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414 results on '"Sacchetti, Gianni"'

6. New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from β-Thalassemic Patients.

Author

Zuccato, Cristina, Cosenza, Lucia Carmela, Tupini, Chiara, Finotti, Alessia, Sacchetti, Gianni, Simoni, Daniele, Gambari, Roberto, and Lampronti, Ilaria

Subjects
FETAL hemoglobin, BIOLOGICAL assay, HEAT shock proteins, GLOBIN, SICKLE cell anemia
Abstract

Induction of fetal hemoglobin (HbF) is highly beneficial for patients carrying β-thalassemia, and novel HbF inducers are highly needed. Here, we describe a new class of promising HbF inducers characterized by an isoxazole chemical skeleton and obtained through modification of two natural molecules, geldanamycin and radicicol. After preliminary biological assays based on benzidine staining and RT-qPCR conducted on human erythroleukemic K562 cells, we employed erythroid precursors cells (ErPCs) isolated from β-thalassemic patients. ErPCs weretreated with appropriate concentrations of isoxazole derivatives. The accumulation of globin mRNAs was studied by RT-qPCR, and hemoglobin production by HPLC. We demonstrated the high efficacy of isozaxoles in inducing HbF. Most of these derivatives displayed an activity similar to that observed using known HbF inducers, such as hydroxyurea (HU) or rapamycin; some of the analyzed compounds were able to induce HbF with more efficiency than HU. All the compounds were active in reducing the excess of free α-globin in treated ErPCs. All the compounds displayed a lack of genotoxicity. These novel isoxazoles deserve further pre-clinical study aimed at verifying whether they are suitable for the development of therapeutic protocols for β-thalassemia. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Convolvulus pluricaulis Choisy’s Extraction, Chemical Characterization and Evaluation of the Potential Effects on Glycaemic Balance in a 3T3-L1 Adipocyte Cell Model

Author

Melloni, Elisabetta, primary, Grassilli, Silvia, additional, Romani, Arianna, additional, Rimondi, Erika, additional, Marcuzzi, Annalisa, additional, Zauli, Enrico, additional, Secchiero, Paola, additional, Paganetto, Guglielmo, additional, Guerrini, Alessandra, additional, Sacchetti, Gianni, additional, and Tacchini, Massimo, additional

Published
2023
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12. A Comparative Study on Chemical Compositions and Biological Activities of Four Amazonian Ecuador Essential Oils: Curcuma longa L. (Zingiberaceae), Cymbopogon citratus (DC.) Stapf, (Poaceae), Ocimum campechianum Mill. (Lamiaceae), and Zingiber officinale Roscoe (Zingiberaceae)

Author

Guerrini, Alessandra, primary, Tacchini, Massimo, additional, Chiocchio, Ilaria, additional, Grandini, Alessandro, additional, Radice, Matteo, additional, Maresca, Immacolata, additional, Paganetto, Guglielmo, additional, and Sacchetti, Gianni, additional

Published
2023
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14. New TMA (4,6,4′-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease

Author

Tupini, Chiara, primary, Chilin, Adriana, additional, Rossi, Alice, additional, De Fino, Ida, additional, Bragonzi, Alessandra, additional, D’Aversa, Elisabetta, additional, Cosenza, Lucia Carmela, additional, Vaccarin, Christian, additional, Sacchetti, Gianni, additional, Borgatti, Monica, additional, Tamanini, Anna, additional, Dechecchi, Maria Cristina, additional, Sanvito, Francesca, additional, Gambari, Roberto, additional, Cabrini, Giulio, additional, and Lampronti, Ilaria, additional

Published
2022
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15. Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening

Author

Vaccarin, Christian, primary, Gabbia, Daniela, additional, Franceschinis, Erica, additional, De Martin, Sara, additional, Roverso, Marco, additional, Bogialli, Sara, additional, Sacchetti, Gianni, additional, Tupini, Chiara, additional, Lampronti, Ilaria, additional, Gambari, Roberto, additional, Cabrini, Giulio, additional, Dechecchi, Maria Cristina, additional, Tamanini, Anna, additional, Marzaro, Giovanni, additional, and Chilin, Adriana, additional

