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1. How Sustainable Is the Governance for Sustainability in Higher Education? Insights from an Italian Case Study

Author

Sacchi, Alessandra, Molino, Monica, Dansero, Egidio, Rossi, Alessia Antonella, and Ghislieri, Chiara

Abstract

Purpose: Higher education (HE) institutions can play a fundamental role in achieving the Sustainable Development Goals. However, universities often face various obstacles to sustainability management, leading to a lack of strategies for implementing governance for sustainability (GFS). The purpose of this paper is to propose a model, based on work and organizational psychology (WOP), for the analysis, promotion and implementation of GFS in HE. The model includes five dimensions: culture, leadership, teamwork, communication and transition management. Design/methodology/approach: Using a mixed methods approach, GFS was investigated in four Piedmontese (Northern Italy) universities and in their sustainability network, applying the model proposed in this paper. Findings: The five dimensions of the model have proven to be fundamental to the development of GFS in HE. Each dimension was filled with experiences from specific contexts through data collection, highlighting specificities and barriers. Furthermore, the mixed methods approach and the WOP perspective proved to be effective in addressing sustainable transitions in HE. Originality/value: A practical proposal for analyzing and improving HE sustainable transitions in a WOP perspective is still missing, as well as a model that identifies organizational dimensions that should be monitored. This study not only provides an example of this transition but also confirms the importance that the literature attributes to the specificities and barriers of dimensions such as culture, leadership, teamwork, communication and transition management in this context.

Published
2023
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5. Safety and immune response kinetics of GRAd-COV2 vaccine: phase 1 clinical trial results

Author

Agrati, Chiara, Castilletti, Concetta, Battella, Simone, Cimini, Eleonora, Matusali, Giulia, Sommella, Andrea, Sacchi, Alessandra, Colavita, Francesca, Contino, Alessandra M., Bordoni, Veronica, Meschi, Silvia, Gramigna, Giulia, Barra, Federica, Grassi, Germana, Bordi, Licia, Lapa, Daniele, Notari, Stefania, Casetti, Rita, Bettini, Aurora, Francalancia, Massimo, Ciufoli, Federica, Vergori, Alessandra, Vita, Serena, Gentile, Michela, Raggioli, Angelo, Plazzi, Maria M., Bacchieri, Antonella, Nicastri, Emanuele, Antinori, Andrea, Milleri, Stefano, Lanini, Simone, Colloca, Stefano, Girardi, Enrico, Camerini, Roberto, Ippolito, Giuseppe, Vaia, Francesco, Folgori, Antonella, and Capone, Stefania

Published
2022
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6. Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D’Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Published
2022
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7. Persistent Spike-specific T cell immunity despite antibody reduction after 3 months from SARS-CoV-2 BNT162b2-mRNA vaccine

Author

Agrati, Chiara, Castilletti, Concetta, Goletti, Delia, Sacchi, Alessandra, Bordoni, Veronica, Mariotti, Davide, Notari, Stefania, Matusali, Giulia, Meschi, Silvia, Petrone, Linda, Aiello, Alessandra, Najafi Fard, Saeid, Farroni, Chiara, Colavita, Francesca, Lapa, Daniele, Leone, Sara, Agresta, Alessandro, Capobianchi, Maria, Ippolito, Giuseppe, Vaia, Francesco, and Puro, Vincenzo

Published
2022
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8. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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10. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
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12. Intrathecal production of anti-EBV Viral Capsid Antigen IgG is associated with Neurocognition and tau pathology in people with HIV

Author

Trunfio, Mattia, primary, Sacchi, Alessandra, additional, Vai, Daniela, additional, Pittaluga, Fabrizia, additional, Croce, Michele, additional, Cavallo, Rossana, additional, Imperiale, Daniele, additional, Bonora, Stefano, additional, Di Perri, Giovanni, additional, Letendre, Scott Lee, additional, and Calcagno, Andrea, additional

Published
2023
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13. Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Author

Agrati, Chiara, Sacchi, Alessandra, Bordoni, Veronica, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Casetti, Rita, Tartaglia, Eleonora, Lalle, Eleonora, D’Abramo, Alessandra, Castilletti, Concetta, Marchioni, Luisa, Shi, Yufang, Mariano, Andrea, Song, Jin-Wen, Zhang, Ji-Yuan, Wang, Fu-Sheng, Zhang, Chao, Fimia, Gian Maria, Capobianchi, Maria R., Piacentini, Mauro, Antinori, Andrea, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, and Ippolito, Giuseppe

