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2. Immature reticulocyte fraction: A novel biomarker of hemodynamic severity in pulmonary arterial hypertension

Author

Brownstein, Adam J, Wilkinson, Jared D, Liang, Lloyd L, Channick, Richard N, Saggar, Rajan, and Kim, Airie

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Lung, Hematology, Women's Health, Rare Diseases, 2.1 Biological and endogenous factors, Cardiovascular, erythropoiesis, iron deficiency, pulmonary hypertension, red blood cell indices, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

Various erythropoietic abnormalities are highly prevalent among patients with pulmonary arterial hypertension (PAH) and associated with worse disease severity. Given the poorly understood yet important roles of dysregulated erythropoiesis and iron metabolism in PAH, we sought to further characterize the hematologic and iron profiles in PAH and their relationship to PAH severity. We recruited 67 patients with PAH and 13 healthy controls. Hemodynamics attained within 1 year of blood sample collection were available for 36 patients. Multiple hematologic, iron, and inflammatory parameters were evaluated for their association with hemodynamics. The subset with hemodynamic data consisted of 29 females (81%). The most common etiologies were idiopathic PAH (47%) and connective tissue disease-related PAH (33%). 19 (53%) had functional class 3 or 4 symptomatology, and 12 (33%) were on triple pulmonary vasodilator therapy. Immature reticulocyte fraction (IRF) had significant positive correlations with mean pulmonary artery (PA) pressure (mPAP) (0.59, p

Published
2024

4. Age-stratified Assessment of Brain Volumetric Segmentation on the Indian Population Using Quantitative Magnetic Resonance Imaging

Author

Syed Nasser, Nisha, Venugopal, Vasantha K., Veenstra, Cynthia, Johansson, Peter, Rajan, Sriram, Mahajan, Kabir, Naik, Swati, Masand, Ravi, Yadav, Pratiksha, Khanduri, Sachin, Singhal, Suman, Bhargava, Rajat, Kabra, Utkarsh, Gupta, Sanjay, Saggar, Kavita, Varaprasad, Balaji, Aggrawal, Kushagra, Rao, Adinarayana, K.S., Manoj, Dakhole, Atul, Kelkar, Abhimanyu, Benjamin, Geena, Sodani, Varsha, Goyal, Pradeep, and Mahajan, Harsh

Published
2024
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5. Management and outcomes in pulmonary arterial hypertension patients with sepsis

Author

Flynn, Spencer, Chen, Haidee, Kerbel, Russell, Gupta, Summer, Jasuja, Sonia, Saggar, Rajan, Channick, Richard, and Sherman, Alexander

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Minority Health, Infectious Diseases, Hematology, Sepsis, Rare Diseases, Cardiovascular, Infection, Good Health and Well Being, Humans, Male, Female, Retrospective Studies, Middle Aged, Aged, Fluid Therapy, Pulmonary Arterial Hypertension, Adult, Logistic Models, Propensity Score, Case-Control Studies, Pulmonary arterial hypertension, Fluid resuscitation, Cardiorespiratory Medicine and Haematology, Respiratory System, Cardiovascular medicine and haematology
Abstract

BackgroundSepsis is a common cause of death in patients with pulmonary arterial hypertension (PAH). Treatment requires careful fluid management and hemodynamic support. This study compares patients with or without PAH presenting with sepsis with a focus on initial fluid resuscitation.MethodsThis retrospective analysis compared adults with and without PAH admitted for sepsis at two academic hospitals between 2013 and 2022. Prior PAH diagnosis was verified by review of right heart catheterization data and sepsis present on admission was verified by chart review. Demographics, vital signs, laboratory values, imaging results, treatment approaches, and all-cause mortality data were obtained. Controls were propensity score weighted by age, sex, and Charlson Comorbidity index. Logistic regression models controlling for age and Charlson comorbidity indices were used to examine factors associated with survival.ResultsThirty patients admitted for sepsis with pre-existing PAH were compared to 96 matched controls. Controls received significantly more fluids at 24 h compared to PAH patients (median 0 mL v. 1216 mL, p

