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Statement of the problem: Presently, various imaging methods are available for the disclosure of proximal caries. Some recent studies have attempted to determine the diagnostic accuracy of available modalities, but they have shown variable results. Aim: This study was carried out to recognize and examine the correctness of cone-beam computed tomography (CBCT), regular radiographs and the nondirect digital system in the disclosure of interproximal caries. Materials and Method: In this observational tryout study, forty-two extracted non-cavitated, unrestored person molar and premolar teeth were placed in the blocks with proximal surfaces in touch. Then they were appraised by CBCT, formal radiographs and the nondirect digital system for the disclosure of interproximal caries. Four oral and maxillofacial radiologists used a 4-point scale to assess the pictures for the existence or absence of proximal caries. Caries depth was specified by histological examination. The gathered data were assessed by SPSS software using Weighted Kappa and Friedman test. Results: Statistics demonstrated that the accuracy of the indirect digital system was somewhat better than conventional systems. The accuracy of the indirect digital system was better than cone beam system, and this difference was statistically significant. Conclusion: The digital system was better than CBCT in the disclosure of proximal caries. The formal radiography fell in between the two other systems without a statistically significant deviation in detecting caries. Thus, CBCT is not advised to detect proximalcaries because of the higher radiation dose. [ABSTRACT FROM AUTHOR]

Background and Aim: Melanoma is a malignant neoplasm of melanocytic origin that arises from a benign melanocytic lesion or denovo from melanocytes within otherwise normal skin or mucosa. Oral mucosal melanoma is much less than %1of all melanomas. Mucosal melanoma is much more aggressive than its cutaneous counterpart. Due to a real increase in the frequency of melanoma in recent years, we investigate the prevalence of malignant melanoma in the mouth ,head and neck during a 11 years period in Iranian population.Materials and Methods: This study was done on the pathology records of patients admitted to the Department of Pathology, School of Dentistry Shahid Beheshti ,Lughman Hakim, Shohada,Taleghani hospitals and Institute cancer of Imam Khomeini. In this study the variables like gender, age, location of the lesion, recurrence and metastasis was evaluated. The chi-square test was used to analyze information obtained from the research.Result:Of the 191679 cases accessed during the 11-year period, 262(0.14%) were identified as oral& maxillofacial malignant melanomas. The average age of melanoma was 50+-11/01years and the incidence in men was higher than women. The most common clinical feature was discoloration (46.9%)and then was ulceration (18.6%).Of all cases 24.8% had metastases. The most common site was the neck and cheek, and the most common area in the mouth, was reported in palate. Conclusion:Frequency of head and neck melanoma was 0.14% of all studied cases. The most common and the least common sites were neck and chin, respectively. Most cases of oral melanoma were localized in the palate and the incidence in men was higher than women. [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate the histopathologic diagnoses and radiographic characteristics of lesions associated with impacted teeth. In this retrospective study, 2624 biopsy reports were assessed. If the report was a record of a pericoronal lesion, the age and sex of the patient and the location, microscopic diagnosis, radiographic features, and size of the lesion were recorded. The Pearson chi-square, Kruskal-Wallis, and Fisher exact tests were used for statistical analysis. In total, 189 patients (7.2%) had lesions associated with impacted teeth. The mean (SD) age of affected patients was 25.91 (14.38) years, and 51.9% of patients with pericoronal lesions were male. The most common lesion sites were the posterior region of the maxilla (43.3%) and the posterior region of the mandible (38.0%). Dentigerous cysts (DCs) constituted 64.6% of the lesions, and odontogenic keratocysts (OKCs) represented 18.5%. Radiographs were available in 153 cases, and most lesions were radiolucent (96.1%), had well-defined outlines (99.3%), and were unilocular (87.6%). Lesions larger than 2.0 cm were 5.5 times more likely than smaller lesions to be diagnosed as non-DC lesions (P = 0.001; Kruskal-Wallis test). Although most of the lesions associated with impacted teeth were DCs, there were other lesions with aggressive behavior, such as OKCs, ameloblastomas, and glandular odontogenic cysts, which require more extensive treatment. Lesions that were 2.0 cm or greater showed a higher probability of being non-DC lesions., Competing Interests: No conflicts of interest reported.

Background: This study aimed to assess the accuracy of two different endodontic guides for fiber post removal., Methods: In this in vitro study, 54 maxillary canine fiber posts were mounted on 36 maxillary stone casts; 18 teeth were mounted unilaterally, and 36 teeth were mounted bilaterally. Static endodontic guides were fabricated according to baseline cone-beam computed tomography (CBCT) and intraoral optical scans using Blue Sky software. In the single-sleeve endodontic guides group (SSG), two anterior and two posterior teeth were included in a 5-unit guide. In the double-sleeve endodontic guides group (DSG) group, the guide was passed through the midline to include both canine teeth and extended by 2 teeth posterior to the canine teeth bilaterally (a 10-unit guide). After drilling, postoperative CBCT scans were taken and superimposed on the virtually designed path, and the maximum coronal deviation (MCD) at the marginal entry point of the tooth, maximum apical deviation (MAD) at 10 mm apical to the tooth margin, and maximum angular deflection (MAnD) of the drill were calculated., Results: The mean MCD, MAD, and MAnD were 0.34 mm, 0.6 mm, and 2.32 degrees, respectively, in the SSG and 0.31 mm, 0.7 mm, and 2.37 degrees, respectively, in the DSG. The two groups were not significantly different from each other in terms of MCD (P = 0.573), MAD (P = 0.290), or MAnD (P = 0.896)., Conclusions: The accuracies of the two techniques, the extended double sleeve guide and the single sleeve guide, were comparable and thus DSG may be used for removal of fiber posts in adjacent or distant teeth., (© 2024. The Author(s).)