Published
2020
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14. Multi-omics approach to COVID-19: a domain-based literature review

Author

Montaldo, Chiara, Messina, Francesco, Abbate, Isabella, Antonioli, Manuela, Bordoni, Veronica, Aiello, Alessandra, Ciccosanti, Fabiola, Colavita, Francesca, Farroni, Chiara, Najafi Fard, Saeid, Giombini, Emanuela, Goletti, Delia, Matusali, Giulia, Rozera, Gabriella, Rueca, Martina, Sacchi, Alessandra, Piacentini, Mauro, Agrati, Chiara, Fimia, Gian Maria, Capobianchi, Maria Rosaria, Lauria, Francesco Nicola, and Ippolito, Giuseppe

Published
2021
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17. Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome

Author

Sacchi, Alessandra, Grassi, Germana, Bordoni, Veronica, Lorenzini, Patrizia, Cimini, Eleonora, Casetti, Rita, Tartaglia, Eleonora, Marchioni, Luisa, Petrosillo, Nicola, Palmieri, Fabrizio, D’Offizi, Gianpiero, Notari, Stefania, Tempestilli, Massimo, Capobianchi, Maria Rosaria, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, Locatelli, Franco, Antinori, Andrea, Ippolito, Giuseppe, and Agrati, Chiara

Published
2020
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22. Measure of anxiety in selection interviews: An Italian validation of the Performance Anxiety Scale.

Author

Sacchi, Alessandra and Molino, Monica

Subjects
*PERFORMANCE anxiety, *JOB applications, *CONVENIENCE sampling (Statistics), *CONFIRMATORY factor analysis, *EMPLOYMENT interviewing
Abstract

According to McCarthy and Goffin (2004), selection interview anxiety (SIA) is expressed by feelings of nervousness or apprehension that are relatively stable within job applicants across employment interview situations and can be organized into five distinct dimensions. These dimensions constitute the five scales of the Measure of Anxiety in Selection Interview (MASI) questionnaire. The principal aim of this study is to evaluate the Italian adaptation of one of the five scales of the MASI, namely the Performance Anxiety Scale, which is a short and efficient instrument consisting of six items. Data were collected from a convenience sample of 203 participants who reported having recently participated in at least one job interview. Confirmatory factor analysis confirmed the one-factor structure of the Performance Anxiety Scale, which also showed good reliability. Finally, the results confirmed some hypotheses derived from the literature about the scale's relations with other constructs and gender differences. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Humoral and T-cell immune response after three doses of mRNA SARS-CoV-2 vaccines in fragile patients: the Italian VAX4FRAIL study

Author

Corradini, Paolo, Agrati, Chiara, Apolone, Giovanni, Mantovani, Alberto, Giannarelli, Diana, Marasco, Vincenzo, Bordoni, Veronica, Sacchi, Alessandra, Matusali, Giulia, Salvarani, Carlo, Zinzani, Pier Luigi, Mantegazza, Renato, Tagliavini, Fabrizio, Lupo-Stanghellini, Maria Teresa, Ciceri, Fabio, Damian, Silvia, Uccelli, Antonio, Fenoglio, Daniela, Silvestris, Nicola, Baldanti, Fausto, Piaggio, Giulia, Ciliberto, Gennaro, Morrone, Aldo, Locatelli, Franco, Sinno, Valentina, Rescigno, Maria, Costantini, Massimo, Corradini, Paolo, Agrati, Chiara, Apolone, Giovanni, Mantovani, Alberto, Giannarelli, Diana, Marasco, Vincenzo, Bordoni, Veronica, Sacchi, Alessandra, Matusali, Giulia, Salvarani, Carlo, Zinzani, Pier Luigi, Mantegazza, Renato, Tagliavini, Fabrizio, Lupo-Stanghellini, Maria Teresa, Ciceri, Fabio, Damian, Silvia, Uccelli, Antonio, Fenoglio, Daniela, Silvestris, Nicola, Baldanti, Fausto, Piaggio, Giulia, Ciliberto, Gennaro, Morrone, Aldo, Locatelli, Franco, Sinno, Valentina, Rescigno, Maria, and Costantini, Massimo

