2, there was an improvement in OS in the PR/SD (Figure E) and ER cohorts (Figure F) but no improvement among the PP cohort (D). Multivariable analysis of patients in era 2 identified only age (HR 1.05, 95% CI=1.03-1.07, P Conclusions: Though there has been an improvement in survival among cHL cases with PTF treated in the most recent years, the outcome of patients with PP did not change significantly across eras. Patients with PP disease should be prioritized for clinical trials incorporating newer agents and innovative cellular therapy to current available effective treatments. Disclosures Epperla: Pharmacyclics: Honoraria; Verastem Oncology: Speakers Bureau. Costa:Abbvie: Consultancy; Karyopharm: Consultancy; Fujimoto Pharmaceutical Corporation Japan: Other: Advisor; Sanofi: Consultancy, Honoraria, Speakers Bureau; GSK: Consultancy, Honoraria, Research Funding; Amgen: Consultancy, Honoraria, Research Funding, Speakers Bureau; Janssen: Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Research Funding. Cashen:Novartis: Other: Speaker's Bureau; Seattle Genetics: Other: Speaker's Bureau; Celgene: Other: Speaker's Bureau. Hamadani:Otsuka: Research Funding; Takeda: Research Funding; Pharmacyclics: Consultancy; ADC Therapeutics: Consultancy, Research Funding; Merck: Research Funding; Sanofi Genzyme: Research Funding, Speakers Bureau; Celgene: Consultancy; Janssen: Consultancy; Medimmune: Consultancy, Research Funding. Barta:Mundipharma: Honoraria; Celgene: Research Funding; Takeda: Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Honoraria, Research Funding; Bayer: Consultancy, Research Funding; Mundipharma: Honoraria; Merck: Research Funding; Celgene: Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees. Reddy:Celgene: Consultancy; BMS: Consultancy, Research Funding; Genentech: Research Funding; Abbvie: Consultancy; KITE Pharma: Consultancy. Karmali:Gilead/Kite; Juno/Celgene: Consultancy, Speakers Bureau; Takeda, BMS: Other: Research Funding to Institution; Astrazeneca: Speakers Bureau. Bello:Celgene: Speakers Bureau. Chavez:Novartis: Membership on an entity's Board of Directors or advisory committees; Kite: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Bayer: Membership on an entity's Board of Directors or advisory committees; Karyopharm: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Genentech: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau. Svoboda:AstraZeneca: Consultancy; Celgene: Research Funding; Incyte: Research Funding; Pharmacyclics: Consultancy, Research Funding; Kyowa: Consultancy; Merck: Research Funding; BMS: Consultancy, Research Funding; Seattle Genetics: Consultancy, Research Funding. Glenn:BMS: Research Funding; Merck: Research Funding; Genentech: Research Funding. Cohen:Lymphoma Research Foundation: Research Funding; Seattle Genetics, Inc.: Consultancy, Research Funding; ASH: Research Funding; Takeda Pharmaceuticals North America, Inc.: Research Funding; Gilead/Kite: Consultancy; Bristol-Meyers Squibb Company: Research Funding; Genentech, Inc.: Consultancy, Research Funding; Janssen Pharmaceuticals: Consultancy; LAM Therapeutics: Research Funding; UNUM: Research Funding; Hutchison: Research Funding; Astra Zeneca: Research Funding.
