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6 results on '"Saghar Saber Amoli"'

1. Characteristics, outcome, duration of hospitalization, and cycle threshold of patients with COVID-19 referred to four hospitals in Babol City: a multicenter retrospective observational study on the fourth, fifth, and sixth waves

Author

Farzin Sadeghi, Mehrdad Halaji, Hoda Shirafkan, Abazar Pournajaf, Hossein Ghorbani, Sara Babazadeh, Nafiseh Ezami, Kobra Fallhpour, Fatemeh Fakhraie, Shahrbano Gorjinejad, Saghar Saber Amoli, Fatemeh Hejazi Amiri, Mahnaz Baghershiroodi, Zahra Ahmadnia, Maryam Salehi, Mehdi Tourani, Jalal Jafarzadeh, Farzane Shanehbandpour Tabari, Seyed Raheleh Ahmadian, Rouzbeh Mohammadi Abandansari, Farzaneh Jafarian, Samaneh Rouhi, Arezoo Zabihollahi, Sarina Mostafanezhad, Fatemeh Saeedi, Arefeh Ebrahimian, Zeinab Deldar, Mahmoud Sadeghi Haddad Zavareh, Masoumeh Bayani, Mana Bazi Broun, Moein Shirzad, Siamak Sabbaghi, Mohsen Mohammadi, Rabeae Rahmani, and Yousef Yahyapour

Subjects
COVID-19, SARS-CoV-2, Alpha variant, Delta variant, Omicron variant, Hospitalization, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The aim of the present study was to compare the epidemiological patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infections, hospitalizations, deaths, and duration of hospitalization during the fourth, fifth and sixth epidemic waves of coronavirus disease 2019 (COVID-19) in Iran. Methods A multicenter retrospective observational study was conducted on hospitalized patients in four hospitals in the Babol district of northern Iran. The study periods were during the fourth, fifth, and sixth waves of the epidemic in Iran, (March 2021 to March 2022). A total of 13,312 patients with suspected COVID-19 were included. Patient demographics, medical history, length of hospital stay, and clinical outcomes were obtained from the hospital information system. Data on the cycle threshold (Ct) and SARS-CoV2 variant were collected for SARS-CoV2-positive cases. Results The highest number of hospitalized patients was reported during the fifth (Delta) wave (5231; 39.3%), while the lowest number of hospitalized patients was reported during the sixth (Omicron) wave (2143; 16.1%). In total, 6459 (48.5%) out of 13,312 hospitalized patients with suspected COVID-19 had a positive rRT-PCR result. The fifth (Delta) wave had the highest number of SARS-CoV2 rRT-PCR-positive hospitalized patients (3573, 55.3%), while the sixth (Omicron) wave had the lowest number (835, 12.9%). Moreover, 238 (3.7%) patients with laboratory-confirmed COVID-19 died. The hospital mortality rate was 6.8% in the fourth (Alpha) wave, which reduced to 2.7 and 3.5% in the fifth (Delta) and sixth (Omicron) waves, respectively (p

Published
2024
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2. One-year prevalence and the association between SARS-CoV-2 cycle threshold, comorbidity and outcomes in population of Babol, North of Iran (2020-2021).

Author

Mehrdad Halaji, Abazar Pournajaf, Farzin Sadeghi, Ali Hasanzadeh, Mohammad Chehrazi, Hemmat Gholinia, Fatemeh Hejazi Amiri, Saghar Saber Amoli, Mostafa Javanian, Masoumeh Bayani, Mahmoud Sadeghi Haddad Zavareh, Mehran Shokri, Arefeh Babazadeh, Mana Bazi Broun, Mohsen Mohammadi, Hamed Mehdinezhad, Mahmoud Monadi, Parviz Amri Maleh, Hamid Reza Nouri, Abdolreza Daraei, Mahdie Yousefnia Pasha, Mehdi Tourani, Seyed Raheleh Ahmadian, Nadia Esmailzadeh, Seyyedeh Maedeh Mirtabar, Shakiba Asadi, Behnaz Yousefghahary, Mansour Babaei, Majid Nabipour, and Yousef Yahyapour

Subjects
covid-19, hospitalized, health care worker, outpatient, cycle threshold (ct), Internal medicine, RC31-1245
Abstract