Published
2024

8. Management and outcomes in pulmonary arterial hypertension patients with sepsis

Author

Spencer Flynn, Haidee Chen, Russell Kerbel, Summer Gupta, Sonia Jasuja, Rajan Saggar, Richard Channick, and Alexander Sherman

Subjects
Pulmonary arterial hypertension, Sepsis, Fluid resuscitation, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Sepsis is a common cause of death in patients with pulmonary arterial hypertension (PAH). Treatment requires careful fluid management and hemodynamic support. This study compares patients with or without PAH presenting with sepsis with a focus on initial fluid resuscitation. Methods This retrospective analysis compared adults with and without PAH admitted for sepsis at two academic hospitals between 2013 and 2022. Prior PAH diagnosis was verified by review of right heart catheterization data and sepsis present on admission was verified by chart review. Demographics, vital signs, laboratory values, imaging results, treatment approaches, and all-cause mortality data were obtained. Controls were propensity score weighted by age, sex, and Charlson Comorbidity index. Logistic regression models controlling for age and Charlson comorbidity indices were used to examine factors associated with survival. Results Thirty patients admitted for sepsis with pre-existing PAH were compared to 96 matched controls. Controls received significantly more fluids at 24 h compared to PAH patients (median 0 mL v. 1216 mL, p

Published
2024
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12. Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial

Author

Niharika Gajawelli, Andrew D. Geoly, Jean-Marie Batail, Xiaoqian Xiao, Adi Maron-Katz, Eleanor Cole, Azeezat Azeez, Ian H. Kratter, Manish Saggar, and Nolan R. Williams

Subjects
Therapeutics. Psychotherapy, RC475-489
Abstract

Abstract SNT is a high-dose accelerated intermittent theta-burst stimulation (iTBS) protocol coupled with functional-connectivity-guided targeting that is an efficacious and rapid-acting therapy for treatment-resistant depression (TRD). We used resting-state functional MRI (fMRI) data from a double-blinded sham-controlled randomized controlled trial1 to reveal the neural correlates of SNT-based symptom improvement. Neurobehavioral data were acquired at baseline, post-treatment, and 1-month follow-up. Our primary analytic objective was to investigate changes in seed-based functional connectivity (FC) following SNT and hypothesized that FC changes between the treatment target and the sgACC, DMN, and CEN would ensue following active SNT but not sham. We also investigated the durability of post-treatment observed FC changes at a 1-month follow-up. Study participants included transcranial magnetic stimulation (TMS)-naive adults with a primary diagnosis of moderate-to-severe TRD. Fifty-four participants were screened, 32 were randomized, and 29 received active or sham SNT. An additional 5 participants were excluded due to imaging artifacts, resulting in 12 participants per group (Sham: 5F; SNT: 5F). Although we did not observe any significant group × time effects on the FC between the individualized stimulation target (L-DLPFC) and the CEN or sgACC, we report an increased magnitude of negative FC between the target site and the DMN post-treatment in the active as compared to sham SNT group. This change in FC was sustained at the 1-month follow-up. Further, the degree of change in FC was correlated with improvements in depressive symptoms. Our results provide initial evidence for the putative changes in the functional organization of the brain post-SNT.

Published
2024
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14. Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.

Author

Fryer, Susanna, Segal, Zindel, Brown, Jesse, Saggar, Manish, Mathalon, Daniel, Eisendrath, Stuart, Lee, Alex, and Pasquini, Lorenzo

Subjects
Connectivity gradients, Default mode network, Functional connectivity, Graph theory, Treatment-resistant major depressive disorder, Humans, Depressive Disorder, Major, Magnetic Resonance Imaging, Brain, Cerebral Cortex, Antidepressive Agents
Abstract

