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4. Molecular Grouping and Outcomes of Young Children with Newly Diagnosed Ependymoma Treated on the Multi-Institutional SJYC07 Trial

Author

Upadhyaya, Santhosh A, Robinson, Giles W, Onar-Thomas, Arzu, Orr, Brent A, Billups, Catherine A, Bowers, Daniel C, Bendel, Anne E, Hassall, Tim, Crawford, John R, Partap, Sonia, Fisher, Paul G, Tatevossian, Ruth G, Seah, Tiffany, Qaddoumi, Ibrahim A, Vinitsky, Anna, Armstrong, Gregory T, Sabin, Noah D, Tinkle, Christopher L, Klimo, Paul, Indelicato, Danny J, Boop, Frederick A, Merchant, Thomas E, Ellison, David W, and Gajjar, Amar

Subjects
Cancer, Brain Cancer, Rare Diseases, Pediatric, Brain Disorders, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Chemoradiotherapy, Chemotherapy, Adjuvant, Child, Preschool, Ependymoma, Female, Humans, Infant, Infant, Newborn, Male, Neurosurgical Procedures, Progression-Free Survival, Radiotherapy, Adjuvant, Treatment Outcome, 1q gain, chemotherapy, clinical target volume, ependymoma groups, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundThis report documents the clinical characteristics, molecular grouping, and outcome of young children with ependymoma treated prospectively on a clinical trial.MethodsFifty-four children (aged ≤3 y) with newly diagnosed ependymoma were treated on the St Jude Young Children 07 (SJYC07) trial with maximal safe surgical resection, 4 cycles of systemic chemotherapy, consolidation therapy using focal conformal radiation therapy (RT) (5-mm clinical target volume), and 6 months of oral maintenance chemotherapy. Molecular groups were determined by tumor DNA methylation using Infinium Methylation EPIC BeadChip and profiled on the German Cancer Research Center/Molecular Neuropathology 2.0 classifier.ResultsOne of the 54 study patients had metastases (cerebrospinal fluid positive) at diagnosis. Gross or near-total resection was achieved in 48 (89%) patients prior to RT. At a median follow-up of 4.4 years (range, 0.2-10.3 y), 4-year progression-free survival (PFS) was 75.1% ± 7.2%, and overall survival was 92.6% ± 4.4%. The molecular groups showed no significant difference in PFS (4-year estimates: posterior fossa ependymoma group A [PF-EPN-A; 42/54], 71.2% ± 8.3%; supratentorial ependymoma positive for v-rel avian reticuloendotheliosis viral oncogene homolog A [ST-EPN-RELA; 8/54], 83.3% ± 17.0%; and supratentorial ependymoma positive for Yes-associated protein [4/54], 100%, P = 0.22). Subtotal resection prior to RT was associated with an inferior PFS compared with gross or near-total resection (4-year PFS: 41.7% ± 22.5% vs 79.0% ± 7.1%, P = 0.024), as was PF-EPN-A group with 1q gain (P = 0.05). Histopathologic grading was not associated with outcomes (classic vs anaplastic; P = 0.89).ConclusionsIn this prospectively treated cohort of young children with ependymoma, ST-EPN-RELA tumors had a more favorable outcome than reported from retrospective data. Histologic grade did not impact outcome. PF-EPN-A with 1q gain and subtotal resection were associated with inferior outcomes.

Published
2019

5. Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma

Author

Merchant, Thomas E, Bendel, Anne E, Sabin, Noah D, Burger, Peter C, Shaw, Dennis W, Chang, Eric, Wu, Shengjie, Zhou, Tianni, Eisenstat, David D, Foreman, Nicholas K, Fuller, Christine E, Anderson, Edwina Templeton, Hukin, Juliette, Lau, Ching C, Pollack, Ian F, Laningham, Fred H, Lustig, Robert H, Armstrong, Floyd D, Handler, Michael H, Williams-Hughes, Chris, Kessel, Sandra, Kocak, Mehmet, Ellison, David W, and Ramaswamy, Vijay

