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727 results on '"Sabourin, Jean-Christophe"'

5. Ultrafast Gene Fusion Assessment for Nonsquamous NSCLC

Author

Hofman, Véronique, Heeke, Simon, Bontoux, Christophe, Chalabreysse, Lara, Barritault, Marc, Bringuier, Pierre Paul, Fenouil, Tanguy, Benzerdjeb, Nazim, Begueret, Hugues, Merlio, Jean Philippe, Caumont, Charline, Piton, Nicolas, Sabourin, Jean-Christophe, Evrard, Solène, Syrykh, Charlotte, Vigier, Anna, Brousset, Pierre, Mazieres, Julien, Long-Mira, Elodie, Benzaquen, Jonathan, Boutros, Jacques, Allegra, Maryline, Tanga, Virginie, Lespinet-Fabre, Virginie, Salah, Myriam, Bonnetaud, Christelle, Bordone, Olivier, Lassalle, Sandra, Marquette, Charles-Hugo, Ilié, Marius, and Hofman, Paul

Published
2023
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8. CEA, CA19-9, circulating DNA and circulating tumour cell kinetics in patients treated for metastatic colorectal cancer (mCRC)

Author

Sefrioui, David, Beaussire, Ludivine, Gillibert, André, Blanchard, France, Toure, Emmanuel, Bazille, Céline, Perdrix, Anne, Ziegler, Frédéric, Gangloff, Alice, Hassine, Mélanie, Elie, Caroline, Bignon, Anne-Laure, Parzy, Aurélie, Gomez, Philippe, Thill, Caroline, Clatot, Florian, Sabourin, Jean-Christophe, Frebourg, Thierry, Benichou, Jacques, Bouhier-Leporrier, Karine, Gallais, Marie-Pierre, Sarafan-Vasseur, Nasrin, Michel, Pierre, and Di Fiore, Frédéric

Published
2021
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9. Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice.

Author

Mintet, Elodie, Lavigne, Jérémy, Paget, Vincent, Tarlet, Georges, Buard, Valérie, Guipaud, Olivier, Sabourin, Jean-Christophe, Iruela-Arispe, Maria-Luisa, Milliat, Fabien, and François, Agnès

Subjects
Cells, Cultured, Animals, Humans, Mice, Proctitis, Radiation Injuries, Repressor Proteins, Fluorescent Antibody Technique, Immunohistochemistry, Gene Deletion, Phenotype, Basic Helix-Loop-Helix Transcription Factors, Epithelial-Mesenchymal Transition, Human Umbilical Vein Endothelial Cells, Transcriptome, Biomarkers, Stem Cell Research, Prevention, Digestive Diseases, 2.1 Biological and endogenous factors, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

The current study evaluated the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice. Phenotypic modifications of irradiated, Hey2 siRNA- and Hey2 vector plasmid-transfected human umbilical vein endothelial cells (HUVECs) resembling EndoMT were monitored by qPCR, immunocytochemistry and western blots. Subsequently, in mice, a Cre-LoxP strategy for inactivation of Hey2 specifically in the endothelium was used to study the biological consequences. Total body irradiation and radiation proctitis were monitored to investigate the impact of conditional Hey2 deletion on intestinal stem cells and microvascular compartment radiosensitivity, EndoMT and rectal damage severity. We found that EndoMT occurs in irradiated HUVECs with concomitant Hey2 mRNA and protein increase. While Hey2 silencing has no effect on radiation-induced EndoMT in vitro, Hey2 overexpression is sufficient to induce phenotypic conversion of endothelial cells. In mice, the conditional deletion of Hey2 reduces EndoMT frequency and the severity of rectal tissue damage. Our data indicate that the reduction in mucosal damage occurs through decline in stem/clonogenic epithelial cell loss mediated by microvascular protection. EndoMT is involved in radiation proctitis and this study demonstrates that a strategy based on the reduction of EndoMT mitigates intestinal tissue damage.