Background: Transgingival probing is conventionally used for gingival thickness (GT) measurement. However, invasiveness is a major drawback of transgingival probing. Thus, researchers have been in search of alternative methods for measurement of GT. This study compared the clinical efficacy of intraoral ultrasonography and transgingival probing for measurement of GT in different biotypes., Materials and Methods: This clinical trial was conducted on 34 patients requiring crown lengthening surgery. GT was measured at 40 points with 2- and 4-mm distances from the free gingival margin (FGM) of anterior and premolar teeth of both jaws in each patient by an intraoral ultrasound probe. For measurement of GT by the transgingival probing method, infiltration anesthesia was induced, and a #25 finger spreader (25 mm) was vertically inserted into the soft tissue until contacting bone. The inserted length was measured by a digital caliper with 0.01 mm accuracy. All measurements were made by an operator with high reliability under the supervision of a radiologist. Data were analyzed by t-test, Power and Effect Size formula, and intraclass correlation coefficient (ICC)., Results: The two methods were significantly different in measurement of GT in both thick and thin biotypes at 2- and 4-mm distances (P < 0.001). The two methods had a significant difference in both the mandible (P < 0.001) and maxilla (P < 0.001) and in both the anterior (P < 0.003) and premolar (P < 0.003) regions. Although the difference was statistically significant in t-tests, the power and effect formula proved it to be clinically insignificant. Also, the ICC of the two methods revealed excellent agreement., Conclusion: The results showed optimal agreement of ultrasound and transgingival probing for measurement of GT., Trial Registration: The study was approved by the ethics committee of Shahid Beheshti University of Medical Sciences on 2021-12-28 (IR.SBMU.DRC.REC.1400.138) and registered in the Iranian Registry of Clinical Trials on 2022-03-14 (IRCT20211229053566N1)., (© 2024. The Author(s).)

Background: This study intended to evaluate the association between several endodontic prognostic factors with the presence of periapical lesions (PLs), their volume, and bone characteristics including cortical bone destruction (CBD) and buccal plate bone height (BPBH) in root-filled molar teeth using cone-beam computed tomography., Methods: A collection of 143 scans of endodontically treated maxillary/mandibular first or second molars recorded over 8 years, were obtained from a specialized radiology center. Data on prognostic factors including tooth number, gender, jaw type, the status and number of missed canals, obturation length, restoration type, presence of a separated instrument, presence of a post or screw in the canals, and presence of perforation were collected. The assessed outcomes included PL presence, PL volume, CBD, and BPBH. The association between prognostic factors and outcomes was evaluated using multiple logistic regression models with adjusted covariates and multifactorial ANOVA at a significance level of 0.05., Results: A total of 282 molars from 82 women and 50 men with a mean age of 40.6 ± 12.27 were included. Among those, 139 teeth presented PL with a mean volume of 18.68 mm 3 . CBD was prevalent in 137 teeth and the mean BPBH appeared to be 9.45 mm. The presence of a missed canal (OR = 10.022, P < .05), underfilled canal (OR = 3.725, P < .05), overfilled canal (OR = 15.859, P = .018), and perforation (OR = 15.261, P = .013) was significantly associated with PLs. None of the prognostic factors could considerably contribute to the CBD (P > .05). The presence of a missed canal was positively associated with the PL volume (P < .05). Similarly, missed canals (P < .05), perforation (P < .05), and separated instruments (P = .004) were associated with a significantly reduced BPBH., Conclusions: Overfillings, perforations, missed canals, and underfillings were identified as remarkable predictors of PL, arranged in descending order of their respective impact. The only factor capable of significantly increasing the PL volume was the missed canal. In brief, obturation length errors, perforations, missed canals, and separated instruments were robustly correlated with endodontic failure, which highlights the importance of mitigating the potential for errors by following the fundamentals of endodontics., (© 2023. The Author(s).)

Background: Different imaging techniques, such as multi-detector computed tomography (MDCT) scan and cone beam computed tomography(CBCT), are used to check the structure of the nose before rhinoplasty. This study aimed to evaluate the accuracy of two imaging techniques, MDCT scan, and CBCT, in diagnosing structural Variations in rhinoplasty for the first time., Methods: This diagnostic accuracy study was conducted on 64 rhinoplasty candidates who complained of snoring and sleep apnea or had a positive result in the examination with Cottle's maneuver or modified Cottle technique between February 2021 and October 2022 at 15- Khordad Hospital affiliated to Beheshti University of Medical Sciences. Before rhinoplasty, patients were randomly assigned to one of the CT and CBCT techniques with an equal ratio. Scans were assessed for the presence of Nasal septum deviation (NSD), Mucocele, Concha bullosa, and nasal septal spur by two independent radiologists. The findings of the two methods were evaluated with the results during rhinoplasty as the gold standard., Results: NSD was the most common anatomical variation based on both imaging techniques. The accuracy of CBCT for diagnosing Nasal Septum Deviation and Mucocele was 80% and 75%, respectively. The sensitivity, specificity, and accuracy of CBCT in detecting Concha bullosa were 81.3% and 83.3%, respectively. The Kappa coefficient between CBCT and intraoperative findings for diagnosing NSD and Concha Bullosa was 0.76 and 0.73, respectively (p < 0.05)., Conclusion: CBCT can be considered a suitable method with high accuracy and quality to evaluate the anatomical variations before rhinoplasty., (© 2023. The Author(s).)

Pulp canal calcification (PCC) is common in patients with dentinogenesis imperfecta (DGI). We present endodontic management of multiple anterior and posterior teeth with PCCs in a patient with DGI type II using guided endodontics. A 26-year-old female patient was diagnosed with DGI type II. Clinical examination revealed palatal cusp fracture in tooth #13, microcracks in tooth #14, and a sinus tract in the maxillary right buccal vestibule related to tooth #13. Periapical radiographs revealed PCCs in all teeth, and periapical radiolucencies in several teeth. Due to difficult negotiation of canal orifices, guided endodontic approach was planned. Cone-beam computed tomography (CBCT) was requested and obtained. Intraoral scanning was performed, and CBCT and intraoral scanning data were superimposed. A template was designed and 3D printed. The root canal orifices were successfully negotiated and endodontic treatments were successfully accomplished. At the 1-year follow-up, the endodontically treated teeth were asymptomatic, and periapical lesions were healing., Competing Interests: None.