Subjects
Cancer, Rare Diseases, Pediatric Cancer, Pediatric, Clinical Research, Brain Disorders, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Chemoradiotherapy, Child, Child, Preschool, Cytoreduction Surgical Procedures, Ependymoma, Female, Humans, Infant, Male, Progression-Free Survival, Radiotherapy, Conformal, Supratentorial Neoplasms, Transcription Factor RelA, Treatment Outcome, Young Adult, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PURPOSE:The Children's Oncology Group trial ACNS0121 estimated event-free survival (EFS) and overall survival for children with intracranial ependymoma treated with surgery, radiation therapy, and-selectively-with chemotherapy. Treatment was administered according to tumor location, histologic grade, and extent of resection. The impacts of histologic grade, focal copy number gain on chromosome 1q, and DNA methylation profiles were studied for those undergoing surgery and immediate postoperative conformal radiation therapy (CRT). METHODS:ACNS0121 included 356 newly diagnosed patients (ages 1 to 21 years). Patients with classic supratentorial ependymoma were observed after gross total resection (GTR). Those undergoing subtotal resection received chemotherapy, second surgery, and CRT. The remaining patients received immediate postoperative CRT after near-total resection or GTR. CRT was administered with a 1.0-cm clinical target volume margin. The cumulative total dose was 59.4 Gy, except for patients who underwent GTR and were younger than age 18 months (who received 54 Gy). Patients were enrolled between October 2003 and September 2007 and were observed for 5 years. Supratentorial tumors were evaluated for RELA fusion; infratentorial tumors, for chromosome 1q gain. Classification of posterior fossa groups A and B was made by methylation profiles. RESULTS:The 5-year EFS rates were 61.4% (95% CI, 34.5% to 89.6%), 37.2% (95% CI, 24.8% to 49.6%), and 68.5% (95% CI, 62.8% to 74.2%) for observation, subtotal resection, and near-total resection/GTR groups given immediate postoperative CRT, respectively. The 5-year EFS rates differed significantly by tumor grade (P = .0044) but not by age, location, RELA fusion status, or posterior fossa A/posterior fossa B grouping. EFS was higher for patients with infratentorial tumors without 1q gain than with 1q gain (82.8% [95% CI, 74.4% to 91.2%] v 47.4% [95% CI, 26.0% to 68.8%]; P = .0013). CONCLUSION:The EFS for patients with ependymoma younger than 3 years of age who received immediate postoperative CRT and for older patients is similar. Irradiation should remain the mainstay of care for most subtypes.

Published
2019

6. Supplementary Methods S1 from Systemic Biological Mechanisms of Neurocognitive Dysfunction in Long-Term Survivors of Childhood Hodgkin Lymphoma

Author

Williams, AnnaLynn M., primary, Liu, Wei, primary, Ehrhardt, Matthew J., primary, Mirzaei Salehabadi, Sedigheh, primary, Panoskaltsis-Mortari, Angela, primary, Phillips, Nicholas S., primary, Mulrooney, Daniel A., primary, Flerlage, Jamie E., primary, Yasui, Yutaka, primary, Srivastava, Deokumar, primary, Robison, Leslie L., primary, Hudson, Melissa M., primary, Ness, Kirsten K., primary, Sabin, Noah D., primary, and Krull, Kevin R., primary

Published
2024
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7. Supplementary Table S2 from Systemic Biological Mechanisms of Neurocognitive Dysfunction in Long-Term Survivors of Childhood Hodgkin Lymphoma

Author

Williams, AnnaLynn M., primary, Liu, Wei, primary, Ehrhardt, Matthew J., primary, Mirzaei Salehabadi, Sedigheh, primary, Panoskaltsis-Mortari, Angela, primary, Phillips, Nicholas S., primary, Mulrooney, Daniel A., primary, Flerlage, Jamie E., primary, Yasui, Yutaka, primary, Srivastava, Deokumar, primary, Robison, Leslie L., primary, Hudson, Melissa M., primary, Ness, Kirsten K., primary, Sabin, Noah D., primary, and Krull, Kevin R., primary

Published
2024
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8. Supplementary Figure S1 from Systemic Biological Mechanisms of Neurocognitive Dysfunction in Long-Term Survivors of Childhood Hodgkin Lymphoma

