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2. Contributors

Author

Abbott-Johnson, Winsome, primary, Acar, Niyazi, additional, Achiron, Asaf, additional, Agte, Vaishali, additional, Armstrong, R.A., additional, Aydın, Bahri, additional, Bahmani, Fereshteh, additional, Bretillon, Lionel, additional, Bron, Alain M., additional, Burgansky-Eliash, Zvia, additional, Chaubey, Pramila, additional, Čolak, Emina, additional, Cole, Damian, additional, Comaratta, Marc, additional, Cossenza, M., additional, Creuzot-Garcher, Catherine P., additional, Cubbidge, R.C., additional, Cubbidge, R.P., additional, Cutolo, Carlo Alberto, additional, de Koning-Backus, Alexandra P M, additional, de Oliveira Izar, Maria Cristina, additional, de Velasco, Patricia Coelho, additional, Domith, I., additional, Encarnação, T.G., additional, Erdurmuş, Mesut, additional, Esfandiari, Hamed, additional, Estévez-Santiago, Rocío, additional, Farajzadeh, Asghar, additional, Finnemann, Silvia C., additional, Fonseca, Francisco Antonio Helfenstein, additional, Fortenbach, Christopher, additional, Gehlbach, Peter L., additional, Gite, Snehal, additional, Goldman, Elissa, additional, Grieb, Paweł, additional, Haller, Julia A., additional, Han, Sang Beom, additional, Hayashi, Rijo, additional, Hecht, Idan, additional, Helfenstein, Tatiana, additional, Hogg, Ruth E, additional, Hyon, Joon Young, additional, Jin, Yao, additional, Jiramongkolchai, Kim, additional, K. Reddy, Rahul, additional, Kazal, Frances H., additional, Kerlin, Paul, additional, Kiefte-de Jong, Jessica C, additional, Kishan, Amar U., additional, Klaver, Caroline C W, additional, Kohno, Kimitoshi, additional, Lin, Dingbo, additional, Loewen, Nils A., additional, Maharshak, Idit, additional, Mathew, Shilpa, additional, Mazzoni, Francesca, additional, Miyamoto, Naoya, additional, Modjtahedi, Bobeck S., additional, Morse, Lawrence S., additional, Murahari, Manikanta, additional, Naranjit, Nara, additional, Obi, Robert Kelechi, additional, Olmedilla-Alonso, Begoña, additional, Paes-de-Carvalho, R., additional, Pintea, Adela, additional, Portugal, C.C., additional, Qin, Jiang, additional, Roizenblatt, Marina, additional, Rossi, Tommaso, additional, Rugină, Dumitriţa, additional, Saccà, Sergio Claudio, additional, Sandre, Poliana Capucho, additional, Sangave, Preeti C., additional, Sarkar, Megha, additional, Serfaty, Claudio Alberto, additional, Serra, Horacio M., additional, Shenge, Juliet Adamma, additional, Simavlı, Hüseyin, additional, Socodato, R., additional, Spinazzi, Marco, additional, Srinivasan, Krishnapura, additional, Storey, Philip P., additional, Suárez, María Fernanda, additional, Suvarna, Vasanti, additional, Tosun, Mehmet, additional, Vargas, Jade, additional, Woodside, Jayne V, additional, Wu, Lei, additional, Xi, Chen, additional, Yağcı, Ramazan, additional, Yong, Ji, additional, Zahra Bathaie, S., additional, and Žorić, Lepša, additional

Published
2019
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6. Contributors

