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1. On-time childhood vaccination before and during the COVID-19 pandemic in seven communities: Findings from the New Vaccine Surveillance Network

Author

Hofstetter, Annika M., Klein, Eileen J., Strelitz, Bonnie, Selvarangan, Rangaraj, Schuster, Jennifer E., Boom, Julie A., Sahni, Leila C., Halasa, Natasha B., Stewart, Laura S., Staat, Mary Allen, Rohlfs, Chelsea, Szilagyi, Peter G., Weinberg, Geoffrey A., Williams, John V., Michaels, Marian G., Moline, Heidi, Mirza, Sara A., Harrison, Christopher J., and Englund, Janet A.

Published
2024
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2. Underutilization of Influenza Antiviral Treatment Among Children and Adolescents at Higher Risk for Influenza-Associated Complications--United States, 2023-2024

Author

Frutos, Aaron M., Ahmad, Haris M., Ujamaa, Dawud, O'Halloran, Alissa C., Englund, Janet A., Klein, Eileen J., Zerr, Danielle M., Crossland, Melanie, Staten, Holly, Boom, Julie A., Sahni, Leila C., Halasa, Natasha B., Stewart, Laura S., Hamdan, Olla, Stopczynski, Tess, Schaffner, William, Talbot, H. Keipp, Michaels, Marian G., Williams, John V., Sutton, Melissa, Hendrick, M. Andraya, Staat, Mary A., Schlaudecker, Elizabeth P., Tesini, Brenda L., Felsen, Christina B., Weinberg, Geoffrey A., Szilagyi, Peter G., Anderson, Bridget J., Rowlands, Jemma V., Khalifa, Murtada, Martinez, Marc, Selvarangan, Rangaraj, Schuster, Jennifer E., Lynfield, Ruth, McMahon, Melissa, Kim, Sue, Nunez, Val Tellez, Ryan, Patricia A., Monroe, Maya L., Wang, Yun F., Openo, Kyle P., Meek, James, Yousey-Hindes, Kimberly, Alden, Nisha B., Armistead, Isaac, Rao, Suchitra, Chai, Shua J., Kirley, Pam Daily, Toepfer, Ariana P., Dawood, Fatimah S., Moline, Heidi L., Uyeki, Timothy M., Ellington, Sascha, Garg, Shikha, Bozio, Catherine H., and Olson, Samantha M.

Subjects
Merck & Company Inc., Pfizer Inc., Vaccination, Influenza viruses, Influenza vaccines -- Complications and side effects, Influenza -- Complications and side effects -- Drug therapy, Hospital patients -- Drug therapy, Health
Abstract

Introduction Annually, seasonal influenza virus infections among children and adolescents in the United States are estimated to result in millions of medical visits, tens of thousands of hospitalizations, and hundreds [...]

Published
2024

3. Medical Costs of Respiratory Syncytial Virus–Associated Hospitalizations and Emergency Department Visits in Children Aged Younger Than 5 Years: Observational Findings from the New Vaccine Surveillance Network, 2016-2019

Author

Clopper, Benjamin R., Zhou, Yingtao, Tannis, Ayzsa, Staat, Mary Allen, Rice, Marilyn, Boom, Julie A., Sahni, Leila C., Selvarangan, Rangaraj, Harrison, Christopher J., Halasa, Natasha B., Stewart, Laura S., Weinberg, Geoffrey A., Szilagyi, Peter G., Klein, Eileen J., Englund, Janet A., Rha, Brian, Lively, Joana Y., Ortega-Sanchez, Ismael R., McMorrow, Meredith L., and Moline, Heidi L.

Published
2024
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4. Characteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network

Author

Zambrano, Laura D., Newhams, Margaret M., Simeone, Regina M., Fleming-Dutra, Katherine E., Halasa, Natasha, Wu, Michael, Orzel-Lockwood, Amber O., Kamidani, Satoshi, Pannaraj, Pia S., Chiotos, Kathleen, Cameron, Melissa A., Maddux, Aline B., Schuster, Jennifer E., Crandall, Hillary, Kong, Michele, Nofziger, Ryan A., Staat, Mary A., Bhumbra, Samina S., Irby, Katherine, Boom, Julie A., Sahni, Leila C., Hume, Janet R., Gertz, Shira J., Maamari, Mia, Bowens, Cindy, Levy, Emily R., Bradford, Tamara T., Walker, Tracie C., Schwartz, Stephanie P., Mack, Elizabeth H., Guzman-Cottrill, Judith A., Hobbs, Charlotte V., Zinter, Matt S., Cvijanovich, Natalie Z., Bline, Katherine E., Hymes, Saul R., Campbell, Angela P., Randolph, Adrienne G., Murdock, Meghan, Kelley, Heather, Sanders, Ronald C., Miron, Laura, Barkely, Hannah, Jumarang, Jaycee, Hakimi, Daniel, Niell, Liria Muriscot, Baig, Natasha, Temte, Elizabeth, Thayer, Imogene, Petruccelli, Lexi, Zorensky, Frances, Sierra, Yamila, Gonzalez, Mark D., Ciric, Caroline R., Choi, Jong-Ha C., Baida, Nadine, Randolph, Adrienne G., Kucukak, Suden, Listerud, Eve, Clark, Maya, Dittrich, Rylie, Johnson, Brandi A., Drapeau, Noelle M., Martin, Lora, Malloch, Lacy, Martin, Maygan, Sanders, Cameron, Patterson, Kayla, Sullivan, Melissa, Pruitt, Shannon, Hymes, Saul, Harwayne-Gidansky, Ilana, Rohlfs, Chelsea C., Wolfe, Amber, Phengchomphet, Kathlyn, Bush, Jenny, Mohammed, Fatima A., Stewart, Laura S., Fernandez, Kailee, Abojaib, Leenah, Kyles, Molly J., and Campbell, Angela P.