Published
2017

12. In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury.

Author

Rannou, Emilie, François, Agnès, Toullec, Aurore, Guipaud, Olivier, Buard, Valérie, Tarlet, Georges, Mintet, Elodie, Jaillet, Cyprien, Iruela-Arispe, Maria Luisa, Benderitter, Marc, Sabourin, Jean-Christophe, and Milliat, Fabien

Subjects
Intestines, Intestinal Mucosa, Endothelium, Animals, Mice, Knockout, Mice, Radiation Injuries, Experimental, Cell Survival, Gene Expression Regulation, Gamma Rays, Serpin E2
Abstract

The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an endothelium-dependent mechanism. We investigated whether endothelial-specific PAI-1 deletion could affect radiation-induced intestinal injury. We created a mouse model with a specific deletion of PAI-1 in the endothelium (PAI-1KO(endo)) by a Cre-LoxP system. In a model of radiation enteropathy, survival and intestinal radiation injury were followed as well as intestinal gene transcriptional profile and inflammatory cells intestinal infiltration. Irradiated PAI-1KO(endo) mice exhibited increased survival, reduced acute enteritis severity and attenuated late fibrosis compared with irradiated PAI-1(flx/flx) mice. Double E-cadherin/TUNEL labeling confirmed a reduced epithelial cell apoptosis in irradiated PAI-1KO(endo). High-throughput gene expression combined with bioinformatic analyses revealed a putative involvement of macrophages. We observed a decrease in CD68(+)cells in irradiated intestinal tissues from PAI-1KO(endo) mice as well as modifications associated with M1/M2 polarization. This work shows that PAI-1 plays a role in radiation-induced intestinal injury by an endothelium-dependent mechanism and demonstrates in vivo that the endothelium is directly involved in the progression of radiation-induced enteritis.

Published
2015

14. Multicenter Evaluation of a Novel ROS1 Immunohistochemistry Assay (SP384) for Detection of ROS1 Rearrangements in a Large Cohort of Lung Adenocarcinoma Patients

Author

Hofman, Véronique, Rouquette, Isabelle, Long-Mira, Elodie, Piton, Nicolas, Chamorey, Emmanuel, Heeke, Simon, Vignaud, Jean Michel, Yguel, Clémence, Mazières, Julien, Lepage, Anne-Laure, Bibeau, Frédéric, Begueret, Hugues, Lassalle, Sandra, Lalvée, Salomé, Zahaf, Katia, Benzaquen, Jonathan, Poudenx, Michel, Marquette, Charles-Hugo, Sabourin, Jean-Christophe, Ilié, Marius, and Hofman, Paul

Published
2019
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22. LHCG Receptor in pheochromocytoma

Author

Lopez, Antoine-Guy, primary, Duparc, Celine, additional, Renouf, Sylvie, additional, Sabourin, Jean-Christophe, additional, Buffet, Alexandre, additional, Gimenez-Roqueplo, Anne-Paule, additional, Dubessy, Christophe, additional, Louiset, Estelle, additional, and Lefebvre, Herve, additional

Published
2023
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24. Supplementary Figure S6 from Functional Analysis of Somatic Mutations Affecting Receptor Tyrosine Kinase Family in Metastatic Colorectal Cancer

Author

Duplaquet, Leslie, primary, Figeac, Martin, primary, Leprêtre, Frédéric, primary, Frandemiche, Charline, primary, Villenet, Céline, primary, Sebda, Shéhérazade, primary, Sarafan-Vasseur, Nasrin, primary, Bénozène, Mélanie, primary, Vinchent, Audrey, primary, Goormachtigh, Gautier, primary, Wicquart, Laurence, primary, Rousseau, Nathalie, primary, Beaussire, Ludivine, primary, Truant, Stéphanie, primary, Michel, Pierre, primary, Sabourin, Jean-Christophe, primary, Galateau-Sallé, Françoise, primary, Copin, Marie-Christine, primary, Zalcman, Gérard, primary, De Launoit, Yvan, primary, Fafeur, Véronique, primary, and Tulasne, David, primary

Published
2023
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25. Data from Functional Analysis of Somatic Mutations Affecting Receptor Tyrosine Kinase Family in Metastatic Colorectal Cancer