This study aimed to assess the relationship of impacted mandibular third molars with the mandibular canal on cone beam computed tomography (CBCT) scans. This cross-sectional study was conducted on CBCT scans of 137 patients with 204 impacted mandibular third molars. The relation of age, gender, class of impaction, anatomical position of canal relative to tooth (buccal, lingual, inferior, inter-radicular), tooth angulation (mesioangular, vertical, distoangular, horizontal), relationship of tooth with the mandibular canal (no contact, in contact, relation), relationship of tooth with the mandibular cortex, anatomical site of contact of tooth with the mandibular cortex (buccal, lingual, inferior), and the impression of canal (grooving, no effect) on impacted teeth were evaluated. Data were analyzed using one-way ANOVA, Chi-square test and Fisher's exact test. Class B of impaction (78.9%), inferior position of canal relative to the impacted tooth (53.9%) and mesioangular angulation (53.4%) had the highest frequency, respectively. The relationship of tooth with the mandibular canal was "relation" in most cases (53.4%) followed by no contact (26.9%) and in contact (19.6%). Significant associations were noted between depth of impaction (P < 0.001), tooth angulation (P = 0.024), anatomical position of canal relative to tooth (P < 0.001), relationship of tooth with the mandibular cortex (P = 0.032) and anatomical site of contact of tooth with the mandibular cortex (P = 0.013) with the impacted tooth-mandibular canal relationship. CBCT provides accurate information about the relationship of impacted third molars with the mandibular canal and can decrease the risk of traumatization of inferior alveolar nerve (IAN) during their surgical extraction.

Statement of the Problem: Early detection of caries and the extent of carious lesions for appropriate treatment planning are very important and lead to introduction of new diagnostic tools., Purpose: This study aimed to compare the diagnostic accuracy of VistaCam IX Proxi and bitewing radiography for detection of posterior interproximal caries., Materials and Method: This in vitro study was performed on 40 extracted posterior teeth without cavitated carious lesions. Bitewing radiographs were obtained, infrared (IR) examination was performed, and the teeth were sectioned for histopathological analysis under a stereomicroscope as the gold standard for detection of caries and determination of the extent of carious lesions. Data were analyzed with Cohen's kappa statistic, and Wilcoxon rank sum test., Results: The specificity of VistaCam IX Proxi and bitewing radiography was 71.4% and 87.7%, respectively. Their sensitivity was 100% and 40% for enamel caries, 72.8% and 54.5% for external half dentin caries, and 82.3% and 58.8% for internal half dentin caries, respectively ( p = 0.048)., Conclusion: Bitewing radiography had a higher specificity and lower rate of false positive results. However, VistaCam IX Proxi had higher sensitivity for caries detection with lower rate of false negative results. Considering the higher sensitivity and significantly lower frequency of false negative results by VistaCam IX Proxi, it may be reliably used for caries detection specially enamel caries, and can serve as an adjunct to bitewing radiography., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright: © Journal of Dentistry.)

Introduction: Vaccines stand amongst the most effective medical interventions for the management of infectious diseases, and are pivotal tools for public health. The acceptance of vaccines is heavily influenced by perceptions of efficacy, safety and other modifiable factors., Purpose: This cross-sectional study sought to identify and examine the modifiable factors that can help address COVID-19 vaccine hesitancy and acceptance among cancer patients., Methods: The study was conducted between February and April 2021 using an online survey questionnaire comprising of four domains. The survey was administered to cancer patients in Jordan., Results: Among the 1,029 cancer patients who completed the online questionnaire (response rate= 73%), 58% (n=597) expressed willingness (intent) to take the vaccine. Notably, 72.5% (n=433) of those intending to take the vaccine were currently undergoing treatment. Knowledge and awareness played a significant role, with 54.3% considering them essential for vaccine acceptance. Fear of infection significantly influenced vaccine acceptance (p<0.001), with 66.8% expressing concern about potential infections. Peer encouragement was also a crucial factor, as 82.4% regarded it as an important driver for influencing vaccine acceptance (p<0.001)., Conclusion: Peer encouragement, awareness, and fear emerged as the primary modifiable factors associated with greater vaccine acceptance by patients with active malignancies. Study results suggest that providing personalized and tailored information about vaccinations, focusing on safety and potential interactions with cancer and its treatment, are potentially excellent strategies for improving vaccine acceptance among cancer patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 AlMasri, Al Masri, Darwish, Ammar and Safi.)

Objectives: Different factors can affect the discrepancy between the gray value (GV) measurements obtained from CBCT and the Hounsfield unit (HU) derived from multidetector CT (MDCT), which is considered the gold-standard density scale. This study aimed to explore the impact of region of interest (ROI) location and field of view (FOV) size on the difference between these two scales as a potential source of error., Methods: Three phantoms, each consisting of a water-filled plastic bin containing a dry dentate human skull, were prepared. CBCT scans were conducted using the NewTom VGi evo system, while MDCT scans were performed using Philips system. Three different FOV sizes (8 × 8 cm, 8 × 12 cm, and 12 × 15 cm) were used, and the GVs obtained from eight distinct ROIs were compared with the HUs from the MDCT scans. The ROIs included dental and bony regions within the anterior and posterior areas of both jaws. Statistical analyses were performed using SPSS v. 26., Results: The GVs derived from CBCT images were significantly influenced by both ROI location and FOV size ( p < 0.05 for both factors). Following the comparison between GVs and HUs, the anterior mandibular bone ROI represented the minimum error, while the posterior mandibular teeth exhibited the maximum error. Moreover, the 8 × 8 cm and 12 × 15 cm FOVs resulted in the lowest and highest degrees of GV error, respectively., Conclusions: The ROI location and the FOV size can significantly affect the GVs obtained from CBCT images. It is not recommended to use the GV scale within the posterior mandibular teeth region due to the potential for error. Additionally, selecting smaller FOV sizes, such as 8 × 8 cm, can provide GVs closer to the gold-standard numbers.

Background and Aim: The aim of this study is to evaluate the changes in the temporomandibular joint (TMJ) in patients with temporomandibular disorder (TMD) and the relationship between age, sex, and types of TMJ change using Cone Beam Computed Tomography (CBCT)., Methods and Material: CBCT records of 200 patients (123 women and 67 men) were retrieved and assessed. Right and left TMJs were evaluated separately, resulting in a total of 400 TMJs. The images were analyzed using On demand 3D Application The radiographic findings were classified as erosion, proliferative changes mainly, including flattening and osteophytes of the condyle, sclerosis, Ely cyst, hypoplasia and hyperplasia of the condyles, ankylosis, and joint cavity. Data analysis was performed using descriptive statistics, paired T-tests, and repeated measure ANOVA (Analysis of Variance) in SPSS Software., Results: The most prevalent types of condylar bony changes observed was osteophyte (63.5%) followed by flattening of the articular surface (42%), erosion (40%), ankylosis (10%) and sclerosis (10%). 7.5% of joints showed hyperplastic condyles but only 2% showed hypoplasia. The least prevalent change observed was Ely Cyst (1%). Osteophyte was the most prevalent change observed in all age groups and both sexes except for men aged 31 ~ 50, where flattening was more frequent. A statistically significant difference was found between sex and prevalence of erosion in the age group of 10 ~ 30 (P = 0.001); as well as between sex and condylar hyperplasia in the same age group., Conclusion: Based on the findings of this research, the prevalence of bony changes of TMJ from highest to lowest is as follows: osteophyte, flattening of the articular surface, erosion, ankylosis, sclerosis, hyperplastic condyles, hypoplastic condyles and Ely Cyst. CBCT is an accurate 3 dimensional imaging modality for assessment of TMJ bony structures., (© 2023. The Author(s).)