Published
2023
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6. Early Estimate of Nirsevimab Effectiveness for Prevention of Respiratory Syncytial Virus-Associated Hospitalization Among Infants Entering Their First Respiratory Syncytial Virus Season--New Vaccine Surveillance Network, October 2023-February 2024

Author

Moline, Heidi L., Tannis, Ayzsa, Toepfer, Ariana P., Williams, John V., Boom, Julie A., Englund, Janet A., Halasa, Natasha B., Staat, Mary Allen, Weinberg, Geoffrey A., Selvarangan, Rangaraj, Michaels, Marian G., Sahni, Leila C., Klein, Eileen J., Stewart, Laura S., Schlaudecker, Elizabeth P., Szilagyi, Peter G., Schuster, Jennifer E., Goldstein, Leah, Musa, Samar, Piedra, Pedro A., Zerr, Danielle M., Betters, Kristina A., Rohlfs, Chelsea, Albertin, Christina, Banerjee, Dithi, McKeever, Erin R., Kalman, Casey, Clopper, Benjamin R., McMorrow, Meredith L., and Dawood, Fatimah S.

Subjects
Merck & Company Inc., Palivizumab, Vaccination, Diseases -- Pennsylvania -- United States -- Ohio -- Texas, Infants, Vaccines, Pharmaceutical industry, Health
Abstract

Introduction Respiratory syncytial virus (RSV) is the leading cause of hospitalization in U.S. infants, responsible for 50,000-80,000 hospitalizations annually in children aged Methods Data Collection and Inclusion Criteria The New [...]

Published
2024

7. Embracing Professionalism to Cultivate Vaccine Positivity and Reduce Vaccine Hesitancy.

Author

Lin, Teresa, Grams, Jaimie C., Cunningham, Rachel M., Sahni, Leila C., and Boom, Julie A.

Subjects
COVID-19 pandemic, VACCINE hesitancy, CULTURAL humility, CULTURAL awareness, RESPONSIBILITY
Abstract

Fueled by the coronavirus disease 2019 pandemic, vaccine hesitancy has become more pronounced and challenging given the increased distrust of science, pervasiveness of misinformation, and polarization of ideas. As such, pediatric providers are increasingly on the frontline of vaccine conversations with their patients, families, colleagues, and communities. To respond effectively to vaccine hesitancy, providers should employ professionalism in all aspects of their practice, including commitment to learning and growth, cultural awareness and humility, ethical responsibility to self and others, oral communication, reliability and dependability, teamwork, critical thinking and quantitative reasoning, and the engagement in public discourse around vaccines. By ensuring excellence in each professionalism domain, pediatric providers will have the best chance of enhancing vaccine positivity and minimizing vaccine hesitancy. [Pediatr Ann. 2024;53(12):e465–e472.] [ABSTRACT FROM AUTHOR]

Published
2024
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8. Evaluation of a Modified Vesikari Severity Score as a Research Tool for Assessing Pediatric Acute Gastroenteritis.

Author

Wikswo, Mary E, Weinberg, Geoffrey A, Szilagyi, Peter G, Selvarangan, Rangaraj, Harrison, Christopher J, Klein, Eileen J, Englund, Janet A, Sahni, Leila C, Boom, Julie A, Halasa, Natasha B, Stewart, Laura S, Staat, Mary Allen, Schlaudecker, Elizabeth P, Azimi, Parvin H, Johnston, Samantha H, and Mirza, Sara A

Subjects
RISK assessment, PARENTS, JOB absenteeism, DISEASE duration, RESEARCH funding, RESEARCH methodology evaluation, RETROVIRUS diseases, HOSPITAL emergency services, DESCRIPTIVE statistics, SEVERITY of illness index, GASTROENTERITIS, GUARDIAN & ward, VOMITING, COMPARATIVE studies, EVALUATION, CHILDREN
Abstract

A modified Vesikari severity score (MVSS) is a useful research tool for assessing severity of acute gastroenteritis. We present a MVSS for studies in which a follow-up assessment of symptoms cannot be obtained. The MVSS significantly correlated with other markers of severity, including illness duration and work and school absenteeism. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Rotavirus Vaccine Effectiveness Against Severe Acute Gastroenteritis: 2009-2022.

Author

Diallo, Alpha Oumar, Wikswo, Mary E., Sulemana, Iddrisu, Sahni, Leila C., Boom, Julie A., Ramani, Sasirekha, Selvarangan, Rangaraj, Moffatt, Mary E., Harrison, Christopher J., Halasa, Natasha, Chappell, James, Stewart, Laura, Staat, Mary Allen, Schlaudecker, Elizabeth, Quigley, Christina, Klein, Eileen J., Englund, Janet A., Zerr, Danielle M., Weinberg, Geoffrey A., and Szilagyi, Peter G.

Published
2024
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10. Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-control Investigation

Author

Zambrano, Laura D., Wu, Michael J., Martin, Lora, Malloch, Lacy, Chen, Sabrina, Newhams, Margaret M., Kucukak, Suden, Son, Mary Beth, Sanders, Cameron, Patterson, Kayla, Halasa, Natasha, Fitzgerald, Julie C., Leroue, Matthew K., Hall, Mark, Irby, Katherine, Rowan, Courtney M., Wellnitz, Kari, Sahni, Leila C., Loftis, Laura, Bradford, Tamara T., Staat, Mary, Babbitt, Christopher, Carroll, Christopher L., Pannaraj, Pia S., Kong, Michele, Schuster, Jennifer E., Chou, Janet, Patel, Manish M., Randolph, Adrienne G., Campbell, Angela P., and Hobbs, Charlotte V.

Published
2023
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11. Respiratory Syncytial Virus-Associated Hospitalizations in Children <5 Years: 2016–2022

Author

McMorrow, Meredith L., primary, Moline, Heidi L., additional, Toepfer, Ariana P., additional, Halasa, Natasha B., additional, Schuster, Jennifer E., additional, Staat, Mary A., additional, Williams, John V., additional, Klein, Eileen J., additional, Weinberg, Geoffrey A., additional, Clopper, Benjamin R., additional, Boom, Julie A., additional, Stewart, Laura S., additional, Selvarangan, Rangaraj, additional, Schlaudecker, Elizabeth P., additional, Michaels, Marian G., additional, Englund, Janet A., additional, Albertin, Christina S., additional, Mahon, Barbara E., additional, Hall, Aron J., additional, Sahni, Leila C., additional, and Curns, Aaron T., additional

Published
2024
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12. Accuracy of Influenza ICD-10 Diagnosis Codes in Identifying Influenza Illness in Children