Author

Williams, AnnaLynn M., primary, Liu, Wei, primary, Ehrhardt, Matthew J., primary, Mirzaei Salehabadi, Sedigheh, primary, Panoskaltsis-Mortari, Angela, primary, Phillips, Nicholas S., primary, Mulrooney, Daniel A., primary, Flerlage, Jamie E., primary, Yasui, Yutaka, primary, Srivastava, Deokumar, primary, Robison, Leslie L., primary, Hudson, Melissa M., primary, Ness, Kirsten K., primary, Sabin, Noah D., primary, and Krull, Kevin R., primary

Published
2024
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9. Systemic Biological Mechanisms of Neurocognitive Dysfunction in Long-Term Survivors of Childhood Hodgkin Lymphoma

Author

Williams, AnnaLynn M., primary, Liu, Wei, additional, Ehrhardt, Matthew J., additional, Mirzaei Salehabadi, Sedigheh, additional, Panoskaltsis-Mortari, Angela, additional, Phillips, Nicholas S., additional, Mulrooney, Daniel A., additional, Flerlage, Jamie E., additional, Yasui, Yutaka, additional, Srivastava, Deokumar, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Ness, Kirsten K., additional, Sabin, Noah D., additional, and Krull, Kevin R., additional

Published
2024
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10. Surveillance for subsequent neoplasms of the CNS for childhood, adolescent, and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Bowers, Daniel C, Verbruggen, Lisanne C, Kremer, Leontien C M, Hudson, Melissa M, Skinner, Roderick, Constine, Louis S, Sabin, Noah D, Bhangoo, Ranjeev, Haupt, Riccardo, Hawkins, Mike M, Jenkinson, Helen, Khan, Raja B, Klimo, Paul, Jr, Pretorius, Pieter, Ng, Antony, Reulen, Raoul C, Ronckers, Cécile M, Sadighi, Zsila, Scheinemann, Katrin, Schouten-van Meeteren, Netteke, Sugden, Elaine, Teepen, Jop C, Ullrich, Nicole J, Walter, Andrew, Wallace, W Hamish, Oeffinger, Kevin C, Armstrong, Gregory T, van der Pal, Helena J H, and Mulder, Renée L

Published
2021
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14. High-grade glioma in infants and young children is histologically, molecularly, and clinically diverse: Results from the SJYC07 trial and institutional experience

Author

Chiang, Jason, primary, Bagchi, Aditi, additional, Li, Xiaoyu, additional, Dhanda, Sandeep K, additional, Huang, Jie, additional, Pinto, Soniya N, additional, Sioson, Edgar, additional, Dalton, James, additional, Tatevossian, Ruth G, additional, Jia, Sujuan, additional, Partap, Sonia, additional, Fisher, Paul G, additional, Bowers, Daniel C, additional, Hassall, Timothy E G, additional, Lu, Congyu, additional, Zaldivar-Peraza, Airen, additional, Wright, Karen D, additional, Broniscer, Alberto, additional, Qaddoumi, Ibrahim, additional, Upadhyaya, Santhosh A, additional, Vinitsky, Anna, additional, Sabin, Noah D, additional, Orr, Brent A, additional, Klimo, Paul, additional, Boop, Frederick A, additional, Ashford, Jason M, additional, Conklin, Heather M, additional, Onar-Thomas, Arzu, additional, Zhou, Xin, additional, Ellison, David W, additional, Gajjar, Amar, additional, and Robinson, Giles W, additional

Published
2023
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16. Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

Author

Pajtler, Kristian W., Wen, Ji, Sill, Martin, Lin, Tong, Orisme, Wilda, Tang, Bo, Hübner, Jens-Martin, Ramaswamy, Vijay, Jia, Sujuan, Dalton, James D., Haupfear, Kelly, Rogers, Hazel A., Punchihewa, Chandanamali, Lee, Ryan, Easton, John, Wu, Gang, Ritzmann, Timothy A., Chapman, Rebecca, Chavez, Lukas, Boop, Fredrick A., Klimo, Paul, Sabin, Noah D., Ogg, Robert, Mack, Stephen C., Freibaum, Brian D., Kim, Hong Joo, Witt, Hendrik, Jones, David T. W., Vo, Baohan, Gajjar, Amar, Pounds, Stan, Onar-Thomas, Arzu, Roussel, Martine F., Zhang, Jinghui, Taylor, J. Paul, Merchant, Thomas E., Grundy, Richard, Tatevossian, Ruth G., Taylor, Michael D., Pfister, Stefan M., Korshunov, Andrey, Kool, Marcel, and Ellison, David W.