Introduction: This study aimed to assess the alveolar bone thickness (ABT) and labiolingual inclination of maxillary and mandibular central incisors in patients with Class I and II skeletal patterns with normal-angle, high-angle, and low-angle vertical patterns., Methods: The study sample consisted of 200 cone-beam computed tomography scans of patients with skeletal Class I and II malocclusions. Each group was further divided into low-angle, normal-angle, and high-angle subgroups. Labiolingual inclinations of maxillary and mandibular central incisors and ABT were measured at 4 levels from the cementoenamel junction in the labial and lingual surfaces. The Kolmogorov-Smirnov test, independent t test, 2-way analysis of variance, and Spearman's correlation test were applied for statistical analyses., Results: The only significant difference between Class I and II groups regarding the ABT was found at the labial side of the maxillary central incisor, 9 mm apical to the crest. At this level, the mean ABT was 0.87 mm in patients with a skeletal Class I malocclusion, which was significantly greater than that in patients with a skeletal Class II malocclusion with a mean ABT of 0.66 mm (P = 0.02). Comparisons among the vertical subgroups revealed that on the labial and lingual sides of the mandible, as well as the palatal side of the maxilla, significantly thinner alveolar bone was found in patients with high-angle growth patterns than those with normal-angle and low-angle patterns in both sagittal groups (P <0.05). Significant weak to moderate correlations were found between ABT and tooth inclination (P <0.05)., Conclusions: Significant differences in ABT covering central incisors between patients with skeletal Class I and II malocclusion are merely observed at the labial surface of the maxilla, 9 mm apical to the cementoenamel junction. Compared with patients with normal-angle and low-angle, those with a high-angle growth pattern and Class I and II sagittal relationships have thinner alveolar bone support around maxillary and mandibular incisors., (Copyright © 2023 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Background: This study was conducted to compare the pain levels in patients and the clinical efficacy of grafts obtained using two techniques, namely de-epithelialized gingival graft (DGG) and subepithelial connective tissue graft (SCTG), in combination with coronally advanced flap (CAF) for the treatment of multiple adjacent gingival recessions., Methods: Twelve patients were treated using DGG+CAF on one side and SCTG+CAF on the other. The patients' pain levels at the surgical site, the number of analgesics taken on days 3 and 7, the mean root coverage (MRC), the percentage of complete root coverage (CRC), color match, and gingival thickness (GT) at the graft recipient site were evaluated 6 months after surgery., Results: The total number of analgesics taken during the 7-day period after surgery and pain levels at the surgical site from day 3 to day 7 were significantly higher in the DGG+CAF group compared to the SCTG+CAF group ( P =0.001). In the 6-month follow-up, color match and CRC were significantly higher in the SCTG+CAF group, while GT was significantly higher in the DGG+CAF group. There was no significant difference in MRC between the two groups., Conclusion: The pain and analgesic consumption levels were higher in the DGG+CAF group compared to the SCTG+CAF group, and the recipient site had a weaker color match. However, this technique can lead to a greater increase in the thickness of the grafted area., Competing Interests: The authors declare that they have no competing interests., (© 2023 The Author(s).)

Introduction: This study aimed to assess the quantity and quality of available bone to provide the autologous bone graft from mandibular ramus., Material and Methods: CBCT scans were collected and mandibular ramus was evaluated by measuring a variety of parameters including volume, bone height, cortical, and cancellous bone thickness. Data analysis was performed using descriptive statistics and inferential statistics. We used the Kolmogorov-Smirnov test for the evaluation of data normality. We then applied Pearson correlation and independent t -test for normal variables, and Spearman and Mann-Whitney correlation tests for abnormal variables. Statistical analysis was performed using SPSS version 19 and P value < 0.05 was considered significant., Results: A total of 52 women and 32 men (aged 21 to 70) were included in this study. The mean bone volume was 2.7 ± 0.70 cm 3 [95%confidence interval (CI) 1.3-4.5]. The mean bone density in the middle section was 1016.36 ± 231.58 Gy value (95% CI 475.6-1520.9). Kolmogorov-Smirnov test revealed that the variables such as apical cortical/cancellous ratio ( P  = 0.005), middle-cancellous bone thickness ( P = 0.016), and middle cortical/cancellous ratio ( P  = 0.005) were abnormal and the rest were normal. Bone density, as well as the amount of cortical bone in the middle and apical regions, had a significant reverse correlation with age ( P  < 0.001)., Conclusion: The volume, density, and cortical/cancellous ratio are independent of sex. The reverse relationship between age and bone density, as well as the amount of cortical bone in several parts, indicates a decrease in bone quality with aging., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest., (© The Association of Oral and Maxillofacial Surgeons of India 2021.)

Objective: This study sought to compare the thickness of hard and soft tissues between edentulous and contralateral tooth sites., Materials and Methods: This split-mouth study evaluated 153 partially edentulous patients. The measurements were made on cone-beam computed tomography (CBCT) scans. The soft tissue thickness was measured at the cementoenamel junctional (CEJ) level, and at 2, 4, and 6 mm apical to the CEJ in the facial and palatal aspects. The bone thickness of the opposite quadrant was also recorded at 2, 4, and 6 mm apical to the CEJ. The Mann-Whitney U test and the Spearman's rank correlation coefficient were applied for further statistical analyses., Results: At the edentulous sites, significant soft tissue loss was noted at the CEJ level ( p  < 0.0001) and a considerable gain was noted at 2, 4, and 6 mm apical to the CEJ ( p  = 0.004, p  < 0.0001, p  ≤ 0.0001, respectively). A significant hard tissue loss was noted at 2 mm apical to the CEJ but a significant hard tissue gain was observed at the edentulous sites ( p  < 0.0001). The soft tissue gain at 6 mm apical to the CEJ was significantly associated with an increase in buccolingual diameter ( p  = 0.004) while the hard tissue loss at 2 mm apical to the CEJ was significantly correlated with a reduction in buccolingual diameter ( p  = 0.020)., Conclusion: Different amounts of tissue thickness alterations occurred in different levels of socket., Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest to this study., (© The Association of Oral and Maxillofacial Surgeons of India 2021.)