Author

Duplaquet, Leslie, primary, Figeac, Martin, primary, Leprêtre, Frédéric, primary, Frandemiche, Charline, primary, Villenet, Céline, primary, Sebda, Shéhérazade, primary, Sarafan-Vasseur, Nasrin, primary, Bénozène, Mélanie, primary, Vinchent, Audrey, primary, Goormachtigh, Gautier, primary, Wicquart, Laurence, primary, Rousseau, Nathalie, primary, Beaussire, Ludivine, primary, Truant, Stéphanie, primary, Michel, Pierre, primary, Sabourin, Jean-Christophe, primary, Galateau-Sallé, Françoise, primary, Copin, Marie-Christine, primary, Zalcman, Gérard, primary, De Launoit, Yvan, primary, Fafeur, Véronique, primary, and Tulasne, David, primary

Published
2023
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26. Supplementary Table S1 from Functional Analysis of Somatic Mutations Affecting Receptor Tyrosine Kinase Family in Metastatic Colorectal Cancer

Author

Duplaquet, Leslie, primary, Figeac, Martin, primary, Leprêtre, Frédéric, primary, Frandemiche, Charline, primary, Villenet, Céline, primary, Sebda, Shéhérazade, primary, Sarafan-Vasseur, Nasrin, primary, Bénozène, Mélanie, primary, Vinchent, Audrey, primary, Goormachtigh, Gautier, primary, Wicquart, Laurence, primary, Rousseau, Nathalie, primary, Beaussire, Ludivine, primary, Truant, Stéphanie, primary, Michel, Pierre, primary, Sabourin, Jean-Christophe, primary, Galateau-Sallé, Françoise, primary, Copin, Marie-Christine, primary, Zalcman, Gérard, primary, De Launoit, Yvan, primary, Fafeur, Véronique, primary, and Tulasne, David, primary

Published
2023
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27. Characteristics and Outcomes of Patients with Lung Cancer Harboring Multiple Molecular Alterations: Results from the IFCT Study Biomarkers France

Author

Guibert, Nicolas, Barlesi, Fabrice, Descourt, Renaud, Léna, Hervé, Besse, Benjamin, Beau-Faller, Michèle, Mosser, Jean, Pichon, Eric, Merlio, Jean-Philippe, Ouafik, L'Houcine, Guichard, François, Mastroianni, Bénédicte, Moreau, Lionel, Wdowik, Annie, Sabourin, Jean-Christophe, Lemoine, Antoinette, Missy, Pascale, Langlais, Alexandra, Moro-Sibilot, Denis, and Mazières, Julien

Published
2017
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28. Supplementary Figure 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Author

Salaun, Bruno, primary, Zitvogel, Laurence, primary, Asselin-Paturel, Carine, primary, Morel, Yannis, primary, Chemin, Karine, primary, Dubois, Clarisse, primary, Massacrier, Catherine, primary, Conforti, Rosa, primary, Chenard, Marie Pierre, primary, Sabourin, Jean-Christophe, primary, Goubar, Aicha, primary, Lebecque, Serge, primary, Pierres, Michel, primary, Rimoldi, Donata, primary, Romero, Pedro, primary, and Andre, Fabrice, primary

Published
2023
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29. Supplementary Table 1 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Author

Salaun, Bruno, primary, Zitvogel, Laurence, primary, Asselin-Paturel, Carine, primary, Morel, Yannis, primary, Chemin, Karine, primary, Dubois, Clarisse, primary, Massacrier, Catherine, primary, Conforti, Rosa, primary, Chenard, Marie Pierre, primary, Sabourin, Jean-Christophe, primary, Goubar, Aicha, primary, Lebecque, Serge, primary, Pierres, Michel, primary, Rimoldi, Donata, primary, Romero, Pedro, primary, and Andre, Fabrice, primary

Published
2023
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30. Data from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Author

Salaun, Bruno, primary, Zitvogel, Laurence, primary, Asselin-Paturel, Carine, primary, Morel, Yannis, primary, Chemin, Karine, primary, Dubois, Clarisse, primary, Massacrier, Catherine, primary, Conforti, Rosa, primary, Chenard, Marie Pierre, primary, Sabourin, Jean-Christophe, primary, Goubar, Aicha, primary, Lebecque, Serge, primary, Pierres, Michel, primary, Rimoldi, Donata, primary, Romero, Pedro, primary, and Andre, Fabrice, primary

Published
2023
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31. Supplementary Figure 1 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Author