Subjects
T-cell immunity, humoral immunity, SARS-CoV-2 mRNA vaccine, Fragile patient
Abstract

BackgroundPatients with solid or hematological tumors, neurological and immune-inflammatory disorders represent potentially fragile subjects with increased risk to experience severe COVID-19 and inadequate response to SARS-CoV2 vaccination.MethodsWe designed a prospective Italian multicentric study to assess humoral and T-cell response to SARS-CoV2 vaccination in patients (n=378) with solid tumors (ST), hematological malignancies (HM), neurological (ND) and immuno-rheumatological diseases (ID). The immunogenicity of primary vaccination schedule and of the booster dose were analyzed.ResultsOverall, patient seroconversion rate after two doses was 62.1%. A significant lower rate was observed in HM (52.4%) and ID (51.9%) patients compared to ST (95.6%) and ND (70.7%); a lower median level of antibodies was detected in HM and ID versus the others (pConclusionsImmunosuppressive treatment more than disease type per se is a risk factor for low humoral response after vaccination. The booster dose can improve both humoral and T-cell response.Article’s main point-Lower rate of seroconversion was observed in fragile patients as compared to healthy controls-The booster dose improves humoral and T-cell response in all fragile patient groups-Immunosuppressive treatment was associated with the worst humoral response to vaccination, but had no effects on T-cell responses.

Published
2022

26. Myeloid-Derived Suppressor Cells in COVID-19: The Paradox of Good

Author

Grassi, Germana, primary, Notari, Stefania, additional, Gili, Simona, additional, Bordoni, Veronica, additional, Casetti, Rita, additional, Cimini, Eleonora, additional, Tartaglia, Eleonora, additional, Mariotti, Davide, additional, Agrati, Chiara, additional, and Sacchi, Alessandra, additional

Published
2022
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28. Additional file 1 of Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D’Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Abstract

Additional file 1: Tables S1: Demographics, clinical baseline characteristics, therapy and cause of death of COVID-19 patients.

Published
2022
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29. Humoral and T-Cell Immune Response After 3 Doses of Messenger RNA Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Fragile Patients: The Italian VAX4FRAIL Study.

Author

Corradini, Paolo, Agrati, Chiara, Apolone, Giovanni, Mantovani, Alberto, Giannarelli, Diana, Marasco, Vincenzo, Bordoni, Veronica, Sacchi, Alessandra, Matusali, Giulia, Salvarani, Carlo, Zinzani, Pier Luigi, Mantegazza, Renato, Tagliavini, Fabrizio, Lupo-Stanghellini, Maria Teresa, Ciceri, Fabio, Damian, Silvia, Uccelli, Antonio, Fenoglio, Daniela, Silvestris, Nicola, and Baldanti, Fausto

Subjects
RESEARCH, COVID-19, NEUROLOGICAL disorders, IMMUNIZATION, IMMUNOGLOBULINS, COVID-19 vaccines, HEALTH outcome assessment, VACCINE immunogenicity, SEROCONVERSION, RISK assessment, MESSENGER RNA, RESEARCH funding, HEMATOLOGIC malignancies, DESCRIPTIVE statistics, T cells, CELLULAR immunity, LOGISTIC regression analysis, LONGITUDINAL method
Abstract

Background Patients with solid or hematological tumors or neurological and immune-inflammatory disorders are potentially fragile subjects at increased risk of experiencing severe coronavirus disease 2019 and an inadequate response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Methods We designed a prospective Italian multicenter study to assess humoral and T-cell responses to SARS-CoV-2 vaccination in patients (n = 378) with solid tumors (ST), hematological malignancies (HM), neurological disorders (ND), and immunorheumatological diseases (ID). A group of healthy controls was also included. We analyzed the immunogenicity of the primary vaccination schedule and booster dose. Results The overall seroconversion rate in patients after 2 doses was 62.1%. Significantly lower rates were observed in HM (52.4%) and ID (51.9%) than in ST (95.6%) and ND (70.7%); a lower median antibody level was detected in HM and ID versus ST and ND (P <.0001). Similar rates of patients with a positive SARS-CoV-2 T-cell response were found in all disease groups, with a higher level observed in ND. The booster dose improved the humoral response in all disease groups, although to a lesser extent in HM patients, whereas the T-cell response increased similarly in all groups. In the multivariable logistic model, independent predictors of seroconversion were disease subgroup, treatment type, and age. Ongoing treatment known to affect the immune system was associated with the worst humoral response to vaccination (P <.0001) but had no effect on T-cell responses. Conclusions Immunosuppressive treatment more than disease type per se is a risk factor for a low humoral response after vaccination. The booster dose can improve both humoral and T-cell responses. [ABSTRACT FROM AUTHOR]