Introduction: Canines are the second most common tooth in terms of impaction. Impacted teeth can be associated with some different indices of dental arch and dentoalveolar structures. The aim of this study was to evaluate maxillary arch width as well as volume and depth of palate in patients with maxillary impacted canine by cone beam computed tomography (CBCT)., Methods: In this cross-sectional study, 45 CBCT images of patients with unilateral maxillary impacted canines were examined. All patients had palatally impacted canines. Three parameters of maxillary arch width, palatal volume and palatal depth were assessed using axial and sagittal incisions on the CBCT images. Then all the measurements on the impacted side were compared with the non-impacted side. Data were entered into SPSS software and paired sample t-test and Student's t-test were used to comparison. The significance level of 0.05 was considered., Results: The maxillary arch width on the impacted side was significantly less than the normal side (P < 0.001). The mean depth of the palate was 14.86 ± 3.53 mm. There was a significant correlation between canine impaction and Palatal volume (R = 0.728 and P-value< 0.001), but no significant correlation between canine impaction and Maxillary arch width was shown (R = 0.15 and p-value = 0.326)., Conclusion: The impacted canine was significantly associated with a reduction in the width of the maxillary arch on the affected side, and it made no difference if the impacted side was left or right. Also, impacted canine teeth were significantly associated with volume reduction on the affected side., Competing Interests: The authors declare no conflict of interest., (© 2022 The Authors.)

Materials and Methods: In this in vitro experimental study, titanium implants, teeth with cobalt-chromium (Co-Cr) intracanal posts, and teeth with mesio-occluso-distal (MOD) amalgam restorations were placed in an empty socket of the extracted third molar of a human mandible. These metallic materials were differently arranged in the exomass (zone outside of the FOV). A polypropylene tube containing dipotassium phosphate was placed in the empty socket of the right canine tooth in a dry human mandible. CBCT scans were taken with a NewTom VGI (Verona, Italy) scanner using a 6 × 6 cm and an 8 × 8 cm FOV. The histogram tool of OnDemand software (Cybermed, Seoul, Korea) was used to select circles with a 1.5 mm diameter as the (ROI) at the center of the homogenous solution of dipotassium phosphate tube on the axial plane. The mean gray value (GV) and its standard deviation (SD) in the region of interest (ROI) were calculated ( P > 0.05). The data were analyzed by SPSS 26., Results: The reduction in the size of the FOV significantly decreased the mean GV ( P < 0.001). Metal objects in the exomass significantly decreased the mean GV ( P < 0.001), and minimum mean GV and maximum SD were recorded for amalgam, followed by Co-Cr intracanal posts, and titanium implants. The unilateral presence of a metal object was associated with a higher mean GV and lower SD ( P < 0.001)., Conclusion: Using a smaller FOV increases the size of the exomass, which may negatively affect the image quality. Metal objects in the exomass decrease the GV of CBCT scans and adversely affect the image quality., Competing Interests: The authors declare that there are no conflicts interests., (Copyright © 2022 Yaser Safi et al.)

Purpose: The aim of this study was to introduce a category of jaw lesions comprising cysts and tumors associated with scalloped borders., Materials and Methods: General search engines and specialized databases including Google Scholar, PubMed, PubMed Central, and Scopus, as well as an authoritative textbook, were used to find relevant studies by using keywords such as "jaw lesion," "jaw disease," "scalloping," "scalloped border," "scalloped margin," "irregular border," and "irregular margin." Out of 289 articles, 252 records were removed because they were duplicates, did not have a relevant title, or did not mention the frequency of findings described using the term "scalloped border." Finally, 37 closely related articles were chosen., Results: According to the relevant literature, scalloped borders are found most frequently in ameloblastoma, followed by simple bone cyst, central giant cell granuloma, odontogenic keratocyst, and glandular odontogenic cyst., Conclusion: The lesions most frequently reported to have scalloped borders are ameloblastoma, central giant cell granuloma, odontogenic keratocyst, simple bone cyst, and glandular odontogenic cyst., Competing Interests: Conflicts of Interest: None, (Copyright © 2022 by Korean Academy of Oral and Maxillofacial Radiology.)

Background: Artifacts fault image quality but handling several factors can affect it. This study was conducted to investigate the effect of object size on artifacts in cone-beam computed tomography systems., Methods: Five phantoms, each containing a titanium implant in a sheep bone block, were fabricated of various sizes ranging from XS to XL: The M phantom was the same size as the device's field of view (FOV). The L and XL phantoms were 20 and 40% larger than the FOV while the S and XS phantoms were 20 and 40% smaller than FOV, respectively. Ballistic gelatin was used to fill the phantoms. Phantoms were scanned by NewTom VGI and HDXWill Q-FACE. The mean and standard deviation (SD) of gray values in each 120 ROI was obtained by OnDemand software. The contrast to noise ratio (CNR) was also calculated., Results: The gray value in S and M phantoms were more homogenous. The lowest SD value (10.20) was found in S phantom. The highest value for SD (125.16) was observed in XL phantom. The lowest (4.47) and highest (9.92) CNR were obtained in XL and S phantoms, respectively. HDXWill Q-FACE recorded a higher SD and a lower CNR than NewTom VGI (P < 0.05)., Conclusion: Object dimensions of the FOV size or up to 20% smaller provided better image quality. Since the dimensions of soft tissue in most patients are larger than the selective FOV, it is recommended that in CBCT artifacts studies, an object with dimensions closer to the patient's dimensions be used to better relate the results with the clinical condition, because the sample dimensions affect the amount of artifacts., (© 2022. The Author(s).)