Author

Antoon, James W., primary, Stopczynski, Tess, additional, Amarin, Justin Z., additional, Stewart, Laura S., additional, Boom, Julie A., additional, Sahni, Leila C., additional, Michaels, Marian G., additional, Williams, John V., additional, Englund, Janet A., additional, Klein, Eileen J., additional, Staat, Mary A., additional, Schlaudecker, Elizabeth P., additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E., additional, Weinberg, Geoffrey A., additional, Szilagyi, Peter G., additional, Perez, Ariana, additional, Moline, Heidi L., additional, Spieker, Andrew J., additional, Grijalva, Carlos G., additional, Olson, Samantha M., additional, and Halasa, Natasha B., additional

Published
2024
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13. Maternal Vaccination and Risk of Hospitalization for Covid-19 Among Infants

Author

Halasa, Natasha B., Olson, Samantha M., Staat, Mary A., Newhams, Margaret M., Price, Ashley M., Pannaraj, Pia S., Boom, Julie A., Sahni, Leila C., Chiotos, Kathleen, Cameron, Melissa A., Bline, Katherine E., Hobbs, Charlotte V., Maddux, Aline B., Coates, Bria M., Michelson, Kelly N., Heidemann, Sabrina M., Irby, Katherine, Nofziger, Ryan A., Mack, Elizabeth H., Smallcomb, Laura, Schwartz, Stephanie P., Walker, Tracie C., Gertz, Shira J., Schuster, Jennifer E., Kamidani, Satoshi, Tarquinio, Keiko M., Bhumbra, Samina S., Maamari, Mia, Hume, Janet R., Crandall, Hillary, Levy, Emily R., Zinter, Matt S., Bradford, Tamara T., Flori, Heidi R., Cullimore, Melissa L., Kong, Michele, Cvijanovich, Natalie Z., Gilboa, Suzanne M., Polen, Kara N., Campbell, Angela P., Randolph, Adrienne G., and Patel, Manish M.

Published
2023
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14. SARS-CoV-2 Epidemiology and COVID-19 mRNA Vaccine Effectiveness Among Infants and Children Aged 6 Months-4 Years--New Vaccine Surveillance Network, United States, July 2022-September 2023

Author

Tannis, Ayzsa, Englund, Janet A., Perez, Ariana, Harker, Elizabeth J., Staat, Mary Allen, Schlaudecker, Elizabeth P., Halasa, Natasha B., Stewart, Laura S., Williams, John V., Michaels, Marian G., Selvarangan, Rangaraj, Schuster, Jennifer E., Sahni, Leila C., Boom, Julie A., Weinberg, Geoffrey A., Szilagyi, Peter G., Clopper, Benjamin R., Zhou, Yingtao, McMorrow, Meredith L., Klein, Eileen J., and Moline, Heidi L.

Subjects
United States. National Institutes of Health, Merck & Company Inc., Pfizer Inc., Vaccination, Medical research, Medicine, Experimental, Messenger RNA, Infection, Children -- Health aspects, Epidemiology, Vaccines, Disease susceptibility, Pharmaceutical industry, Health
Abstract

Introduction SARS-CoV-2 infection in young children and adolescents commonly manifests as a mild or asymptomatic illness; however, some children are at risk for severe disease, including those with certain chronic [...]

Published
2023

16. Respiratory Syncytial Virus-Associated Hospitalizations in Children <5 Years: 2016-2022.

Author

McMorrow, Meredith L., Moline, Heidi L., Toepfer, Ariana P., Halasa, Natasha B., Schuster, Jennifer E., Staat, Mary A., Williams, John V., Klein, Eileen J., Weinberg, Geoffrey A., Clopper, Benjamin R., Boom, Julie A., Stewart, Laura S., Selvarangan, Rangaraj, Schlaudecker, Elizabeth P., Michaels, Marian G., Englund, Janet A., Albertin, Christina S., Mahon, Barbara E., Hall, Aron J., and Sahni, Leila C.

Published
2024
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17. Reemergence of Mycoplasma pneumoniae Infections in Children and Adolescents After the COVID-19 Pandemic, United States, 2018-2024

Author

Edens, Chris, Clopper, Benjamin R., DeVies, Jourdan, Benitez, Alvaro, McKeever, Erin R., Johns, Dylan, Wolff, Bernard, Selvarangan, Rangaraj, Schuster, Jennifer E., Weinberg, Geoffrey A., Szilagyi, Peter G., Dawood, Fatimah S., Radhakrishnan, Lakshmi, Quigley, Christina, Sahni, Leila C., Halasa, Natasha, Stewart, Laura S., McMorrow, Meredith L., Whitaker, Brett, Zerr, Danielle M., Avadhanula, Vasanthi, Williams, John V., Michaels, Marian G., Kite-Powell, Aaron, Englund, Janet A., Staat, Mary Allen, Hartnett, Kathleen, Moline, Heidi L., Cohen, Adam L., and Diaz, Maureen

Subjects
Bacterial pneumonia -- Health aspects, Drug resistance in microorganisms -- Health aspects, Pneumonia -- Health aspects, Health
Abstract

Mycoplasma pneumoniae is a common cause of respiratory infections, particularly in school-aged children. Most infections display as a mild respiratory illness sometimes referred to as 'walking pneumonia.' However, some persons [...]

Published
2024

18. Understanding Variation in Rotavirus Vaccine Effectiveness Estimates in the United States: The Role of Rotavirus Activity and Diagnostic Misclassification

Author

Amin, Avnika B., Lash, Timothy L., Tate, Jacqueline E., Waller, Lance A., Wikswo, Mary E., Parashar, Umesh D., Stewart, Laura S., Chappell, James D., Halasa, Natasha B., Williams, John V., Michaels, Marian G., Hickey, Robert W., Klein, Eileen J., Englund, Janet A., Weinberg, Geoffrey A., Szilagyi, Peter G., Staat, Mary Allen, McNeal, Monica M., Boom, Julie A., Sahni, Leila C., Selvarangan, Rangaraj, Harrison, Christopher J., Moffatt, Mary E., Schuster, Jennifer E., Pahud, Barbara A., Weddle, Gina M., Azimi, Parvin H., Johnston, Samantha H., Payne, Daniel C., Bowen, Michael D., and Lopman, Benjamin A.

