Search

Your search keyword '"Saibil, Fred"' showing total 178 results
Start Over Author "Saibil, Fred"
178 results on '"Saibil, Fred"'

1. Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn’s Disease

Author

Turpin, Williams, Espin-Garcia, Osvaldo, Bedrani, Larbi, Madsen, Karen, Meddings, Jonathan B, Raygoza Garay, Juan Antonio, Silverberg, Mark S, Smith, Michelle I, Griffiths, Anne M, Moayyedi, Paul, Marshall, John K, Mack, David, Seidman, Ernest G, Ropeleski, Mark, Feagan, Brian G, Jacobson, Kevan, Turner, Dan, Walters, Thomas, Paterson, Andrew D, Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O, Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hilary, Surette, Michael, Turner, Dan, Walters, Tom, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Cvitkovitch, Dennis, Otley, Anthony, Panancionne, Remo, Bernstein, Charles, Deslandres, Colette, Leddin, Desmond, Daly, Donald, Saibil, Fred, Aumais, Guy, Huynh, Hein, Brill, Herbert, Steinhart, Hillary, Wrobel, Iwona, Critch, Jeff, Hyams, Jeff, Jones, Jennifer, McGrath, Jerry, Dieleman, Leo, Cino, Maria, Dirks, Martha, Leleiko, Neal, Pare, Pierre, Panancionne, Remo, Silverberg, Mark S, Griffiths, Anne M, Marshall, John K, Mack, David, Seidman, Ernest G, Ropeleski, Mark, Feagan, Brian G, Jacobson, Kevan, Walters, Thomas, Xu, Wei, and Croitoru, Kenneth

Published
2019
Full Text
View/download PDF

5. The Impact of Magnetic Resonance Enterography and Capsule Endoscopy on the Re-classification of Disease in Patients with Known Crohn’s Disease: A Prospective Israeli IBD Research Nucleus (IIRN) Study

Author

Greener, Tomer, Klang, Eyal, Yablecovitch, Doron, Lahat, Adi, Neuman, Sandra, Levhar, Nina, Avidan, Benjamin, Yanai, Henit, Dotan, Iris, Chowers, Yehuda, Weiss, Batya, Saibil, Fred, Amitai, Marianne M., Ben-Horin, Shomron, Kopylov, Uri, and Eliakim, Rami

Published
2016
Full Text
View/download PDF

7. Folic acid for the prevention of colorectal adenomas

Author

Cole, Bernard F., Baron, John A., Sandler, Robert S., Haile, Robert W., Ahnen, Dennis J., Bresalier, Robert S., McKeown-Eyssen, Gail, Summers, Robert W., Rothstein, Richard I., Burke, Carol A., Snover, Dale C., Church, Timothy R., Allen, John I., Robertson, Douglas J., Beck, John H., Byers, Tim, Mandel, Jack S., Mott, Leila A., Pearson, Loretta H., Barry, Elizabeth L., Rees, Judy R., Marcon, Norman, Saibil, Fred, Ueland, Per Magne, and Greenberg, E.Robert

Subjects
Folic acid -- Health aspects, Colorectal cancer -- Prevention, Colorectal cancer -- Risk factors
Abstract

A clinical trial carried out to observe the safety and efficiency of folic acid supplements to prevent colorectal adenomas is presented. Its result states that it does not reduce the risk but increase the risk of having colorectal adenomas.

Published
2007

9. A randomized trial of aspirin to prevent colorectal adenomas

Author

Baron, John A., Cole, Bernard F., Sandler, Robert S., Haile, Robert W., Ahnen, Dennis, Bresalier, Robert, McKeown-Eyssen, Gail, Summers, Robert W., Rothstein, Richard, Burke, Carol A., Snover, Dale C., Church, Timothy R., Allen, John I., Beach, Michael, Beck, Gerald J., Bond, John H., Byers, Tim, Greenberg, E. Robert, Mandel, Jack S., Marcon, Norman, Mott, Leila A., Pearson, Loretta, Saibil, Fred, and Stolk, Rosalind U. van

Subjects
Colorectal cancer -- Prevention, Aspirin -- Evaluation
Abstract

Low-doses of aspirin may prevent colorectal cancer from getting worse, according to a study of 1,121 patients who had recently been diagnosed with colorectal tumors. The progression of the cancer was slower in patients who took 81 milligrams of aspirin, compared to the patients who took 325 milligrams of aspirin or a placebo.