Background: The maxillary palatine process (MPP) is an excellent source of autogenous bone transplants for anterior maxillary reconstruction. This research aimed to determine the quantity and quality of accessible MPP as a donor location., Methods: Cone-beam computed tomography (CBCT) scans of patients referred to the School of Dentistry were evaluated by a certified examiner. The harvestable MPP was defined as the space between the distal surfaces of maxillary first premolars. OnDemand 3D Imaging software was used to determine bone properties. SPSS software was used to investigate the following variables: Bone characteristics are correlated with age and gender, accessible volume, and palatal width and height. P <0.05 was defined as the level of statistical significance., Results: This study was performed on CBCT scans of 81 subjects (41 females and 40 males). MPP volume and palatal heights were 1.33±0.53 cm3 and 20.86±5.51 mm, respectively. Maximum bone density was observed around lateral incisors. Palatal width was 33.81±2.42 mm between canines and 41.81±2.66 mm between premolars. The MPP volume was significantly greater in males ( P <0.001). Additionally, there was a positive correlation between the volume and palatal width ( P <0.05)., Conclusion: Within the constraints of this research, there is a limited supply of MMP accessible for use as a graft source, and it is best suited for treating localized bone lesions. The favorable link between palatal breadth and harvestable volume aids the surgeon in estimating the quantity of bone accessible during the first evaluation., Competing Interests: The authors declare that they have no known competing and financial interests or personal relationships that could have influenced the work reported in this paper., (© 2022 The Author(s).)

The aim of this study was to assess the occupational exposure from portable X-ray device without stray radiation protection shield measured using thermoluminescent dosemeters (TLDs). A total of 108 intraoral periapical radiographies of six sextants were performed. The TLDs were located on right index finger and left palm, between the pupils of the eyes at the edges of the Nasion point, Manubrium of Sternum bone and genital area. The detected mean doses per procedure were 70, 99, 60, 51, 51 and 58 μSv in the right finger, left palm, level of the Nasion point, under left clavicle, above the sternum manubrium and at the gonad area, respectively. Maximum number of radiographic images that the operator is allowed to perform depends on eye exposure and in accordance with International Commission on Radiological Protection is 0.16 (0.12-0.23) per hour or 1.28 (0.96-1.84) per day., (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

This study sought to assess the morphological variations of the posterior mandible and propose a classification for ridge morphology based on cone-beam computed tomography (CBCT) data. This retrospective, cross-sectional study evaluated 130 CBCT scans of patients with edentulous mandibles. Qualitative variables including lingual and crestal concavity, vertical, horizontal and angular limitations, and ridge morphology were assessed at 631 sites on CBCT scans of 87 males and 43 females. A classification for ridge morphology in the posterior mandible was proposed based on the collected data. The kappa coefficient was calculated to assess the intra-observer agreement, and data were analyzed using the chi-square test and Pearson's correlation test. The frequency of lingual concavity increased from the anterior towards the posterior region relative to the mental foramen (P < 0.05). The maximum frequency of lingual concavity (11.1%) was noted at 21 mm distance from the mental foramen while its minimum frequency (4.1%) was noted at 5 mm from the mental foramen (P < 0.05). Ridge morphology, defined as ridge angulation < 15°, no lingual or crestal concavity, no limitation in width, and 8-10 mm height, had the highest frequency. Its suggested treatment plan included a 10-mm implant without width limitation or severe angulation. The majority of common morphologies had no width limitation with ridge angulation < 15°. Height limitation was only present in two of them, which can be resolved by placement of a short implant or ridge augmentation.

In this retrospective cross-sectional study, cone beam computed tomography (CBCT) was used to assess the bone quantity variations in the posterior mandible of edentulous patients. The crestal cortical bone thickness, buccal cortical bone thickness, lingual cortical bone thickness, ridge height, ridge width, ridge angle, lingual concavity depth, and cortical to cancellous bone surface area ratio were measured at 631 sites on 130 CBCT scans of edentulous patients. The patient sample comprised 87 men and 43 women with a mean (SD) age of 63.0 (11.8) years. One calibrated observer made all of the measurements. The intraobserver agreement was calculated, and the results of the measurements were analyzed with the independent t test and Pearson correlation test. The crestal, buccal, and lingual cortical bone thickness and ridge angle decreased significantly with age, while the ridge width increased significantly with age (P < 0.05). The buccal and lingual cortical bone thickness, ridge height, ridge angle, and lingual concavity depth were significantly greater in men (P < 0.05). The buccal cortical bone thickness, ridge width, ridge angle, and lingual concavity depth increased significantly from the anterior toward the posterior region relative to the mental foramen (P < 0.05). A ridge height of greater than 8.0 mm, a ridge width of greater than 6.0 mm, and a ridge angle of less than 15° were noted in 74%, 80%, and 80% of the sites, respectively (P < 0.05). The anatomical variations found in the mandibular posterior region of edentulous patients necessitate comprehensive CBCT assessment prior to implant placement in this area., Competing Interests: The authors report no conflict of interest pertaining to any of the products or companies discussed in this article.

Objectives: Dental implant is a commonly used treatment modality for replacement of the missing teeth. The aim of the present study was to evaluate a number of bone-related factors at the implant site preoperatively by cone-beam computed tomography (CBCT)., Materials and Methods: A total of 400 implant sites were evaluated on CBCT images. The height, width, angle of residual ridge, thickness of cortical bone crest, and the ridge concavity were evaluated on cross sectional images at four regions: the anterior maxilla, anterior mandible, posterior maxilla, and posterior mandible., Results: The highest thickness of cortical bone was observed in posterior mandible followed by anterior mandible, anterior maxilla, and posterior maxilla. In the mandible, the mean buccal concavity was higher in the anterior than in the posterior region (P = 0.0094). The measurements indicated that in both the maxilla (P = 0.0256) and mandible (P < 0.0001), the residual ridge width was lower in the anterior than in the posterior region; while the height of the residual ridge was higher in the anterior than in the posterior region in the mandible (P < 0.0001). In the maxilla, the remaining ridge angle in the anterior region was greater than that in the posterior region (P < 0.0001)., Conclusion: Anatomical variations detected on CBCT results in personalized treatment planning considering best site and the best fixture in terms of size and position prior to implant fixture insertion.