Published
2022
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19. Medical Costs of RSV-associated Hospitalizations and Emergency Department Visits in Children Aged <5 years: Observational Findings from the New Vaccine Surveillance Network (NVSN), 2016-2019

Author

Clopper, Benjamin R., primary, Zhou, Yingtao, additional, Tannis, Ayzsa, additional, Staat, Mary Allen, additional, Rice, Marilyn, additional, Boom, Julie A., additional, Sahni, Leila C., additional, Selvarangan, Rangaraj, additional, Harrison, Christopher J., additional, Halasa, Natasha B., additional, Stewart, Laura S., additional, Weinberg, Geoffrey A., additional, Szilagyi, Peter G., additional, Klein, Eileen J., additional, Englund, Janet A., additional, Rha, Brian, additional, Lively, Joana Y., additional, Ortega-Sanchez, Ismael R., additional, McMorrow, Meredith L., additional, and Moline, Heidi L., additional

Published
2024
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20. Notes from the Field: Reemergence of Mycoplasma pneumoniae Infections in Children and Adolescents After the COVID-19 Pandemic, United States, 2018–2024

Author

Edens, Chris, primary, Clopper, Benjamin R., additional, DeVies, Jourdan, additional, Benitez, Alvaro, additional, McKeever, Erin R., additional, Johns, Dylan, additional, Wolff, Bernard, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E., additional, Weinberg, Geoffrey A., additional, Szilagyi, Peter G., additional, Dawood, Fatimah S., additional, Radhakrishnan, Lakshmi, additional, Quigley, Christina, additional, Sahni, Leila C., additional, Halasa, Natasha, additional, Stewart, Laura S., additional, McMorrow, Meredith L., additional, Whitaker, Brett, additional, Zerr, Danielle M., additional, Avadhanula, Vasanthi, additional, Williams, John V., additional, Michaels, Marian G., additional, Kite-Powell, Aaron, additional, Englund, Janet A., additional, Staat, Mary Allen, additional, Hartnett, Kathleen, additional, Moline, Heidi L., additional, Cohen, Adam L., additional, and Diaz, Maureen, additional

Published
2024
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22. Respiratory Syncytial Virus-Associated Hospitalizations Among Children &lt;5 Years Old: 2016 to 2020

Author

Curns, Aaron T., primary, Rha, Brian, additional, Lively, Joana Y., additional, Sahni, Leila C., additional, Englund, Janet A., additional, Weinberg, Geoffrey A., additional, Halasa, Natasha B., additional, Staat, Mary A., additional, Selvarangan, Rangaraj, additional, Michaels, Marian, additional, Moline, Heidi, additional, Zhou, Yingtao, additional, Perez, Ariana, additional, Rohlfs, Chelsea, additional, Hickey, Robert, additional, Lacombe, Kirsten, additional, McHenry, Rendie, additional, Whitaker, Brett, additional, Schuster, Jennifer, additional, Pulido, Claudia Guevara, additional, Strelitz, Bonnie, additional, Quigley, Christina, additional, DNP, Gina Weddle, additional, Avadhanula, Vasanthi, additional, Harrison, Christopher J., additional, Stewart, Laura S., additional, Schlaudecker, Elizabeth, additional, Szilagyi, Peter G., additional, Klein, Eileen J., additional, Boom, Julie, additional, Williams, John V., additional, Langley, Gayle, additional, Gerber, Susan I., additional, Hall, Aron J., additional, and McMorrow, Meredith L., additional

Published
2024
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23. Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Author

Bowen, Michael D, Mijatovic-Rustempasic, Slavica, Esona, Mathew D, Teel, Elizabeth N, Gautam, Rashi, Sturgeon, Michele, Azimi, Parvin H, Baker, Carol J, Bernstein, David I, Boom, Julie A, Chappell, James, Donauer, Stephanie, Edwards, Kathryn M, Englund, Janet A, Halasa, Natasha B, Harrison, Christopher J, Johnston, Samantha H, Klein, Eileen J, McNeal, Monica M, Moffatt, Mary E, Rench, Marcia A, Sahni, Leila C, Selvarangan, Rangaraj, Staat, Mary A, Szilagyi, Peter G, Weinberg, Geoffrey A, Wikswo, Mary E, Parashar, Umesh D, and Payne, Daniel C

Subjects
Prevention, Vaccine Related, Clinical Research, Pediatric, Immunization, Infectious Diseases, Good Health and Well Being, Child, Child, Preschool, Epidemiological Monitoring, Female, Genotype, Humans, Infant, Male, Rotavirus, Rotavirus Infections, Rotavirus Vaccines, United States, rotavirus, genotype, prevalence, surveillance, vaccine, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundGroup A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006.MethodsOver 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping.ResultsIn the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype.ConclusionsContinued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.

Published
2016

24. Enterovirus D68–Associated Acute Respiratory Illness — New Vaccine Surveillance Network, United States, July–October, 2017 and 2018

Author

Kujawski, Stephanie A., Midgley, Claire M., Rha, Brian, Lively, Joana Y., Nix, W. Allan, Curns, Aaron T., Payne, Daniel C., Englund, Janet A., Boom, Julie A., Williams, John V., Weinberg, Geoffrey A., Staat, Mary A., Selvarangan, Rangaraj, Halasa, Natasha B., Klein, Eileen J., Sahni, Leila C., Michaels, Marian G., Shelley, Lynne, McNeal, Monica, Harrison, Christopher J., Stewart, Laura S., Lopez, Adriana S., Routh, Janell A., Patel, Manisha, Oberste, M. Steven, Watson, John T., and Gerber, Susan I.

Published
2019

25. Long-term Consistency in Rotavirus Vaccine Protection: RV5 and RV1 Vaccine Effectiveness in US Children, 2012–2013

Author

Payne, Daniel C, Selvarangan, Rangaraj, Azimi, Parvin H, Boom, Julie A, Englund, Janet A, Staat, Mary Allen, Halasa, Natasha B, Weinberg, Geoffrey A, Szilagyi, Peter G, Chappell, James, McNeal, Monica, Klein, Eileen J, Sahni, Leila C, Johnston, Samantha H, Harrison, Christopher J, Baker, Carol J, Bernstein, David I, Moffatt, Mary E, Tate, Jacqueline E, Mijatovic-Rustempasic, Slavica, Esona, Mathew D, Wikswo, Mary E, Curns, Aaron T, Sulemana, Iddrisu, Bowen, Michael D, Gentsch, Jon R, and Parashar, Umesh D

