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4. First Muon-Neutrino Disappearance Study with an Off-Axis Beam

Author

T2K Collaboration, Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Anerella, M. D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calland, R., Calvet, D., Rodriguez, J. Caravaca, Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De Rosa, G., de André, J. P. A. M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Duboyski, T., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M. A., Giffin, S., Giganti, C., Gilje, K., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Hadley, D. R., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hiraki, T., Hirose, E., Holeczek, J., Horikawa, S., Huang, K., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laing, A., Laveder, M., Lawe, M., Lee, K. P., Le, P. T., Levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Lister, C., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Magaletti, L., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Naples, D., Navin, M. L., Nicholls, T. C., Nielsen, B., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J. A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Sinclair, P. D., Siyad, M., Smith, B. M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Veledar, O., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikström, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
High Energy Physics - Experiment
Abstract

We report a measurement of muon-neutrino disappearance in the T2K experiment. The 295-km muon-neutrino beam from Tokai to Kamioka is the first implementation of the off-axis technique in a long-baseline neutrino oscillation experiment. With data corresponding to 1.43 10**20 protons on target, we observe 31 fully-contained single muon-like ring events in Super-Kamiokande, compared with an expectation of 104 +- 14 (syst) events without neutrino oscillations. The best-fit point for two-flavor nu_mu -> nu_tau oscillations is sin**2(2 theta_23) = 0.98 and |\Delta m**2_32| = 2.65 10**-3 eV**2. The boundary of the 90 % confidence region includes the points (sin**2(2 theta_23),|\Delta m**2_32|) = (1.0, 3.1 10**-3 eV**2), (0.84, 2.65 10**-3 eV**2) and (1.0, 2.2 10**-3 eV**2)., Comment: 7 pages, 4 figures

Published
2012
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5. Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector

Author

Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Anerella, M. D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De Rosa, G., de André, J. P. A. M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K. P., Le, P. T., Levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M. L., Nelson, B., Nicholls, T. C., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J. A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikström, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

Precise measurement of neutrino beam direction and intensity was achieved based on a new concept with modularized neutrino detectors. INGRID (Interactive Neutrino GRID) is an on-axis near detector for the T2K long baseline neutrino oscillation experiment. INGRID consists of 16 identical modules arranged in horizontal and vertical arrays around the beam center. The module has a sandwich structure of iron target plates and scintillator trackers. INGRID directly monitors the muon neutrino beam profile center and intensity using the number of observed neutrino events in each module. The neutrino beam direction is measured with accuracy better than 0.4 mrad from the measured profile center. The normalized event rate is measured with 4% precision., Comment: 32 pages, 27 figures, submitted to Nucl. Instr. and Meth. A

Published
2011
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6. Indication of Electron Neutrino Appearance from an Accelerator-produced Off-axis Muon Neutrino Beam

Author

T2K Collaboration, Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Coleman, W., Collazuol, G., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., DeRosa, G., de Andre, J. P. A. M., dePerio, P., Delbart, A., Densham, C., DiLodovico, F., DiLuise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hastings, S., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kudenko, Y., Kulkarni, N., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K. P., Le, P. T., Levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Murdoch, M., Murphy, S., Myslik, J., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M. L., Nelson, B., Nicholls, T. C., Nishikawa, K., Nishino, H., Nowak, J. A., Noy, M., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sanchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Syiad, M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Strabel, C., Sulak, L. R., Sulej, R., Sutcliffe, P., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikstrom, G., Wilkes, R. J., Wilking, M. J., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
High Energy Physics - Experiment
Abstract

The T2K experiment observes indications of $\nu_\mu\rightarrow \nu_e$ appearance in data accumulated with $1.43\times10^{20}$ protons on target. Six events pass all selection criteria at the far detector. In a three-flavor neutrino oscillation scenario with $|\Delta m_{23}^2|=2.4\times10^{-3}$ eV$^2$, $\sin^2 2\theta_{23}=1$ and $\sin^2 2\theta_{13}=0$, the expected number of such events is 1.5$\pm$0.3(syst.). Under this hypothesis, the probability to observe six or more candidate events is 7$\times10^{-3}$, equivalent to 2.5$\sigma$ significance. At 90% C.L., the data are consistent with 0.03(0.04)$<\sin^2 2\theta_{13}<$ 0.28(0.34) for $\delta_{\rm CP}=0$ and a normal (inverted) hierarchy., Comment: 20 pages, 6 figures, version published in PRL

Published
2011
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9. Brush-like Polymer Prodrug with Aggregation-Induced Emission Features for Precise Intracellular Drug Tracking

Author

Naghibi, S, Sabouri, S, Hong, Y, Jia, Z, Tang, Y, Naghibi, S, Sabouri, S, Hong, Y, Jia, Z, and Tang, Y

Abstract

In this study, a brush-like polymer with aggregation-induced emission (AIE) features was synthesized for drug delivery and intracellular drug tracking. The polymer consisting of tetraphenylethene (TPE) chain-end as well as oligo-poly (ethylene glycol) (PEG) and hydrazine functionalities was successfully synthesized through copper (0)-mediated reversible-deactivation radical polymerization (Cu0-mediated RDRP). Anticancer drug doxorubicin (DOX) was conjugated to the polymer and formed a prodrug named TPE-PEGA-Hyd-DOX, which contains 11% DOX. The hydrazone between DOX and polymer backbone is a pH-sensitive linkage that can control the release of DOX in slightly acidic conditions, which can precisely control the DOX release rate. The drug release of 10% after 96 h in normal cell environments compared with about 40% after 24 h in cancer cell environments confirmed the influence of the hydrazone bond. The ratiometric design of fluorescent intensities with peaks at 410 nm (emission due to AIE feature of TPE) and 600 nm (emission due to ACQ feature of DOX) provides an excellent opportunity for this product as a precise intracellular drug tracker. Cancer cells confocal microscopy showed negligible DOX solution uptake, but an intense green emission originated from prodrug uptake. Moreover, a severe red emission in the DOX channel confirmed a promising level of drug release from the prodrug in the cytoplasm. The merged images of cancer cells confirmed the high performance of the TPE-PEGA-Hyd-DOX compound in the viewpoints of cellular uptake and drug release. This polymer prodrug successfully demonstrates low cytotoxicity in healthy cells and high performance in killing cancer cells.

Published
2022

13. Construction of a Highly Sensitive Thiol-Reactive AIEgen-Peptide Conjugate for Monitoring Protein Unfolding and Aggregation in Cells

Author

Sabouri, S, Liu, M, Zhang, S, Yao, B, Soleimaninejad, H, Baxter, AA, Armendariz-Vidales, G, Subedi, P, Duan, C, Lou, X, Hogan, CF, Heras, B, Poon, IKH, Hong, Y, Sabouri, S, Liu, M, Zhang, S, Yao, B, Soleimaninejad, H, Baxter, AA, Armendariz-Vidales, G, Subedi, P, Duan, C, Lou, X, Hogan, CF, Heras, B, Poon, IKH, and Hong, Y

Abstract

Impairment of the protein quality control network leads to the accumulation of unfolded and aggregated proteins. Direct detection of unfolded protein accumulation in the cells may provide the possibility for early diagnosis of neurodegenerative diseases. Here a new platform based on a peptide-conjugated thiol-reactive aggregation-induced emission fluorogen (AIEgen), named MI-BTD-P (or D1), for labeling and tracking unfolded proteins in cells is reported. In vitro experiments with model proteins show that the non-fluorescent D1 only becomes highly fluorescent when reacted with the thiol group of free cysteine (Cys) residues on unfolded proteins but not glutathione or folded proteins with buried or surface exposed Cys. When the labeled unfolded proteins form aggregates, D1 fluorescence intensity is further increased, and fluorescence lifetime is prolonged. D1 is then used to measure unfolded protein loads in cells by flow cytometry and track the aggregate formation of the D1 labeled unfolded proteins using confocal microscopy. In combination with fluorescence lifetime imaging technique, the proteome at different folding statuses can be better differentiated, demonstrating the versatility of this new platform. The rational design of D1 demonstrates the outlook of incorporation of diverse functional groups to achieve maximal sensitivity and selectivity in biological samples.