Maby, Pauline, primary, Tougeron, David, primary, Hamieh, Mohamad, primary, Mlecnik, Bernhard, primary, Kora, Hafid, primary, Bindea, Gabriela, primary, Angell, Helen K., primary, Fredriksen, Tessa, primary, Elie, Nicolas, primary, Fauquembergue, Emilie, primary, Drouet, Aurélie, primary, Leprince, Jérôme, primary, Benichou, Jacques, primary, Mauillon, Jacques, primary, Le Pessot, Florence, primary, Sesboüé, Richard, primary, Tuech, Jean-Jacques, primary, Sabourin, Jean-Christophe, primary, Michel, Pierre, primary, Frébourg, Thierry, primary, Galon, Jérôme, primary, and Latouche, Jean-Baptiste, primary

Published
2023
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32. Supplementary Figure 2 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Author

Maby, Pauline, primary, Tougeron, David, primary, Hamieh, Mohamad, primary, Mlecnik, Bernhard, primary, Kora, Hafid, primary, Bindea, Gabriela, primary, Angell, Helen K., primary, Fredriksen, Tessa, primary, Elie, Nicolas, primary, Fauquembergue, Emilie, primary, Drouet, Aurélie, primary, Leprince, Jérôme, primary, Benichou, Jacques, primary, Mauillon, Jacques, primary, Le Pessot, Florence, primary, Sesboüé, Richard, primary, Tuech, Jean-Jacques, primary, Sabourin, Jean-Christophe, primary, Michel, Pierre, primary, Frébourg, Thierry, primary, Galon, Jérôme, primary, and Latouche, Jean-Baptiste, primary

Published
2023
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33. Data from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Author

Maby, Pauline, primary, Tougeron, David, primary, Hamieh, Mohamad, primary, Mlecnik, Bernhard, primary, Kora, Hafid, primary, Bindea, Gabriela, primary, Angell, Helen K., primary, Fredriksen, Tessa, primary, Elie, Nicolas, primary, Fauquembergue, Emilie, primary, Drouet, Aurélie, primary, Leprince, Jérôme, primary, Benichou, Jacques, primary, Mauillon, Jacques, primary, Le Pessot, Florence, primary, Sesboüé, Richard, primary, Tuech, Jean-Jacques, primary, Sabourin, Jean-Christophe, primary, Michel, Pierre, primary, Frébourg, Thierry, primary, Galon, Jérôme, primary, and Latouche, Jean-Baptiste, primary

Published
2023
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34. Supplementary Figure Legends 1-2, Table Legend and Methods from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Author

Salaun, Bruno, primary, Zitvogel, Laurence, primary, Asselin-Paturel, Carine, primary, Morel, Yannis, primary, Chemin, Karine, primary, Dubois, Clarisse, primary, Massacrier, Catherine, primary, Conforti, Rosa, primary, Chenard, Marie Pierre, primary, Sabourin, Jean-Christophe, primary, Goubar, Aicha, primary, Lebecque, Serge, primary, Pierres, Michel, primary, Rimoldi, Donata, primary, Romero, Pedro, primary, and Andre, Fabrice, primary

Published
2023
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35. Supplementary Figure 3 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Author

Maby, Pauline, primary, Tougeron, David, primary, Hamieh, Mohamad, primary, Mlecnik, Bernhard, primary, Kora, Hafid, primary, Bindea, Gabriela, primary, Angell, Helen K., primary, Fredriksen, Tessa, primary, Elie, Nicolas, primary, Fauquembergue, Emilie, primary, Drouet, Aurélie, primary, Leprince, Jérôme, primary, Benichou, Jacques, primary, Mauillon, Jacques, primary, Le Pessot, Florence, primary, Sesboüé, Richard, primary, Tuech, Jean-Jacques, primary, Sabourin, Jean-Christophe, primary, Michel, Pierre, primary, Frébourg, Thierry, primary, Galon, Jérôme, primary, and Latouche, Jean-Baptiste, primary

Published
2023
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36. Supplementary Figure Legend from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Author

Maby, Pauline, primary, Tougeron, David, primary, Hamieh, Mohamad, primary, Mlecnik, Bernhard, primary, Kora, Hafid, primary, Bindea, Gabriela, primary, Angell, Helen K., primary, Fredriksen, Tessa, primary, Elie, Nicolas, primary, Fauquembergue, Emilie, primary, Drouet, Aurélie, primary, Leprince, Jérôme, primary, Benichou, Jacques, primary, Mauillon, Jacques, primary, Le Pessot, Florence, primary, Sesboüé, Richard, primary, Tuech, Jean-Jacques, primary, Sabourin, Jean-Christophe, primary, Michel, Pierre, primary, Frébourg, Thierry, primary, Galon, Jérôme, primary, and Latouche, Jean-Baptiste, primary