Background: The present study aimed to investigate the one-year prevalence of SARS-CoV-2, common comorbidities and demographic information among negative- and positive rRT-PCR in health care workers (HCW), hospitalized and outpatients. Also, the association between SARS-CoV-2 cycle threshold (Ct) and the outcomes of patients were analyzed in Babol, northern Iran. Methods: This large retrospective cross-sectional study was performed between March 2020 and March 2021. The records of 19232 hospitalized, outpatients and HCW suspected to COVID-19 were collected from teaching hospitals in the North of Iran. Results: Out of the 19232 suspected to COVID-19 patients, 7251 (37.7%) had a positive rRT-PCR result; 652 (9%), 4599 (63.4%) and 2000 (27.6%) of those were categorized as HCW, hospitalized and outpatients, respectively. Moreover, between the hospitalized and the outpatient group, 10.2 and 0.8% cases died, whereas no death cases were reported in the HCW. Furthermore, it seems that death rate was significantly different between the three groups of Ct value, the highest mortality in those with Ct between 21 and 30 (group B=7.6%) and the lowest in the group with the highest Ct (between 31 and 40 = 5.5%) (p

Published
2022

3. Prevalence and Viral Load Determination of BK Polyomavirus among Iranian Patients with Brain Tumors

Author

Saghar Saber Amoli, Arqavan Zebardast, Hossein Keyvani, Yousef Yahyapour, Seyed Mohammad Ghodsi, Mahmood Maniati, and Farzin Sadeghi

Subjects
bk human polyomavirus, brain tumors, tumor antigen, Internal medicine, RC31-1245
Abstract

Background: Due to persistent infections of human central nervous system (CNS), polyomaviruses have been identified as one of the risk factors for brain tumor development. Human BK virus is of significant interest due to its experimental neuro-oncogenic potential and the possible association with CNS neoplasms. However, the results of different studies are discrepant. In the present study, we aimed to investigate the prevalence of BK virus genome and quantify BK viral load in Iranian patients with primary and metastatic brain malignancies. Methods: To assess the prevalence of BK virus sequences, a total of 58 fresh brain tumors were examined by quantitative real-time PCR. The BK viral load was determined as viral copy number per cell. Results: Of the 58 brain tumor samples BK tumor antigen (TAg) sequences were detected in 26 (44.8%) of cases. In primary brain tumors, BK virus sequences were recognized more frequently in schwannomas (15.5%) and meningiomas (12.1%). The mean BK virus TAg copy number in positive cases was 0.20×10-3±0.27×10-3 (range 0.01×10-3- 0.8×10-3) copies per cell. Conclusion: Taken together, in the present study low copy numbers of BK virus TAg gene was detected in brain tumor cells, which can indicate that BK virus may contribute to tumor induction by indirect mechanisms or neuro-persistence of this virus without any pathological consequences.

Published
2021

4. Higher viral load of Epstein-Barr virus in gastric cancer compared with non-cancerous gastroduodenal tissues

Author

Arghavan, Zebardast, Maryam, Pazhoohan, Azadeh Yazdani, Cherati, Maryam, Salehi, Saghar Saber, Amoli, Yousef, Yahyapour, Mohammad, Ranaee, Javad Shokri, Shirvani, and Farzin, Sadeghi

Subjects
hemic and lymphatic diseases, Original Article
Abstract

INTRODUCTION: Epstein-Barr Virus (EBV)-associated gastric cancer is a distinct molecular subtype of gastrointestinal carcinomas as defined by the Cancer Genome Atlas. METHODS: In the present study 237 samples from Iranian patients diagnosed with gastric cancer and gastroduodenal disease were retrospectively examined for EBV infection by quantitative Real-Time PCR. RESULTS: Of the 237 samples tested, EBV DNA was detected in 37 samples (15.6%), in 13 of the 81 gastric cancer cases (16%), and 24 of the 156 non-cancerous samples (15.4%). The EBV infection rate was found higher in patients with gastric ulcer (35%) and duodenal ulcer (21.9%) compared to patients with gastric cancer (16%) and gastritis (19.6%). The EBV-encoded small RNA (EBER) copy number in the gastric cancer group (mean = 2.14×10(−1) with range of 2.14×10(−2) to 4.10×10(−1) copies/ cell) was higher than gastroduodenal diseases group (mean = 1.39×10(−2) with range 1.11×10(−3) to 2.35×10(−2) copies/ cell), and this difference was statistically significant (P >0.001) CONCLUSION: The higher number of copies of EBV-EBER in the gastric cancer group compared to the non-cancer group confirmed the possible role of EBV in inducing cancer.