Published
2023
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30. The interplay between SARS-CoV-2 infected airway epithelium and immune cells modulates regulatory/inflammatory signals

Author

Bordoni, Veronica, primary, Matusali, Giulia, additional, Mariotti, Davide, additional, Antonioli, Manuela, additional, Cimini, Eleonora, additional, Sacchi, Alessandra, additional, Tartaglia, Eleonora, additional, Casetti, Rita, additional, Grassi, Germana, additional, Notari, Stefania, additional, Castilletti, Concetta, additional, Fimia, Gian Maria, additional, Capobianchi, Maria Rosaria, additional, Ippolito, Giuseppe, additional, and Agrati, Chiara, additional

Published
2022
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31. Humoral and T-cell immune response after three doses of mRNA SARS-CoV-2 vaccines in fragile patients: the Italian VAX4FRAIL study

Author

Corradini, Paolo, primary, Agrati, Chiara, additional, Apolone, Giovanni, additional, Mantovani, Alberto, additional, Giannarelli, Diana, additional, Marasco, Vincenzo, additional, Bordoni, Veronica, additional, Sacchi, Alessandra, additional, Matusali, Giulia, additional, Salvarani, Carlo, additional, Zinzani, Pier Luigi, additional, Mantegazza, Renato, additional, Tagliavini, Fabrizio, additional, Lupo-Stanghellini, Maria Teresa, additional, Ciceri, Fabio, additional, Damian, Silvia, additional, Uccelli, Antonio, additional, Fenoglio, Daniela, additional, Silvestris, Nicola, additional, Baldanti, Fausto, additional, Piaggio, Giulia, additional, Ciliberto, Gennaro, additional, Morrone, Aldo, additional, Locatelli, Franco, additional, Sinno, Valentina, additional, Rescigno, Maria, additional, and Costantini, Massimo, additional

Published
2022
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32. GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults

Author

Lanini, Simone, primary, Capone, Stefania, additional, Antinori, Andrea, additional, Milleri, Stefano, additional, Nicastri, Emanuele, additional, Camerini, Roberto, additional, Agrati, Chiara, additional, Castilletti, Concetta, additional, Mori, Federica, additional, Sacchi, Alessandra, additional, Matusali, Giulia, additional, Gagliardini, Roberta, additional, Ammendola, Virginia, additional, Cimini, Eleonora, additional, Grazioli, Fabiana, additional, Scorzolini, Laura, additional, Napolitano, Federico, additional, Plazzi, Maria M., additional, Soriani, Marco, additional, De Luca, Aldo, additional, Battella, Simone, additional, Sommella, Andrea, additional, Contino, Alessandra M., additional, Barra, Federica, additional, Gentile, Michela, additional, Raggioli, Angelo, additional, Shi, Yufang, additional, Girardi, Enrico, additional, Maeurer, Markus, additional, Capobianchi, Maria R., additional, Vaia, Francesco, additional, Piacentini, Mauro, additional, Kroemer, Guido, additional, Vitelli, Alessandra, additional, Colloca, Stefano, additional, Folgori, Antonella, additional, and Ippolito, Giuseppe, additional

Published
2022
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35. Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection

Author

Sacchi, Alessandra, primary, Grassi, Germana, additional, Notari, Stefania, additional, Gili, Simona, additional, Bordoni, Veronica, additional, Tartaglia, Eleonora, additional, Casetti, Rita, additional, Cimini, Eleonora, additional, Mariotti, Davide, additional, Garotto, Gabriele, additional, Beccacece, Alessia, additional, Marchioni, Luisa, additional, Bibas, Michele, additional, Nicastri, Emanuele, additional, Ippolito, Giuseppe, additional, and Agrati, Chiara, additional