Published
2021

16. Examining Dark Triad traits in relation to mental toughness and physical activity in young adults

Author

Sabouri S, Gerber M, Sadeghi Bahmani D, Lemola S, Clough PJ, Kalak N, Shamsi M, Holsboer-Trachsler E, and S

Subjects
young adults, Dark Triad, Physical activity, gender, Neurosciences. Biological psychiatry. Neuropsychiatry, Neurology. Diseases of the nervous system, RC346-429, Mental toughness, RC321-571
Abstract

Sarah Sabouri,1 Markus Gerber,2 Dena Sadeghi Bahmani,3 Sakari Lemola,4 Peter J Clough,5 Nadeem Kalak,3 Mahin Shamsi,1 Edith Holsboer-Trachsler,3 Serge Brand2,3 1Faculty of Educational Sciences and Psychology, AllamehTabataba’i University, Tehran, Iran; 2Department of Sport, Exercise and Health, Sport Science Section, University of Basel, 3Center for Affective, Stress and Sleep Disorders, Psychiatric Clinics of the University of Basel, 4Faculty of Psychology, University of Basel, Basel, Switzerland; 5Department of Psychology, Manchester Metropolitan University, Manchester,UK Objective: The Dark Triad (DT) describes a set of three closely related personality traits: Machiavellianism, narcissism, and psychopathy. Mental toughness (MT) refers to a psychological construct combining confidence, commitment, control, and challenge. High MT is related to greater physical activity (PA) and, relative to men, women have lower MT scores. The aims of the present study were 1) to investigate the association between DT, MT, and PA, and 2) to compare the DT, MT, and PA scores of men and women.Methods: A total of 341 adults (M=29years; 51.6% women; range: 18–37years) took part in the study. Participants completed a series of questionnaires assessing DT, MT, and PA.Results: Machiavellianism, narcissism, and psychopathy were all significantly associated with higher MT scores (rs =0.45, 0.50, and 0.20, respectively). DT traits and MT were associated with more vigorous PA. Compared to men, women participants had lower scores for DT traits (overall score and psychopathy), while no differences were found for MT or PA in both sexes.Conclusion: DT traits, high MT, and vigorous PA are interrelated. This pattern of results might explain why, for instance, successful professional athletes can at the same time be tough and ruthless. Keywords: dark triad, mental toughness, physical activity, young adults, sex

Published
2016

17. Retracted: Is immunosuppression, induced by neonatal thymectomy, compatible with poor reproductive performance in adult male rats?

Author

Ommati, M. M., primary, Tanideh, N., additional, Rezakhaniha, B., additional, Wang, J., additional, Sabouri, S., additional, Vahedi, M., additional, Dormanesh, B., additional, Koohi Hosseinabadi, O., additional, Rahmanifar, F., additional, Moosapour, S., additional, Akhlaghi, A., additional, Heidari, R., additional, and Zamiri, M. J., additional

Published
2017
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19. A Single-Chip GaAs MMIC Image-Rejection Front-End for Digital European Cordless Telecommunications

Author

Sabouri-S., Farahnaz, Christensen, Christian, and Larsen, Torben

Subjects
Cordless telephones -- Design and construction, Telecommunication -- Research, Microwave integrated circuits -- Usage, Noise generators (Electronics) -- Research, Business, Computers, Electronics, Electronics and electrical industries
Abstract

An active image-rejection filter is presented in this paper, which applies actively coupled passive resonators. The filter has very low noise and high insertion gain, which may eliminate the use of a low-noise amplifier (LNA) in front-end applications. The GaAs monolithic-microwave integrated-circuit (MMIC) chip area is 3.3 [mm.sup.2]. The filter has 12-dB insertion gain, 45-dB image rejection, 6.2-dB noise figure, and dissipates 4.3 mA from a 3-V supply. A MMIC mixer is also presented. The mixer applies two single-gate MESFET's on a 2.2-[mm.sup.2] GaAs substrate. The mixer has 2.5-dB conversion gain and better than 8-dB single-sideband (SSB) noise figure with a current dissipation of 3.5 mA applying a single 5-V supply. The mixer exhibits very good local oscillator (LO)/RF and LO/IF isolation of better than 30 and 17 dB, respectively. Finally, the entire front-end, including the LNA, image rejection filter, and mixer functions is realized on a 5.7-[mm.sup.2] GaAs substrate. The front-end has a conversion gain of 15 dB and an image rejection of more than 53 dB with 0-dBm LO power. The SSB noise figure is better than 6.4 dB. The total power dissipation of the front-end is 33 mW. The MMIC's are applicable as a single-block LNA and image-rejection filter, mixer, and single-block front-end in digital European cordless telecommunications. With minor modifications, the MMIC's can be applied in other wireless communication systems working around 2 GHz, e.g., GSM-1800 and GSM-1900. Index Terms--Active filter, mixer, MMIC, single chip front-end.

Published
2000

20. A single-chip GaAs MMIC image-rejection front-end for digital European cordless telecommunications

Author

F. Sabouri-S, C. Christensen, and T. Larsen

Subjects
Engineering, Radiation, business.industry, Amplifier, Local oscillator, Electrical engineering, Condensed Matter Physics, Noise figure, Image response, Filter (video), Electrical and Electronic Engineering, Telecommunications, business, Active filter, Monolithic microwave integrated circuit, Insertion gain
Abstract

An active image-rejection filter is presented in this paper, which applies actively coupled passive resonators. The filter has very low noise and high insertion gain, which may eliminate the use of a low-noise amplifier (LNA) in front-end applications. The GaAs monolithic-microwave integrated-circuit (MMIC) chip area is 3.3 mm/sup 2/. The filter has 12-dB insertion gain, 45-dB image rejection, 6.2-dB noise figure, and dissipates 4.3 mA from a 3-V supply. An MMIC mixer is also presented. The mixer applies two single-gate MESFETs on a 2.2-mm/sup 2/ GaAs substrate. The mixer has 2.5-dB conversion gain and better than 8-dB single-sideband (SSB) noise figure with a current dissipation of 3.5 mA applying a single 5-V supply. The mixer exhibits very good local oscillator (LO)/RF and LO/IF isolation of better than 30 and 17 dB, respectively, Finally, the entire front-end, including the LNA, image rejection filter, and mixer functions is realized on a 5.7-mm/sup 2/ GaAs substrate. The front-end has a conversion gain of 15 dB and an image rejection of more than 53 dB with 0-dBm LO power. The SSB noise figure is better than 6.4 dB, The total power dissipation of the front-end is 33 mW. The MMIC's are applicable as a single-block LNA and image-rejection filter, mixer, and single-block front-end in digital European cordless telecommunications. With minor modifications, the MMIC's can be applied in other wireless communication systems working around 2 GHz, e.g., GSM-1800 and GSM-1900.

Published
2000
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22. Examining Dark Triad traits in relation to mental toughness and physical activity in young adults.

Author

Sabouri, S, Gerber, M, Sadeghi Bahmani, D, Lemola, S, Clough, PJ, Kalak, N, Shamsi, M, Holsboer-Trachsler, E, Brand, S, Sabouri, S, Gerber, M, Sadeghi Bahmani, D, Lemola, S, Clough, PJ, Kalak, N, Shamsi, M, Holsboer-Trachsler, E, and Brand, S

Abstract

OBJECTIVE: The Dark Triad (DT) describes a set of three closely related personality traits: Machiavellianism, narcissism, and psychopathy. Mental toughness (MT) refers to a psychological construct combining confidence, commitment, control, and challenge. High MT is related to greater physical activity (PA) and, relative to men, women have lower MT scores. The aims of the present study were 1) to investigate the association between DT, MT, and PA, and 2) to compare the DT, MT, and PA scores of men and women. METHODS: A total of 341 adults (M=29 years; 51.6% women; range: 18-37 years) took part in the study. Participants completed a series of questionnaires assessing DT, MT, and PA. RESULTS: Machiavellianism, narcissism, and psychopathy were all significantly associated with higher MT scores (rs =0.45, 0.50, and 0.20, respectively). DT traits and MT were associated with more vigorous PA. Compared to men, women participants had lower scores for DT traits (overall score and psychopathy), while no differences were found for MT or PA in both sexes. CONCLUSION: DT traits, high MT, and vigorous PA are interrelated. This pattern of results might explain why, for instance, successful professional athletes can at the same time be tough and ruthless.