Published
2018
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17. Data from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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18. Supplemental Table 2 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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19. Supplemental Table 1 from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., primary, Bhakta, Nickhill, primary, Baassiri, Malek, primary, Eissa, Hesham, primary, Chemaitilly, Wassim, primary, Green, Daniel M., primary, Mulrooney, Daniel A., primary, Armstrong, Gregory T., primary, Brinkman, Tara M., primary, Klosky, James L., primary, Krull, Kevin R., primary, Sabin, Noah D., primary, Wilson, Carmen L., primary, Huang, I-Chan, primary, Bass, Johnnie K., primary, Hale, Karen, primary, Kaste, Sue, primary, Khan, Raja B., primary, Srivastava, Deo Kumar, primary, Yasui, Yutaka, primary, Joshi, Vijaya M., primary, Srinivasan, Saumini, primary, Stokes, Dennis, primary, Hoehn, Mary Ellen, primary, Wilson, Matthew, primary, Ness, Kirsten K., primary, and Robison, Leslie L., primary

Published
2023
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22. Imaging of pediatric brain tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee/ASPNR White Paper

Author

Jaju, Alok, primary, Li, Yi, additional, Dahmoush, Hisham, additional, Gottardo, Nicholas G, additional, Laughlin, Suzanne, additional, Mirsky, David, additional, Panigrahy, Ashok, additional, Sabin, Noah D., additional, Shaw, Dennis, additional, Storm, Phillip B., additional, Poussaint, Tina Young, additional, Patay, Zoltan, additional, and Bhatia, Aashim, additional

Published
2022
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23. A Phase IV Trial of Proton Therapy in Children: The First Report from the SJPROTON1 Study

Author

Lucas, John T., primary, Marker, Matthew, additional, Becksfort, Jared, additional, Patni, Tushar, additional, Faught, Austin M., additional, Tinkle, Christopher L., additional, Groben, Valerie J., additional, Burghen, Elizabeth, additional, Ruleman, Haley, additional, Hua, Chia-Ho, additional, Kaste, Sue C., additional, Acharya, Sahaja, additional, Sabin, Noah D., additional, Hudson, Melissa, additional, Wu, Shengjie, additional, Li, Yimei, additional, Krasin, Matthew J., additional, and Merchant, Thomas E., additional

Published
2022
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27. Primary hypothyroidism in childhood cancer survivors: Prevalence, risk factors, and long‐term consequences

Author

Chemaitilly, Wassim, primary, Li, Zhenghong, additional, Brinkman, Tara M., additional, Delaney, Angela, additional, Huang, Sujuan, additional, Bjornard, Kari L., additional, Lam, Catherine G., additional, Wilson, Carmen L., additional, Barnes, Nicole, additional, Clark, Karen L., additional, Krasin, Matthew J., additional, Metzger, Monika L., additional, Sheyn, Anthony, additional, Bishop, Michael W., additional, Sabin, Noah D., additional, Howell, Rebecca M., additional, Helmig, Sara, additional, Shulkin, Barry L., additional, Triplett, Brandon M., additional, Pui, Ching‐Hong, additional, Gajjar, Amar, additional, Srivastava, Deo Kumar, additional, Green, Daniel M., additional, Armstrong, Gregory T., additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Ness, Kristen K., additional, Sklar, Charles A., additional, and Krull, Kevin R., additional

Published
2021
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30. [11C]-Methionine PET for Identification of Pediatric High-Grade Glioma Recurrence

Author

Bag, Asim K., primary, Wing, Melissa N., additional, Sabin, Noah D., additional, Hwang, Scott N., additional, Armstrong, Gregory T., additional, Han, Yuanyuan, additional, Li, Yimei, additional, Snyder, Scott, additional, Robinson, Giles W., additional, Qaddoumi, Ibrahim, additional, Broniscer, Alberto, additional, Lucas, John T., additional, and Shulkin, Barry L., additional

