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The problems of solvability and construction of solutions of a nonlinear Fredholm functional-integral equation of the first kind with degenerate kernel and nonlinear deviation are considered. Using the method of regularization in combination with the method of degenerate kernel, an implicit functional equation with nonlinear deviation is obtained. Since Fredholm functional-integral equation of the first kind is illposed, the boundary conditions to ensure the uniqueness of the solution is used. In order to use the method of successive approximations and prove the unique solvability, the obtained implicit functional equation is transformed to the nonlinear Volterra type functional-integral equation of the second kind. The unique solvability of the problem is proved. [ABSTRACT FROM AUTHOR]

The clinical course of hypoplastic anemia (HA) has been assessed in 21 patients with uterine bleedings. The disease was associated with severe onset and progress, profound pancytopenia and myelodepression or even critical states. Superimposed infectious inflammatory and other diseases aggravated HA by promoting hemorrhagic events, especially uterine bleedings. An initial treatment using packed erythrocyte transfusions and glucocorticoid hormones reversed anemia and hemorrhages in 11 of 21 patients with HA. Splenectomy was performed in 8 and ovariectomy in 1 of 11 patients whose blood and bone marrow tests improved after the treatment. The other 12 patients were maintained on transfusion and drug regimens. The efficacy of splenectomy and other interventions for HA in women with uterine bleedings depends on an response to received treatments.