1. Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation
- Author
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Srinivas Pramod Junutula, Sai Geethika Reddy Padide, Sai Kiran Dubasi, Venkateshwarlu Eggadi, Gireesh Kumar Miryala, Sharvana Bhava Bandaru Sheshagiri, and Manasa Soumya Koppolu
- Subjects
Drug ,Olanzapine ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,media_common.quotation_subject ,therapeutic drug monitoring ,olanzapine ,Clinical correlation ,Drug Administration Schedule ,Young Adult ,Therapeutic index ,Rating scale ,Medicine ,Humans ,Pharmacology (medical) ,Intensive care medicine ,High-performance liquid chromatography and therapeutic range ,media_common ,Aged ,Pharmacology ,Psychiatric Status Rating Scales ,medicine.diagnostic_test ,business.industry ,Disease progression ,Middle Aged ,medicine.disease ,schizophrenia ,Therapeutic drug monitoring ,Schizophrenia ,Female ,Schizophrenic Psychology ,Drug Monitoring ,business ,medicine.drug ,Research Article ,Antipsychotic Agents - Abstract
AIM: The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically. SUBJECTS AND METHODS: The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression. RESULTS: Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range. CONCLUSION: Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.
- Published
- 2021