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136 results on '"Safarian S"'

1. Study of the Effects of Acetazolamide on Decreasing Viability of Breast Cancer Cells in T-47D Cell Line

Author

Abdolmohammadi M.H, Ejheian F, Safarian S, and Mohammadpour R

Subjects
Acetazolamide, Breast Neoplasms, Apoptosis, Cell Cycle, Flow Cytometry, Medicine (General), R5-920
Abstract

Background and Objectives: This study aimed at investigating the inhibitory effect of acetazolamide on the growth and proliferation of breast cancer cells (T47-D).Methods: The appearance of morphological symptoms of apoptosis was checked after staining with Annexin-PI using fluorescent microscope. Flow cytometric studies were used for determination of the amount and type of cellular death and also for analyzing the cell division cycle. The amounts of caspase-3 activity and DNA laddering were determined in the treated cells and compared with samples of the control group. Unilateral variance test was used to analyze data (p

Published
2011

45. QSAR Analysis for ADA upon Interaction with a Series of Adenine Derivatives as Inhibitors

Author

Moosavi‐Movahedi, A. A., primary, Safarian, S., additional, Hakimelahi, G. H., additional, Ataei, G., additional, Ajloo, D., additional, Panjehpour, S., additional, Riahi, S., additional, Mousavi, M. F., additional, Mardanyan, S., additional, Soltani, N., additional, Khalafi‐Nezhad, A., additional, Sharghi, H., additional, Moghadamnia, H., additional, and Saboury, A. A., additional

Published
2004
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48. Determination of some phenolic compounds in Crocus sativus L. corms and its antioxidant activities study.

Author

Esmaeili, N., Ebrahimzadeh, H., Abdi, K., and Safarian, S.

Subjects
SAFFRON crocus, CORMS, PHENOLS, ANTIOXIDANTS, PLANT extracts, RESEARCH
Abstract

It is well known that phenolic compounds are constituents of many plants. In this study, the total phenolics content in Crocus sativus L. corms in dormancy and waking stages were determined by the Folin-Ciocalteu method. Analysis was carried out by gas chromatography-mass spectrometry (GC-MS) after silylation by N-methyl-N-trimethylsilyl trifluroacetamide (MSTFA) + %1 trimethyl iodosilane (TMIS). Numerous compounds were detected and 11 compounds were identified. The highest phenolics content in waking corms was observed for gentisic acid (5.693 ± 0.057 μg/g) and the lowest for gallic acid (0.416 ± 0.006 μg/g); also these two phenolic compounds are the highest (0.929 ± 0.015 μg/g) and lowest (0.017 ± 0.001 μg/g) phenolics in dormant corms, respectively. The results from quantization and GC-MS analysis showed a high concentration of phenolic compounds in waking corms than the dormant stage. Furthermore, the radical scavenging activities of saffron corms were studied by 1,1-diphenyl-2-pycrylhydrazyl (DPPH) test and EC50 values were determined about 2055 ppm and 8274 ppm for waking and dormant corms, respectively. [ABSTRACT FROM AUTHOR]

Published
2011
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50. Analysis of Concrete Ring-Beam and Column Systems for Silo Hopper Support--General Case.

Author

Safarian, S. S. and Harris, E. C.

Abstract

Presents an analysis for the general case of a ring beam (for support of a silo hopper) in which the 4 to 12 equally spaced columns may be eccentric to the ring beam. This is an extension of an earlier paper in which the analysis was limited to the case of columns centered on the ring-beam axis. An example illustrates the application of the analysis and related tables. [ABSTRACT FROM AUTHOR]

Published
1984

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