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- 2019
25. Pneumothorax following combination chemotherapy with bevacizumab: A case report and review of the literature
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Alrifai, Taha, primary, Saba, Raya, additional, Rifai, Dana, additional, Pandit, Sarbagya, additional, and Kozma, Kelley, additional
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- 2019
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26. Mutation Clearance after Transplantation for Myelodysplastic Syndrome
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Duncavage, Eric J., primary, Jacoby, Meagan A., additional, Chang, Gue Su, additional, Miller, Christopher A., additional, Edwin, Natasha, additional, Shao, Jin, additional, Elliott, Kevin, additional, Robinson, Joshua, additional, Abel, Haley, additional, Fulton, Robert S., additional, Fronick, Catrina C., additional, O’Laughlin, Michelle, additional, Heath, Sharon E., additional, Brendel, Kimberly, additional, Saba, Raya, additional, Wartman, Lukas D., additional, Christopher, Matthew J., additional, Pusic, Iskra, additional, Welch, John S., additional, Uy, Geoffrey L., additional, Link, Daniel C., additional, DiPersio, John F., additional, Westervelt, Peter, additional, Ley, Timothy J., additional, Trinkaus, Kathryn, additional, Graubert, Timothy A., additional, and Walter, Matthew J., additional
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- 2018
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27. Not So Typical: Development of Atypical Chronic Myeloid Leukemia in a Patient With Chronic Myeloid Leukemia
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Saba, Raya, primary, Bhamidipati, Pavan Kumar, additional, and Cashen, Amanda, additional
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- 2017
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28. Buccal Epithelium, Cigarette Smoking, and Lung Cancer: Review of the Literature
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Saba, Raya, primary, Halytskyy, Oleksandr, additional, Saleem, Nasir, additional, and Oliff, Ira A., additional
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- 2017
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29. Reduced Subclone Diversity in Clonal Cytopenia of Undetermined Significance Compared to Myelodysplastic Syndrome
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Chavez, Monique, Srivatsan, Sridhar N, Miller, Christopher A, Menssen, Andrew J., Khanna, Ajay, Shao, Jin, Fronick, Catrina, Fulton, Robert, Heath, Sharon E, Logothetis, Constantine, Burton, Tasha, Donaldson, Victoria, Cabrera, Claudia, Saba, Raya, Vij, Kiran R., Duncavage, Eric J., Jacoby, Meagan, and Walter, Matthew J.
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Introduction: Clonal cytopenias of undetermined significance (CCUS) and myelodysplastic syndromes (MDS) represent a disease continuum that are distinguished by the presence of dysplasia in >10% of blood cells. However, morphologic dysplasia is subject to high inter-observer variability, suggesting that dysplasia may not be ideal to differentiate CCUS from MDS. Defining the clonal architecture of samples from cytopenic patients may provide a more accurate objective measure of disease status than dysplasia. We hypothesize that the number and size of subclones is reduced in patients with CCUS compared to MDS, suggesting that increased subclonal diversity is a hallmark of higher-risk disease.
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- 2023
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30. Phase II Trial of Duvelisib Maintenance after Autologous Stem Cell Transplant in T-Cell and B-Cell Non-Hodgkin Lymphomas: Results of Safety Lead in
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Saba, Raya, Mehta-Shah, Neha, Ghobadi, Armin, DiPersio, John F., Cashen, Amanda F, and Wu, Ningying
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Introduction
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- 2023
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31. Pulmonary Arterial Hypertension Secondary to Ethanol Sclerotherapy for Renal Artery Embolization
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Saba, Raya, Davis, James, Balavenkataraman, Arvind, Mirrakhimov, Aibek E., Barbaryan, Aram, Chalise, Shyam, and Iroegbu, Nkemakolam
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Article Subject - Abstract
Pulmonary arterial hypertension (PAH) has been reported as a major complication to consider and promptly manage in the use of ethanol sclerotherapy. Most of the available data on the development of PAH is derived from the use of ethanol for embolization of arteriovenous malformation, but it has been rarely reported in its other fields of application. We describe a case of outpatient renal artery embolization using ethanol, in which respiratory failure develops secondary to PAH despite adhering to safe practice protocols. We highlight the importance of pulmonary arterial pressure monitoring and the treatment steps to follow in order to avoid irreversible fatal outcomes.
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- 2014
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32. Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease
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Mirrakhimov, Aibek E., Ali, Alaa M., Barbaryan, Aram, Anusim, Nwabundo, Saba, Raya, Kwatra, Shawn G., Hussain, Nasir, Zdunek, Teresita, and Gilman, Alan D.
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Article Subject ,hemic and lymphatic diseases - Abstract
Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a case of a 70-year-old African-American male who presented to our hematology clinic complaining of fatigue. Clinical exam and computed tomography imaging did not reveal splenic enlargement. Blood work-up revealed pancytopenia and bone marrow was diagnostic for hairy cell leukemia.The patient was started on cladribine, with gradual improvement of his symptoms and blood count abnormalities. Therefore, it is essential to keep hairy cell leukemia in the differential of pancytopenia even in the absence of a splenomegaly.