Published
2021
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38. Additional file 1 of Multi-omics approach to COVID-19: a domain-based literature review

Author

Montaldo, Chiara, Messina, Francesco, Abbate, Isabella, Antonioli, Manuela, Bordoni, Veronica, Aiello, Alessandra, Ciccosanti, Fabiola, Colavita, Francesca, Farroni, Chiara, Najafi Fard, Saeid, Giombini, Emanuela, Goletti, Delia, Matusali, Giulia, Rozera, Gabriella, Rueca, Martina, Sacchi, Alessandra, Piacentini, Mauro, Agrati, Chiara, Fimia, Gian Maria, Capobianchi, Maria Rosaria, Lauria, Francesco Nicola, and Ippolito, Giuseppe

Abstract

Additional file 1. Scoping review protocol. Working method and tools used by the domain groups. Table S1. Selected articles catalogued by domain. Table S2. Tables of evidence. A) Virus characterization and viral entry: B) Host signature: C) Pathways: D. Phenotypes. Table S3. B) Conceptual table: SARS-CoV-2 entry. Tabla S4. Immune response to SARS-CoV-2 infection in lung and other tissues (A), peripheral blood (B) and specific cell types in blood immune cells (C). Pathways, host signature (differentially expressed genes and proteins) and body districts, subset per specific omics data: host proteomics, bulk RNAseq and scRNAseq. Table S5. Pathogenic mechanisms in COVID-19 phenotype: SARS-CoV-2���host interactions in the lung. (A), DEG and DEP analysis in other organs and tissues (B) Hub genes and pathway of innate immune response (C), Comorbidities COVID-19 associated not sharing COVID-19 pathogenesis (D), Comorbidities associated and related to COVID-19 pathway (E). Omics and pathway involved were split by different phenotypes: severe, mild/asymptomatic and other Infections. Annexes: Annex 1���Report from Working Group 1: Molecular characterisation of the virus; Annex 2���Report from Working Group 2���Pathways; Annex 3���Report from Working Group 3- Host signatures; Annex 4���Report from Working Group 4���Phenotype. Glossary.

Published
2021
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40. Transglutaminase 2 Regulates Innate Immunity by Modulating the STING/TBK1/IRF3 Axis

Author

Occhigrossi, Luca, primary, Rossin, Federica, additional, D’Eletto, Manuela, additional, Farrace, Maria Grazia, additional, Ciccosanti, Fabiola, additional, Petrone, Linda, additional, Sacchi, Alessandra, additional, Nardacci, Roberta, additional, Falasca, Laura, additional, Del Nonno, Franca, additional, Palucci, Ivana, additional, Smirnov, Evgeni, additional, Barlev, Nick, additional, Agrati, Chiara, additional, Goletti, Delia, additional, Delogu, Giovanni, additional, Fimia, Gian Maria, additional, and Piacentini, Mauro, additional

Published
2021
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41. PMN-MDSC Frequency Discriminates Active Versus Latent Tuberculosis and Could Play a Role in Counteracting the Immune-Mediated Lung Damage in Active Disease

Author

Grassi, Germana, primary, Vanini, Valentina, additional, De Santis, Federica, additional, Romagnoli, Alessandra, additional, Aiello, Alessandra, additional, Casetti, Rita, additional, Cimini, Eleonora, additional, Bordoni, Veronica, additional, Notari, Stefania, additional, Cuzzi, Gilda, additional, Mosti, Silvia, additional, Gualano, Gina, additional, Palmieri, Fabrizio, additional, Fraziano, Maurizio, additional, Goletti, Delia, additional, Agrati, Chiara, additional, and Sacchi, Alessandra, additional

Published
2021
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42. GRAd-COV2, a gorilla adenovirus based candidate vaccine against COVID-19, is safe and immunogenic in young and older adults