Author

Abbott-Johnson, Winsome, primary, Acar, Niyazi, additional, Agte, Vaishali, additional, Agudelo, Daniel, additional, Altea, Maria Antonietta, additional, Armstrong, R.A., additional, Aung, Tin, additional, Aydın, Bahri, additional, Bahmani, Fereshteh, additional, Balmer, D., additional, Bathaie, S. Zahra, additional, Bell, Lynne, additional, Berendschot, Tos T.J.M., additional, Bernstein, Paul S., additional, Besch, Brian M., additional, Bourassa, Philippe, additional, Bozard, R.B., additional, Bretillon, Lionel, additional, Bron, Alain M., additional, Buaud, Benjamin, additional, Buitendijk, Gabriëlle H.S., additional, Butler, Laurie T., additional, Caporossi, Aldo, additional, Caragiuli, Stefano, additional, Cartier, Chloé, additional, Cartiglia, Cristina, additional, Chan, Chi-Ming, additional, Chang, Min-Lee, additional, Charles, Bashira A., additional, Chew, Emily Y., additional, Cheng, Ching-Yu, additional, Chiu, Chung-Jung, additional, Chopra, Deepika, additional, Coelho de Velasco, Patricia, additional, Coman, David, additional, Combe, Nicole, additional, Corella, Dolores, additional, Cossenza, M., additional, Costa, Simonetta, additional, Creuzot-Garcher, Catherine P., additional, Cristina de Oliveira Izar, Maria, additional, Cubbidge, R.P., additional, Cwanger, Alyssa, additional, Delcourt, Cécile, additional, Delyfer, Marie-Noëlle, additional, Domith, I.C.L., additional, Dunaief, David, additional, Dunaief, Joshua L., additional, Elanchezhian, Rajan, additional, Eller, Andrew W., additional, Encarnação, T.G., additional, Erdurmuş, Mesut, additional, Espósito, Evangelina, additional, Farajzadeh, Asghar, additional, Field, David T., additional, Finnemann, Silvia C., additional, Fliesler, Steven J., additional, Froger, Nicolas, additional, Ganapathy, P.S., additional, Ganapathy, V., additional, Garcia-Medina, Jose J., additional, Geraldine, Pitchairaj, additional, Giannantonio, Carmen, additional, Gibson, C.R., additional, Gite, Snehal, additional, Goldenberg-Cohen, N., additional, Gole, Glen, additional, Gorovoy, Ian R., additional, Haller, Julia A., additional, Hark, Lisa, additional, Hayashi, Rijo, additional, He, Hui, additional, Helfenstein, Tatiana, additional, Helfenstein Fonseca, Francisco Antonio, additional, Hosoya, Ken-ichi, additional, Huang, Yi-Ling, additional, Hung, Chi-Feng, additional, Ibberson, M., additional, Izumi, Hiroto, additional, Izzotti, Alberto, additional, Järvinen, Riikka L., additional, Ji, Hua, additional, Jin, Yao, additional, Joffre, Corinne, additional, Joo, Choun-Ki, additional, Jung, Sang Hoon, additional, Kallio, Heikki P., additional, Kerlin, Paul, additional, Kim, Eun Chul, additional, Kim, Jin Sook, additional, Kishan, Amar U., additional, Klaver, Caroline C.W., additional, Kohno, Kimitoshi, additional, Korobelnik, Jean-François, additional, Kubo, Yoshiyuki, additional, Larmo, Petra S., additional, Lauterbach, Ryszard, additional, Li, Ling-Jun, additional, Lin, Dingbo, additional, Lopez-Galvez, M.I., additional, Lu, Yi, additional, Lu, Zhi-Quan, additional, Manco Lavado, F., additional, Marcocci, Claudio, additional, Mathew, Shilpa, additional, Mazzotta, Cosimo, additional, Menconi, Francesca, additional, Miyamoto, Naoya, additional, Modjtahedi, Bobeck S., additional, Morse, Lawrence S., additional, Mount, Sarah W., additional, Muralidharan, Arumugam R., additional, Nicholson, Benjamin P., additional, Paes-de-Carvalho, R., additional, Pastor, J.C., additional, Pawlik, Dorota, additional, Payne, John F., additional, Petrovič, Daniel, additional, Picaud, Serge, additional, Pinazo-Duran, Maria D., additional, Pintea, Adela Mariana, additional, Plat, Jogchum, additional, Portugal, C.C., additional, Prasad, Ananda S., additional, Preedy, Victor R., additional, Qin, Jiang, additional, Roduit, R., additional, Romagnoli, Costantino, additional, Rougier, Marie-Bénédicte, additional, Rugină, Dumitriţa Olivia, additional, Sabanayagam, Charumathi, additional, Saccà, Sergio Claudio, additional, Sahel, José-Alain, additional, Saint-Amour, Dave, additional, Sanz-Solana, Pedro, additional, Saw, Seang Mei, additional, Schorderet, D.F., additional, Serfaty, Claudio Alberto, additional, Serra, Horacio M., additional, Sethna, Saumil, additional, Siak, Jay, additional, Simavlı, Hüseyin, additional, Smith, S.B., additional, Smith, S.M., additional, Socodato, R., additional, Spinazzi, Marco, additional, Srinivasan, K., additional, Storey, Philip, additional, Suárez, María Fernanda, additional, Tajmir-Riahi, H.A., additional, Tan, Gavin S., additional, Tangpricha, Vin, additional, Tawara, Akihiko, additional, Teresa, P. Archana, additional, Thomas, Philip A., additional, Tosun, Mehmet, additional, Urrets-Zavalía, Julio A., additional, Vachali, Preejith P., additional, Vaysse, Carole, additional, Viau, Sabrina, additional, Williams, Claire M., additional, Wong, Tien Y., additional, Xi, Chen, additional, Yağcı, Ramazan, additional, Yan, Jia, additional, Yang, Baoru, additional, Yong, Ji, additional, Zanon-Moreno, Vicente, additional, Zhu, Xiangjia, additional, and Zwart, S.R., additional