BACKGROUND: Treatment-resistant depression (TRD) refers to patients with major depressive disorder who do not remit after 2 or more antidepressant trials. TRD is common and highly debilitating, but its neurobiological basis remains poorly understood. Recent neuroimaging studies have revealed cortical connectivity gradients that dissociate primary sensorimotor areas from higher-order associative cortices. This fundamental topography determines cortical information flow and is affected by psychiatric disorders. We examined how TRD impacts gradient-based hierarchical cortical organization. METHODS: In this secondary study, we analyzed resting-state functional magnetic resonance imaging data from a mindfulness-based intervention enrolling 56 patients with TRD and 28 healthy control subjects. Using gradient extraction tools, baseline measures of cortical gradient dispersion within and between functional brain networks were derived, compared across groups, and associated with graph theoretical measures of network topology. In patients, correlation analyses were used to associate measures of cortical gradient dispersion with clinical measures of anxiety, depression, and mindfulness at baseline and following the intervention. RESULTS: Cortical gradient dispersion was reduced within major intrinsic brain networks in patients with TRD. Reduced cortical gradient dispersion correlated with increased network degree assessed through graph theory-based measures of network topology. Lower dispersion among default mode, control, and limbic network nodes related to baseline levels of trait anxiety, depression, and mindfulness. Patients baseline limbic network dispersion predicted trait anxiety scores 24 weeks after the intervention. CONCLUSIONS: Our findings provide preliminary support for widespread alterations in cortical gradient architecture in TRD, implicating a significant role for transmodal and limbic networks in mediating depression, anxiety, and lower mindfulness in patients with TRD.

Published
2023

35. Reforming Higher Education for Equity: The Role of Evidence and Leadership

Author

Shamit Saggar

Subjects
Theory and practice of education, LB5-3640
Abstract

Over the past two decades, Australia’s higher education sector has experienced rapid growth, driven by the establishment of the demand-driven funding system for domestic enrolments in 2010 and increased international enrolments. This expansion has led to an increase in both domestic attainment and internationalisation, positioning higher education as a critical sector within the national economy. However, despite this growth, persistent challenges around student equity, leadership, and institutional accountability remain. This article explores how the Bradley Review’s reforms and subsequent policies have shaped student access and equity in Australian universities, with a focus on the limitations of existing programs. It also addresses the need for a renewed focus on evidence-based practices, highlighting how leadership can drive meaningful change in the sector. By examining these key issues, the article contributes to ongoing debates about the role of universities in social mobility and enhancing equitable outcomes. --- Reforming higher education for equity: The role of evidence and leadership by Shamit Saggar is licensed under CC BY 4.0

Published
2024
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36. Narrow Band Organic Photodiode with Photoresponse at 808 nm for Photoplethysmography

Author

Siddhartha Saggar, Atul Shukla, Shih‐Chun Lo, and Ebinazar B. Namdas

Subjects
near‐infrared sensing, organic semiconductors, photodetectors, photoplethysmography, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

The fabrication and characterization of an all polymers‐based bulk heterojunction type organic photodiode having a narrowband response in the near‐infrared spectral region with full width at half‐maxima of 63 nm is reported. The active layer of the photodiode constitutes a 1:1 (by weight) blend of poly[4,8‐bis(5‐(2‐ethylhexyl)thiophen‐2‐yl)benzo[1,2‐b;4,5‐b']dithiophene‐2,6‐diyl‐alt‐(4‐(2‐ethylhexyl)‐3‐fluorothieno[3,4‐b]thiophene‐)‐2‐carboxylate‐2‐6‐diyl)] (PCE10) and poly{[N,N′‐bis(2‐octyldodecyl)‐naphthalene‐1,4,5,8‐bis(dicarboximide)‐2,6‐diy1]‐alt‐5,5′‐(2,2′‐dithiophene)} (N2200) deposited using solution processing. The device exhibits a linear dynamic range of 35 dB, response speed of 893 kHz, and specific‐detectivity of 109 Jones at 808 nm excitation wavelength. The narrowband response is achieved using the charge collection narrowing mechanism in a 2.7 μm thick junction device.

Published
2024
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37. Dynamic autonomic nervous system states arise during emotions and manifest in basal physiology.