Published
2021
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34. A Phase IV Trial of Proton Therapy in Children: The First Report from SJPROTON1

Author

Lucas, John T., primary, Marker, Matt, additional, Becksfort, Jared, additional, Patni, Tushar, additional, Faught, Austin M., additional, Tinkle, Christopher L., additional, Groben, Valerie J., additional, Burghen, Elizabeth, additional, Ruleman, Haley, additional, Hua, Chia-Ho, additional, Kaste, Sue C., additional, Acharya, Sahaja, additional, Sabin, Noah D., additional, Hudson, Melissa M., additional, Wu, Shengjie, additional, Li, Yimei, additional, Krasin, Matthew J., additional, and Merchant, Thomas E., additional

Published
2021
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35. Cohort Profile: The St. Jude Lifetime Cohort Study (SJLIFE) for paediatric cancer survivors

Author

Howell, Carrie R, primary, Bjornard, Kari L, additional, Ness, Kirsten K, additional, Alberts, Nicole, additional, Armstrong, Gregory T, additional, Bhakta, Nickhill, additional, Brinkman, Tara, additional, Caron, Eric, additional, Chemaitilly, Wassim, additional, Green, Daniel M, additional, Folse, Tim, additional, Huang, I-Chan, additional, Jefferies, John L., additional, Kaste, Sue, additional, Krull, Kevin R, additional, Lanctot, Jennifer Q, additional, Mulrooney, Daniel A, additional, Neale, Geoffrey, additional, Nichols, Kim E, additional, Sabin, Noah D, additional, Shelton, Kyla, additional, Srivastava, Deo Kumar, additional, Wang, Zhaoming, additional, Wilson, Carmen, additional, Yasui, Yutaka, additional, Zaidi, Alia, additional, Zhang, Jinghui, additional, Robison, Leslie L, additional, Hudson, Melissa M, additional, and Ehrhardt, Matthew J, additional

Published
2020
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40. Primary hypothyroidism in childhood cancer survivors: Prevalence, risk factors, and long‐term consequences.

Author

Chemaitilly, Wassim, Li, Zhenghong, Brinkman, Tara M., Delaney, Angela, Huang, Sujuan, Bjornard, Kari L., Lam, Catherine G., Wilson, Carmen L., Barnes, Nicole, Clark, Karen L., Krasin, Matthew J., Metzger, Monika L., Sheyn, Anthony, Bishop, Michael W., Sabin, Noah D., Howell, Rebecca M., Helmig, Sara, Shulkin, Barry L., Triplett, Brandon M., and Pui, Ching‐Hong

Subjects
THYROID cancer, CHILDHOOD cancer, CANCER survivors, CARDIOVASCULAR diseases risk factors, HEALTH outcome assessment, HYPOTHYROIDISM
Abstract

Background: Data on primary hypothyroidism and its long‐term impact on the health, cognition, and quality of life (QOL) of childhood cancer survivors are limited. This study examined the prevalence of and risk factors for primary hypothyroidism and its associations with physical, neurocognitive, and psychosocial outcomes. Methods: This was a retrospective study with a cross‐sectional health outcome analysis of an established cohort comprising 2965 survivors of childhood cancer (52.8% male; median current age, 30.9 years, median time since cancer diagnosis, 22.3 years). Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between primary hypothyroidism and cancer‐related risk factors, cardiovascular disease risk factors, frailty, neurocognitive and QOL outcomes, social attainment, and subsequent thyroid carcinoma. Associations between serum free thyroxine and thyrotropin levels at assessment and health outcomes were explored. Results: The prevalence of primary hypothyroidism was 14.7% (95% CI, 13.5%‐16.0%). It was more likely in females (OR, 1.06; 95% CI, 1.03‐1.08), was less likely in non‐Whites (OR, 0.96; 95% CI, 0.93‐0.99), was associated with thyroid radiotherapy (higher risk at higher doses), and was more common if cancer was diagnosed at an age ≥ 15.0 years versus an age < 5 years (OR, 1.05; 95% CI, 1.01‐1.09). Primary hypothyroidism was associated with frailty (OR, 1.54; 95% CI, 1.05‐2.26), dyslipidemia (OR, 1.52; 95% CI, 1.14‐2.04), impaired physical QOL (OR, 1.66; 95% CI, 1.12‐2.48), and having health care insurance (OR, 1.51; 95% CI, 1.07‐2.12). Conclusions: Primary hypothyroidism is common in survivors and is associated with unfavorable physical health and QOL outcomes. The impact of thyroid hormone replacement practices on these outcomes should be investigated further. In this study, primary hypothyroidism affects 14.7% of 2965 survivors of childhood cancer, and it is associated with adverse health and quality of life. Associations between thyroid function tests and health outcomes are explored. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Associations between Persistent Inflammation and Oxidative Stress with Neurocognitive Impairment in Long-Term Hodgkin Lymphoma Survivors and Community Controls