Published
2014
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7. Glaucoma

Author

Saccà, Sergio Claudio, primary, Cartiglia, Cristina, additional, and Izzotti, Alberto, additional

Published
2014
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21. Cover Image, Volume 231, Number 9, September 2016

Author

Saccà, Sergio Claudio, primary, Gandolfi, Stefano, additional, Bagnis, Alessandro, additional, Manni, Gianluca, additional, Damonte, Gianluca, additional, Traverso, Carlo Enrico, additional, and Izzotti, Alberto, additional

Published
2016
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32. The Dysfunction of the Trabecular Meshwork During Glaucoma Course.

Author

Saccà, Sergio Claudio, Pulliero, Alessandra, and Izzotti, Alberto

Subjects
*GLAUCOMA, *CANCELLOUS bone, *TISSUE analysis, *LATERAL geniculate body, *MITOCHONDRIAL pathology, *OXIDATIVE stress
Abstract

Primary open angle glaucoma is a multi-tissue disease that targets, in an ascending order, the trabecular meshwork, the optic nerve head, the lateral geniculate nuclei, and the visual cortex. Oxidative stress and vascular damage play major roles in triggering apoptotic cell loss in these tissues. Molecular alterations occurring in the ocular anterior chamber during the early course of glaucoma trigger this cell loss. These molecular events are mainly of endogenous origin and related to the long-term accumulation of oxidative damages arising from mitochondrial failure and endothelial dysfunction. This situation results in decreased antioxidant defences in aqueous humour and apoptosis activation in trabecular meshwork cells as triggered by severe mitochondrial damage altering tissue function and integrity. The presence of neural proteins in glaucomatous aqueous humour indicate that a molecular interconnection exists between the anterior and the posterior chamber tissues. Trabecular meshwork and lamina cribrosa share a common neuro-ectodermal embryological, which contribute to explain the interconnection between anterior and the posterior chamber during glaucoma pathogenesis. During glaucoma, proteins deriving from the damage occurring in endothelial trabecular meshwork cells are released into aqueous humour. Accordingly, aqueous humour composition is characterised in glaucomatous patients by the presence of proteins deriving from apoptosis activation, mitochondrial damage, loss of intercellular connections, antioxidant decrease. Many questions remain unanswered, but molecular events illuminate TM damage and indicate that trabecular cell protection plays a role in the treatment and prevention of glaucoma. J. Cell. Physiol. 230: 510-525, 2015. © 2014 Wiley Periodicals, Inc., A Wiley Company [ABSTRACT FROM AUTHOR]

Published
2015
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35. The Eye, Oxidative Damage and Polyunsaturated Fatty Acids.

Author

Saccà, Sergio Claudio, Ferrari, Daniele, Cutolo, Carlo Alberto, Corazza, Paolo, and Traverso, Carlo Enrico

Abstract

Polyunsaturated fatty acids (PUFA) are known to have numerous beneficial effects, owing to their anti-inflammatory and antioxidant properties. From a metabolic standpoint, the mitochondria play a fundamental role in cellular homeostasis, and oxidative stress can affect their functioning. Indeed, the mitochondria are the main source of ROS, and an imbalance between ROS and antioxidant defenses leads to oxidative stress. In addition, aging, the decline of cellular functions, and continual exposure to light underlie many diseases, particularly those of the eye. Long-term exposure to insults, such as UV light, visible light, ionizing radiation, chemotherapeutics, and environmental toxins, contribute to oxidative damage in ocular tissues and expose the aging eye to considerable risk of pathological consequences of oxidative stress. Ample antioxidant defenses responsible for scavenging free radicals are essential for redox homeostasis in the eye, indeed, eye tissues, starting from the tear film, which normally are exposed to high oxygen levels, have strong antioxidant defenses that are efficient for protecting against ROS-related injuries. On the contrary, instead, the trabecular meshwork is not directly exposed to light and its endothelial cells are poorly equipped with antioxidant defenses. All this makes the eye a target organ of oxidative damage. This review focuses on the role of the polyunsaturated fatty acids in the human eye, particularly in such pathologies as dry eye, glaucoma, and macular degeneration, in which dietary PUFA supplementation can be a valid therapeutic aid. [ABSTRACT FROM AUTHOR]

Published
2018
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37. Common aspects between glaucoma and brain neurodegeneration.