Determining the position of the Inferior alveolar nerve (IAN) is an important factor prior to any surgical procedure in the mandible such as dental implant insertion and surgical tooth extraction. The aim of this study was to compare the position of IAN in partially edentulous patients in the lower first and second molars in both missing and dentate sides. A total of 200 CBCT scans were chosen randomly and examined. On cross-sectional views, the distance between lower border of IAN canal and upper border of inferior cortex of mandible (IC) were measured at the site of dentate and edentulous mandibular first and second molar. Paired-sample t-test was used to analyze and compare measurements on right and left sides. A total of 100 males and 100 females with mean age of 46.05 ± 12.33 years were included. The IC distance measured in four pairs were as follows: Pair one: 80 cases with right missing 6 (mean ± SD = 3.73 ± 1.29 mm) and left present 6 (mean ± SD = 3.42 ± 1.20 mm), Pair two: 20 cases with right present 6 (mean = 3.20 ± 1.48 mm) and left missing 6 (mean ± SD = 3.96 ± 1.62 mm), Pair three: 54 cases of right missing 7 (mean ± SD = 3.83 ± 1.74 mm) and left present 7 (mean ± SD = 3.62 ± 1.74 mm), and Pair four: 46 case of right present 7 (mean ± SD = 3.49 ± 1.56 mm) and left missing 7 (mean ± SD = 3.84 ± 1.42). The IAN was statistically more distant from inferior cortex of mandible in the edentulous parts compared with the non-edentulous part (P < 0.05). The IAN was positioned farther from the inferior cortex of mandible in edentulous sites compared with dentate parts. Cautious consideration is essential in any surgical procedure and dental implant operations to prevent IAN injury.

This study determined the influential factors in buccal and lingual plate perforation around dental implants using cone-beam computed tomography (CBCT). In this retrospective, cross-sectional study, CBCT scans of dental implants taken for purposes not related to this study from 2017 to 2018 were retrieved from the archives of a private dental clinic. Demographic information, implant site, length, diameter, shape, and angulation, buccal and lingual plate thickness, buccolingual diameter of bone, and presence of crestal bone resorption were all assessed on CBCT scans. Data were analyzed using chi-squared, Mann-Whitney, Kruskal-Wallis, and independent t-tests. Of 604 implants, 88 had caused bone perforation in 41 females (46.6%) and 47 males (53.4%) with a mean age of 54.97 ± 13.99 years; 83% of perforations were in the maxilla; 55.7% of implants causing perforation were cylindrical and 44.3% were conical. The mean length and diameter of implants was 11.78 ± 1.91 mm, and 4.49 ± 0.76 mm, respectively; 38.9% of perforations were in the buccal and 18.2% in the lingual plate, and 42% were in the apical region. Crestal bone loss was noted in 58% of perforation cases. The mean angular deviation of implants was 19.13 ± 12.41°. Implant length and diameter had a significant association with the occurrence of perforation in the mandible (P < 0.05). Perforations had a higher frequency in the posterior maxilla, and mainly in the apical region. The buccal plate was thin in the anterior maxilla, with minimum thickness in the apical region. Lingual plate perforation had the highest frequency in the mandible.

Purpose: Dental implants are widely used for the rehabilitation of edentulous sites. This study investigated the occurrence of dental implant malpositioning as shown on post-implantation cone-beam computed tomography (CBCT) and to identify related factors., Materials and Methods: Samples with at least 1 malpositioned dental implant were collected from a central radiology clinic in Tehran, Iran from January 2017 to January 2019. Variables such as demographic characteristics, length and diameter of implants, type of implant, sites of implant insertion, different types of implant malpositioning problems (cortical plate perforation, interference with anatomical structures), angulation of the implant, and the severity of malpositioning were assessed. In addition, the incidence of implant fracture and over-drilling was evaluated. Data were statistically analyzed using the chi-square test, 1-sample t-test, and Spearman correlation coefficients., Results: In total, 252 patients referred for implant postoperative CBCT evaluations were assessed. The cases of implant malpositioning included perforation of the buccal cortical plate (19.4%), perforation of the lingual cortical plate (14.3%), implant proximity to an adjacent implant (19.0%), implant proximity to an adjacent tooth (3.2%), interference with anatomical structures (maxillary sinus: 18.3%, mandibular canal: 11.1%, nasal cavity: 6.3%, mental foramen: 5.6%, and incisive canal: 0.4%). Implant fracture and over-drilling were found in 1.6% and 0.8% of cases, respectively. Severity was categorized as mild (9.5%), moderate (35.7%), severe (37.7%), and extreme (17.1%), and 52.4% of implants had inappropriate angulation., Conclusion: CBCT imaging is recommended for detecting dental implant malpositioning. The most common and severe type of malpositioning was buccal cortex perforation., Competing Interests: Conflicts of Interest: None, (Copyright © 2021 by Korean Academy of Oral and Maxillofacial Radiology.)

Background: Bone volume plays a pivotal role in the success of dental implant treatment. Autogenous bone grafts should be harvested from reliable sites in the maxillofacial region. This study sought to assess the quantity and quality of bone in the mandibular symphysis for autogenous bone graft harvesting using cone-beam computed tomography (CBCT)., Methods: This cross-sectional study evaluated the CBCT scans of 78 adults presenting to three oral and maxillofacial radiology centers. The vertical (VD) and horizontal (HD) alveolar bone dimensions, cortical thickness (CT), and cancellous to cortical bone ratio (C/C) were measured in the interforaminal region of the mandible at the sites of central incisor to first premolar teeth. The interforaminal distance (ID) and the anterior loop length were also measured. Nonparametric statistical tests were used to analyze the data with respect to sex, age, and tooth position., Results: The median VD, HD, and CT of the symphysis were 20.21 (3.26), 4.13 (0.37), and 2.25 (0.23) mm, respectively. The median C/C was 1.51 (0.11). The median ID was 52.24 (8.24) mm, and the median anterior loop length was 1.82 (1.06) mm. Significant differences were observed in all parameters among different teeth. Most of the measured parameters were greater in males compared with females. There were significant differences in ID, VD, and CT between different age groups., Conclusions: The quantity and quality of the available bone in the mandibular symphysis for bone graft harvesting vary by gender, age, and harvesting site, necessitating careful preoperative evaluation., (© 2021. The Author(s).)