Author

Noohi, Fatemeh, Veziris, Christina, Kosik, Eena, Holley, Sarah, Brown, Jesse, Roy, Ashlin, Chow, Tiffany, Saggar, Manish, Kramer, Joel, Miller, Bruce, Rosen, Howard, Seeley, William, Sturm, Virginia, Allen, Isabel, Lee, Alex, and Pasquini, Lorenzo

Subjects
autonomic nervous system, baseline, dynamic systems, emotions, physiology, resting state, Humans, Aged, Autonomic Nervous System, Emotions, Love, Disgust, Sadness
Abstract

The outflow of the autonomic nervous system (ANS) is continuous and dynamic, but its functional organization is not well understood. Whether ANS patterns accompany emotions, or arise in basal physiology, remain unsettled questions in the field. Here, we searched for brief ANS patterns amidst continuous, multichannel physiological recordings in 45 healthy older adults. Participants completed an emotional reactivity task in which they viewed video clips that elicited a target emotion (awe, sadness, amusement, disgust, or nurturant love); each video clip was preceded by a pre-trial baseline period and followed by a post-trial recovery period. Participants also sat quietly for a separate 2-min resting period to assess basal physiology. Using principal components analysis and unsupervised clustering algorithms to reduce the second-by-second physiological data during the emotional reactivity task, we uncovered five ANS states. Each ANS state was characterized by a unique constellation of patterned physiological changes that differentiated among the trials of the emotional reactivity task. These ANS states emerged and dissipated over time, with each instance lasting several seconds on average. ANS states with similar structures were also detectable in the resting period but were intermittent and of smaller magnitude. Our results offer new insights into the functional organization of the ANS. By assembling short-lived, patterned changes, the ANS is equipped to generate a wide range of physiological states that accompany emotions and that contribute to the architecture of basal physiology.

Published
2023

38. Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

Author

Hong, Jason, Medzikovic, Lejla, Sun, Wasila, Wong, Brenda, Ruffenach, Grégoire, Rhodes, Christopher J., Brownstein, Adam, Liang, Lloyd L., Aryan, Laila, Li, Min, Vadgama, Arjun, Kurt, Zeyneb, Schwantes-An, Tae-Hwi, Mickler, Elizabeth A., Gräf, Stefan, Eyries, Mélanie, Lutz, Katie A., Pauciulo, Michael W., Trembath, Richard C., Perros, Frédéric, Montani, David, Morrell, Nicholas W., Soubrier, Florent, Wilkins, Martin R., Nichols, William C., Aldred, Micheala A., Desai, Ankit A., Trégouët, David-Alexandre, Umar, Soban, Saggar, Rajan, Channick, Richard, Tuder, Rubin M., Geraci, Mark W., Stearman, Robert S., Yang, Xia, and Eghbali, Mansoureh

Published
2024
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39. Outcomes and Prognostic Factors of Pulmonary Hypertension Patients Undergoing Emergent Endotracheal Intubation

Author

Hong, Andrew W, Toppen, William, Lee, Joyce, Wilhalme, Holly, Saggar, Rajan, and Barjaktarevic, Igor Z

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Clinical Research, Comparative Effectiveness Research, Rehabilitation, Good Health and Well Being, Adult, Humans, Retrospective Studies, Prognosis, Intubation, Intratracheal, Cohort Studies, Intensive Care Units, endotracheal intubation, pulmonary hypertension, right heart failure, critical care, mechanical ventilation, vasopressor agents, acute kidney injury, Nursing, Emergency & Critical Care Medicine, Clinical sciences
Abstract