Subjects
Prevention, Health Services, Immunization, Infectious Diseases, Patient Safety, Clinical Research, Vaccine Related, Pediatric, Digestive Diseases, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, Infection, Antigens, Viral, Child, Child, Preschool, Emergency Medical Services, Enzyme-Linked Immunosorbent Assay, Epidemiological Monitoring, Feces, Female, Gastroenteritis, Genotype, Hospitalization, Humans, Infant, Male, RNA, Viral, Rotavirus Infections, Rotavirus Vaccines, Treatment Outcome, United States, Vaccines, Attenuated, rotavirus vaccine, RV1-Rotarix, RV5-RotaTeq, acute gastroenteritis, surveillance, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundUsing a multicenter, active surveillance network from 2 rotavirus seasons (2012 and 2013), we assessed the vaccine effectiveness of RV5 (RotaTeq) and RV1 (Rotarix) rotavirus vaccines in preventing rotavirus gastroenteritis hospitalizations and emergency department (ED) visits for numerous demographic and secular strata.MethodsWe enrolled children hospitalized or visiting the ED with acute gastroenteritis (AGE) for the 2012 and 2013 seasons at 7 medical institutions. Stool specimens were tested for rotavirus by enzyme immunoassay and genotyped, and rotavirus vaccination histories were compared for rotavirus-positive cases and rotavirus-negative AGE controls. We calculated the vaccine effectiveness (VE) for preventing rotavirus associated hospitalizations and ED visits for each vaccine, stratified by vaccine dose, season, clinical setting, age, predominant genotype, and ethnicity.ResultsRV5-specific VE analyses included 2961 subjects, 402 rotavirus cases (14%) and 2559 rotavirus-negative AGE controls. RV1-specific VE analyses included 904 subjects, 100 rotavirus cases (11%), and 804 rotavirus-negative AGE controls. Over the 2 rotavirus seasons, the VE for a complete 3-dose vaccination with RV5 was 80% (confidence interval [CI], 74%-84%), and VE for a complete 2-dose vaccination with RV1 was 80% (CI, 68%-88%).Statistically significant VE was observed for each year of life for which sufficient data allowed analysis (7 years for RV5 and 3 years for RV1). Both vaccines provided statistically significant genotype-specific protection against predominant circulating rotavirus strains.ConclusionsIn this large, geographically and demographically diverse sample of US children, we observed that RV5 and RV1 rotavirus vaccines each provided a lasting and broadly heterologous protection against rotavirus gastroenteritis.

Published
2015

26. Durability of Original Monovalent mRNA Vaccine Effectiveness Against COVID-19 Omicron–Associated Hospitalization in Children and Adolescents — United States, 2021–2023.

Author

Zambrano, Laura D., Newhams, Margaret M., Simeone, Regina M., Payne, Amanda B., Michael Wu, OrzelLockwood, Amber O., Halasa, Natasha B., Calixte, Jemima M., Pannaraj, Pia S., Mongkolrattanothai, Kanokporn, Boom, Julie A., Sahni, Leila C., Kamidani, Satoshi, Chiotos, Kathleen, Cameron, Melissa A., Maddux, Aline B., Irby, Katherine, Schuster, Jennifer E., Mack, Elizabeth H., and Biggs, Austin

Subjects
COVID-19 vaccines, HEALTH outcome assessment, VACCINE effectiveness, HOSPITAL care, VASOCONSTRICTORS
Abstract

Pediatric COVID-19 vaccination is effective in preventing COVID-19–related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021–October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19–related hospitalization and critical illness among U.S. children and adolescents aged 5–18 years, using a case-control design. Too few children and adolescents received bivalent or updated monovalent vaccines to separately evaluate their effectiveness. Most case-patients (persons with a positive SARS-CoV-2 test result) were unvaccinated, despite the high frequency of reported underlying conditions associated with severe COVID-19. VE of the original monovalent vaccine against COVID-19–related hospitalizations was 52% (95% CI = 33%–66%) when the most recent dose was administered <120 days before hospitalization and 19% (95% CI = 2%–32%) if the interval was 120–364 days. VE of the original monovalent vaccine against COVID-19–related hospitalization was 31% (95% CI = 18%–43%) if the last dose was received any time within the previous year. VE against critical COVID-19–related illness, defined as receipt of noninvasive or invasive mechanical ventilation, vasoactive infusions, extracorporeal membrane oxygenation, and illness resulting in death, was 57% (95% CI = 21%–76%) when the most recent dose was received <120 days before hospitalization, 25% (95% CI = –9% to 49%) if it was received 120–364 days before hospitalization, and 38% (95% CI = 15%–55%) if the last dose was received any time within the previous year. VE was similar after excluding children and adolescents with *These senior authors contributed equally to this report. documented immunocompromising conditions. Because of the low frequency of children who received updated COVID-19 vaccines and waning effectiveness of original monovalent doses, these data support CDC recommendations that all children and adolescents receive updated COVID-19 vaccines to protect against severe COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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27. 2644. Presence of Respiratory Viruses in the Upper Respiratory Tract of Febrile Infants ≤90 Days Old is Associated with Lower Prevalence of Invasive Bacterial Infection

Author

Nicholson, Erin G, primary, Stopczynski, Tess, additional, Sahni, Leila C, additional, Avadhanula, Vasanthi, additional, Piedra, Pedro A, additional, Amarin, Justin Z, additional, Chappell, James, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Williams, John V, additional, Michaels, Marian G, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Burkel, Veronica, additional, Moline, Heidi L, additional, Halasa, Natasha B, additional, and Boom, Julie A, additional

Published
2023
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28. 1755. Hospitalizations for Respiratory Viruses among Children 5–17 Years of Age in the Pre-COVID-19 Pandemic Era, the New Vaccine Surveillance Network, 2016–2020

Author

Sahni, Leila C, primary, Amarin, Justin Z, additional, Stopczynski, Tess, additional, Spieker, Andrew J, additional, Stewart, Laura S, additional, Staat, Mary A, additional, Quigley, Christina M, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Michaels, Marian G, additional, Williams, John V, additional, Szilagyi, Peter G, additional, Weinberg, Geoffrey A, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Clopper, Benjamin R, additional, Moline, Heidi L, additional, Avadhanula, Vasanthi, additional, Munoz, Flor M, additional, Piedra, Pedro A, additional, Halasa, Natasha B, additional, and Boom, Julie A, additional

Published
2023
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29. 1733. Effectiveness of Influenza Vaccination Against Influenza-Associated Emergency Department (ED) Visits and Hospitalizations Among Children With and Without Underlying Medical Conditions, New Vaccine Surveillance Network (NVSN), 2015-2016 through 2019-2020 Influenza Seasons

