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24 results on '"Sadovnick, Adele D."'

1. Maternal age and birth defects: a population study

Author

Baird, Patricia A., Sadovnick, Adele D., and Yee, Irene M.L.

Subjects
Birth defects -- Demographic aspects, Maternal age -- Health aspects, Birth defects -- British Columbia, Birth defects -- Statistics
Published
1991

2. Depressive symptoms and family history in seasonal and nonseasonal mood disorders

Author

Allen, Judith M., Lam, Raymond W., Remick, Ronald A., and Sadovnick, Adele D.

Subjects
Depression, Mental -- Diagnosis, Affective disorders -- Diagnosis, Seasonal affective disorder -- Diagnosis, Health, Psychology and mental health
Abstract

Objective: The authors' goal was to compare the symptoms and family history of seasonal affective disorder with those of nonseasonal mood disorders. Method: From a subspecialty mood disorders clinic, 34 patients with major depression, seasonal pattern (seasonal affective disorder), diagnosed with DSM-III-R criteria, were matched in age, sex, and diagnostic subtype (recurrent unipolar, bipolar I, or bipolar II) to 34 patients with nonseasonal mood disorders. Data on symptoms during the most recent depressive episode were obtained by chart review and compared by using chi-square tests. Family history data for first-degree relatives of patients with seasonal and nonseasonal mood disorders were gathered by using the family history method, and diagnoses were based on Family History Research Diagnostic Criteria. Results: Patients with seasonal affective disorder reported significantly more hypersomnia, hyperphagia, and weight gain and reported less suicidal ideation and morning worsening of mood than the patients with nonseasonal mood disorders. No differences were found in family histories of mood disorders, other psychiatric disorders, and any psychiatric disorder between the groups with seasonal versus nonseasonal mood disorders. Alcoholism was found more frequently in the relatives of the patients with seasonal affective disorder. Conclusions: Differences in symptoms between seasonal and nonseasonal mood disorders provide some support for seasonal affective disorder as a diagnostic subtype of mood disorders. However, the genetic loading for mood disorders (of unspecified seasonality), as determined by the family history method, is similar for seasonal and nonseasonal mood disorders.

Published
1993

6. APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease

Author

Schellenberg, Gerard D., Anderson, Leojean, O'dahl, Sheldon, Wisjman, Ellen M., Sadovnick, Adele D., Ball, Melvyn J., Larson, Eric B., Kukull, Walter A., Martin, George M., Roses, Allen D., and Bird, Thomas D.

Subjects
Original Articles
Abstract

The amyloid precursor protein (APP) gene codes for the precursor to the β-protein found in the amyloid deposits of Alzheimer disease (AD). Recently Goate et al. identified in codon 717 of this gene a missense mutation which segregates with AD in a familial AD (FAD) kindred. The same mutation was also found in affected subjects from a second FAD family but not in other FAD families or in normal controls. The following work was undertaken to determine the frequency of the codon 717 mutation in FAD and nonfamilial AD cases and in normal controls. We tested 76 FAD families, 127 “sporadic” AD subjects, 16 Down syndrome cases, and 256 normal controls for this mutation, and none were positive. We also tested for the APP codon 693 mutation associated with hereditary cerebral hemorrhage with amyloidosis–Dutch type, for PRIP gene missense mutations at codons 102, 117, and 200, and for the PRIP insertion mutations which are associated with Creutzfeld-Jakob disease and Gerstmann-Straussler Scheinker syndrome. No examples of these mutations were found in our population. Thus these APP and PRIP mutations are rare in both FAD and nonfamilial AD.

Published
1991

8. Life expectancy in Down syndrome adults

Author

Baird, Patricia A. and Sadovnick, Adele D.

Subjects
Life expectancy -- Research, Epidemiological research -- Analysis, Down syndrome -- Patient outcomes
Published
1988

9. A full genome search in multiple sclerosis

Author

Ebers, George C., primary, Kukay, Kim, additional, Bulman, Dennis E., additional, Sadovnick, Adele D., additional, Rice, George, additional, Anderson, Carol, additional, Armstrong, Holly, additional, Cousin, Keith, additional, Bell, Robert B., additional, Hader, Walter, additional, Paty, Donald W., additional, Hashimoto, Stanley, additional, Oger, Joel, additional, Duquette, Pierre, additional, Warren, Sharon, additional, Gray, Trevor, additional, O'Connor, Paul, additional, Nath, Avindra, additional, Auty, Anthony, additional, Metz, Luanne, additional, Francis, Gordon, additional, Paulseth, John E., additional, Murray, T. John, additional, Pryse-Phillips, William, additional, Nelson, Robert, additional, Freedman, Mark, additional, Brunet, Donald, additional, Bouchard, Jean-Pierre, additional, Hinds, David, additional, and Risch, Neil, additional

Published
1996
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13. Epidemiology and genetics of multiple sclerosis

Author

Compston, Alastair and Sadovnick, Adele D.

Abstract

Epidemiological data suggest an aetiological role for both genetic and environmental factors in multiple sclerosis (MS), but these have yet to be fully characterized. It is probable that MS susceptibility is determined by polygenes but specific loci need to be identified.

Published
1992

18. A Population-Based Study of Multiple Sclerosis in Twins

Author

Ebers, George C., primary, Bulman, Dennis E., additional, Sadovnick, Adele D., additional, Paty, Donald W., additional, Warren, Sharon, additional, Hader, Walter, additional, Murray, T. Jock, additional, Seland, T. Peter, additional, Duquette, Pierre, additional, Grey, Trevor, additional, Nelson, Robert, additional, Nicolle, Michael, additional, and Brunet, Donald, additional

Published
1986
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23. The Influence of Gender on the Susceptibility to Multiple Sclerosis in Sibships

Author

Sadovnick, Adele D., Bulman, Dennis E., Hashimoto, Lara, D'Hooghe, Marie B., and Ebers, George C.

Abstract

• A population-based study of pairs of relatives (siblings, second- and third-degree) concordant for multiple sclerosis did not show an excess of like-sexed pairs. In addition, data on human lymphocyte antigen typing for sibling pairs concordant for multiple sclerosis did not find an increase in haplotype sharing for like-sexed pairs. These data do not support the notion that sex-related factors influence multiple-sclerosis susceptibility in families.

Published
1991
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