Published
2022

5. Evidence of Epstein-Barr Virus Infection Association With Gastric Cancer and Gastroduodenal Diseases

Author

Yousef Yahyapour, Arghavan Zebardast, Saghar Saber Amoli, Maryam Pazhoohan, Mohammad Ranaee, Javad Shokri Shirvani, Azadeh Yazdani Cherati, and Farzin Sadeghi

Subjects
business.industry, hemic and lymphatic diseases, Immunology, medicine, Cancer, medicine.disease, business, Epstein–Barr virus infection
Abstract

Background: Epstein-Barr virus (EBV) is detected in epithelial tumors, such as nasopharyngeal carcinoma and gastric cancer (GC). EBV-associated gastric cancer is a distinct molecular subtype of gastrointestinal carcinomas as defined by Cancer Genome Atlas. This gamma-Herpes virus is present in approximately 10% of gastric carcinomas.Methods: The present study aimed to investigate the presence of EBV genome in gastric cancer and other gastroduodenal diseases either alone or together with Helicobacter pylori (HP). We examined 237 samples from Iranian patients diagnosed with GC and gastroduodenal disease for EBV infection by quantitative Real-Time PCR.Results: Of the 237 samples tested, EBV DNA was detected in 37 samples (15.6%), in 13 of the 81 GC cases (16%), and 24 of the 156 non-cancerous samples (15.4%). All samples containing EBV were gastric cancer of the intestinal type. Of 37 EBV-positive samples, 20 (54.1%) were over 55 years old and 20 (54.1%) were male. The EBV-EBER (EBV-encoded small RNA) DNA copy number in the gastric cancer group (mean = 2.14×10-1 copies/cell) was higher than that in the gastroduodenal disease group (mean = 1.39×10-2 copies/cell), and this difference was statistically significant (P> 0.001). Moreover, the concurrent infections with EBV and HP were detected in 17 out of 35 EBER-positive samples (48.6%), 6 (17/1%) cases were in the gastric cancer group and 11 (31/4%) cases were in the gastroduodenal disease group.Conclusions: In the present study, a high incidence (16%) of EBVaGC was observed in Babol city, Northern Iran. Also, the higher number of copies of EBV EBER DNA in the GC group than in the non-cancer group confirmed the possible role of EBV in inducing cancer. EBVaGC is not endemic in any region and varies in different nations. Therefore, further studies are needed to determine the role of this virus in the development of GC and other gastroduodenal diseases.

Published
2021
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6. Presence of JC Polyomavirus in Nonneoplastic Inflamed Colon Mucosa and Primary and Metastatic Colorectal Cancer

Author

Farzin Sadeghi, Nadia Esmailzadeh, Ahad Alizadeh, Aynaz Khademian, Mohammad Ranaee, and Saghar Saber Amoli

Subjects
business.industry, Colorectal cancer, Cell, Pharmaceutical Science, Rectum, Colon mucosa, medicine.disease, Primary tumor, Metastasis, medicine.anatomical_structure, Antigen, Cancer research, Medicine, business, Viral load, Research Article
Abstract

Background: Despite decades of epidemiologic and histopathologic investigations, the association between JC polyomavirus (JCPyV) infection and colorectal cancer (CRC) remains controversial. Objective: This study tested the presence of JCPyV sequences and determined the viral load in a series of colorectal samples from Iranian patients. In total, 223 formalin-fixed paraffin-embedded samples from patients diagnosed with primary and metastatic CRC as well as with nonneoplastic inflamed colon mucosa were analyzed by quantitative real-time PCR for the presence of JCPyV large tumor antigen (LT-Ag) sequences. Results: JCPyV LT-Ag sequences were detected in 18.6% of the CRC tissues and in 15.5% of the nonneoplastic control group. Viral LT-Ag was quantified in 18/100 primary colon adenocarcinomas, 2/10 metastatic adenocarcinomas, and 1/3 primary adenocarcinomas of the rectum. Two JCPyV-positive metastatic tumors presented a negative test result for JCPyV in the corresponding primary tumor. The median JCPyV LT-Ag copy number was 64 × 10–2 per cell and 14 × 10–2 per cell in the CRC cases and the nonneoplastic samples, respectively. There was no statistically significant difference between the two study groups regarding median LT-Ag DNA load (p = 0.059). Among the JCPyV-positive samples, the LT-Ag DNA load was higher in 2 metastatic tumors (from a patient with lung metastasis: 232 × 10–2 copies per cell; from a patient with liver metastasis: 121 × 10–2 copies per cell). Conclusions: The detection of JCPyV DNA at low copy numbers (lower than 1 viral copy per cell equivalent) and the absence of viral sequences in the corresponding primary tumors of the JCPyV-positive metastatic samples weaken the hypothesis of an etiological role of JCPyV in primary CRC induction.

Published
2019
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