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2. Evaluación de la afectación de los ganglios linfáticos del cuello en los pacientes iraníes con carcinoma maxilofacial de células escamosas

Author

Danesteh, Hossein, Sadeghzadeh, Azita, and Dehghani, Farshad

Subjects
Health Sciences, Lymph nodes
Abstract

[eng] Background: Oral squamous cell carcinoma (OSCC) is the predominant malignancy of oral cavity (about 90% of oral malignant lesions). This study aimed to evaluate the long-term extent of lymph node involvement of the neck among patients with maxillofacial SCC after the surgery. Methods: In this cross-sectional study, 32 patients with maxillofacial SCC who underwent surgery were evaluated for any type of lymph node involvement (necrotic, reactive, or metastatic) at 3, 6, 12, and 24 months. Data was acquitted through clinical and paraclinical examinations such as CT scan, ultrasound of the neck area, pathology and histology. Results: The SCC of posterior mandible had more lymph node involvement (P=0.02). Compared to moderately/poorly differentiated cases, patients with well-differentiated histopathological grade had lower lymph node involvement (P=0.01). TNM stage had no influence on lymph node involvement (P>0.05). Patients with neck dissection and reconstruction (P=0.003) as well as those who received postoperative radiotherapy or chemotherapy/radiotherapy together (P=0.001 and 0.005 respectively) had lower degree of lymph node involvement. Post-operative lymph node involvement was significantly more in patients with the positive CT scan status of bilateral metastatic lymphadenopathy in zones 1, 2 and 3 before the operation in comparison to other statuses like bilateral benign lymph nodes (p=0.001) or lymphadenopathy in just one or two zones (1and/or 2) (P>0.05). Conclusion: We determined the effect of different parameters on lymph node involvement and determined some positive and negative correlations. Furthermore, some parameters like age, gender, and TNM staging had no influence on the mentioned outcome. [spa] Antecedentes: El carcinoma oral de células escamosas (CCE) es la neoplasia maligna predominante de la cavidad oral (alrededor del 90% de las lesiones malignas orales). El objetivo de este estudio es evaluar la extensión a largo plazo de la afectación de los ganglios linfáticos del cuello entre los pacientes con CCE maxilofacial después de la cirugía. Métodos: En este estudio transversal, 32 pacientes con CCE maxilofacial sometidos a cirugía fueron evaluados para cualquier tipo de afectación ganglionar (necrótica, reactiva o metastásica) a los 3, 6, 12 y 24 meses. Los datos se absolvieron mediante exámenes clínicos y paraclínicos como la tomografía computarizada, la ecografía de la zona del cuello, la patología y la histología. Resultados: El CCE de la mandíbula posterior tenía más afectación de los ganglios linfáticos (P=0,02). En comparación con los casos moderadamente/pobremente diferenciados, los pacientes con grado histopatológico bien diferenciado tenían menor afectación ganglionar (P=0,01). El estadio TNM no influyó en la afectación de los ganglios linfáticos (P>0,05). Los pacientes con disección y reconstrucción del cuello (P=0,003), así como los que recibieron radioterapia postoperatoria o quimioterapia/radioterapia conjuntamente (P=0,001 y 0,005 respectivamente) tuvieron menor grado de afectación ganglionar. La afectación ganglionar postoperatoria fue significativamente mayor en los pacientes con el estado positivo en la TC de linfadenopatía metastásica bilateral en las zonas 1, 2 y 3 antes de la operación en comparación con otros estados como los ganglios linfáticos benignos bilaterales (p=0,001) o la linfadenopatía en sólo una o dos zonas (1y/o 2) (P>0,05). Conclusión: Determinamos el efecto de diferentes parámetros sobre la afectación ganglionar y determinamos algunas correlaciones positivas y negativas. Además, algunos parámetros como la edad, el sexo y el estadiaje TNM no influyeron en el resultado mencionado

Published
2022

3. Evaluation of the neck lymph node involvement in outcome of iranian patients with maxillofacial squamous cell carcinoma