Author

Noble, Emma K, primary, Hayek, Haya, additional, Stewart, Laura S, additional, Sahni, Leila C, additional, Boom, Julie A, additional, Michaels, Marian G, additional, Williams, John V, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Clopper, Benjamin R, additional, Moline, Heidi L, additional, Halasa, Natasha B, additional, and Olson, Samantha M, additional

Published
2023
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30. 1104. Characteristics and Seasonality of Children Hospitalized with Parainfluenza Virus Infections (PIV), including PIV-4, New Vaccine Surveillance Network, 2016–2020

Author

de St. Maurice, Annabelle M, primary, Qwaider, Yasmeen Z, additional, Stopczynski, Tess, additional, Williams, John V, additional, Michaels, Marian G, additional, Sahni, Leila C, additional, Boom, Julie A, additional, Spieker, Andrew J, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Zhou, Yingtao, additional, Moline, Heidi L, additional, Szilagyi, Peter G, additional, Halasa, Natasha B, additional, and Weinberg, Geoffrey A, additional

Published
2023
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31. 905. Epidemiology of Enterovirus D68 in the US: New Vaccine Surveillance Network, 2017–2022

Author

Clopper, Benjamin R, primary, Moline, Heidi L, additional, Midgley, Claire, additional, Lopez, Adriana S, additional, Ng, Terry Fei Fan, additional, Perez, Ariana, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Sahni, Leila C, additional, Boom, Julie A, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Halasa, Natasha B, additional, Stewart, Laura S, additional, Hickey, Robert, additional, Michaels, Marian G, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Klein, Eileen J, additional, and Englund, Janet A, additional

Published
2023
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32. 650. Antibiotic Use among Children Seeking Medical Care with Acute Gastroenteritis within the New Vaccine Surveillance Network, United States, 2011-2021

Author

Balachandran, Neha, primary, Wikswo, Mary, additional, Boom, Julie A, additional, Sahni, Leila C, additional, Selvarangan, Rangaraj, additional, Harrison, Christopher J, additional, Halasa, Natasha B, additional, Stewart, Laura S, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Staat, Mary A, additional, Burrell, Allison, additional, Williams, John V, additional, Michaels, Marian G, additional, Parashar, Umesh D, additional, and Mirza, Sara, additional

Published
2023
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34. Respiratory Virus Surveillance Among Children with Acute Respiratory Illnesses--New Vaccine Surveillance Network, United States, 2016-2021

Author

Perez, Ariana, Lively, Joana Y., Curns, Aaron, Weinberg, Geoffrey A., Halasa, Natasha B., Staat, Mary Allen, Szilagyi, Peter G., Stewart, Laura S., McNeal, Monica M., Clopper, Benjamin, Zhou, Yingtao, Whitaker, Brett L., LeMasters, Elizabeth, Harker, Elizabeth, Englund, Janet A., Klein, Eileen J., Selvarangan, Rangaraj, Harrison, Christopher J., Boom, Julie A., Sahni, Leila C., Michaels, Marian G., Williams, John V., Langley, Gayle E., Gerber, Susan I., Campbell, Angela, Hall, Aron J., Rha, Brian, MD, and McMorrow, Meredith

Subjects
Medical research, Medicine, Experimental, Vaccination, Medical centers, Influenza vaccines, Influenza, Health, University of Rochester. School of Medicine and Dentistry, Baylor College of Medicine
Abstract

The New Vaccine Surveillance Network (NVSN) is a prospective, active, population-based surveillance platform that enrolls children with acute respiratory illnesses (ARIs) at seven pediatric medical centers. ARIs are caused by [...]

Published
2022

36. Respiratory Syncytial Virus-Associated Hospitalizations Among Children <5 Years Old: 2016 to 2020.

Author

Curns, Aaron T., Rha, Brian, Lively, Joana Y., Sahni, Leila C., Englund, Janet A., Weinberg, Geoffrey A., Halasa, Natasha B., Staat, Mary A., Selvarangan, Rangaraj, Michaels, Marian, Moline, Heidi, Yingtao Zhou, Perez, Ariana, Rohlfs, Chelsea, Hickey, Robert, Lacombe, Kirsten, McHenry, Rendie, Whitaker, Brett, Schuster, Jennifer, and Pulido, Claudia Guevara

Published
2024
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37. Maternal Vaccine Effectiveness Against Influenza-Associated Hospitalizations and Emergency Department Visits in Infants.

Author

Sahni, Leila C., Olson, Samantha M., Halasa, Natasha B., Stewart, Laura S., Michaels, Marian G., Williams, John V., Englund, Janet A., Klein, Eileen J., Staat, Mary A., Schlaudecker, Elizabeth P., Selvarangan, Rangaraj, Schuster, Jennifer E., Weinberg, Geoffrey A., Szilagyi, Peter G., Boom, Julie A., Patel, Manish M., and Muñoz, Flor M.

Published
2024
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40. Characteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network

Author

Zambrano, Laura D., Newhams, Margaret M., Simeone, Regina M., Fleming-Dutra, Katherine E., Halasa, Natasha, Wu, Michael, Orzel-Lockwood, Amber O., Kamidani, Satoshi, Pannaraj, Pia S., Chiotos, Kathleen, Cameron, Melissa A., Maddux, Aline B., Schuster, Jennifer E., Crandall, Hillary, Kong, Michele, Nofziger, Ryan A., Staat, Mary A., Bhumbra, Samina S., Irby, Katherine, Boom, Julie A., Sahni, Leila C., Hume, Janet R., Gertz, Shira J., Maamari, Mia, Bowens, Cindy, Levy, Emily R., Bradford, Tamara T., Walker, Tracie C., Schwartz, Stephanie P., Mack, Elizabeth H., Guzman-Cottrill, Judith A., Hobbs, Charlotte V., Zinter, Matt S., Cvijanovich, Natalie Z., Bline, Katherine E., Hymes, Saul R., Campbell, Angela P., and Randolph, Adrienne G.