Published
2022
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17. Nutrients and Main Secondary Metabolites Characterizing Extracts and Essential Oil from Fruits of Ammodaucus leucotrichus Coss. & Dur. (Western Sahara)

Author

Abdi Bellau, Mohamed Lamin, primary, Chiurato, Matteo Andrea, additional, Maietti, Annalisa, additional, Fantin, Giancarlo, additional, Tedeschi, Paola, additional, Marchetti, Nicola, additional, Tacchini, Massimo, additional, Sacchetti, Gianni, additional, and Guerrini, Alessandra, additional

Published
2022
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19. Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti

Author

Scalvenzi Laura, Radice Matteo, Toma Luciano, Severini Francesco, Boccolini Daniela, Bella Antonino, Guerrini Alessandra, Tacchini Massimo, Sacchetti Gianni, Chiurato Matteo, Romi Roberto, and Di Luca Marco

Subjects
Ocimum campechianum, Ocotea quixos, Piper aduncum, Essential oil, Larvicidal activity, Aedes aegypti, Infectious and parasitic diseases, RC109-216
Abstract

Aedes aegypti, the main arbovirus vector of the Yellow fever, Dengue, Chikungunya and Zika viruses, is widely distributed in tropical and subtropical areas throughout the world. Preventive control efforts have been implemented worldwide aimed at reducing its impact on human health. The recent reduction of chemicals available for vector control due to their negative impact on the environment and human health and the increase in mosquito resistance to insecticides have driven the research community to identify and evaluate sustainable alternatives to synthetic insecticides. In this study, the potential larvicidal effect of essential oils extracted from Ocimum campechianum, Ocotea quixos and Piper aduncum were tested in vitro. GC and GC–MS analyses showed that the main compounds were eugenol (18%), 1,8-cineole (39%) and dillapiole (48%), respectively. Susceptibility to essential oils was measured according to the WHO protocol. After 24 h, the mean percentage mortality ranged from 2.7 to 100% for P. aduncum, from 2.2 to 100% for O. campechianum, and from 2.9 to 100% for O. quixos. The highest potential was displayed by P. aduncum, followed by O. campechianum and O. quixos, with LC50 values of 25.7, 69.3 and 75.5 ppm, respectively. The rapid and effective larvicidal activity of these three oils led us to consider these results to be promising, also considering the possibility of local cultivation of these plants in tropical and subtropical areas and the simple technology for their large-scale preparation and production. Further studies are needed to evaluate the individual components and their activity as larvicides.

Published
2019
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20. A comprehensive ethnobotanical profile of Ocimum campechianum (Lamiaceae): from traditional medicine to phytochemical and pharmacological evidences

Author

Guardado Yordi, Estela, primary, Matos, Maria J., additional, Buso, Piergiacomo, additional, Martínez, Amaury Pérez, additional, Asanza, Mercedes, additional, Scalvenzi, Laura, additional, Manfredini, Stefano, additional, Tacchini, Massimo, additional, Radice, Matteo, additional, and Sacchetti, Gianni, additional

Published
2022
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26. Phytochemical analysis and potential natural compounds against SARS-CoV-2/COVID-19 in essential oils derived from medicinal plants originating from Lebanon. An information note.

Author

Saab, Antoine M., Tacchini, Massimo, Sacchetti, Gianni, Contini, Carlo, Schulz, Hartwig, Lampronti, Ilaria, Gambari, Roberto, Makhlouf, Hassane, Tannoury, Mona, Venditti, Alessandro, Bianco, Armandodoriano, and Racagni, Giorgio

Subjects
ESSENTIAL oils, MEDICINAL plants, FENNEL, SALVIA, SPEARMINT, CORONAVIRUS disease treatment
Abstract