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- 2014
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33. Rare case of sarcoidosis presenting with pancytopenia, acute renal failure and hypercalcaemia
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Saba, Raya, primary, Khreis, Mahmoud, additional, Francisque, Frantz, additional, and Saleem, Nasir, additional
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- 2016
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34. The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy
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Saba, Raya, primary, Alsayed, Alhareth, additional, Zacny, James P., additional, and Dudek, Arkadiusz Z., additional
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- 2016
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35. Unusual Case of Osteomyelitis and Discitis in a Drug User with a Background of Chronic Back Pain: Do Not Miss the Serious Etiologies
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Ali, Alaa M., Khan, Moona, Kwatra, Shawn G., Barbaryan, Aram, Hussain, Nasir, Saba, Raya, and Mirrakhimov, Aibek E.
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Article Subject - Abstract
Chronic back pain is a common presenting complaint that is frequently encountered by clinicians. The challenge for clinicians is identifying the relatively few patients with a significant probability of a more serious problem that requires further evaluation. Such individuals require further evaluation for possible occult malignancy, infection, or fracture. We present a case of a 50-year-old male with a past medical history of chronic back pain and IV drug abuse who presented with acute back pain and in whom a diagnosis of vertebral osteomyelitis was missed during multiple visits to the emergency room.
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- 2013
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36. Multicentric Reticulohistiocytosis Presenting with Papulonodular Skin Lesions and Arthritis Mutilans
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Saba, Raya, Kwatra, Shawn G., Upadhyay, Bishwas, Mirrakhimov, Aibek E., and Khan, Farah N.
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musculoskeletal diseases ,Article Subject - Abstract
Multicentric reticulohistiocytosis is a rare multisystem disorder of unknown etiology that is characterized by erosive polyarthritis and papulonodular lesions on the skin, mucous membranes, and internal organs. We report the case of a 54-year-old female who was misdiagnosed as having rheumatoid arthritis and underwent numerous joint replacement surgeries for progressively destructive arthritis in her hands, shoulders, hips, and knees. The patient finally received a diagnosis of multicentric reticulohistiocytosis after histopathological examination of the patient’s left knee arthroplasty which revealed a diffuse histiocytic infiltrate, multinucleated giant cells, and finely granulated eosinophilic cytoplasm with a ground-glass appearance.
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- 2013
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37. Ibuprofen-Induced Hemolytic Anemia
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Barbaryan, Aram, Iyinagoro, Chioma, Nwankwo, Nwabundo, Ali, Alaa M., Saba, Raya, Kwatra, Shawn G., Hussain, Nasir, Uzoka, Chukwuemeka C., Prueksaritanond, Suartcha, and Mirrakhimov, Aibek E.
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Article Subject ,hemic and lymphatic diseases - Abstract
Drug-induced immune hemolytic anemia is a rare condition with an incidence of 1 per million of the population. We report the case of a 36-year-old female who presented to the emergency department complaining of shortness of breath and dark colored urine. Physical examination was significant for pale mucous membranes. The patient reported using ibuprofen for a few days prior to presentation. Complete blood count performed before starting ibuprofen revealed normal platelets and hemoglobin values. On admission, the patient had evidence of hemolytic anemia with hemoglobin of 4.9 g/dL, hematocrit of 14.2%, lactate dehydrogenase 435 IU/L, and reticulocytosis 23.2%. Further testing ruled out autoimmune disease, lymphoma, and leukemia as etiologies for the patient’s new onset hemolytic anemia. Ibuprofen was immediately stopped with a gradual hematologic recovery within 3 days.
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- 2013
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38. Malignant Mesothelioma after Household Exposure to Asbestos
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Saba, Raya, Aronu, Godson Nnamdi, Bhatti, Ravinder Pal, Mirrakhimov, Aibek E., Anusim, Nwabundo, Barbaryan, Aram, Kwatra, Shawn G., and Iroegbu, Nkemakolam
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Article Subject - Abstract
Malignant mesothelioma (MM) is an aggressive cancer that has been closely linked to asbestos exposure. Initially recognized as an occupational cancer in male workers, MM was later found to occur in their family members as well. We report the case of an 89-year-old female who presented with abdominal distention, pain, and findings consistent with malignant ascites. Family history was significant for fatal mesothelioma in her husband of 40 years, who was a worker at a tile factory. The diagnosis of MM was confirmed on pathologic examination of the omental core biopsy.