Published
2024
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41. Effectiveness of Maternal Vaccination with mRNA COVID-19 Vaccine During Pregnancy Against COVID-19-Associated Hospitalization in Infants Aged <6 Months--17 States, July 2021-January 2022

Author

Halasa, Natasha B., Olson, Samantha M., Staat, Mary A., Newhams, Margaret M., Price, Ashley M., Boom, Julie A., Sahni, Leila C., Cameron, Melissa A., Pannaraj, Pia S., Bline, Katherine E., Bhumbra, Samina S., Bradford, Tamara T., Chiotos, Kathleen, Coates, Bria M., Cullimore, Melissa L., Cvijanovich, Natalie Z., Flori, Heidi R., Gertz, Shira J., Heidemann, Sabrina M., Hobbs, Charlotte V., Hume, Janet R., Irby, Katherine, Kamidani, Satoshi, Kong, Michele, Levy, Emily R., Mack, Elizabeth H., Maddux, Aline B., Michelson, Kelly N., Nofziger, Ryan A., Schuster, Jennifer E., Schwartz, Stephanie P., Smallcomb, Laura, Tarquinio, Keiko M., Walker, Tracie C., Zinter, Matt S., Gilboa, Suzanne M., Polen, Kara N., Campbell, Angela P., Randolph, Adrienne G., and Patel, Manish M.

Subjects
United States. National Institutes of Health, Vaccination, Breast feeding, Infants, Messenger RNA, Health, Children's Hospital (Boston, Massachusetts), Children's Hospital of Philadelphia
Abstract

On February 15, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). COVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to [...]

Published
2022

42. Effectiveness of BNT162b2 (Pfizer-BioNTech) mRNA Vaccination Against Multisystem Inflammatory Syndrome in Children Among Persons Aged 12-18 Years--United States, July-December 2021

Author

Zambrano, Laura D., Newhams, Margaret M., Olson, Samantha M., Halasa, Natasha B., Price, Ashley M., Boom, Julie A., Sahni, Leila C., Kamidani, Satoshi, Tarquinio, Keiko M., Maddux, Aline B., Heidemann, Sabrina M., Bhumbra, Samina S., Bline, Katherine E., Nofziger, Ryan A., Hobbs, Charlotte V., Bradford, Tamara T., Cvijanovich, Natalie Z., Irby, Katherine, Mack, Elizabeth H., Cullimore, Melissa L., Pannaraj, Pia S., Kong, Michele, Walker, Tracie C., Gertz, Shira J., Michelson, Kelly N., Cameron, Melissa A., Chiotos, Kathleen, Maamari, Mia, Schuster, Jennifer E., Orzel, Amber O., Patel, Manish M., Campbell, Angela P., and Randolph, Adrienne G.

Subjects
United States. Food and Drug Administration, United States. Centers for Disease Control and Prevention, Pfizer Inc., Vaccination, Messenger RNA, Infection, Health, Children's Hospital (Boston, Massachusetts), Children's Hospital of Philadelphia, Comirnaty (Vaccine)
Abstract

On January 7, 2022, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). Multisystem inflammatory syndrome in children (MIS-C) is a severe postinfectious hyperinflammatory condition, [...]

Published
2022

43. 880. Molecular Subtyping and Macrolide-Resistance Determination of Mycoplasma pneumoniae from Children Enrolled in New Vaccine Surveillance Network in the United States during 2015 to 2020

Author

Adhikari, Bishnu, primary, Harrison, Christopher J, additional, Lee, Brian R, additional, Schuster, Jennifer E, additional, Moffatt, Mary E, additional, Avadhanula, Vasanthi, additional, Sahni, Leila C, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Staat, Mary A, additional, McNeal, Monica, additional, Kobayashi, Miwako, additional, Diaz, Maureen H, additional, Perez, Ariana, additional, Curns, Aaron T, additional, Lu, Xiaoyan, additional, and Selvarangan, Rangaraj, additional

Published
2022
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44. 2167. Use and Timing of Antiviral Therapy for Influenza in Hospitalized U.S. Children, 2016–2020

Author

Amarin, Justin Z, primary, Stewart, Laura S, additional, Potter, Molly, additional, Spieker, Andrew J, additional, Chappell, James, additional, Williams, John, additional, Boom, Julie A, additional, Englund, Janet A, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Staat, Mary A, additional, Weinberg, Geoffrey A, additional, Klein, Eileen J, additional, Sahni, Leila C, additional, Munoz, Flor M, additional, Szilagyi, Peter G, additional, Harrison, Christopher J, additional, Campbell, Angela P, additional, Patel, Manish M, additional, and Halasa, Natasha B, additional

Published
2022
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45. 2196. Frequencies of Adenovirus Types in U.S. Children with Acute Respiratory Illness, 2016–2019

Author

Probst, Varvara, primary, Stopczynski, Tess, additional, Amarin, Justin Z, additional, Spieker, Andrew J, additional, Rahman, Herdi Kurnia, additional, Stewart, Laura S, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Michaels, Marian G, additional, Williams, John, additional, Boom, Julie A, additional, Sahni, Leila C, additional, Avadhanula, Vasanthi, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, McNeal, Monica, additional, Harrison, Christopher J, additional, Moffatt, Mary E, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Curns, Aaron T, additional, Perez, Ariana, additional, Clopper, Benjamin R, additional, Rha, Brian, additional, Gerber, Susan I, additional, Chappell, James, additional, and Halasa, Natasha B, additional

Published
2022
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46. Factors Associated With COVID-19 Non-vaccination in Adolescents Hospitalized Without COVID-19

Author

Sahni, Leila C, primary, Price, Ashley M, additional, Olson, Samantha M, additional, Newhams, Margaret M, additional, Pannaraj, Pia S, additional, Maddux, Aline B, additional, Halasa, Natasha B, additional, Bline, Katherine E, additional, Cameron, Melissa A, additional, Schwartz, Stephanie P, additional, Walker, Tracie C, additional, Irby, Katherine, additional, Chiotos, Kathleen, additional, Nofziger, Ryan A, additional, Mack, Elizabeth H, additional, Smallcomb, Laura, additional, Bradford, Tamara T, additional, Kamidani, Satoshi, additional, Tarquinio, Keiko M, additional, Cvijanovich, Natalie Z, additional, Schuster, Jennifer E, additional, Bhumbra, Samina S, additional, Levy, Emily R, additional, Hobbs, Charlotte V, additional, Cullimore, Melissa L, additional, Coates, Bria M, additional, Heidemann, Sabrina M, additional, Gertz, Shira J, additional, Kong, Michele, additional, Flori, Heidi R, additional, Staat, Mary A, additional, Zinter, Matt S, additional, Hume, Janet R, additional, Chatani, Brandon M, additional, Gaspers, Mary G, additional, Maamari, Mia, additional, Randolph, Adrienne G, additional, Patel, Manish M, additional, and Boom, Julie A, additional