Published
2016

23. مروري بر فینگولیمد؛ اولین داروي خوراکی براي مالتیپلاسکلروزیس

Author

Amirimoghadam, P., Alimardanzadeh, M., and Sabouri, S.

Abstract

Multiple sclerosis (MS) is a progressive neurological autoimmune disease that usually starts in the late third and early forth decades of life. Demyelination of neurons in the central nervous system (CNS) and, subsequently, loss of nerve cells is the known disease pathogenesis. The disease is controlled by a class of medicines which are mainly immunomodulators. Fingolimod (FIN) is the first approved oral medication for controlling relapsing-remitting type of MS. It is chemically modified form of a fungus metabolite with long history of use in traditional Chinese medicine. Its mechanism of action is through functional antagonism of sphingosine-1 phosphate receptors which leads to lymphocyte entrapment in lymphoid tissues and reduction of their circulating number in the CNS. FIN efficacy comparing with placebo and first line therapies for MS (e.g. Interferon) has been proved through several clinical trials. Common side effects of FIN are usually mild and are well tolerated. FIN can pass through placenta and has been assigned to pregnancy category C according to the observed effects in animal studies. Since the drug molecule is secreted into milk, lactation during consumption is not recommended. Considering oral administration and mild side effects of FIN, it can be useful in management of MS. However, due to the incidence of some rare but serious adverse effects such as systemic viral infections, macular edema, and cardiovascular complications, physicians should investigate patient's clinical status and underlying comorbidities carefully. [ABSTRACT FROM AUTHOR]

Published
2018

24. Walnut leaf extract-based green synthesis of selenium nanoparticles via microwave irradiation and their characteristics assessment

Author

Sheikhlou Kosar, Allahyari Somaiyeh, Sabouri Sima, Najian Yahya, and Jafarizadeh-Malmiri Hoda

Subjects
green synthesis, microwave heating, physicochemical properties, selenium nanoparticles, walnut leaf, Agriculture, Agriculture (General), S1-972
Abstract

Selenium nanoparticles (Se NPs) have predominant characteristics compared to that in their bulk usage due to their high surface-to-volume ratio. The walnut (Juglans regia L.) leaf extract containing different bioactive compounds that act as reductant and stabilizing agents has been used for the green synthesis of the Se NPs. Influences of two synthetic variables, namely, the amount of selenium salt solution ranging from 15 to 25 mL and the amount of walnut leaf extract ranging from 1 to 5 mL, on broad emission peak (λmax) and absorbance of colloidal solutions having Se NPs were evaluated via the response surface methodology. Obtained results indicated that using microwave radiation (800 W for 4 min) and 5 mL of walnut leaf extract and 15 mL of selenium salt solution, Se NPs with λmax, absorbance, particle size, polydispersity index, and zeta potential values of 375 nm, 3.65% absorbance unit (a.u.), 208 nm, 0.206, and −24.7 mV were synthesized, which had high bactericidal activity toward Escherichia coli and Staphylococcus aureus. The transmission electron microscopy analysis also indicated that spherical and monodispersed Se NPs with a mean particle size of 150 nm were formed using the walnut leaf extract.

Published
2020
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25. Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector

Author

Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J.B., Andreopoulos, C., Andrieu, B., Anerella, M.D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G.J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B.E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F.d.M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S.B., Bravar, A., Bronner, C., Brook-Roberge, D.G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S.L., Carver, A., Castillo, R., Catanesi, M.G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G.S., Davis, S., Day, M., De Rosa, G., de André, J.P.A.M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Dinh Tran, P., Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J.E., Escudero, L., Esposito, L.S., Fechner, M., Ferrero, A., Finch, A.J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G.L., Gannaway, F.C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Ghosh, A.K., Golan, T., Goldhaber, M., Gomez-Cadenas, J.J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M.D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P.F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N.C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R.L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A.K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S.J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R.A., Joo, K.K., Jover-Manas, G.V., Jung, C.K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J.Y., Kim, S.B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L.L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K.P., Le, P.T., Levy, J.M., Licciardi, C., Lim, I.T., Lindner, T., Litchfield, R.P., Litos, M., Longhin, A., Lopez, G.D., Loverre, P.F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A.D., Marone, A.J., Marteau, J., Martin, J.F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E.L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K.S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C.A., Minamino, A., Mineev, O., Mine, S., Missert, A.D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J.F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M.L., Nelson, B., Nicholls, T.C., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J.A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S.M., Otani, M., Owen, R.A., Oyama, Y., Ozaki, T., Pac, M.Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G.F., Perkin, J.D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J.-M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J.L., Radicioni, E., Ratoff, P.N., Raufer, T.M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P.A., Rondio, E., Roney, J.M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D.I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, R.J., Smy, M., Sobczyk, J.T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S.Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H.A., Tanaka, M., Tanaka, M.M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L.F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J.J., Waldron, A.V., Walter, C.W., Wanderer, P.J., Wang, J., Ward, M.A., Ward, G.P., Wark, D., Wascko, M.O., Weber, A., Wendell, R., West, N., Whitehead, L.H., Wikström, G., Wilkes, R.J., Wilking, M.J., Williamson, Z., Wilson, J.R., Wilson, R.J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E.D., Zito, M., Zmuda, J., Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J.B., Andreopoulos, C., Andrieu, B., Anerella, M.D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G.J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B.E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F.d.M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S.B., Bravar, A., Bronner, C., Brook-Roberge, D.G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S.L., Carver, A., Castillo, R., Catanesi, M.G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G.S., Davis, S., Day, M., De Rosa, G., de André, J.P.A.M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Dinh Tran, P., Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J.E., Escudero, L., Esposito, L.S., Fechner, M., Ferrero, A., Finch, A.J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G.L., Gannaway, F.C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Ghosh, A.K., Golan, T., Goldhaber, M., Gomez-Cadenas, J.J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M.D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P.F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N.C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R.L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A.K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S.J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R.A., Joo, K.K., Jover-Manas, G.V., Jung, C.K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J.Y., Kim, S.B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L.L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K.P., Le, P.T., Levy, J.M., Licciardi, C., Lim, I.T., Lindner, T., Litchfield, R.P., Litos, M., Longhin, A., Lopez, G.D., Loverre, P.F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A.D., Marone, A.J., Marteau, J., Martin, J.F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E.L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K.S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C.A., Minamino, A., Mineev, O., Mine, S., Missert, A.D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J.F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M.L., Nelson, B., Nicholls, T.C., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J.A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S.M., Otani, M., Owen, R.A., Oyama, Y., Ozaki, T., Pac, M.Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G.F., Perkin, J.D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J.-M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J.L., Radicioni, E., Ratoff, P.N., Raufer, T.M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P.A., Rondio, E., Roney, J.M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D.I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, R.J., Smy, M., Sobczyk, J.T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S.Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H.A., Tanaka, M., Tanaka, M.M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L.F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J.J., Waldron, A.V., Walter, C.W., Wanderer, P.J., Wang, J., Ward, M.A., Ward, G.P., Wark, D., Wascko, M.O., Weber, A., Wendell, R., West, N., Whitehead, L.H., Wikström, G., Wilkes, R.J., Wilking, M.J., Williamson, Z., Wilson, J.R., Wilson, R.J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E.D., Zito, M., and Zmuda, J.

Abstract

Precise measurement of neutrino beam direction and intensity was achieved based on a new concept with modularized neutrino detectors. INGRID (Interactive Neutrino GRID) is an on-axis near detector for the T2K long baseline neutrino oscillation experiment. INGRID consists of 16 identical modules arranged in horizontal and vertical arrays around the beam center. The module has a sandwich structure of iron target plates and scintillator trackers. INGRID directly monitors the muon neutrino beam profile center and intensity using the number of observed neutrino events in each module. The neutrino beam direction is measured with accuracy better than 0.4 mrad from the measured profile center. The normalized event rate is measured with 4% precision.

