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To maintain ideal working conditions by removing heat, a particular technique must be applied. This research examines how nanofluids affect computer cooling microchannel heating devices. The experiment's working fluids are 25% Therminol-55 and 75% sprinkling water. The mixture contains silicon carbide (SiC), titanium oxide (TiO2), and zinc oxide (ZnO) nanoparticles. It includes 0.25% to 1.5% nanoparticles and flows at 0.025 to 0.080 kg/s at 25°C to 40°C. Central processing unit temperature, heat transfer rate, pressure losses, and pumping power have been examined. SiC-THERMINOL/SPRINKLING WATER at 1.5% concentration and 0.080 kg/s had a 9% lower temperature and 31% larger heat transfer coefficient than the base fluid. SiC-TL/SW has the highest pressure decrease and pumping force power compared to TiO2-TL/SW. Because nanofluid beats basic fluid in computer cooling, a little increase in pumping force power and pressure reduction may be tolerated.