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A series of small coinage metal(I) clusters has been selectively synthesized using 2-(diphenylphosphino)-1,10-phenanthroline (L), a new promising dimetal-binding P,N,N′-ligand (L). Its reaction with CuI yields the complex [Cu2L2(μ2-I)]2[Cu2I4], while the treatment of L with Au(tht)Cl/Ag+ or Au(tht)Cl/Cu+ systems leads to the assembly of [Au2AgL2Cl2]+, [Au2CuL2Cl2]+, [CuAuL2]2+ and [AgAuL2]2+ clusters. Theoretical analysis revealed pronounced intermetallic close shell interactions in these di- and trinuclear ensembles. At 298 K, the title compounds exhibit an orange and near-infrared (NIR) phosphorescence with lifetimes of 0.344–38 μs and quantum efficiencies of 1–21%. Theoretical considerations suggest a 3(M+L)LCT type for the observed phosphorescence. In addition, the above clusters exhibit a strong dose-dependent cytotoxic effect on A549, HepG2, Hep2 and MRC5 human cells with IC50 values ranging from 1.26 to 11.1 μM. [ABSTRACT FROM AUTHOR]

11H-Indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) and tryptanthrin-6-oxime are potent c-Jun N-terminal kinase 3 (JNK-3) inhibitors demonstrating neuroprotective, anti-inflammatory and anti-arthritic activity. However, the stereochemical configuration of the oxime carbon–nitrogen double bond (E- or Z-) in these compounds was so far unknown. In this contribution, we report the results of the determination of the double bond configuration in the solid state by single crystal X-ray diffraction and in solution by 1D and 2D NMR techniques and DFT calculations. It was found that both in the solid state and in solution, IQ-1 adopts the E-configuration stabilized by intermolecular hydrogen bonds, in contrast to previously assumed Z-configuration that could be stabilized only by an intramolecular hydrogen bond. [ABSTRACT FROM AUTHOR]