Published
2023
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37. Supplementary Table 1 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Author

Maby, Pauline, primary, Tougeron, David, primary, Hamieh, Mohamad, primary, Mlecnik, Bernhard, primary, Kora, Hafid, primary, Bindea, Gabriela, primary, Angell, Helen K., primary, Fredriksen, Tessa, primary, Elie, Nicolas, primary, Fauquembergue, Emilie, primary, Drouet, Aurélie, primary, Leprince, Jérôme, primary, Benichou, Jacques, primary, Mauillon, Jacques, primary, Le Pessot, Florence, primary, Sesboüé, Richard, primary, Tuech, Jean-Jacques, primary, Sabourin, Jean-Christophe, primary, Michel, Pierre, primary, Frébourg, Thierry, primary, Galon, Jérôme, primary, and Latouche, Jean-Baptiste, primary

Published
2023
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38. Supplementary Figure 2 from TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

Author

Salaun, Bruno, primary, Zitvogel, Laurence, primary, Asselin-Paturel, Carine, primary, Morel, Yannis, primary, Chemin, Karine, primary, Dubois, Clarisse, primary, Massacrier, Catherine, primary, Conforti, Rosa, primary, Chenard, Marie Pierre, primary, Sabourin, Jean-Christophe, primary, Goubar, Aicha, primary, Lebecque, Serge, primary, Pierres, Michel, primary, Rimoldi, Donata, primary, Romero, Pedro, primary, and Andre, Fabrice, primary

Published
2023
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39. Supplementary Table 2 from Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

Author

Maby, Pauline, primary, Tougeron, David, primary, Hamieh, Mohamad, primary, Mlecnik, Bernhard, primary, Kora, Hafid, primary, Bindea, Gabriela, primary, Angell, Helen K., primary, Fredriksen, Tessa, primary, Elie, Nicolas, primary, Fauquembergue, Emilie, primary, Drouet, Aurélie, primary, Leprince, Jérôme, primary, Benichou, Jacques, primary, Mauillon, Jacques, primary, Le Pessot, Florence, primary, Sesboüé, Richard, primary, Tuech, Jean-Jacques, primary, Sabourin, Jean-Christophe, primary, Michel, Pierre, primary, Frébourg, Thierry, primary, Galon, Jérôme, primary, and Latouche, Jean-Baptiste, primary

Published
2023
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40. Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