Author

Williams, AnnaLynn M, primary, Mulrooney, Daniel A., additional, Liu, Wei, additional, Ehrhardt, Matt J., additional, Mirzaei Salehabadi, Sedigheh, additional, Panoskaltsis-Mortari, Angela, additional, Srivastava, Deokumar, additional, Yasui, Yutaka, additional, Hudson, Melissa M., additional, Robison, Leslie L., additional, Sabin, Noah D, additional, and Krull, Kevin R., additional

Published
2019
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43. Association Between Anesthesia Exposure and Neurocognitive and Neuroimaging Outcomes in Long-term Survivors of Childhood Acute Lymphoblastic Leukemia

Author

Banerjee, Pia, primary, Rossi, Michael G., additional, Anghelescu, Doralina L., additional, Liu, Wei, additional, Breazeale, Ashley M., additional, Reddick, Wilburn E., additional, Glass, John O., additional, Phillips, Nicholas S., additional, Jacola, Lisa M., additional, Sabin, Noah D., additional, Inaba, Hiroto, additional, Srivastava, Deokumar, additional, Robison, Leslie L., additional, Pui, Ching-Hon, additional, Hudson, Melissa M., additional, and Krull, Kevin R., additional

Published
2019
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44. Automatic image processing pipeline for tracking longitudinal vessel changes in magnetic resonance angiography

Author

Hsu, Chih‐Yang, primary, Li, Yimei, additional, Han, Yuanyuan, additional, Elijovich, Lucas, additional, Sabin, Noah D., additional, Abuelem, Tarek, additional, Torabi, Radmehr, additional, Faught, Austin, additional, Hua, Chia‐Ho, additional, Klimo, Paul, additional, Merchant, Thomas E., additional, and Lucas, John T., additional

Published
2019
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45. Growth hormone deficiency and neurocognitive function in adult survivors of childhood acute lymphoblastic leukemia

Author

Krull, Kevin R., primary, Li, Chenghong, additional, Phillips, Nicholas S., additional, Cheung, Yin Ting, additional, Brinkman, Tara M., additional, Wilson, Carmen L., additional, Armstrong, Gregory T., additional, Khan, Raja B., additional, Merchant, Thomas E., additional, Sabin, Noah D., additional, Srivastava, DeoKumar, additional, Pui, Ching‐Hon, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, Sklar, Charles A., additional, and Chemaitilly, Wassim, additional

Published
2019
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46. Cohort Profile: The St. Jude Lifetime Cohort Study (SJLIFE) for paediatric cancer survivors.

Author

Howell, Carrie R, Bjornard, Kari L, Ness, Kirsten K, Alberts, Nicole, Armstrong, Gregory T, Bhakta, Nickhill, Brinkman, Tara, Caron, Eric, Chemaitilly, Wassim, Green, Daniel M, Folse, Tim, Huang, I-Chan, Jefferies, John L., Kaste, Sue, Krull, Kevin R, Lanctot, Jennifer Q, Mulrooney, Daniel A, Neale, Geoffrey, Nichols, Kim E, and Sabin, Noah D

Subjects
VERBAL learning, MUSCLE mass, BODY image, CHILDHOOD cancer, CANCER survivors, RESEARCH, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding, TUMORS, LONGITUDINAL method
Abstract