Published
2012

27. Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector

Author

Abe, K., primary, Abgrall, N., additional, Ajima, Y., additional, Aihara, H., additional, Albert, J.B., additional, Andreopoulos, C., additional, Andrieu, B., additional, Anerella, M.D., additional, Aoki, S., additional, Araoka, O., additional, Argyriades, J., additional, Ariga, A., additional, Ariga, T., additional, Assylbekov, S., additional, Autiero, D., additional, Badertscher, A., additional, Barbi, M., additional, Barker, G.J., additional, Barr, G., additional, Bass, M., additional, Batkiewicz, M., additional, Bay, F., additional, Bentham, S., additional, Berardi, V., additional, Berger, B.E., additional, Bertram, I., additional, Besnier, M., additional, Beucher, J., additional, Beznosko, D., additional, Bhadra, S., additional, Blaszczyk, F.d.M., additional, Blocki, J., additional, Blondel, A., additional, Bojechko, C., additional, Bouchez, J., additional, Boyd, S.B., additional, Bravar, A., additional, Bronner, C., additional, Brook-Roberge, D.G., additional, Buchanan, N., additional, Budd, H., additional, Calvet, D., additional, Cartwright, S.L., additional, Carver, A., additional, Castillo, R., additional, Catanesi, M.G., additional, Cazes, A., additional, Cervera, A., additional, Chavez, C., additional, Choi, S., additional, Christodoulou, G., additional, Coleman, J., additional, Collazuol, G., additional, Coleman, W., additional, Connolly, K., additional, Curioni, A., additional, Dabrowska, A., additional, Danko, I., additional, Das, R., additional, Davies, G.S., additional, Davis, S., additional, Day, M., additional, De Rosa, G., additional, de André, J.P.A.M., additional, de Perio, P., additional, Dealtry, T., additional, Delbart, A., additional, Densham, C., additional, Di Lodovico, F., additional, Di Luise, S., additional, Dinh Tran, P., additional, Dobson, J., additional, Dore, U., additional, Drapier, O., additional, Dufour, F., additional, Dumarchez, J., additional, Dytman, S., additional, Dziewiecki, M., additional, Dziomba, M., additional, Emery, S., additional, Ereditato, A., additional, Escallier, J.E., additional, Escudero, L., additional, Esposito, L.S., additional, Fechner, M., additional, Ferrero, A., additional, Finch, A.J., additional, Frank, E., additional, Fujii, Y., additional, Fukuda, Y., additional, Galymov, V., additional, Ganetis, G.L., additional, Gannaway, F.C., additional, Gaudin, A., additional, Gendotti, A., additional, George, M., additional, Giffin, S., additional, Giganti, C., additional, Gilje, K., additional, Ghosh, A.K., additional, Golan, T., additional, Goldhaber, M., additional, Gomez-Cadenas, J.J., additional, Gomi, S., additional, Gonin, M., additional, Grant, N., additional, Grant, A., additional, Gumplinger, P., additional, Guzowski, P., additional, Haesler, A., additional, Haigh, M.D., additional, Hamano, K., additional, Hansen, C., additional, Hansen, D., additional, Hara, T., additional, Harrison, P.F., additional, Hartfiel, B., additional, Hartz, M., additional, Haruyama, T., additional, Hasegawa, T., additional, Hastings, N.C., additional, Hatzikoutelis, A., additional, Hayashi, K., additional, Hayato, Y., additional, Hearty, C., additional, Helmer, R.L., additional, Henderson, R., additional, Higashi, N., additional, Hignight, J., additional, Hillairet, A., additional, Hirose, E., additional, Holeczek, J., additional, Horikawa, S., additional, Hyndman, A., additional, Ichikawa, A.K., additional, Ieki, K., additional, Ieva, M., additional, Iida, M., additional, Ikeda, M., additional, Ilic, J., additional, Imber, J., additional, Ishida, T., additional, Ishihara, C., additional, Ishii, T., additional, Ives, S.J., additional, Iwasaki, M., additional, Iyogi, K., additional, Izmaylov, A., additional, Jamieson, B., additional, Johnson, R.A., additional, Joo, K.K., additional, Jover-Manas, G.V., additional, Jung, C.K., additional, Kaji, H., additional, Kajita, T., additional, Kakuno, H., additional, Kameda, J., additional, Kaneyuki, K., additional, Karlen, D., additional, Kasami, K., additional, Kato, I., additional, Kawamuko, H., additional, Kearns, E., additional, Khabibullin, M., additional, Khanam, F., additional, Khotjantsev, A., additional, Kielczewska, D., additional, Kikawa, T., additional, Kim, J., additional, Kim, J.Y., additional, Kim, S.B., additional, Kimura, N., additional, Kirby, B., additional, Kisiel, J., additional, Kitching, P., additional, Kobayashi, T., additional, Kogan, G., additional, Koike, S., additional, Konaka, A., additional, Kormos, L.L., additional, Korzenev, A., additional, Koseki, K., additional, Koshio, Y., additional, Kouzuma, Y., additional, Kowalik, K., additional, Kravtsov, V., additional, Kreslo, I., additional, Kropp, W., additional, Kubo, H., additional, Kubota, J., additional, Kudenko, Y., additional, Kulkarni, N., additional, Kurimoto, Y., additional, Kurjata, R., additional, Kutter, T., additional, Lagoda, J., additional, Laihem, K., additional, Laveder, M., additional, Lee, K.P., additional, Le, P.T., additional, Levy, J.M., additional, Licciardi, C., additional, Lim, I.T., additional, Lindner, T., additional, Litchfield, R.P., additional, Litos, M., additional, Longhin, A., additional, Lopez, G.D., additional, Loverre, P.F., additional, Ludovici, L., additional, Lux, T., additional, Macaire, M., additional, Mahn, K., additional, Makida, Y., additional, Malek, M., additional, Manly, S., additional, Marchionni, A., additional, Marino, A.D., additional, Marone, A.J., additional, Marteau, J., additional, Martin, J.F., additional, Maruyama, T., additional, Maryon, T., additional, Marzec, J., additional, Masliah, P., additional, Mathie, E.L., additional, Matsumura, C., additional, Matsuoka, K., additional, Matveev, V., additional, Mavrokoridis, K., additional, Mazzucato, E., additional, McCauley, N., additional, McFarland, K.S., additional, McGrew, C., additional, McLachlan, T., additional, Messina, M., additional, Metcalf, W., additional, Metelko, C., additional, Mezzetto, M., additional, Mijakowski, P., additional, Miller, C.A., additional, Minamino, A., additional, Mineev, O., additional, Mine, S., additional, Missert, A.D., additional, Mituka, G., additional, Miura, M., additional, Mizouchi, K., additional, Monfregola, L., additional, Moreau, F., additional, Morgan, B., additional, Moriyama, S., additional, Muir, A., additional, Murakami, A., additional, Muratore, J.F., additional, Murdoch, M., additional, Murphy, S., additional, Myslik, J., additional, Nagai, N., additional, Nakadaira, T., additional, Nakahata, M., additional, Nakai, T., additional, Nakajima, K., additional, Nakamoto, T., additional, Nakamura, K., additional, Nakayama, S., additional, Nakaya, T., additional, Naples, D., additional, Navin, M.L., additional, Nelson, B., additional, Nicholls, T.C., additional, Nielsen, C., additional, Nishikawa, K., additional, Nishino, H., additional, Nitta, K., additional, Nobuhara, T., additional, Nowak, J.A., additional, Obayashi, Y., additional, Ogitsu, T., additional, Ohhata, H., additional, Okamura, T., additional, Okumura, K., additional, Okusawa, T., additional, Oser, S.M., additional, Otani, M., additional, Owen, R.A., additional, Oyama, Y., additional, Ozaki, T., additional, Pac, M.Y., additional, Palladino, V., additional, Paolone, V., additional, Paul, P., additional, Payne, D., additional, Pearce, G.F., additional, Perkin, J.D., additional, Pettinacci, V., additional, Pierre, F., additional, Poplawska, E., additional, Popov, B., additional, Posiadala, M., additional, Poutissou, J.-M., additional, Poutissou, R., additional, Przewlocki, P., additional, Qian, W., additional, Raaf, J.L., additional, Radicioni, E., additional, Ratoff, P.N., additional, Raufer, T.M., additional, Ravonel, M., additional, Raymond, M., additional, Retiere, F., additional, Robert, A., additional, Rodrigues, P.A., additional, Rondio, E., additional, Roney, J.M., additional, Rossi, B., additional, Roth, S., additional, Rubbia, A., additional, Ruterbories, D., additional, Sabouri, S., additional, Sacco, R., additional, Sakashita, K., additional, Sánchez, F., additional, Sarrat, A., additional, Sasaki, K., additional, Scholberg, K., additional, Schwehr, J., additional, Scott, M., additional, Scully, D.I., additional, Seiya, Y., additional, Sekiguchi, T., additional, Sekiya, H., additional, Shibata, M., additional, Shimizu, Y., additional, Shiozawa, M., additional, Short, S., additional, Siyad, M., additional, Smith, R.J., additional, Smy, M., additional, Sobczyk, J.T., additional, Sobel, H., additional, Sorel, M., additional, Stahl, A., additional, Stamoulis, P., additional, Steinmann, J., additional, Still, B., additional, Stone, J., additional, Stodulski, M., additional, Strabel, C., additional, Sulej, R., additional, Suzuki, A., additional, Suzuki, K., additional, Suzuki, S., additional, Suzuki, S.Y., additional, Suzuki, Y., additional, Swierblewski, J., additional, Szeglowski, T., additional, Szeptycka, M., additional, Tacik, R., additional, Tada, M., additional, Taguchi, M., additional, Takahashi, S., additional, Takeda, A., additional, Takenaga, Y., additional, Takeuchi, Y., additional, Tanaka, K., additional, Tanaka, H.A., additional, Tanaka, M., additional, Tanaka, M.M., additional, Tanimoto, N., additional, Tashiro, K., additional, Taylor, I., additional, Terashima, A., additional, Terhorst, D., additional, Terri, R., additional, Thompson, L.F., additional, Thorley, A., additional, Toki, W., additional, Tobayama, S., additional, Tomaru, T., additional, Totsuka, Y., additional, Touramanis, C., additional, Tsukamoto, T., additional, Tzanov, M., additional, Uchida, Y., additional, Ueno, K., additional, Vacheret, A., additional, Vagins, M., additional, Vasseur, G., additional, Wachala, T., additional, Walding, J.J., additional, Waldron, A.V., additional, Walter, C.W., additional, Wanderer, P.J., additional, Wang, J., additional, Ward, M.A., additional, Ward, G.P., additional, Wark, D., additional, Wascko, M.O., additional, Weber, A., additional, Wendell, R., additional, West, N., additional, Whitehead, L.H., additional, Wikström, G., additional, Wilkes, R.J., additional, Wilking, M.J., additional, Williamson, Z., additional, Wilson, J.R., additional, Wilson, R.J., additional, Wongjirad, T., additional, Yamada, S., additional, Yamada, Y., additional, Yamamoto, A., additional, Yamamoto, K., additional, Yamanoi, Y., additional, Yamaoka, H., additional, Yamauchi, T., additional, Yanagisawa, C., additional, Yano, T., additional, Yen, S., additional, Yershov, N., additional, Yokoyama, M., additional, Yuan, T., additional, Zalewska, A., additional, Zalipska, J., additional, Zambelli, L., additional, Zaremba, K., additional, Ziembicki, M., additional, Zimmerman, E.D., additional, Zito, M., additional, and Zmuda, J., additional