Author

Passot, Guillaume, Kim, Bradford J., Glehen, Olivier, Mehran, Reza J., Kopetz, Scott E., Goere, Diane, Overman, Michael J., Pocard, Marc, Marchal, Frédéric, Conrad, Claudius, Aloia, Thomas A., Vauthey, Jean-Nicolas, Chun, Yun Shin, Abba, Julio, Abboud, Karine, Alyami, Mohammad, Arvieux, Catherine, Asnacios, Amani, Averous, Gerlinde, Bakrin, Naoual, Bardier, Armelle, Rejeb, Houda Ben, Bereder, Jean-Marc, Bernard, Jean-Louis, Bibeau, Frédéric, Bonnefoy, Isabelle, Borg, Christophe, Boschetti, Gilles, Bouarioua, Nadia, Bouche, Olivier, Bouzard, Dominique, Brigand, Cécile, Cacheux, Wulfran, Capitain, Olivier, Carrère, Sébastien, Carretier, Michel, Castel, Benjamin, Chauvenet, Marion, Chevallier, Anne, Coffin, Benoît, Costan, Cristina, Cotte, Eddy, Courvoisier, Thomas, Dahan, Laetitia, Dartigues, Peggy, De Chaisemartin, Cécile, Dechelotte, Pierre, Deguelte-Lardière, Sophie, Delpero, Jean-Robert, Del Grande, Jean, Demarchi, Martin, Desandes, Emmanuel, Desolneux, Grégoire, Dufour, Patrick, Dumont, Frédéric, Durand-Fontanier, Sylvaine, Eveno, Clarisse, Evrard, Serge, Facy, Olivier, Farkhondeh, Fereshteh, Fontaine, Juliette, Gagniere, Johan, Galais, Marie-Pierre, Ghouti, Laurent, Gilly, François-Noël, Goasguen, Nicolas, Gornet, Jean-Marc, Gourdiole, Pierre, Guerin-Meyer, Véronique, Guilloit, Jean-Marc, Guimbaud, Rosine, Guyon, Frédéric, Heyd, Bruno, Heymann, Marie-Françoise, Isaac, Sylvie, Jouet, Pauline, Jourdan-Enfer, Peggy, Jouve, Jean-Louis, Kaci, Rachid, Karoui, Mehdi, Kianmanesh, Reza, Kirzin, Sylvain, Kurtz, Jean-Emmanuel, Labrousse, François, Lebrun-Ly, Valérie, Lefevre, Jérémie, Lelong, Bernard, Lemaistre, Anne-Elisabeth, Leroux-Broussier, Agnès, Levillain, Pierre, Linot, Benjamin, Dico, Réa Lo, Loi, Valéria, Lorimier, Gérard, Mahammat, Abakar, Malka, David, Marchal, Frédéric, Mariani, Antoine, Mariani, Pascale, Mariette, Christophe, Martin, Laurent, Meeus, Pierre, Meffert, Jean-Luc, Messager, Mathieu, Michel, Pierre, Msika, Simon, Muron, Thierry, Noel, Georges, Ortega-Deballon, Pablo, Paquette, Brice, Peoc’h, Michel, Petorin, Caroline, Peyrat, Patrice, Pezet, Denis, Piessen, Guillaume, Pirro, Nicolas, Pocard, Marc, Poizat, Flora, Porcheron, Jack, Poulet, Anaïs, Portales, Fabienne, la Denise, Justine Prost a, Quenet, François, Rat, Patrick, Rebischung, Christine, Regimbeau, Jean-Marc, Rivoirard, Romain, Rohr, Serge, Rougier, Philippe, Rousselot, Pierre, Saban-Roche, Léa, Sabate, Jean-Marc, Sabbagh, Charles, Sabourin, Jean-Christophe, Samalin-Scalzi, Emmanuelle, Seitz, Jean-François, Selves, Janick, Senellart, Helène, Serrano, Martine, Sgabura, Olivia, Sielezneff, Igor, Svrcek, Magali, Taibi, Abdelkader, Taieb, Julien, Thibaudeau, Emilie, Tougeron, David, Tuech, Jean-Jacques, Valmary-Degano, Séverine, Vaudoyer, Delphine, Verriele-Beurrier, Véronique, Villeneuve, Laurent, Volet, Julien, Wernert, Romuald, Ychou, Marc, You, Benoît, Zaanan, Aziz, Zinzindohoue, Franck, and on behalf of the BIG-RENAPE Working Group

Published
2017
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41. Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)

Author

Barlesi, Fabrice, Mazieres, Julien, Merlio, Jean-Philippe, Debieuvre, Didier, Mosser, Jean, Lena, Hervé, Ouafik, L'Houcine, Besse, Benjamin, Rouquette, Isabelle, Westeel, Virginie, Escande, Fabienne, Monnet, Isabelle, Lemoine, Antoinette, Veillon, Rémi, Blons, Hélène, Audigier-Valette, Clarisse, Bringuier, Pierre-Paul, Lamy, Régine, Beau-Faller, Michèle, Pujol, Jean-Louis, Sabourin, Jean-Christophe, Penault-Llorca, Frédérique, Denis, Marc G, Lantuejoul, Sylvie, Morin, Franck, Tran, Quân, Missy, Pascale, Langlais, Alexandra, Milleron, Bernard, Cadranel, Jacques, Soria, Jean-Charles, and Zalcman, Gérard

Published
2016
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44. Assessment of endobronchial ultrasound‐guided bronchoscopy (EBUS) intranodal forceps biopsy added to EBUS 19‐gauge transbronchial needle aspiration: A blinded pathology panel analysis.