Published
2022
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47. Enterovirus D68-Associated Acute Respiratory Illness--New Vaccine Surveillance Network, United States, July-November 2018-2020

Author

Shah, Melisa M., Perez, Ariana, Lively, Joana Y., Avadhanula, Vasanthi, Boom, Julie A., Chappell, James, Englund, Janet A., Fregoe, Wende, Halasa, Natasha B., Harrison, Christopher J., Hickey, Robert W., Klein, Eileen J., McNeal, Monica M., Michaels, Marian G., Moffatt, Mary E., Otten, Catherine, Sahni, Leila C., Schlaudecker, Elizabeth, Schuster, Jennifer E., Selvarangan, Rangaraj, Staat, Mary A., Stewart, Laura S., Weinberg, Geoffrey A., Williams, John V., Ng, Terry Fan Fei, Routh, Janell A., Gerber, Susan I., McMorrow, Meredith L., Rha, Brian, and Midgley, Claire M.

Subjects
Respiratory tract diseases, Vaccines, Health
Abstract

Enterovirus D68 (EV-D68) is associated with a broad spectrum of illnesses, including mild to severe acute respiratory illness (ARI) and acute flaccid myelitis (AFM). Enteroviruses, including EV-D68, are typically detected [...]

Published
2021

48. Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12-18 Years--United States, June-September 2021

Author

Olson, Samantha M., Newhams, Margaret M., Halasa, Natasha B., Price, Ashley M., Boom, Julie A., Sahni, Leila C., Irby, Katherine, Walker, Tracie C., Schwartz, Stephanie P., Pannaraj, Pia S., Maddux, Aline B., Bradford, Tamara T., Nofziger, Ryan A., Boutselis, Benjamin J., Cullimore, Melissa L., Mack, Elizabeth H., Schuster, Jennifer E., Gertz, Shira J., Cvijanovich, Natalie Z., Kong, Michele, Cameron, Melissa A., Staat, Mary A., Levy, Emily R., Chatani, Brandon M., Chiotos, Kathleen, Zambrano, Laura D., Campbell, Angela P., Patel, Manish M., and Randolph, Adrienne G.

Subjects
United States. Food and Drug Administration, Pfizer Inc., Vaccination, Messenger RNA, Hospital patients, Pharmaceutical industry, Health, Children's Hospital (New Orleans, Louisiana), Children's Hospital (Boston, Massachusetts)
Abstract

On October 19, 2021, this report was posted as an MMWR Early Release on the MMWR website (https:llwww.cdc.gov/mmwr). Pfizer-BioNTech COVID-19 vaccine is authorized for use in children and adolescents aged [...]

Published
2021

49. Effectiveness of Maternal mRNA COVID-19 Vaccination During Pregnancy Against COVID-19–Associated Hospitalizations in Infants Aged <6 Months During SARS-CoV-2 Omicron Predominance — 20 States, March 9, 2022–May 31, 2023.

Author

Simeone, Regina M., Zambrano, Laura D., Halasa, Natasha B., Fleming-Dutra, Katherine E., Newhams, Margaret M., Wu, Michael J., Orzel-Lockwood, Amber O., Kamidani, Satoshi, Pannaraj, Pia S., Irby, Katherine, Maddux, Aline B., Hobbs, Charlotte V., Cameron, Melissa A., Boom, Julie A., Sahni, Leila C., Kong, Michele, Nofziger, Ryan A., Schuster, Jennifer E., Crandall, Hillary, and Hume, Janet R.

Subjects
CORONAVIRUS diseases, VACCINATION, PREGNANCY, HOSPITAL care, INFANT care
Abstract

Infants aged <6 months are not eligible for COVID-19 vaccination. Vaccination during pregnancy has been associated with protection against infant COVID-19–related hospitalization. The Overcoming COVID-19 Network conducted a case-control study during March 9, 2022–May 31, 2023, to evaluate the effectiveness of maternal receipt of a COVID-19 vaccine dose (vaccine effectiveness [VE]) during pregnancy against COVID-19–related hospitalization in infants aged <6 months and a subset of infants aged <3 months. VE was calculated as (1 – adjusted odds ratio) x 100% among all infants aged <6 months and <3 months. Case-patients (infants hospitalized for COVID-19 outside of birth hospitalization and who had a positive SARS-CoV-2 test result) and control patients (infants hospitalized for COVID-19–like illness with a negative SARS-CoV-2 test result) were compared. Odds ratios were determined using multivariable logistic regression, comparing the odds of receipt of a maternal COVID-19 vaccine dose (completion of a 2-dose vaccination series or a third or higher dose) during pregnancy with maternal nonvaccination between case- and control patients. VE of maternal vaccination during pregnancy against COVID-19–related hospitalization was 35% (95% CI = 15%–51%) among infants aged <6 months and 54% (95% CI = 32%–68%) among infants aged <3 months. Intensive care unit admissions occurred in 23% of all case-patients, and invasive mechanical ventilation was more common among infants of unvaccinated (9%) compared with vaccinated mothers (1%) (p = 0.02). Maternal vaccination during pregnancy provides some protection against COVID-19–related hospitalizations among infants, particularly those aged <3 months. Expectant mothers should remain current with COVID-19 vaccination to protect themselves and their infants from hospitalization and severe outcomes associated with COVID-19. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Sustained Within-season Vaccine Effectiveness Against Influenza-associated Hospitalization in Children: Evidence From the New Vaccine Surveillance Network, 2015–2016 Through 2019–2020

Author

Sahni, Leila C, primary, Naioti, Eric A, additional, Olson, Samantha M, additional, Campbell, Angela P, additional, Michaels, Marian G, additional, Williams, John V, additional, Staat, Mary Allen, additional, Schlaudecker, Elizabeth P, additional, McNeal, Monica M, additional, Halasa, Natasha B, additional, Stewart, Laura S, additional, Chappell, James D, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Szilagyi, Peter G, additional, Weinberg, Geoffrey A, additional, Harrison, Christopher J, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Azimi, Parvin H, additional, Singer, Monica N, additional, Avadhanula, Vasanthi, additional, Piedra, Pedro A, additional, Munoz, Flor M, additional, Patel, Manish M, additional, and Boom, Julie A, additional

Published
2022
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