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- 2013
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39. ERG Expression in Prostate Needle Biopsy
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Lee, Sandra L., primary, Yu, Darryl, additional, Wang, Cheng, additional, Saba, Raya, additional, Liu, Shuhong, additional, Trpkov, Kiril, additional, Donnelly, Bryan, additional, and Bismar, Tarek A., additional
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- 2015
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40. Breast Osteosarcoma 29 Years after Radiation Therapy for Epithelial Breast Cancer
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Nwankwo, Nwabundo, primary, Barbaryan, Aram, additional, Ali, Alaa M., additional, Hussain, Nasir, additional, Saba, Raya, additional, Prueksaritanond, Suartcha, additional, Mirrakhimov, Aibek E., additional, Zdunek, Teresita, additional, and Bucher, Nora, additional
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- 2013
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41. Primary Diffuse Large B-Cell Lymphoma of the Ascending Colon
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Barbaryan, Aram, primary, Ali, Alaa M., additional, Kwatra, Shawn G., additional, Saba, Raya, additional, Prueksaritanond, Suartcha, additional, Hussain, Nasir, additional, Mirrakhimov, Aibek E., additional, Vladimirskiy, Natalya, additional, Zdunek, Teresita, additional, and Gilman, Alan D., additional
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- 2013
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42. Left Inguinal Adenopathy Two Years after Cytoreductive Surgery: A Rare Sign of Recurrence
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Mirrakhimov, Aibek E., primary, Nwankwo, Nwabundo, additional, Barbaryan, Aram, additional, Saba, Raya, additional, Ali, Alaa M., additional, Kwatra, Shawn G., additional, Hussain, Nasir, additional, Senussi, Mourad H., additional, Velasquez Kho, Erwin, additional, and Gilman, Alan D., additional
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- 2013
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43. Mycobacterium kansasiiInfection in a Patient Receiving Biologic Therapy—Not All Reactive Interferon Gamma Release Assays Are Tuberculosis
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Saleem, Nasir, Saba, Raya, Maddika, Srikanth, and Weinstein, Mitchell
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Mycobacterium kansasii, a nontuberculous mycobacterium, can lead to lung disease similar to tuberculosis. Immunotherapeutic biologic agents predispose to infections with mycobacteria, including M kansasii. T-cell–mediated interferon gamma release assays like QuantiFERON-TB Gold Test (QFT) are widely used by clinicians for the diagnosis of infections with Mycobacterium tuberculosis; however, QFT may also show positive result with certain nontuberculous mycobacterial infections. We report a case of M kansasiipulmonary infection, with a positive QFT, in an immunocompromised patient receiving prednisone, leflunomide and tocilizumab, a humanized anti–interleukin-6 receptor monoclonal antibody. This case highlights the risk of mycobacterial infections with the use of various biologic agents and the need for caution when interpreting the results of interferon gamma release assays.
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- 2017
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44. Non-healing pharyngeal ulcer in a middle-aged Caucasian man.
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Nwankwo, Nwabundo, Saba, Raya, Mirrakhimov, Aibek E., and Rao, Shesh
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TOMOGRAPHY ,DIFFERENTIAL diagnosis ,EPSTEIN-Barr virus ,HOARSENESS ,PHARYNX ,ULCERS ,SYMPTOMS ,T-cell lymphoma ,DIAGNOSIS ,THERAPEUTICS - Abstract
Extranodal natural killer NK/T-cell lymphoma is a rare malignancy. The disease is common in some Asian countries such as China, Japan as well as in South America. We present a case of extranodal NK/T-cell lymphoma which presented as a pharyngeal ulcer in a 35-year-old Caucasian man. [ABSTRACT FROM AUTHOR]
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- 2013
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45. New pulmonary nodules in a patient with rheumatoid arthritis.
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Saba, Raya, Ali, Alaa M., Kwatra, Shawn G., and Mirrakhimov, Aibek E.
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LUNG tumors ,RHEUMATOID arthritis ,GRANULOMATOSIS with polyangiitis ,DISEASE complications - Abstract
The article presents a case study of a 35-year-old man whose medical history includes rheumatoid arthritis and rheumatoid pulmonary nodules as well as Graves' disease. He was admitted to a hospital due to onset fever, cough and worsening dyspnoea. The article discusses a case of pulmonary nodules with rheumatoid arthritis.
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- 2013
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46. Intra-abdominal haematoma.
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Saba, Raya, Kwatra, Shawn G., Ali, Alaa M., and Mirrakhimov, Aibek E.