Author

Danesteh, Hossein, Sadeghzadeh, Azita, and Dehghani, Farshad

Subjects
stomatognathic diseases, Health Sciences, Lymph nodes
Abstract

[eng] Background: Oral squamous cell carcinoma (OSCC) is the predominant malignancy of oral cavity (about 90% of oral malignant lesions). This study aimed to evaluate the long-term extent of lymph node involvement of the neck among patients with maxillofacial SCC after the surgery. Methods: In this cross-sectional study, 32 patients with maxillofacial SCC who underwent surgery were evaluated for any type of lymph node involvement (necrotic, reactive, or metastatic) at 3, 6, 12, and 24 months. Data was acquitted through clinical and paraclinical examinations such as CT scan, ultrasound of the neck area, pathology and histology. Results: The SCC of posterior mandible had more lymph node involvement (P=0.02). Compared to moderately/poorly differentiated cases, patients with well-differentiated histopathological grade had lower lymph node involvement (P=0.01). TNM stage had no influence on lymph node involvement (P>0.05). Patients with neck dissection and reconstruction (P=0.003) as well as those who received postoperative radiotherapy or chemotherapy/radiotherapy together (P=0.001 and 0.005 respectively) had lower degree of lymph node involvement. Post-operative lymph node involvement was significantly more in patients with the positive CT scan status of bilateral metastatic lymphadenopathy in zones 1, 2 and 3 before the operation in comparison to other statuses like bilateral benign lymph nodes (p=0.001) or lymphadenopathy in just one or two zones (1and/or 2) (P>0.05). Conclusion: We determined the effect of different parameters on lymph node involvement and determined some positive and negative correlations. Furthermore, some parameters like age, gender, and TNM staging had no influence on the mentioned outcome., [spa] Antecedentes: El carcinoma oral de células escamosas (CCE) es la neoplasia maligna predominante de la cavidad oral (alrededor del 90% de las lesiones malignas orales). El objetivo de este estudio es evaluar la extensión a largo plazo de la afectación de los ganglios linfáticos del cuello entre los pacientes con CCE maxilofacial después de la cirugía. Métodos: En este estudio transversal, 32 pacientes con CCE maxilofacial sometidos a cirugía fueron evaluados para cualquier tipo de afectación ganglionar (necrótica, reactiva o metastásica) a los 3, 6, 12 y 24 meses. Los datos se absolvieron mediante exámenes clínicos y paraclínicos como la tomografía computarizada, la ecografía de la zona del cuello, la patología y la histología. Resultados: El CCE de la mandíbula posterior tenía más afectación de los ganglios linfáticos (P=0,02). En comparación con los casos moderadamente/pobremente diferenciados, los pacientes con grado histopatológico bien diferenciado tenían menor afectación ganglionar (P=0,01). El estadio TNM no influyó en la afectación de los ganglios linfáticos (P>0,05). Los pacientes con disección y reconstrucción del cuello (P=0,003), así como los que recibieron radioterapia postoperatoria o quimioterapia/radioterapia conjuntamente (P=0,001 y 0,005 respectivamente) tuvieron menor grado de afectación ganglionar. La afectación ganglionar postoperatoria fue significativamente mayor en los pacientes con el estado positivo en la TC de linfadenopatía metastásica bilateral en las zonas 1, 2 y 3 antes de la operación en comparación con otros estados como los ganglios linfáticos benignos bilaterales (p=0,001) o la linfadenopatía en sólo una o dos zonas (1y/o 2) (P>0,05). Conclusión: Determinamos el efecto de diferentes parámetros sobre la afectación ganglionar y determinamos algunas correlaciones positivas y negativas. Además, algunos parámetros como la edad, el sexo y el estadiaje TNM no influyeron en el resultado mencionado

Published
2022

4. Immunoexpression of p53 mutant-type in Iranian patients with primary and recurrence oral squamous cell carcinoma.

Author

Daneste, Hossein, Sadeghzadeh, Azita, Mokhtari, Maral, Mohammadkhani, Hossein, Lavaee, Fatemeh, and Moayedi, Javad