Published
2012
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35. Field detection of CO and CH4 by NIR 2f modulation laser spectroscopy.

Author

Khorsandi, A., Bagherian, S., Sabouri, S. Ghavami, Romano, C., and Schade, W.

Subjects
FIELD desorption mass spectrometry, LASER spectroscopy, DETECTORS, POLLUTANTS, TUNABLE lasers
Abstract

A novel compact fiber-coupled NIR system based on a DFB diode laser source is employed as a portable and sensitive gas sensor for trace detection of combustion pollutant molecules. We demonstrate the performance of such an NIR gas sensor by tracing the absorption lines of CO and CH4 using 2f-WMS technique at moderate temperature of T ∼ 600°C in the recuperator channel of an industrial furnace provided by Mobarakeh steel company. This measurement shows the excellent sensitivity of the applied NIR gas sensor to the on-line and in-situ monitoring of such molecular species. [ABSTRACT FROM AUTHOR]

Published
2011

37. Diagnostic Accuracy of Multi-Slice Computed Tomographic (MSCT) Angiography in the Detection of Cerebral Aneurysms.

Author

Haghighatkhah, H. R., Sabouri, S., Borzouyeh, F., Bagherzadeh, M. H., Bakhshandeh, H., and Jalali, A. H.

Subjects
*INTRACRANIAL aneurysm diagnosis, *DIGITAL angiography, *CEREBROVASCULAR disease diagnosis, *TOMOGRAPHY, *DIAGNOSTIC imaging, *NONINVASIVE diagnostic tests
Abstract

Background/Objective: Multislice computed tomographic (MSCT) angiography is a rapid and minimally invasive method for the detection of intracranial aneurysms. The purpose of this study was to compare MSCT angiography with digital subtraction angiography (DSA) in the diagnosis of cerebral aneurysms. Patients and Methods: In this cross sectional study we evaluated 111 consecutive patients [42(37.8%) male and 69(62.2%) female], who were admitted under clinical symptoms and signs, suggestive of harboring an intracranial aneurysm by using a four detector MSCT angiography. Then we compared results of MSCT angiography with DSA results as a gold standard method. DSA was performed by bilateral selective common carotid artery injections and either unilateral or bilateral vertebral artery injections, as necessary. MSCT angiography images were interpreted by one radiologist and DSA was performed by another radiologist who was blinded to the interpretation of the MSCT angiograms. Results: The mean±SD age of the patients was 49.1±13.6 years (range: 12-84 years). We performed MSCT in 111 and DSA in 85 patients. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive and negative likelihood ratio (LR) of MSCT angiography, when compared with DSA as the gold standard, were 100%, 90%, 87.5%, 100%, 10 and 0, respectively. Conclusion: MSCT angiography seems to be an accurate and non-invasive imaging modality in the diagnosis of intracranial aneurysms. [ABSTRACT FROM AUTHOR]

Published
2008

38. Radiological Findings of Pulmonary Tuberculosis in Infants and Young Children.

Author

Khatami, A., Sabouri, S., Ghoroubi, J., Rassouli, N., and Gorji, F. Abdollah

Subjects
*TUBERCULOSIS diagnosis, *LUNG radiography, *CHEST disease diagnosis, *PEDIATRIC diagnosis, *DIAGNOSTIC imaging, *MEDICAL radiology, *NONINVASIVE diagnostic tests
Abstract

Background/Objective: Pulmonary tuberculosis (TB) is a common worldwide lung infection. It remains an important cause of morbidity and mortality. Radiographic manifestations of pulmonary tuberculosis are diverse and varied. This study was performed to define the various radiographic manifestations of this infection in the pediatric age group in children who were referred to Mofid Children's Hospital. Patients and Methods: We reviewed chest x-rays of 30 pulmonary TB patients admitted to our hospital to ascertain the extent of parenchymal and mediastinal involvements on chest xray. Results: Male to female ratio was 1.7:1. The patients' age ranged from 2-163 months with a mean age of 36.9 months. Mediastinal lymphadenopathy was detected in 90% of the cases and pulmonary involvement, especially alveolar shadowing was seen in 83.3% of the cases (of which 43.3% had an air-space pattern and 40% had an interstitial pattern). 19 of the 30 patients (66.3%) were under 36 months, in which 17 of the 19 patients (89.5%) revealed lymphadenopathy. Therefore 63% of all detected lymphadenopathies were seen in this age group. Mediastinal lymphadenopathy was more common on the right side (73.3%). Furthermore, 60% of all alveolar infiltrations were seen on the right side. Conclusion: Pulmonary tuberculosis most commonly represents as a mediastinal and thereafter as a parenchymal involvement. Hilo-mediastinal lymphadenopathy is the most common presentation in infants and young children. [ABSTRACT FROM AUTHOR]