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ABDOMEN ,SUBCUTANEOUS injections ,HEMATOMA ,TOMOGRAPHY ,ENOXAPARIN - Abstract
The article discusses the uncommon case of rectus sheath haematoma which is a potentially lie-threatening consequence of the administration of enoxaparin. It presents a case study of a 65-year-old man who was referred to the hospital for bilateral leg swelling and shortness of breath. It mentions that the rectus sheath haematoma is an uncommon complication of anticoagulation therapy.
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- 2013
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47. Metastatic adenocarcinoma of the colon in a 21-year-old African-American woman.
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Saba, Raya, Kwatra, Shawn G., Mohammedabdul, Mubeenkhan, and Mirrakhimov, Aibek E.
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ADENOCARCINOMA ,BLACK people ,COLON tumors ,DIFFERENTIAL diagnosis ,METASTASIS ,TOMOGRAPHY ,HEREDITARY nonpolyposis colorectal cancer ,DIAGNOSIS - Abstract
The article discusses the case of a 21-year-old African-American woman with severe abdominal pain, vomiting, and nausea. It says that the patient underwent various tests such as computed tomography (CT) scan and exploratory laparoscopy with biopsy, and was diagnosed with stage IV adenocarcinoma of the colon. It adds that the patient had longer hospital stay and transfers to the intensive care unit to receive radiotherapy, chemotherapy, and pain control.
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- 2013
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48. Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease
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E. Mirrakhimov, Aibek, M. Ali, Alaa, Barbaryan, Aram, Anusim, Nwabundo, Saba, Raya, G. Kwatra, Shawn, Hussain, Nasir, Zdunek, Teresita, and D. Gilman, Alan
- Abstract
Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a case of a 70-year-old African-American male who presented to our hematology clinic complaining of fatigue. Clinical exam and computed tomography imaging did not reveal splenic enlargement. Blood work-up revealed pancytopenia and bone marrow was diagnostic for hairy cell leukemia.The patient was started on cladribine, with gradual improvement of his symptoms and blood count abnormalities. Therefore, it is essential to keep hairy cell leukemia in the differential of pancytopenia even in the absence of a splenomegaly.
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- 2014
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49. 8. Reduced subclone diversity in clonal cytopenia of undetermined significance compared to myelodysplastic syndrome.
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Srivatsan, Sridhar Nonavinkere, Chavez, Monique, Miller, Christopher, Menssen, Andrew, Khanna, Ajay, Fronick, Catrina, Fulton, Robert, Heath, Sharon, Logothetis, Constantine, Burton, Tasha, Donaldson, Victoria, Cabrera, Claudia, Vij, Ravi, Duncavage, Eric, Shao, Jin, Saba, Raya, Jacoby, Megan, and Walter, Matthew J.
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SOMATIC mutation , *WHOLE genome sequencing , *ACUTE myeloid leukemia , *MYELODYSPLASTIC syndromes , *BONE marrow - Abstract
Clonal cytopenias of undetermined significance (CCUS) is a precursor state to myelodysplastic syndrome (MDS), a blood cancer, and is distinguished solely on the absence of morphologic dysplasia, which has diagnostic variability. Determining differences in clonal architecture (total number and size of clones) may provide an objective assessment of disease status. We hypothesized that CCUS patients will have reduced molecular disease burden with fewer subclones compared to MDS patients suggesting that MDS is at higher risk of progressing to secondary acute myeloid leukemia (sAML). We performed whole genome sequencing with higher exome coverage (eWGS) on bone marrow (n=58) or peripheral blood (n=4) and paired normal DNA from baseline banked samples from patients with CCUS (n=13), MDS (n=29), and sAML (n=20) to define clonal architecture. While the median number of total validated somatic mutations per sample was not different between CCUS, MDS, and sAML, the median variant allele frequency of the dominant clone was lower in CCUS (21.3%) compared to MDS (39.2%, p<0.05) and sAML (45.2%, p<0.001). Additionally, the proportion of patients without subclones was higher for CCUS (5/13 [38.5%]) compared to MDS and sAML (4/29 [13.8%] and 0/20 [0%], respectively, p ≤ 0.0006), suggesting that CCUS samples have reduced subclonal diversity compared to MDS. The data suggest that leveraging clonal architecture and subclonal diversity in the evaluation of patients with low blood counts could provide an objective measure to characterize and monitor disease burden in CCUS and MDS, and potentially assess risk of sAML progression, rather than relying on dysplasia alone. [ABSTRACT FROM AUTHOR]