Background: Emergent endotracheal intubations (ETI) in pulmonary hypertension (PH) patients are associated with increased mortality. Post-intubation interventions that could increase survivability in this population have not been explored. We evaluate early clinical characteristics and complications following emergent endotracheal intubation and seek predictors of adverse outcomes during this post-intubation period. Methods: Retrospective cohort analysis of adult patients with groups 1 and 3 PH who underwent emergent intubation between 2005-2021 in medical and liver transplant ICUs at a tertiary medical center. PH patients were compared to non-PH patients, matched by Charlson Comorbidity Index. Primary outcomes were 24-h post-intubation and inpatient mortalities. Various 24-h post-intubation secondary outcomes were compared between PH and control cohorts. Results: We identified 48 PH and 110 non-PH patients. Pulmonary hypertension was not associated with increased 24-h mortality (OR 1.32, 95%CI 0.35-4.94, P = .18), but was associated with inpatient mortality (OR 4.03, 95%CI 1.29-12.5, P = .016) after intubation. Within 24 h post-intubation, PH patients experienced more frequent acute kidney injury (43.5% vs. 19.8%, P = .006) and required higher norepinephrine dosing equivalents (6.90 [0.13-10.6] mcg/kg/min, vs. 0.20 [0.10-2.03] mcg/kg/min, P = .037). Additionally, the median P/F ratio (PaO2/FiO2) was lower in PH patients (96.3 [58.9-201] vs. 233 [146-346] in non-PH, P = .001). Finally, a post-intubation increase in PaCO2 was associated with mortality in the PH cohort (post-intubation change in PaCO2 +5.14 ± 16.1 in non-survivors vs. -18.7 ± 28.0 in survivors, P = .007). Conclusions: Pulmonary hypertension was associated with worse outcomes after emergent endotracheal intubation than similar patients without PH. More importantly, our data suggest that the first 24 hours following intubation in the PH group represent a particularly vulnerable period that may determine long-term outcomes. Early post-intubation interventions may be key to improving survival in this population.

Published
2023

40. Expert consensus on the management of systemic sclerosis-associated interstitial lung disease.

Author

Rahaghi, Franck, Hsu, Vivien, Kaner, Robert, Mayes, Maureen, Rosas, Ivan, Saggar, Rajan, Steen, Virginia, Strek, Mary, Bernstein, Elana, Bhatt, Nitin, Castelino, Flavia, Chung, Lorinda, Domsic, Robyn, Flaherty, Kevin, Gupta, Nishant, Kahaleh, Bashar, Martinez, Fernando, Morrow, Lee, Moua, Teng, Patel, Nina, Shlobin, Oksana, Southern, Brian, Volkmann, Elizabeth, and Khanna, Dinesh

Subjects
Algorithms, Autoimmune diseases, Connective tissue diseases, Drug therapy, Pulmonary fibrosis, Humans, Consensus, Immunosuppressive Agents, Lung Diseases, Interstitial, Lung, Mycophenolic Acid, Scleroderma, Systemic
Abstract

BACKGROUND: Systemic sclerosis (SSc) is a rare, complex, connective tissue disorder. Interstitial lung disease (ILD) is common in SSc, occurring in 35-52% of patients and accounting for 20-40% of mortality. Evolution of therapeutic options has resulted in a lack of consensus on how to manage this condition. This Delphi study was initiated to develop consensus recommendations based on expert physician insights regarding screening, progression, treatment criteria, monitoring of response, and the role of recent therapeutic advances with antifibrotics and immunosuppressants in patients with SSc-ILD. METHODS: A modified Delphi process was completed by pulmonologists (n = 13) and rheumatologists (n = 12) with expertise in the management of patients with SSc-ILD. Panelists rated their agreement with each statement on a Likert scale from - 5 (complete disagreement) to + 5 (complete agreement). Consensus was predefined as a mean Likert scale score of ≤  - 2.5 or ≥  + 2.5 with a standard deviation not crossing zero. RESULTS: Panelists recommended that all patients with SSc be screened for ILD by chest auscultation, spirometry with diffusing capacity of the lungs for carbon monoxide, high-resolution computed tomography (HRCT), and/or autoantibody testing. Treatment decisions were influenced by baseline and changes in pulmonary function tests, extent of ILD on HRCT, duration and degree of dyspnea, presence of pulmonary hypertension, and potential contribution of reflux. Treatment success was defined as stabilization or improvement of signs or symptoms of ILD and functional status. Mycophenolate mofetil was identified as the initial treatment of choice. Experts considered nintedanib a therapeutic option in patients with progressive fibrotic ILD despite immunosuppressive therapy or patients contraindicated/unable to tolerate immunotherapy. Concomitant use of nintedanib with MMF/cyclophosphamide can be considered in patients with advanced disease at initial presentation, aggressive ILD, or significant disease progression. Although limited consensus was achieved on the use of tocilizumab, the experts considered it a therapeutic option for patients with early SSc and ILD with elevated acute-phase reactants. CONCLUSIONS: This modified Delphi study generated consensus recommendations for management of patients with SSc-ILD in a real-world setting. Findings from this study provide a management algorithm that will be helpful for treating patients with SSc-ILD and addresses a significant unmet need.