11-17 Health outcomes research findings have had a major influence on changes in paediatric cancer therapy and have informed health-screening strategies of childhood cancer survivors. 7-10 Current understanding of late health outcomes in adult survivors of childhood cancer has largely been the result of a number of cohort studies that have been instrumental in identifying, quantifying and characterizing cancer treatment-related health risks. Robust characterization of health outcomes and cancer-, cancer treatmentand health behaviour-related exposures provide an unparalleled opportunity to identify novel associations and to refine our understanding of the effects of cancer and its treatment on the health of aging survivors. Whereas SJLIFE does not specify age at cancer diagnosis, SJCRH generally restricts acceptance to children<25 years of age at the time of cancer diagnosis. [Extracted from the article]

Published
2021
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47. Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

Author

Robinson, Giles W, primary, Rudneva, Vasilisa A, additional, Buchhalter, Ivo, additional, Billups, Catherine A, additional, Waszak, Sebastian M, additional, Smith, Kyle S, additional, Bowers, Daniel C, additional, Bendel, Anne, additional, Fisher, Paul G, additional, Partap, Sonia, additional, Crawford, John R, additional, Hassall, Tim, additional, Indelicato, Daniel J, additional, Boop, Frederick, additional, Klimo, Paul, additional, Sabin, Noah D, additional, Patay, Zoltan, additional, Merchant, Thomas E, additional, Stewart, Clinton F, additional, Orr, Brent A, additional, Korbel, Jan O, additional, Jones, David T W, additional, Sharma, Tanvi, additional, Lichter, Peter, additional, Kool, Marcel, additional, Korshunov, Andrey, additional, Pfister, Stefan M, additional, Gilbertson, Richard J, additional, Sanders, Robert P, additional, Onar-Thomas, Arzu, additional, Ellison, David W, additional, Gajjar, Amar, additional, and Northcott, Paul A, additional

Published
2018
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48. MBCL-44. THE MOLECULAR AND CLINICAL LANDSCAPE OF INFANT MEDULLOBLASTOMA (iMB): RESULTS AND MOLECULAR ANALYSIS FROM A PROSPECTIVE, MULTICENTER PHASE II TRIAL (SJYC07)

Author

Robinson, Giles W, primary, Rudneva, Vasilisa A, additional, Buchhalter, Ivo, additional, Billups, Catherine A, additional, Waszak, Sebastian M, additional, Smith, Kyle, additional, Bowers, Daniel C, additional, Bendel, Anne, additional, Fisher, Paul, additional, Partap, Sonia, additional, Crawford, John, additional, Hassall, Tim, additional, Indelicato, Daniel J, additional, Boop, Frederick, additional, Klimo, Paul, additional, Sabin, Noah D, additional, Patay, Zoltan, additional, Merchant, Thomas E, additional, Stewart, Clinton F, additional, Orr, Brent A, additional, Korbel, Jan O, additional, Jones, David T W, additional, Sharma, Tanvi, additional, Lichter, Peter, additional, Kool, Marcel, additional, Korshunov, Andrey, additional, Pfister, Stefan M, additional, Gilbertson, Richard J, additional, Sanders, Robert P, additional, Onar-Thomas, Arzu, additional, Ellison, David W, additional, Gajjar, Amar, additional, and Northcott, Paul A, additional

Published
2018
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50. Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Author

Hudson, Melissa M., primary, Ehrhardt, Matthew J., additional, Bhakta, Nickhill, additional, Baassiri, Malek, additional, Eissa, Hesham, additional, Chemaitilly, Wassim, additional, Green, Daniel M., additional, Mulrooney, Daniel A., additional, Armstrong, Gregory T., additional, Brinkman, Tara M., additional, Klosky, James L., additional, Krull, Kevin R., additional, Sabin, Noah D., additional, Wilson, Carmen L., additional, Huang, I-Chan, additional, Bass, Johnnie K., additional, Hale, Karen, additional, Kaste, Sue, additional, Khan, Raja B., additional, Srivastava, Deo Kumar, additional, Yasui, Yutaka, additional, Joshi, Vijaya M., additional, Srinivasan, Saumini, additional, Stokes, Dennis, additional, Hoehn, Mary Ellen, additional, Wilson, Matthew, additional, Ness, Kirsten K., additional, and Robison, Leslie L., additional

Published
2017
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