Published
2008

40. First muon-neutrino disappearance study with an off-axis beam

Author

Abe, K, Abgrall, N, Ajima, Y, Aihara, H, Albert, JB, Andreopoulos, C, Andrieu, B, Anerella, MD, Aoki, S, Araoka, O, Argyriades, J, Ariga, A, Ariga, T, Assylbekov, S, Autiero, D, Badertscher, A, Barbi, M, Barker, GJ, Barr, G, Bass, M, Batkiewicz, M, Bay, F, Bentham, S, Berardi, V, Berger, BE, Bertram, I, Besnier, M, Beucher, J, Beznosko, D, Bhadra, S, Blaszczyk, FDMM, Blondel, A, Bojechko, C, Bouchez, J, Boyd, SB, Bravar, A, Bronner, C, Brook-Roberge, DG, Buchanan, N, Budd, H, Calland, RG, Calvet, D, Caravaca Rodríguez, J, Cartwright, SL, Carver, A, Castillo, R, Catanesi, MG, Cazes, A, Cervera, A, Chavez, C, Choi, S, Christodoulou, G, Coleman, J, Collazuol, G, Coleman, W, Connolly, K, Curioni, A, Dabrowska, A, Danko, I, Das, R, Davies, GS, Davis, S, Day, M, De Rosa, G, De André, JPAM, De Perio, P, Dealtry, T, Delbart, A, Densham, C, Di Lodovico, F, Di Luise, S, Dinh Tran, P, Dobson, J, Dore, U, Drapier, O, Duboyski, T, Dufour, F, Dumarchez, J, Dytman, S, Dziewiecki, M, Dziomba, M, Emery, S, Ereditato, A, Escallier, JE, Escudero, L, Esposito, LS, Fechner, M, Ferrero, A, Finch, AJ, Frank, E, Fujii, Y, Fukuda, Y, Galymov, V, Ganetis, GL, Gannaway, FC, Gaudin, A, Gendotti, A, George, MA, Giffin, S, Giganti, C, Gilje, K, Ghosh, AK, Golan, T, Goldhaber, M, Gomez-Cadenas, JJ, Gomi, S, Gonin, M, Grant, N, Grant, A, Gumplinger, P, Guzowski, P, Hadley, DR, Haesler, A, Haigh, MD, Hamano, K, Hansen, C, Hansen, D, Hara, T, Harrison, PF, Hartfiel, B, Hartz, M, Haruyama, T, Hasegawa, T, Hastings, NC, Hatzikoutelis, A, Hayashi, K, Hayato, Y, Hearty, C, Helmer, RL, Henderson, R, Higashi, N, Hignight, J, Hillairet, A, Hiraki, T, Hirose, E, Holeczek, J, Horikawa, S, Huang, K, Hyndman, A, Ichikawa, AK, Ieki, K, Ieva, M, Iida, M, Ikeda, M, Ilic, J, Imber, J, Ishida, T, Ishihara, C, Ishii, T, Ives, SJ, Iwasaki, M, Iyogi, K, Izmaylov, A, Jamieson, B, Johnson, RA, Joo, KK, Jover-Manas, GV, Jung, CK, Kaji, H, Kajita, T, Kakuno, H, Kameda, J, Kaneyuki, K, Karlen, D, Kasami, K, Kato, I, Kawamuko, H, Kearns, E, Khabibullin, M, Khanam, F, Khotjantsev, A, Kielczewska, D, Kikawa, T, Kim, J, Kim, JY, Kim, SB, Kimura, N, Kirby, B, Kisiel, J, Kitching, P, Kobayashi, T, Kogan, G, Koike, S, Konaka, A, Kormos, LL, Korzenev, A, Koseki, K, Koshio, Y, Kouzuma, Y, Kowalik, K, Kravtsov, V, Kreslo, I, Kropp, W, Kubo, H, Kubota, J, Kudenko, Y, Kulkarni, N, Kurimoto, Y, Kurjata, R, Kutter, T, Lagoda, J, Laihem, K, Laveder, M, Lawe, M, Lee, KP, Le, PT, Levy, JM, Licciardi, C, Lim, IT, Lindner, T, Lister, C, Litchfield, RP, Litos, M, Longhin, A, Lopez, GD, Loverre, PF, Ludovici, L, Lux, T, MacAire, M, Magaletti, L, Mahn, K, Makida, Y, Malek, M, Manly, S, Marchionni, A, Marino, AD, Marone, AJ, Marteau, J, Martin, JF, Maruyama, T, Maryon, T, Marzec, J, Masliah, P, Mathie, EL, Matsumura, C, Matsuoka, K, Matveev, V, Mavrokoridis, K, Mazzucato, E, McCauley, N, McFarland, KS, McGrew, C, McLachlan, T, Messina, M, Metcalf, W, Metelko, C, Mezzetto, M, Mijakowski, P, Miller, CA, Minamino, A, Mineev, O, Mine, S, Missert, AD, Mituka, G, Miura, M, Mizouchi, K, Monfregola, L, Moreau, F, Morgan, B, Moriyama, S, Muir, A, Murakami, A, Muratore, JF, Murdoch, M, Murphy, S, Myslik, J, Nagai, N, Nakadaira, T, Nakahata, M, Nakai, T, Nakajima, K, Nakamoto, T, Nakamura, K, Nakayama, S, Nakaya, T, Naples, D, Navin, ML, Nicholls, TC, Nielsen, B, Nielsen, C, Nishikawa, K, Nishino, H, Nitta, K, Nobuhara, T, Nowak, JA, Obayashi, Y, Ogitsu, T, Ohhata, H, Okamura, T, Okumura, K, Okusawa, T, Oser, SM, Otani, M, Owen, RA, Oyama, Y, Ozaki, T, Pac, MY, Palladino, V, Paolone, V, Paul, P, Payne, D, Pearce, GF, Perkin, JD, Pettinacci, V, Pierre, F, Poplawska, E, Popov, B, Posiadala, M, Poutissou, J-M, Poutissou, R, Przewlocki, P, Qian, W, Raaf, JL, Radicioni, E, Ratoff, PN, Raufer, TM, Ravonel, M, Raymond, M, Reeves, M, Retiere, F, Robert, A, Rodrigues, PA, Rondio, E, Roney, JM, Rossi, B, Roth, S, Rubbia, A, Ruterbories, D, Sabouri, S, Sacco, R, Sakashita, K, Sánchez, F, Sarrat, A, Sasaki, K, Scholberg, K, Schwehr, J, Scott, M, Scully, DI, Seiya, Y, Sekiguchi, T, Sekiya, H, Shibata, M, Shimizu, Y, Shiozawa, M, Short, S, Sinclair, PD, Siyad, M, Smith, BM, Smith, RJ, Smy, M, Sobczyk, JT, Sobel, H, Sorel, M, Stahl, A, Stamoulis, P, Steinmann, J, Still, B, Stone, J, Strabel, C, Sulej, R, Suzuki, A, Suzuki, K, Suzuki, S, Suzuki, SY, Suzuki, Y, Szeglowski, T, Szeptycka, M, Tacik, R, Tada, M, Taguchi, M, Takahashi, S, Takeda, A, Takenaga, Y, Takeuchi, Y, Tanaka, K, Tanaka, HA, Tanaka, M, Tanaka, MM, Tanimoto, N, Tashiro, K, Taylor, I, Terashima, A, Terhorst, D, Terri, R, Thompson, LF, Thorley, A, Toki, W, Tobayama, S, Tomaru, T, Totsuka, Y, Touramanis, C, Tsukamoto, T, Tzanov, M, Uchida, Y, Ueno, K, Vacheret, A, Vagins, M, Vasseur, G, Veledar, O, Wachala, T, Walding, JJ, Waldron, AV, Walter, CW, Wanderer, PJ, Wang, J, Ward, MA, Ward, GP, Wark, D, Wascko, MO, Weber, A, Wendell, R, West, N, Whitehead, LH, Wikström, G, Wilkes, RJ, Wilking, MJ, Williamson, Z, Wilson, Wilson, RJ, Wongjirad, T, Yamada, S, Yamada, Y, Yamamoto, A, Yamamoto, K, Yamanoi, Y, Yamaoka, H, Yamauchi, T, Yanagisawa, C, Yano, T, Yen, S, Yershov, N, Yokoyama, M, Yuan, T, Zalewska, A, Zalipska, J, Zambelli, L, Zaremba, K, Ziembicki, M, Zimmerman, ED, Zito, M, and Zmuda, J

Subjects
Physics::Instrumentation and Detectors, hep-ex, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Physics::Accelerator Physics, High Energy Physics::Experiment, 7. Clean energy
Abstract

We report a measurement of muon-neutrino disappearance in the T2K experiment. The 295-km muon-neutrino beam from Tokai to Kamioka is the first implementation of the off-axis technique in a long-baseline neutrino oscillation experiment.

41. Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector

Author

Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Anerella, M. D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De Rosa, G., de André, J. P. A. M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K. P., Le, P. T., levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., Mccauley, N., McFarland, K. S., Mcgrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M. L., Nelson, B., Nicholls, T. C., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J. A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikström, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., Zmuda, J., Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Anerella, M. D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De Rosa, G., de André, J. P. A. M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K. P., Le, P. T., levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., Mccauley, N., McFarland, K. S., Mcgrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M. L., Nelson, B., Nicholls, T. C., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J. A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikström, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Abstract

Precise measurement of neutrino beam direction and intensity was achieved based on a new concept with modularized neutrino detectors. INGRID (Interactive Neutrino GRID) is an on-axis near detector for the T2K long baseline neutrino oscillation experiment. INGRID consists of 16 identical modules arranged in horizontal and vertical arrays around the beam center. The module has a sandwich structure of iron target plates and scintillator trackers. INGRID directly monitors the muon neutrino beam profile center and intensity using the number of observed neutrino events in each module. The neutrino beam direction is measured with accuracy better than 0.4 mrad from the measured profile center. The normalized event rate is measured with 4% precision.

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43. Sex-Specific Mechanisms of Fluoride-Induced Gonadal Injury: A Multi-Omics Investigation into Reproductive Toxicity and Gut Microbiota Disruption.

Author

Ommati MM, Jin Y, Zamiri MJ, Retana-Marquez S, Nategh Ahmadi H, Sabouri S, Song SZ, Heidari R, and Wang HW

Subjects
Animals, Male, Female, Mice, Bacteria classification, Bacteria genetics, Bacteria isolation & purification, Bacteria metabolism, Bacteria drug effects, Testis drug effects, Testis metabolism, Gonads drug effects, Gonads metabolism, Humans, Transcriptome, Multiomics, Gastrointestinal Microbiome drug effects, Fluorides toxicity, Mice, Inbred ICR, Reproduction drug effects, Oxidative Stress drug effects
Abstract

Fluoride, a common agricultural additive used to enhance plant resilience and pest control, poses toxicity risks when exposure surpasses safe thresholds, affecting ecosystems and human health. While its reproductive toxicity is recognized, the sex-specific and cross-generational effects remain underexplored. To address this gap, we employed an integrative approach combining transcriptomics (next-generation sequencing (NGS)), bioinformatic network analysis, gut microbiota sequencing, and in vivo functional assays. ICR mice (F0 generation), both male and female, were exposed to fluoride (100 mg/L in drinking water) for 35 days, continuing through gestation and offspring weaning. Our transcriptomic analysis revealed significant upregulation of autophagy (via the PI3K-AKT-mTOR pathway) and oxidative stress-induced mitochondrial dysfunction in gonadal tissue, with more pronounced effects observed in males. Further integrated analyses of transcriptomic and metabolomic data, supported by in vivo experiments, highlighted oxidative stress, mitochondrial dysfunction, and PI3K-AKT-mTOR pathway activation with stronger effects in males. The principal component analysis confirmed sex-specific transcriptome alterations, with males showing more substantial disruption. Additionally, 16S rRNA sequencing identified significant gut dysbiosis, particularly in males, with an increased Firmicutes/Bacteroidetes ratio and higher abundances of Oscillospirales and Anaerovoracaceae . Moreover, our study identified significant correlations between specific gut microbiota (e.g., Firmicutes , Proteobacteria ) and autophagy, oxidative stress, and mitochondrial dysfunction pathways, with notable sex-dependent differences. These findings suggest that gut microbiota may play a critical role in modulating fluoride-induced reproductive toxicity, particularly through their effects on oxidative stress and cellular homeostasis. The breakdown of the gut barrier and elevated serum/gonadal lipopolysaccharide (LPS) levels in fluoride-treated mice further established a link between gut dysbiosis and fluoride-induced reproductive toxicity. These findings underscore the importance of considering sex differences in xenobiotic-induced reproductive and developmental toxicity.

Published
2025
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44. Fluoride-Induced Autophagy and Apoptosis in the Mouse Ovary: Genomic Insights into IL-17 Signaling and Gut Microbiota Dysbiosis.

Author

Ommati MM, Zuo Q, Sabouri S, Retana-Marquez S, Nategh Ahmadi H, Gholami A, Eftekhari A, Shojaei S, Lijuan L, Heidari R, and Wang HW

Subjects
Animals, Female, Mice, Fluorides toxicity, Pregnancy, Autophagy drug effects, Gastrointestinal Microbiome drug effects, Apoptosis drug effects, Dysbiosis chemically induced, Interleukin-17 genetics, Interleukin-17 metabolism, Ovary drug effects, Ovary metabolism, Signal Transduction drug effects
Abstract

Chronic fluoride (F) exposure is linked to gonadotoxicity in females, yet the underlying molecular mechanisms remain unclear. This study investigated fluoride-induced reprotoxicity using advanced genomic profiling. RNA-seq analysis identified significant activation of autophagy, apoptosis, and IL-17 signaling pathways in fluoride-exposed female mice. To explore these mechanisms, F0 pregnant mice were exposed to deionized water (control) or 100 mg/L sodium fluoride (NaF) during gestation and throughout the F1 generation ( n = 16 females/group), covering puberty to weaning and maturity. NaF exposure caused significant reductions in body weight, organ coefficients, and pathological indices, with increased ovarian autophagic vacuoles, mitochondrial injuries, and elevated serum/ovary LPS levels in F1 females. qRT-PCR, fluorescent staining, biochemical assays, and Western blotting confirmed the activation of IL-17 signaling, apoptosis, and autophagy. Moreover, 16S rRNA sequencing revealed gut microbiota dysbiosis in NaF-exposed F1 females, potentially exacerbating ovary injury via serum LPS elevation. The gut dysbiosis could justify deteriorated serum LPS levels and its connection to F-induced ovary injury. These findings provide mechanistic insights into fluoride-induced reprotoxicity, emphasizing the interplay of IL-17 signaling, autophagy, and apoptosis in disrupting cellular homeostasis and suggesting potential therapeutic targets.

Published
2025
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45. Long-term taurine supplementation regulates brain mitochondrial dynamics in mice.

Author

Rezaei H, Wang HW, Tian W, Zhao J, Najibi A, Retana-Márquez S, Rafiei E, Rowhanirad A, Sabouri S, Kiafar M, Fazlinezhad R, Niknahad AM, Evazzadeh F, Anousheh ST, Ommati MM, Niknahad H, and Heidari R

Subjects
Animals, Mice, Male, Depression drug therapy, Dietary Supplements, Memory drug effects, Cognition drug effects, Behavior, Animal drug effects, Taurine pharmacology, Taurine administration & dosage, Mitochondrial Dynamics drug effects, Brain drug effects, Brain metabolism, Mitochondria drug effects, Mitochondria metabolism, Anxiety
Abstract

Background: Taurine (TAU) is the most abundant non-protein amino acid in the central nervous system (CNS). However, the molecular mechanism of TAU in the CNS is still poorly understood. Meanwhile, disruption in mitochondrial dynamics is evident in CNS disorders. This study aimed to investigate the effect of TAU on mitochondrial dynamics., Methods: TAU (0.25, 0.5 and 1% in drinking water) was administered to young mice for six months. Several memory/cognition parameters and indices of anxiety/depression were assessed. Meanwhile, various mitochondrial indices and the expression/activity of genes involved in mitochondrial biogenesis and dynamics (Akt, CREB, NRF1, TFAM, PGC-1α, Mfn1, Mfn2, UCP2, PINK1, OPA1, Drp1 and Fis1) were examined., Results: TAU significantly enhanced memory performance, suppressed anxiety and depression-like behaviour, increased mitochondrial biogenesis/dynamics and improved mitochondrial indices. It should be mentioned that there was no significant difference between different concentrations of TAU in changing most brain mitochondrial dynamic biomarkers in the current study., Conclusions: These findings offer more insights into the molecular mechanism for TAU's action in the CNS. However, there is a need for further research to confirm these effects in humans. Overall, this study suggests the potential application of TAU in various neurological disorders and the need for clinical studies on the effects of this amino acid in the brain., (© 2024 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.)

Published
2025
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46. Isolation, characterization, and potential application of Acinetobacter baumannii phages against extensively drug-resistant strains.