Published
2023

41. Sex Differences in Outcomes of Percutaneous Pulmonary Artery Thrombectomy in Patients With Pulmonary Embolism.

Author

Agarwal, Manyoo A, Dhaliwal, Jasmeet S, Yang, Eric H, Aksoy, Olcay, Press, Marcella, Watson, Karol, Ziaeian, Boback, Fonarow, Gregg C, Moriarty, John M, Saggar, Rajan, and Channick, Richard

Subjects
Pulmonary Artery, Humans, Pulmonary Embolism, Treatment Outcome, Thrombectomy, Retrospective Studies, Cross-Sectional Studies, Sex Characteristics, United States, Female, Male, disparities, hospitalizations, outcomes, pulmonary embolism, sex, sex differences, thrombectomy, Lung, Patient Safety, Cardiovascular, Clinical Trials and Supportive Activities, Clinical Research, Aging, Good Health and Well Being, &nbsp, differences, Clinical Sciences, Respiratory System
Abstract

BackgroundThe sex differences in use, safety outcomes, and health-care resource use of patients with pulmonary embolism (PE) undergoing percutaneous pulmonary artery thrombectomy are not well characterized.Research questionWhat are the sex differences in outcomes for patients diagnosed with PE who undergo percutaneous pulmonary artery thrombectomy?Study design and methodsThis retrospective cross-sectional study used national inpatient claims data to identify patients in the United States with a discharge diagnosis of PE who underwent percutaneous thrombectomy between January 2016 and December 2018. We evaluated the demographics, comorbidities, safety outcomes (in-hospital mortality), and health-care resource use (discharge to home, length of stay, and hospital charges) of patients with PE undergoing percutaneous thrombectomy.ResultsAmong 1,128,904 patients with a diagnosis of PE between 2016 and 2018, 5,160 patients (0.5%) underwent percutaneous pulmonary artery thrombectomy. When compared with male patients, female patients showed higher procedural bleeding (16.9% vs 11.2%; P < .05), required more blood transfusions (11.9% vs 5.7%; P < .05), and experienced more vascular complications (5.0% vs 1.5%; P < .05). Women experienced higher in-hospital mortality (16.9% vs 9.3%; adjusted OR, 1.9; 95% CI, 1.2-3.0; P = .003) when compared with men. Although length of stay and hospital charges were similar to those of men, women were less likely to be discharged home after surviving hospitalization (47.9% vs 60.3%; adjusted OR, 0.7; 95% CI, 0.50-0.99; P = .04).InterpretationIn this large nationwide cohort, women with PE who underwent percutaneous thrombectomy showed higher morbidity and in-hospital mortality compared with men.