Author

Lachkar, Samy, Faur, Quentin, Marguet, Florent, Veresezan, Liana, Bubenheim, Michael, Salaün, Mathieu, Thiberville, Luc, Sabourin, Jean‐Christophe, Guisier, Florian, and Piton, Nicolas

Subjects
LYMPHATIC disease diagnosis, TUMOR diagnosis, STATISTICAL significance, ULTRASONIC imaging, CONFIDENCE intervals, LYMPH nodes, RETROSPECTIVE studies, FISHER exact test, MANN Whitney U Test, QUALITY assurance, DESCRIPTIVE statistics, BRONCHOSCOPY, NEEDLE biopsy, EVALUATION
Abstract

Background: Endobronchial ultrasound‐guided (EBUS) transbronchial needle aspiration (TBNA) has significantly improved the diagnostic workup for intrathoracic lymphadenopathies. More recently, EBUS intranodal forceps biopsy (IFB) has been developed in an attempt to maximize diagnostic yield by providing additional tissue. In this study, we aimed to assess the improvement of diagnostic yield with EBUS‐TBNA combined with EBUS‐IFB, compared to EBUS‐TBNA alone. Methods: Consecutive patients who had 19‐G EBUS‐TBNA and EBUS‐IFB from August 30, 2018, to September 28, 2021, were included. Four senior pathologists retrospectively analyzed, independently and blindly, first, only the EBUS‐TBNA samples (cell block), then, at least 1 month later, both samples from EBUS‐TBNA and from EBUS‐IFB together. Results: Fifty patients were included in the study and 52 lymph nodes were analyzed. Diagnostic yield was 77% (40/52) for EBUS‐TBNA alone and 94% (49/52) when combined with EBUS‐IFB (p = 0.023). Malignancy was diagnosed with EBUS‐TBNA combined with EBUS‐IFB in 25/26 cases (96%), versus 22/26 (85%) with EBUS‐TBNA alone (p = 0.35); and 4/5 (80%) versus 2/5 (40%) for lymphoma specifically. Kappa interobserver agreement was 0.92 for EBUS‐IFB and 0.87 for EBUS‐TBNA alone. Nonmalignant condition was diagnosed with EBUS‐TBNA combined with EBUS‐IFB in 24/26 cases (92%), versus 18/26 (69%) for EBUS‐TBNA alone (p = 0.07). Conclusion: The use of EBUS‐IFB combined with 19‐G EBUS‐TBNA improves the mediastinal lymph node diagnostic yield However the benefit appears to be mainly restricted to nonmalignant histology. [ABSTRACT FROM AUTHOR]

Published
2023
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46. OR20-4 Expression of the Neuropeptide Substance P and the NK1 Receptor in Aldosterone-Producing Adenomas

Author

Amar, Laurence, primary, Cornu, Erika Cornu, additional, Defortescu, Guillaume, additional, Duparc, Céline, additional, Fernandes-Rosa, Fabio L, additional, Lefebvre, Hervé, additional, Louiset, Estelle, additional, Manceau, Gilles, additional, Meatchi, Tchao, additional, Renouf, Sylvie, additional, Sabourin, Jean-Christophe, additional, Zennaro, Maria-Christina, additional, and Lopez, Antoine-Guy, additional

Published
2022
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47. RF33 | PSUN04 Luteinizing Hormone-Chorionic Gonadotrophin Receptor in Pheochromocytomas

Author

Lopez, Antoine-Guy, primary, Duparc, Céline, additional, Renouf, Sylvie, additional, Machevin, Elise, additional, Guillou, Vincent L, additional, Sabourin, Jean-Christophe, additional, Defortescu, Guillaume, additional, Buffet, Alexandre, additional, Gimenez-Roqueplo, Anne-Paule, additional, Dubessy, Christophe, additional, Lefebvre, Hervé, additional, and Louiset, Estelle, additional

Published
2022
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48. Gestational choriocarcinoma associated with a germline TP53 mutation

Author

Brehin, Anne-Claire, Patrier-Sallebert, Sophie, Bougeard, Gaëlle, Side-Pfennig, Gwendoline, Llamas Gutierrez, Francisco, Lamy, Aude, Colasse, Elodie, Kandel-Aznar, Christine, Delnatte, Capucine, Vuillemin, Eric, Sadot-Lebouvier, Sophie, Odent, Sylvie, Sabourin, Jean-Christophe, Golfier, François, and Frebourg, Thierry

Published
2017
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