Author

Rastegar S, Skurnik M, Niaz H, Tadjrobehkar O, Samareh A, Hosseini-Nave H, and Sabouri S

Subjects
Acinetobacter Infections microbiology, Phage Therapy, Sewage virology, Sewage microbiology, Humans, Acinetobacter baumannii virology, Acinetobacter baumannii drug effects, Genome, Viral genetics, Bacteriophages genetics, Bacteriophages isolation & purification, Bacteriophages classification, Bacteriophages physiology, Drug Resistance, Multiple, Bacterial, Host Specificity, Anti-Bacterial Agents pharmacology
Abstract

One of the significant issues in treating bacterial infections is the increasing prevalence of extensively drug-resistant (XDR) strains of Acinetobacter baumannii. In the face of limited or no viable treatment options for extensively drug-resistant (XDR) bacteria, there is a renewed interest in utilizing bacteriophages as a treatment option. Three Acinetobacter phages (vB&#95;AbaS&#95;Ftm, vB&#95;AbaS&#95;Eva, and vB&#95;AbaS&#95;Gln) were identified from hospital sewage and analyzed for their morphology, host ranges, and their genome sequences were determined and annotated. These phages and vB&#95;AbaS&#95;SA1 were combined to form a phage cocktail. The antibacterial effects of this cocktail and its combinations with selected antimicrobial agents were evaluated against the XDR A. baumannii strains. The phages exhibited siphovirus morphology. Out of a total of 30 XDR A. baumannii isolates, 33% were sensitive to vB&#95;AbaS&#95;Ftm, 30% to vB&#95;AbaS&#95;Gln, and 16.66% to vB&#95;AbaS&#95;Eva. When these phages were combined with antibiotics, they demonstrated a synergistic effect. The genome sizes of vB&#95;AbaS&#95;Ftm, vB&#95;AbaS&#95;Eva, and vB&#95;AbaS&#95;Gln were 48487, 50174, and 50043 base pairs (bp), respectively, and showed high similarity. Phage cocktail, when combined with antibiotics, showed synergistic effects on extensively drug-resistant (XDR) strains of A. baumannii. However, the need for further study to fully understand the mechanisms of action and potential limitations of using these phages is highlighted., Competing Interests: Declarations Conflict of interests The authors declare no competing interests. Ethics approval The present study was approved by the Ethics Committee of Kerman University of Medical Sciences (Ethics code: IR.KMU.REC.1400.526.)., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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47. Synergistic effects of bacteriophage cocktail and antibiotics combinations against extensively drug-resistant Acinetobacter baumannii.

Author

Rastegar S, Skurnik M, Tadjrobehkar O, Samareh A, Samare-Najaf M, Lotfian Z, Khajedadian M, Hosseini-Nave H, and Sabouri S

Subjects
Humans, Phage Therapy methods, Microbial Sensitivity Tests, Acinetobacter baumannii virology, Acinetobacter baumannii drug effects, Biofilms drug effects, Biofilms growth & development, Anti-Bacterial Agents pharmacology, Bacteriophages physiology, Acinetobacter Infections microbiology, Acinetobacter Infections therapy, Drug Resistance, Multiple, Bacterial
Abstract

Background: The extensively drug-resistant (XDR) strains of Acinetobacter baumannii have become a major cause of nosocomial infections, increasing morbidity and mortality worldwide. Many different treatments, including phage therapy, are attractive ways to overcome the challenges of antibiotic resistance., Methods: This study investigates the biofilm formation ability of 30 XDR A. baumannii isolates and the efficacy of a cocktail of four tempetate bacteriophages (SA1, Eve, Ftm, and Gln) and different antibiotics (ampicillin/sulbactam, meropenem, and colistin) in inhibiting and degrading the biofilms of these strains., Results: The majority (83.3%) of the strains exhibited strong biofilm formation. The bacteriophage cocktail showed varying degrees of effectiveness against A. baumannii biofilms, with higher concentrations generally leading to more significant inhibition and degradation rates. The antibiotics-bacteriophage cocktail combinations also enhanced the inhibition and degradation of biofilms., Conclusion: The findings suggested that the bacteriophage cocktail is an effective tool in combating A. baumannii biofilms, with its efficacy depending on the concentration. Combining antibiotics with the bacteriophage cocktail improved the inhibition and removal of biofilms, indicating a promising strategy for managing A. baumannii infections. These results contribute to our understanding of biofilm dynamics and the potential of bacteriophage cocktails as a novel therapeutic approach to combat antibiotic-resistant bacteria., (© 2024. The Author(s).)

Published
2024
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48. Drug-induced Tongue Disorders: A Comprehensive Literature Review.

Author

Amiri S, Nikvarz N, and Sabouri S

Abstract

Background: Some drugs cause tongue disorders as adverse effects. Most of the druginduced tongue disorders are benign and will resolve after drug discontinuation. However, the changes in the color or appearance of the tongue may frighten patients and decrease compliance with drug therapy., Objective: To review the literature to find all reports of drug-induced tongue disorders, their presentation, management, and outcome of patients Methods: The search was conducted in Google Scholar and PubMed using key words "ageusia," "burning tongue," "coated tongue," "drug-induced taste disturbances," "dysgeusia," "glossitis," "glossodynia," "hairy tongue," "hypogeusia," "stomatodynia," "stomatopyrosis," "swollen tongue" "tongue discoloration," "tongue irritation," "tongue numbness, "tongue oedema," and "tongue ulcer. All reports that were published from 1980 to 2022 in the English language were included in the study. Reports that were not in English language but had English abstracts with adequate data for extraction were also included., Results: A total of 208 case reports and case series were included. The most reported drug classes were antineoplastic and immunomodulating agents and anti-infectives for systemic use, and the most common tongue disorders were tongue discoloration and black hairy tongue. Having good oral hygiene and discontinuing the offending drug could manage and resolve the problem., Conclusion: Drug-induced tongue disorders are not rare adverse drug reactions. They are benign in most cases, and withholding offending agents results in significant improvement or complete resolution of tongue lesions., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2024
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49. Pesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent Developmental Study in Mice.

Author

Ommati MM, Nozhat Z, Sabouri S, Kong X, Retana-Márquez S, Eftekhari A, Ma Y, Evazzadeh F, Juárez-Rojas L, Heidari R, and Wang HW

Subjects
Animals, Female, Male, Mice, Locomotion drug effects, Humans, TOR Serine-Threonine Kinases metabolism, TOR Serine-Threonine Kinases genetics, Chlorpyrifos toxicity, Chlorpyrifos adverse effects, Autophagy drug effects, Mice, Inbred ICR, Anxiety chemically induced, Anxiety physiopathology, Anxiety metabolism, Depression metabolism, Depression genetics, Depression chemically induced, Depression physiopathology, Oxidative Stress drug effects, Pesticides toxicity, Pesticides adverse effects, Behavior, Animal drug effects
Abstract

Chlorpyrifos (CPF), dichlorvos (DDV), and cypermethrin (CP), as commonly used pesticides, have been implicated in inducing neuropsychiatric disorders, such as anxiety, depression-like behaviors, and locomotor activity impairment. However, the exact molecular mechanisms of these adverse effects, particularly in both sexes and their next-generation effects, remain unclear. In this study, we conducted behavioral analysis, along with cellular assays (monodansylcadaverine staining) and molecular investigations (qRT-PCR and western blotting of mTOR, P62, and Beclin-1) to clear the potential role of autophagy in pesticide-induced behavioral alterations. For this purpose, 42 adult female and 21 male inbred ICR mice (F0) were distributed into seven groups. Maternal mice (F0) and 112 F1 offspring were exposed to 0.5 and 1 ppm of CPF, DDV, and CP through drinking water. F1 male and female animals were studied to assess the sex-specific effects of pesticides on brain tissue. Our findings revealed pronounced anxiogenic effects and impaired locomotor activity in mice. F1 males exposed to CPF (1 ppm) exhibited significantly elevated depression-like behaviors compared to other groups. Moreover, pesticide exposure reduced mTOR and P62 levels, while enhancing the Beclin-1 gene and protein expression. These changes in autophagy signaling pathways, coupled with oxidative and neurogenic damage in the cerebral cortex and hippocampus, potentially contribute to heightened locomotor activity, anxiety, and depression-like behaviors following pesticide exposure. This study underscores the substantial impact of pesticides on both physiological and behavioral aspects, emphasizing the necessity for comprehensive assessments and regulatory considerations for pesticide use. Additionally, the identification of sex-specific responses presents a crucial dimension for pharmaceutical sciences, highlighting the need for tailored therapeutic interventions and further research in this field.

Published
2024
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