Published
2023

42. Immature reticulocyte fraction: A novel biomarker of hemodynamic severity in pulmonary arterial hypertension

Author

Adam J. Brownstein, Jared D. Wilkinson, Lloyd L. Liang, Richard N. Channick, Rajan Saggar, and Airie Kim

Subjects
erythropoiesis, iron deficiency, pulmonary hypertension, red blood cell indices, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779
Abstract

Abstract Various erythropoietic abnormalities are highly prevalent among patients with pulmonary arterial hypertension (PAH) and associated with worse disease severity. Given the poorly understood yet important roles of dysregulated erythropoiesis and iron metabolism in PAH, we sought to further characterize the hematologic and iron profiles in PAH and their relationship to PAH severity. We recruited 67 patients with PAH and 13 healthy controls. Hemodynamics attained within 1 year of blood sample collection were available for 36 patients. Multiple hematologic, iron, and inflammatory parameters were evaluated for their association with hemodynamics. The subset with hemodynamic data consisted of 29 females (81%). The most common etiologies were idiopathic PAH (47%) and connective tissue disease‐related PAH (33%). 19 (53%) had functional class 3 or 4 symptomatology, and 12 (33%) were on triple pulmonary vasodilator therapy. Immature reticulocyte fraction (IRF) had significant positive correlations with mean pulmonary artery (PA) pressure (mPAP) (0.59, p

Published
2024
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43. Correction to: Age-stratified Assessment of Brain Volumetric Segmentation on the Indian Population Using Quantitative Magnetic Resonance Imaging

Author

Syed Nasser, Nisha, Venugopal, Vasantha K., Veenstra, Cynthia, Johansson, Peter, Rajan, Sriram, Mahajan, Kabir, Naik, Swati, Masand, Ravi, Yadav, Pratiksha, Khanduri, Sachin, Singhal, Suman, Bhargava, Rajat, Kabra, Utkarsh, Gupta, Sanjay, Saggar, Kavita, Varaprasad, Balaji, Aggrawal, Kushagra, Rao, Adinarayana, K.S., Manoj, Dakhole, Atul, Kelkar, Abhimanyu, Benjamin, Geena, Sodani, Varsha, Goyal, Pradeep, and Mahajan, Harsh

Published
2024
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44. Kinematics modeling of the gear-based crank mechanism engine regardless of the compressions ratio variations

Author

Amir Sakhraoui, Maroua Saggar, Fayza Ayari, and Rachid Nasri

Subjects
Medicine, Science
Abstract

Abstract In this work, geometric and kinematic modeling of the gear-based crank mechanism engine (GBCM) was performed. To this aim, a mechanical approach based on projective computational methods and mechanism theory laws is applied, to which a parametric study has allowed a conclusion on the geometrical and kinematic behaviors of the moving links. The study concluded that the kinematic quantities at connecting rod head are one-half of those at the piston top head. The extrinsic behavior like the stroke of the connecting rod head is twice the crank radius and the piston kinematic are identical to the conventional engine with the same crankshaft ratio regardless of the compression ratio and any gear wheel radius. Hence, all the extrinsic kinematic properties of a classic crankshaft mechanism of the fixed compression ratio engine remain valid for a gear-based crank mechanism engine and can be used for dynamic calculation purposes.

Published
2024
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48. Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial

Author

Abe, Mitsunori, Abhaichand, Rajpal K, Abhayaratna, Walter P, Abhyankar, Atul, Abidin, Imran B Zainal, Abou Assi, Hiba, Accini Mendoza, Jose L, Adas, Mine, Agaiby, John M, Agarwal, Devendra K, Agha, Maher, Ahmed, Azazuddin, Ahtiainen, Petteri, Aigner, Elmar, Ajay, Naik, Ali, Norsiah, Al-Karadsheh, Amer, Allison, Roy, Allison, Dale C, Alpenidze, Diana, Altuntas, Yuksel, Al-Zoebi, Ayham, Ambuj, Roy, Amerena, John, Anderson, Robert J, Ando, Toshiaki, Andrews, Robert, Antonova, Elizaveta, Appel, Karl-Friedrich, Arantes, Flávia B, Araz, Mustafa, Arbel, Yaron, Arenas León, José L, Argyrakopoulou, Georgia, Ariani, Mehrdad, Arias Mendoza, Maria A, Arif, Ahmed A, Arneja, Jaspal, Aroda, Vanita R, Aronne, Louis J, Arstall, Margaret, Asamoah, Njaimeh, Asanin, Milika, Audish, Hanid, Avram, Rodica, Badat, Aysha, Badiu, Corin V, Bakdash, Wa'el, Bakiner, Okan S, Bandezi, Vuyokazi N, Bang, Liew H, Bansal, Sandeep, Baranyai, Marietta, Barbarash, Olga, Barber, Mark, Barnum, Otis, Barone Rochette, Gilles, Bashkin, Amir, Baum, Seth, Bays, Harold E, Bazzoni Ruiz, Alberto E, Beckowski, Maciej, Beerachee, Yaswin, Bellary, Srikanth, Belousova, Lidia, Berk, Martin, Bernstein, Marc, Berra, Cesare, Beshay, Isaac, Bhagwat, Ajit, Bhan, Arti, Biggs, William C, Billings, Liana, Bitar, Fahed, Block, Bradley, Bo, Simona, Bogdanski, Pawel, Bolshakova, Olga O, Boshchenko, Alla A, Bosworth, Hayden, Botero Lopez, Rodrigo, Bôttcher, Morten, Bourgeois, Ronald, Brautigam, Donald, Breton, Cristian F, Broadley, Andrew, Brockmyre, Andrew P, Brodie, Steven K, Bucci, Marco, Budincevic, Hrvoje, Budoff, Matthew J, Buffman, Barry, Buljubasic, Nediljka, Buranapin, Supawan, Burgess, Lesley, Burguera, Bartolomé, Buriakovska, Olena, Buscemi, Silvio, Busch, Robert, Buse, John B, Buynak, Robert, Byrne, Maria, Caceaune, Elena, Cadena Bonfanti, Alberto J, Calinescu, Cornell V, Call, Robert S, Canecki Varzic, Silvija, Cannon, Kevin, Capehorn, Matt, Cariou, Bertrand, Carr, Jeffrey, Carrillo-Jimenez, Rodolfo, Casas, Marcelo, Castro, Almudena, Celik, Ahmet, Cercato, Cintia, Cermak, Ondrej, Cha, James Y, Chacon, Carolina, Chaicha-Brom, Tira, Chandra, Sandeep, Chettibi, Mohamed, Chevts, Julia, Christopher, Johann, Chrustowski, Witold, Cif, Adriana, Clark, Rebecca, Clark, Wayne, Clifford, Piers, Coetzee, Kathleen, Cogni, Giulia, Colao, Anna Maria, Colquhoun, David M, Concha, Mauricio, Condit, Jonathan, Constance, Christian, Constantin, Ciprian, Constantinescu, Silviana, Corbett, Clive, Cornett, George M, Correia, Marcelo, Cortinovis, Fiorenzo, Cosma, Dana, Creely, Steven, Cross, David, Curtis, Brian, Czochra, Wojciech, Daboul, Nizar Y, Dagdelen, Selcuk, D'agostino, Ronald, Dang, Cuong, Datta, Sudip, Davuluri, Ashwini K, Dawood, Saleem Y, De Jong, Douwe M, De La Cuesta, Carmen, De Los Rios Ibarra, Manuel O, De Pablo, Carmen, De Pauw, Michel, Dela Llana, Alexander, Delibasic, Maja, Delic-Brkljacic, Diana, Demicheli, Thibaud, Denger, Ralf J, Desai, Devang, Desai, Piyush, Desouza, Cyrus V, Dicker, Dror, Djenic, 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2024
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50. Temporary axial-flow mechanical circulatory support and intravenous treprostinil in a patient with D-transposition of the great arteries and atrial switch: A case report

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Bravo-Jaimes, Katia, Venkatesh, Prashanth, Lluri, Gentian, Reardon, Leigh, Cruz, Daniel, Vucicevic, Darko, Yang, Eric H, Nsair, Ali, Saggar, Raj, Channick, Richard, Kwon, Murray, Van Arsdell, Glen, and Aboulhosn, Jamil

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Bioengineering, 1.1 Normal biological development and functioning, atrial switch, pulmonary hypertension, transplantation, right ventricle, mechanical circulatory support, Cardiovascular medicine and haematology
Published
2022

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