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- 2024
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50. An international analysis evaluating frontline bendamustine with rituximab in extranodal marginal zone lymphoma
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Juan Pablo Alderuccio, Luca Arcaini, Marcus P. Watkins, Anne W. Beaven, Geoffrey Shouse, Narendranath Epperla, Michele Spina, Alexandra Stefanovic, Jose Sandoval-Sus, Pallawi Torka, Ash B. Alpert, Adam J. Olszewski, Seo-Hyun Kim, Brian Hess, Sameh Gaballa, Sabarish Ayyappan, Jorge J. Castillo, Lisa Argnani, Timothy J. Voorhees, Raya Saba, Sayan Mullick Chowdhury, Fernando Vargas, Isildinha M. Reis, Deukwoo Kwon, Jonathan S. Alexander, Wei Zhao, Dali Edwards, Peter Martin, Emanuele Cencini, Manali Kamdar, Brian K. Link, Constantine N. Logothetis, Alex F. Herrera, Jonathan W. Friedberg, Brad S. Kahl, Stefano Luminari, Pier Luigi Zinzani, Izidore S. Lossos, Alderuccio, Juan Pablo, Arcaini, Luca, Watkins, Marcus P, Beaven, Anne W, Shouse, Geoffrey, Epperla, Narendranath, Spina, Michele, Stefanovic, Alexandra, Sandoval-Sus, Jose, Torka, Pallawi, Alpert, Ash B, Olszewski, Adam J, Kim, Seo-Hyun, Hess, Brian, Gaballa, Sameh, Ayyappan, Sabarish, Castillo, Jorge J, Argnani, Lisa, Voorhees, Timothy J, Saba, Raya, Chowdhury, Sayan Mullick, Vargas, Fernando, Reis, Isildinha M, Kwon, Deukwoo, Alexander, Jonathan S, Zhao, Wei, Edwards, Dali, Martin, Peter, Cencini, Emanuele, Kamdar, Manali, Link, Brian K, Logothetis, Constantine N, Herrera, Alex F, Friedberg, Jonathan W, Kahl, Brad S, Luminari, Stefano, Zinzani, Pier Luigi, and Lossos, Izidore S
- Subjects
Aged, 80 and over ,Adult ,Lymphoma ,B-Cell ,Marginal Zone ,Lymphoma, B-Cell, Marginal Zone ,Hematology ,Middle Aged ,Herpes Zoster ,Aged ,Antineoplastic Combined Chemotherapy Protocols ,Bendamustine Hydrochloride ,Humans ,Rituximab ,Young Adult ,hemic and lymphatic diseases ,80 and over ,Extranodal marginal zone lymphoma, bendamustine, rituximab - Abstract
Extranodal marginal zone lymphoma (EMZL) is a heterogeneous non-Hodgkin lymphoma. No consensus exists regarding the standard-of-care in patients with advanced-stage disease. Current recommendations are largely adapted from follicular lymphoma, for which bendamustine with rituximab (BR) is an established approach. We analyzed the safety and efficacy of frontline BR in EMZL using a large international consortium. We included 237 patients with a median age of 63 years (range, 21-85). Most patients presented with Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1 (n = 228; 96.2%), stage III/IV (n = 179; 75.5%), and intermediate (49.8%) or high (33.3%) Mucosa Associated Lymphoid Tissue International Prognosis Index (MALT-IPI). Patients received a median of 6 (range, 1-8) cycles of BR, and 20.3% (n = 48) received rituximab maintenance. Thirteen percent experienced infectious complications during BR therapy; herpes zoster (4%) was the most common. Overall response rate was 93.2% with 81% complete responses. Estimated 5-year progression-free survival (PFS) and overall survival (OS) were 80.5% (95% CI, 73.1% to 86%) and 89.6% (95% CI, 83.1% to 93.6%), respectively. MALT-IPI failed to predict outcomes. In the multivariable model, the presence of B symptoms was associated with shorter PFS. Rituximab maintenance was associated with longer PFS (hazard ratio = 0.16; 95% CI, 0.04-0.71; P = .016) but did not impact OS. BR is a highly effective upfront regimen in EMZL, providing durable remissions and overcoming known adverse prognosis factors. This regimen is associated with occurrence of herpes zoster; thus, prophylactic treatment may be considered.
- Published
- 2022
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