The aim of the study is to identify potential natural compounds against SARS-CoV-2 occurring in essential oils (EOs) following literature data attesting their anti-viral activity. The epidemic virus that started in December 2019 in Wuhan, China, has spread worldwide as a global pandemic. The interest in the development of drugs from natural products has increased greatly in recent decades. (EOs) have been studied over the centuries and are known to possess various pharmaceutical properties. Recent antiviral and silico methods are used to discover phyto-compounds, suitable for coronavirus treatment. To obtain this result we employed gas chromatography for the analysis of essential oils from Laurus nobilis, Pinus pinea, Pistacia palaestina, Juniperus oxycedrus, Juniperus excelsa, Pinus brutia, Cupressus sempervirens, Lavandula stoechas, Origanum syriacum, O. ehrenbergi, Salvia tribola, Satureja thymbra, Calamintha origanifolia, Foeniculum vulgare, Mentha longifolia, Cuminum cyminum and Pimpinella anisum. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Phytochemical analysis and potential natural compounds against SARS-CoV-2/COVID-19 in essential oils derived from medicinal plants originating from Lebanon. An information note

Author

Saab, Antoine M., primary, Tacchini, Massimo, additional, Sacchetti, Gianni, additional, Contini, Carlo, additional, Schulz, Hartwig, additional, Lampronti, Ilaria, additional, Gambari, Roberto, additional, Makhlouf, Hassane, additional, Tannoury, Mona, additional, Venditti, Alessandro, additional, Bianco, Armandodoriano, additional, and Racagni, Giorgio, additional

Published
2021
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29. Wild Italian Hyssopus officinalis subsp. aristatus (Godr.) Nyman: From Morphological and Phytochemical Evidences to Biological Activities

Author

Guerrini, Alessandra, primary, Sacchetti, Gianni, additional, Echeverria Guevara, Monica Paulina, additional, Paganetto, Guglielmo, additional, Grandini, Alessandro, additional, Maresca, Immacolata, additional, Menghini, Luigi, additional, Di Martino, Luciano, additional, Marengo, Arianna, additional, and Tacchini, Massimo, additional

Published
2021
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39. Economia circolare: non solo geometrie. La valorizzazione sostenibile degli scarti della filiera vitivinicola

Author

Sacchetti, Gianni, Massi, Alessandro, Guerrini, Alessandra, Tacchini, Massimo, Maresca, Immacolata, Burlini, Ilaria, Grandini, Alessandro, Bernardi, Tatiana, and DE RISI, Carmela

Subjects
LS9_9, cosmesi, LS9_7, LS9_6, materie prime secondarie, filiera vitivinicola, sottoprodotti, filiera vitivinicola, sottoprodotti, materie prime secondarie, estrazioni green, biomolecole, cosmesi, nutraceutica, difesa delle piante, Socio-culturale, Ambientale, Economica, biomolecole, nutraceutica, LS9_5, estrazioni green, difesa delle piante
Published
2018

48. Chemical characterisation, antioxidant and antimicrobial screening for the revaluation of wine supply chain by-products oriented to circular economy.

Author

Tacchini, Massimo, Burlini, Ilaria, Bernardi, Tatiana, De Risi, Carmela, Massi, Alessandro, Guerrini, Alessandra, and Sacchetti, Gianni

Subjects
SUPERCRITICAL fluid extraction, WASTE products, FATTY acid esters, GALLIC acid, SUPPLY chains
Abstract

Aim of the project was the bioassay guided optimisation of extraction methods applied to wine chain by-product to obtain extracts, fractions and biologically active biomolecules with a possible use in the nutraceutical and cosmeceutical industry. Exhausted red and white grape marc were extracted using water:ethanol 50:50 with ultrasound assisted extraction and Naviglio® technology; and also with supercritical fluid extraction (SFE) and steam-distillation obtaining different phytocomplexes. Each extract was characterised by different molecular category: exhausted red grape marc (VCR) by anthocyanins, exhausted white grape marc (VCB) by flavonoids, and grapeseed (VIN) by proanthocyanins. SFE and steam-distillation, instead, highlighted the presence of fatty acids and their ester in every matrix, but terpenoids were not revealed at level major or equal than 0.1%, except for manoyl oxide in VCR (2.89%). VIN was the most abundant matrix in polyphenols (506.24 ± 55.91 mg gallic acid/g dried extract), and it showed the highest antioxidant activity (IC50 of 4.30 μg/mL). Regarding the antimicrobial activity, the hydroalcoholic extracts from VCR, VCB and VIN were tested but no noteworthy activities have been recorded. [ABSTRACT FROM AUTHOR]

Published
2019
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