Author

Lanini, Simone, primary, Capone, Stefania, additional, Antinori, Andrea, additional, Milleri, Stefano, additional, Nicastri, Emanuele, additional, Camerini, Roberto, additional, Agrati, Chiara, additional, Castilletti, Concetta, additional, Mori, Federica, additional, Sacchi, Alessandra, additional, Matusali, Giulia, additional, Gagliardini, Roberta, additional, Ammendola, Virginia, additional, Cimini, Eleonora, additional, Grazioli, Fabiana, additional, Scorzolini, Laura, additional, Napolitano, Federico, additional, Piazzi, Maria Maddalena, additional, Soriani, Marco, additional, De Luca, Aldo, additional, Battella, Simone, additional, Sommella, Andrea, additional, Contino, Alessandra M., additional, Barra, Federica, additional, Gentile, Michela, additional, Raggioli, Angelo, additional, Shi, Yufang, additional, Girardi, Enrico, additional, Maeurer, Markus, additional, Capobianchi, Maria R., additional, Vaia, Francesco, additional, Piacentini, Mauro, additional, Kroemer, Guido, additional, Vitelli, Alessandra, additional, Colloca, Stefano, additional, Folgori, Antonella, additional, and Ippolito, Giuseppe, additional

Published
2021
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43. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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44. Elevated P-Selectin in Severe Covid-19: Considerations for therapeutic options

Author

Agrati, Chiara, primary, Bordoni, Veronica, additional, Sacchi, Alessandra, additional, Grassi, Germana, additional, Petrosillo, Nicola, additional, Nicastri, Emanuele, additional, Del nonno, Franca, additional, D'offizi, Giampiero, additional, Palmieri, Fabrizio, additional, Marchioni, Luisa, additional, Capobianchi, Maria rosaria, additional, Antinori, Andrea, additional, Ippolito, Giuseppe, additional, and Bibas, Michele, additional

Published
2021
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45. Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against SARS-CoV-2 in People Living with HIV (PLWH) Receiving Antiretroviral Therapy (ART) According with Current CD4 T-Lymphocyte Count

Author

Antinori, Andrea, primary, Cicalini, Stefania, additional, Meschi, Silvia, additional, Bordoni, Veronica, additional, Lorenzini, Patrizia, additional, Vergori, Alessandra, additional, Lanini, Simone, additional, De Pascale, Lidya, additional, Matusali, Giulia, additional, Mariotti, Davide, additional, Lepri, Alessandro Cozzi, additional, Gallì, Paola, additional, Pinnetti, Carmela, additional, Gagliardini, Roberta, additional, Mazzotta, Valentina, additional, Mastrorosa, Ilaria, additional, Grisetti, Susanna, additional, Colavita, Francesca, additional, Cimini, Eleonora, additional, Grilli, Elisabetta, additional, Bellagamba, Rita, additional, Lapa, Daniele, additional, Sacchi, Alessandra, additional, Marani, Alessandra, additional, Cerini, Carlo, additional, Candela, Caterina, additional, Fusto, Marisa, additional, Puro, Vincenzo, additional, Castilletti, Concetta, additional, Agrati, Chiara, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, and Group, HIV-VAC Study, additional

Published
2021
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46. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

Author

Tempestilli, Massimo, Caputi, Priscilla, Avataneo, Valeria, Notari, Stefania, Forini, Olindo, Scorzolini, Laura, Marchioni, Luisa, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Lalle, Eleonora, Capobianchi, Maria R, Nicastri, Emanuele, D’Avolio, Antonio, Ippolito, Giuseppe, Agrati, Chiara, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Casetti, Rita, Chiappini, Roberta, Ciaralli, Carmine, Cimini, Eleonora, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Grassi, Germana, Greci, Maria Cristina, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Messina, Francesco, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, and Valli, Maria Beatrice

Subjects
0301 basic medicine, Drug, Male, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID19, media_common.quotation_subject, Critical Illness, 030106 microbiology, Pneumonia, Viral, remdesivir, Loading dose, Gastroenterology, Antiviral Agents, NO, 03 medical and health sciences, Betacoronavirus, Adenosine Triphosphate, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Pandemics, media_common, EC50, Original Research, Aged, Pharmacology, Lung, Alanine, Nucleoside analogue, business.industry, SARS-CoV-2, COVID-19, Recovery of Function, Prodrug, Adenosine Monophosphate, 030104 developmental biology, medicine.anatomical_structure, Infectious Diseases, Pharmacokinetics, COVID19, remdesivir, Female, business, Coronavirus Infections, medicine.drug
Abstract

Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. Methods Remdesivir was administered at 200 mg loading dose on the first day followed by 12 days of 100 mg in two critically ill patients. Blood samples were collected immediately after (C0) and at 1 (C1) and 24 h (C24) after intravenous administration on day 3 until day 9. BAS samples were collected on Days 4, 7 and 9 from both patients while one CSF on Day 7 was obtained in one patient. Remdesivir and GS-441524 concentrations were measured in these samples using a validated UHPLC-MS/MS method. Results We observed higher concentrations of remdesivir at C0 (6- to 7-fold higher than EC50 from in vitro studies) and a notable decay at C1. GS-441524 plasma concentrations reached a peak at C1 and persisted until the next administration. Higher concentrations of GS-441524 were observed in the patient with mild renal dysfunction. Mean BAS/plasma concentration ratios of GS-441524 were 2.3% and 6.4% in Patient 1 and Patient 2, respectively. The CSF concentration found in Patient 2 was 25.7% with respect to plasma. GS-441524 levels in lung and CNS suggest compartmental differences in drug exposure. Conclusions We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.

Published
2020
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47. An inflammatory profile correlates with decreased frequency of cytotoxic cells in COVID-19

Author

Bordoni, Veronica, Sacchi, Alessandra, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Tartaglia, Eleonora, Casetti, Rita, Giancola, Letizia, Bevilacqua, Nazario, Maeurer, Markus, Zumla, Alimuddin, Locatelli, Franco, De Benedetti, Fabrizio, Palmieri, Fabrizio, Marchioni, Luisa, Capobianchi, Maria R, D’Offizi, Gianpiero, Petrosillo, Nicola, Antinori, Andrea, Nicastri, Emanuele, Ippolito, Giuseppe, and Agrati, Chiara

Subjects
Inflammation, Male, Perforin, SARS-CoV-2, Brief Report, MDSC, COVID-19, chemical and pharmacologic phenomena, NK cells, Middle Aged, Lymphocyte Activation, Killer Cells, Natural, Intensive Care Units, AcademicSubjects/MED00290, Italy, Cytokines, Humans, Female, cytotoxic cells, Aged, T-Lymphocytes, Cytotoxic
Abstract

Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.

Published
2020

48. Cerebral Air Embolism: A Non-Thrombotic Cause of Acute Stroke

Author

Campioni Paolo, Ottou Sandrine, Sacchi Alessandra, Grassi Germana, Concetta Castilletti, Gagliardini Roberta, Agrati Chiara, Cicalini Stefania, and Antinori Andrea

Subjects
Respiratory distress, business.industry, medicine.medical_treatment, General Medicine, medicine.disease, Air embolism, Sarilumab, Pneumonia, Anesthesia, Occlusion, medicine, business, Complication, Stroke, Central venous catheter
Abstract

Background: Embolic strokes are due to occlusion of brain arteries mainly by clots, less frequently by non-thrombotic material. Cerebral air embolism (CAE) may occur as complication of medical procedures, although non-iatrogenic sources have been reported. It is a life-threating emergency with poor prognosis both in terms of mortality and disability. Hyperbaric oxygen therapy (HOT) is the gold standard treatment. Methods: We report a series of 4 in-hospital patients with CAE for whom stroke neurologists were activated for acute management. Three patients developed neurological disturbances soon after central venous catheter manipulation, one patient, affected by chronic obstructive pulmonary disease, after prolonged coughing with respiratory distress. Results: All patients experienced seizures, loss of consciousness and bilateral neurological signs. Acute brain computed tomography (CT) revealed intracranial air bubbles. One patient underwent HOT 3 hours after symptoms onset and fully recovered, for the others HOT was contraindicated: one died and 2 presented severe neurological sequelae. Conclusions: Physicians involved in acute stroke management should be aware of CAE and promptly recognize it, especially for in-hospital strokes, and manage this condition together with anesthetists and hyperbaric physicians.

Published
2020

49. Sequential Use of Sarilumab and Baricitinib in Severe COVID-19 Pneumonia: A Case Report

Author

Gagliardini Roberta, Sacchi Alessandra, Campioni Paolo, Cicalini Stefania, Grassi Germana, Ottou Sandrine, Concetta Castilletti, Agrati Chiara, and Antinori Andrea

Subjects
Socio-culturale, General Medicine, Covid-19, Sars-cov2, Anti-IL6, anti-JAK, Cytokine storm, Anti-IL6, Covid-19, Sars-cov2, Cytokine storm, anti-JAK
Published
2020

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