Author

Saccà SC, Paluan F, Gandolfi S, Manni G, Cutolo CA, and Izzotti A

Subjects
Age Factors, Apoptosis, Autophagy, Brain pathology, Cell Death, Humans, Neurons pathology, Oxidative Stress, Alzheimer Disease pathology, Glaucoma pathology, Neurodegenerative Diseases pathology, Parkinson Disease pathology
Abstract

Neurodegeneration can be defined as progressive cell damage to nervous system cells, and more specifically to neurons, which involves morphologic alterations and progressive loss of function until cell death. Glaucoma exhibits many aspects of neurodegenerative disease. This review examines the pathogenesis of glaucoma, comparing it with that of Alzheimer's disease (AD) and Parkinson's disease (PD), highlighting their common features. Indeed, in all three diseases there are not only the same types of pathogenic events, but also similarities of temporal cadences that determine neuronal damage. All three age-related illnesses have oxidative damage and mitochondrial dysfunction as the first pathogenic steps. The consequence of these alterations is the death of visual neurons in glaucoma, cognitive neurons in AD and regulatory motor neurons (substantia nigra) in PD. The study of these common pathogenic events (oxidative stress, mitochondrial dysfunction, protein degradation, apoptosis and autophagy) leads us to consider common therapeutic strategies for the treatment and prevention of these diseases. Also, examination of the genetic aspects of the pathways involved in neurodegenerative processes plays a key role in shedding light on the details of pathogenesis and can suggest new treatments. This review discusses the common molecular aspects involved in these three oxidative-stress and age-related diseases., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Published
2020
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38. Corrigendum to An advanced in vitro model to assess glaucoma onset.

Author

Saccà SC, Tirendi S, Scarfì S, Passalacqua M, Oddone F, Traverso CE, Vernazza S, and Bassi AM

Abstract

In this manuscript, which appeared in ALTEX 37, 265-274 (doi: 10.14573/altex.1909262), the affiliation of Stefania Vernazza should read: Stefania Vernazza 5# 5 IRCCS-Fondazione Bietti, Rome, Italy and the address for correspondence should read: Stefania Vernazza, PhD, IRCCS, Fondazione Bietti via Livenza 3, 00198 Rome, Italy (stefania.vernazza@yahoo.it).

Published
2020
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39. Prevalence and treatment of Helicobacter pylori in patients with blepharitis.

Author

Saccà SC, Pascotto A, Venturino GM, Prigione G, Mastromarino A, Baldi F, Bilardi C, Savarino V, Brusati C, and Rebora A

Subjects
Adult, Anti-Bacterial Agents therapeutic use, Blepharitis microbiology, Breath Tests, Chronic Disease, Drug Therapy, Combination, Eye Infections, Bacterial microbiology, Female, Follow-Up Studies, Helicobacter Infections microbiology, Humans, Italy epidemiology, Male, Middle Aged, Omeprazole therapeutic use, Prevalence, Tetracycline therapeutic use, Tinidazole therapeutic use, Blepharitis drug therapy, Blepharitis epidemiology, Eye Infections, Bacterial drug therapy, Eye Infections, Bacterial epidemiology, Helicobacter Infections drug therapy, Helicobacter Infections epidemiology, Helicobacter pylori isolation & purification
Abstract

Purpose: Helicobacter pylori is a major pathogen etiologically associated with gastritis, peptic ulcer disease, gastric cancer, and primary gastric lymphoma. This study was conducted to investigate a possible association between Helicobacter pylori infection and blepharitis. Two hundred fifty consecutive patients with symptomatic blepharitis and 250 control subjects without blepharitis symptoms were evaluated. After exclusions, the blepharitis group consisted of 186 patients with blepharitis and a control group of 215 patients., Methods: Blepharitis was diagnosed on the basis of findings in ophthalmic and dermatologic examinations. All patients underwent a 13C-urea breath test (UBT) to detect H. pylori infection, and impression cytology was performed before and after eradication therapy. The follow-up period was 4 months +/- 28 days., Results: The blepharitis group showed an H. pylori infection prevalence of approximately 76.3% (UBT-positive group with blepharitis: n = 142 patients), compared with 42.3% of the control group (UBT-positive group with blepharitis [although asymptomatic]: n = 66 patients; UBT-positive group without blepharitis: n = 25 patients). Furthermore, we observed blepharitis in 30.6% (n = 66 patients) of UBT-positive control subjects and 13.4% (n = 29 patients) of UBT-negative control subjects. Impression cytology revealed that blepharitis was more severe in UBT-positive patients than in negative ones, and a clinical improvement in blepharitis was noted in approximately 50% of patients after H. pylori eradication., Conclusions: Even though possible sources of error in defining the association of two highly prevalent conditions must be considered, the data seem to validate an association between H. pylori infection and blepharitis, but may not be indicative of a causal association. Eradication of H. pylori improved ocular cytology results. It is possible that chronic blepharitis is an extradigestive manifestation of H. pylori infection.

Published
2006
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