Purpose - Dental implants in the anterior mandible have become increasingly common due to popular prosthetic treatments. The aim of this study was to evaluate cone beam computed tomography (CBCT) images of mandibles from edentulous patients in need of anterior dental implants to present qualitative descriptions in the mental interforaminal region and to present a new classification. Material and Methods - A total of 180 (CBCT) scans of patients requiring implant installation in the anterior mandible for implant assisted overdenture treatment plan were evaluated regarding parameters such as ridge height, width, inclination, and undercuts. All assessments were performed on the cross-sectional images mesial to the mental foramen. Results - The most common ridge morphology was cylindrical (74.1%) followed by atrophic (19.4%) and undercut (6.4%). The prevalence of atrophic ridge was significantly higher in females and ridge with undercut was significantly more detected in males (P < 0.05). D1 and D2 bone types was detected higher in males than in females (P < 0.05). Conclusion - Cylindrical morphology was the most prevalent features of anterior mandible of edentulous patients. A CBCT scan is a useful diagnostic tool providing important information about anatomical structures and morphological variations in the sites of interest.

Purpose: The mastoid region is ideal for studying sexual dimorphism due to its anatomical position at the base of the skull. This study aimed to determine sex in the Iranian population based on measurements of the mastoid process using different data mining algorithms., Materials and Methods: This retrospective study was conducted on 190 3-dimensional cone-beam computed tomographic (CBCT) images of 105 women and 85 men between the ages of 18 and 70 years. On each CBCT scan, the following 9 landmarks were measured: the distance between the porion and the mastoidale; the mastoid length, height, and width; the distance between the mastoidale and the mastoid incision; the intermastoid distance (IMD); the distance between the lowest point of the mastoid triangle and the most prominent convex surface of the mastoid (MF); the distance between the most prominent convex mastoid point (IMSLD); and the intersecting angle drawn from the most prominent right and left mastoid point (MMCA). Several predictive models were constructed and their accuracy was compared using cross-validation., Results: The results of the t-test revealed a statistically significant difference between the sexes in all variables except MF and MMCA. The random forest model, with an accuracy of 97.0%, had the best performance in predicting sex. The IMSLD and IMD made the largest contributions to predicting sex, while the MMCA variable had the least significant role., Conclusion: These results show the possibility of developing an accurate tool using data mining algorithms for sex determination in the forensic framework., Competing Interests: Conflicts of Interest: None, (Copyright © 2020 by Korean Academy of Oral and Maxillofacial Radiology.)

Implant-supported overdentures are becoming a common treatment modality, providing functional and esthetic results for patients in need of full-mouth rehabilitation. Because anatomical variations in the residual ridge affect treatment planning, the aim of this retrospective study was to present quantitative descriptions of the interforaminal region by evaluating a large series of cone beam computed tomographic (CBCT) images of the mandibles of edentulous patients in need of anterior dental implants. The sample included a total of 180 CBCT scans (360 sites) of patients requiring endosseous implant placement in the anterior region of the mandible for implant-assisted overdentures. The CBCT images were evaluated for parameters such as ridge height, width, angulation, and undercuts; crestal height; and corticocancellous bone ratios. The statistical analyses included the independent-samples t test and chi-square analysis. The mean (SD) ridge height was 18.16 (0.36) mm on the right side and 17.79 (0.38) mm on the left side and was significantly greater in men than in women (P = 0.02). Men also had a significantly greater cortical crest height than women (P = 0.01). The prevalence of ridge undercuts in the buccal cortex was 10.0% on the right side and 7.2% on the left side, and these undercuts had mean (SD) depths of 1.52 (0.62) mm and 1.48 (0.60) mm on the right and left sides, respectively. The ratio of cortical bone to cancellous bone was significantly greater in men than in women (P = 0.03). The mean (SD) ridge angle was 14.51 (6.54) degrees on the right side of the mandible and 13.05 (6.47) degrees on the left side, a statistically significant difference (P = 0.00). Moderate positive correlations were detected between the patient age and both the ridge widths (P = 0.00) and cancellous bone widths (P = 0.01). Moderate negative correlations were detected between the patient age and both ridge height and cortical crest height (P = 0.00). The widest ranges of variation belonged to ridge angle and ridge height, respectively, but the differentiation between the right and left sides was clinically insignificant. Knowledge of the patient's anatomical variations will allow the clinician to formulate an individualized treatment plan., Competing Interests: The authors report no conflicts of interest pertaining to any of the products or companies discussed in this article.

Aim: The aim of the current study was to evaluate the correlation of skeletal age based on cervical vertebrae maturation (CVM) stage and mid-palatal suture (MPS) maturation in an Iranian population., Material and Methods: This was a cross-sectional analytic study. A total number of 93 samples were included. Samples were taken from patients who were in CS3 to CS6 stages of CVM who had cone-beam computed tomography and lateral cephalometry based on inclusion criteria. The maturation of MPS was assessed based on the cone-beam computed tomography images. In the classification of maturation of MPS, there are five stages (A-E) and the suture fusion occurs in stage D. In stage E, the suture is fused completely. The CVM stage (CS1-6) was also assessed based on the lateral cephalograms. Data were analyzed using Spearman correlation with a significance level of 0.05., Results: A total of 51 female individuals with a mean age of 14.98 ± 4.806 and 42 male individuals with a mean age of 15.79 ± 5.135 participated in this study. The correlation coefficient between the CVM stage and MPS maturation was 0.691 in female and 0.754 in male individuals (P < 0.001). Stage D was correlated with CS4., Conclusion: The results demonstrated that CVM stages had a significant but moderate positive correlation with the maturation of MPS. Until CS3, the MPS has not been fused and in CS6 the MPS is fused definitely., (Copyright © 2020 World Federation of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Purpose: The aim of this study was to review the common conditions associated with mandibular canal widening., Materials and Methods: General search engines and specialized databases including Google Scholar, PubMed, PubMed Central, Science Direct, and Scopus were used to find relevant studies by using the following keywords: "mandibular canal," "alveolar canal," "inferior alveolar nerve canal," "inferior dental canal," "inferior mandibular canal," "widening," "enlargement," "distension," "expansion," and "dilation.", Results: In total, 130 articles were found, of which 80 were broadly relevant to the topic. We ultimately included 38 articles that were closely related to the topic of interest. When the data were compiled, the following 7 lesions were found to have a relationship with mandibular canal widening: non-Hodgkin lymphoma, osteosarcoma, schwannoma, neurofibroma, vascular malformation/hemangioma, multiple endocrine neoplasia syndromes, and perineural spreading or invasion., Conclusion: When clinicians encounter a lesion associated with mandibular canal widening, they should immediately consider these entities in the differential diagnosis. Doing so will help dentists make more accurate diagnoses and develop better treatment plans based on patients' radiographs.