Subjects
*SQUAMOUS cell carcinoma, *IRANIANS, *TUMOR suppressor proteins, *P53 protein, *MUTANT proteins
Abstract

Mutations in tumor suppressor p53 protein can occur at different phases of malignant transformation and affect the patient's prognosis. This study aimed to evaluate the expression of mutant p53 protein in Iranian patients with the primary and recurrence oral squamous cell carcinoma (OSCC). This retrospective cross-sectional study conducted on a group of patients with the primary OSCC (n=122) and the control subjects with oral noncancerous reactive lesions (n=80). Immunohistochemistry was performed with the DO-7 monoclonal antibody against p53 protein, and samples with =10% immunostaining were considered positive. Statistical analyses were carried out using SPSS. Positive staining for p53 was observed in none of the control subjects and 57.4% (70 of 122) of the primary OSCC patients (p<0.0001, OR=107.69, 95%CI=6.49-179.0). The p53 immunopositivity had no significant differences between males and females (54.2% vs. 62%, p=0.390), but significantly different between those aged below and over 50 years (p<0.0001, OR=4.52, 95%CI=1.07-12.05). During followup, OSCC recurrence occurred in 104 patients, but the phenotype of the mutant p53 protein in patients who relapsed was the same as in matched primary tumors (p=0.763). Risk of recurrence had no significant differences between p53-positive and p53-negative cases (p=0.953), males and females (p=0.263), and age below and over 50 years (p=0.223). Despite its confirmed diagnostic value, the immunoexpression of the p53 mutant protein in OSCC in cancer recurrence was the same as in the primary tumor. However, further studies with a larger sample size and longer follow-up are needed to confirm or change our conclusions. [ABSTRACT FROM AUTHOR]

Published
2023
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5. The effects of adipose tissue-derived stem cells seeded onto the curcumin-loaded collagen scaffold in healing of experimentally-induced oral mucosal ulcers in rat.

Author

Mardani, Maryam, Sadeghzadeh, Azita, Tanideh, Nader, Andisheh-Tadbir, Azadeh, Lavaee, Fatemeh, Zarei, Moein, and Moayedi, Javad

Subjects
*STEM cells, *ELLAGIC acid, *COLLAGEN, *ULCERS, *TISSUE engineering, *SUPEROXIDE dismutase
Abstract

Objective(s): Various therapeutic approaches, including stem-cell-based strategies and tissue engineering, have been proposed for oral ulcerative lesions. We investigated the effects of adipose tissue-derived stem cells (ADSCs) seeded onto the curcumin-loaded collagen scaffold in the mucosal healing of oral ulcers in rats. Materials and Methods: The current experimental study was conducted on 40 male Sprague-Dawley rats. Oral ulcers were created over both sides of buccal mucosa, and the rats were randomly divided into four equal groups: 1) an untreated group (negative control); 2) Teriadent-treated group (positive control); 3) group treated with curcumin-loaded collagen scaffold; and 4) group received the ADSCs (3 × 106 cells) seeded onto the curcumin-loaded collagen scaffold. Rats were sacrificed on 3rd and 7th day after ulceration for histopathological examination as well as measurement of tissue levels of myeloperoxidase (MPO), superoxide dismutase (SOD), and Interleukin-1 beta (IL-1ß) activity. Results: Compared with the negative control, the tissue levels of MPO and IL-1ß were significantly decreased in all treated groups (P<0.0001); however, the SOD activity was elevated (P<0.0001). The highest SOD activity as well as the lowest MPO and IL-1ß levels were observed in the ADSCs-curcuminloaded collagen scaffold group. The ulcer healing process at 3rd and 7th day follow-up was much more progressed in the ADSCs-curcumin-loaded collagen scaffold group in comparison with the untreated group (P=0.037 and P=0.004, respectively). Conclusion: According to the findings of this study, ADSCs seeded onto the curcumin-loaded collagen scaffold seems to have a promising potential for oral ulcer healing applications. [ABSTRACT FROM AUTHOR]

Published
2020
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