Published
2003

10. Screening and Treatment Outcomes in Adults and Children with Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study

Author

Mahmud, Farid H., primary, Clarke, Antoine B.M., primary, Joachim, Kariym C., primary, Assor, Esther, primary, McDonald, Charlotte, primary, Saibil, Fred, primary, Lochnan, Heather A., primary, Punthakee, Zubin, primary, Parikh, Amish, primary, Advani, Andrew, primary, Shah, Baiju R., primary, Perkins, Bruce A., primary, Zuijdwijk, Caroline S., primary, Mack, David R., primary, Koltin, Dror, primary, Melo, Emilia N. De, primary, Hsieh, Eugene, primary, Mukerji, Geetha, primary, Gilbert, Jeremy, primary, Bax, Kevin, primary, Lawson, Margaret L., primary, Cino, Maria, primary, Beaton, Melanie D., primary, Saloojee, Navaaz A., primary, Lou, Olivia, primary, Gallego, Patricia H., primary, Bercik, Permysl, primary, Houlden, Robyn L., primary, Aronson, Ronnie, primary, Kirsch, Susan E., primary, Paterson, William G., primary, and Marcon, Margaret A., primary

Published
2020
Full Text
View/download PDF

16. Low-dose cyclosporine for the treatment of Crohn's disease

Author

Feagan, Brian G., McDonald, John W.D., Rochon, James, Laupacis, Andreas, Fedorak, Richard N., Kinnear, Douglas, Saibil, Fred, Groll, Aubrey, Archambault, Andre, Gillies, Richard, Valberg, Barbara, and Irvine, E. Jan

Subjects
Cyclosporine -- Evaluation, Crohn's disease -- Drug therapy
Abstract

Low-dose cyclosporine in addition to other treatments for Crohn's disease appears not to improve symptoms or prevent the need for other forms of therapy. Cyclosporine is an immunosuppressive drug. Crohn's disease is an inflammatory bowel disease. A total of 305 patients with Crohn's disease were studied for signs of disease improvement when treated with cyclosporine in addition to their regular therapy. One hundred fifty-one received cyclosporine therapy and 154 received placebo. More than 60% (91) of those in the cyclosporine group had symptoms that worsened in comparison to 52% (80) in the placebo group. Symptoms worsened within a median of 338 days in the cyclosporine group and a median of 492 days in the placebo group. Withdrawals from treatment due to adverse reactions were more frequent in the cyclosporine group than the placebo group, accounting for 14.6% and 3.2% of patients respectively.

Published
1994

19. Impact of a Gluten-Free Diet on Quality of Life and Health Perception in Patients With Type 1 Diabetes and Asymptomatic Celiac Disease.

Author

Weiman, Daniel I., Mahmud, Farid H., Clarke, Antoine B. M., Assor, Esther, McDonald, Charlotte, Saibil, Fred, Lochnan, Heather A., Punthakee, Zubin, Marcon, Margaret A., and CD-DIET Study Group

Subjects
TYPE 1 diabetes, CELIAC disease, GLUTEN-free diet, KETOACIDOSIS, OVERWEIGHT children, QUALITY of life, MEDICAL research, NURSING home residents, BLOOD sugar analysis, RESEARCH, RESEARCH methodology, SENSORY perception, PROGNOSIS, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, PATIENT compliance, LONGITUDINAL method
Abstract

Context: Celiac disease (CD) is a common comorbidity seen in patients with type 1 diabetes (T1D) and is frequently asymptomatic. As chronic conditions requiring significant lifestyle changes, there are limited reports assessing changes in health-related quality of life (HRQoL) during transition to a gluten-free diet (GFD) in patients with T1D who are asymptomatic for CD.Objective: This work aims to prospectively assess HRQoL and health perception in children and adults with T1D and asymptomatic CD after random assignment to GFD vs usual diet.Methods: Patients with T1D aged 8 to 45 years without CD symptoms were serologically screened for CD, with positive results confirmed with intestinal biopsy. Participants were randomly assigned in an open-label fashion to a GFD or gluten-containing diet (GCD) for 12 months. Generic and diabetes-specific HRQoL and self-perceived wellness (SPW) were assessed longitudinally.Results: A total of 2387 T1D patients were serologically screened. CD was biopsy-confirmed in 82 patients and 51 participants were randomly assigned to a GFD (N = 27) or GCD (N = 24). Excellent adherence to the assigned diets was observed. Overall, no changes in generic (P = .73) or diabetes-specific HRQoL (P = .30), or SPW (P = .41) were observed between groups over 12 months. Hemoglobin A1c (HbA1c) and gastrointestinal symptoms were consistent predictors of HRQoL and SPW.Conclusion: HRQoL and SPW were not significantly affected by the adoption of a GFD over 12 months, but worsened with symptom onset and increased HbA1c. Our findings indicate that transition to a GFD can be made successfully in this population without adversely affecting quality of life. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

20. Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study.

Author

Mahmud, Farid H., Clarke, Antoine B.M., Joachim, Kariym C., Assor, Esther, McDonald, Charlotte, Saibil, Fred, Lochnan, Heather A., Punthakee, Zubin, Parikh, Amish, Advani, Andrew, Shah, Baiju R., Perkins, Bruce A., Zuijdwijk, Caroline S., Mack, David R., Koltin, Dror, De Melo, Emilia N., Hsieh, Eugene, Mukerji, Geetha, Gilbert, Jeremy, and Bax, Kevin

Subjects
TYPE 1 diabetes, CELIAC disease, TREATMENT effectiveness, GLUTEN-free diet, CELIAC disease diagnosis, BLOOD sugar analysis, CELIAC disease complications, AUTOANTIBODY analysis, AUTOANTIBODIES, RESEARCH, BIOPSY, BLOOD sugar monitoring, SERODIAGNOSIS, RESEARCH methodology, MEDICAL screening, INGESTION, BLOOD sugar, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, SYMPTOMS, DISEASE complications
Abstract

Objective: To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.Research Design and Methods: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring over 12 months.Results: Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%, N = 1,298] vs. 4.7% [95% CI 3.4-5.9%, N = 1,089], P = 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%, P < 0.0001). Fifty-one participants were randomized to a GFD (N = 27) or GCD (N = 24). No HbA1c differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI -0.79 to 1.08; P = 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4-2.7; P = 0.014) emerged with a GFD.Conclusions: CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

21. Diagnostic Accuracy of Serologic Screening Tests for Celiac Disease in Asymptomatic Adults and Children with Type 1 Diabetes

Author

GOULD, MICHELLE, primary, MAHMUD, FARID H., additional, CLARKE, ANTOINE B., additional, ASSOR, ESTHER, additional, PARIKH, AMISH, additional, ADVANI, ANDREW, additional, PERKINS, BRUCE A., additional, SHAH, BAIJU R., additional, ZUIJDWIJK, CAROLINE S., additional, MCDONALD, CHARLOTTE, additional, MACK, DAVID, additional, KOLTIN, DROR, additional, HSIEH, EUGENE, additional, SZENTGYORGYI, EVA M., additional, SAIBIL, FRED, additional, MUKERJI, GEETHA, additional, LOCHNAN, HEATHER A., additional, GILBERT, JEREMY, additional, BAX, KEVIN, additional, LAWSON, MARGARET L., additional, BEATON, MELANIE D., additional, SALOOJEE, NAV A., additional, LOU, OLIVIA, additional, GALLEGO, PATRICIA H., additional, HOULDEN, ROBYN L., additional, ARONSON, RONNIE, additional, KIRSCH, SUSAN E., additional, PATERSON, WILLIAM G., additional, PUNTHAKEE, ZUBIN, additional, and MARCON, MARGARET A., additional

Published
2018
Full Text
View/download PDF

22. Higher Rates of Celiac Disease Serology and Biopsy Positivity in Adults with Type 1 Diabetes

Author

MAHMUD, FARID H., primary, CLARKE, ANTOINE B., additional, JOACHIM, KARIYM C., additional, ASSOR, ESTHER, additional, PARIKH, AMISH, additional, ADVANI, ANDREW, additional, PERKINS, BRUCE A., additional, SHAH, BAIJU R., additional, ZUIJDWIJK, CAROLINE S., additional, MCDONALD, CHARLOTTE, additional, MACK, DAVID, additional, KOLTIN, DROR, additional, HSIEH, EUGENE, additional, SZENTGYORGYI, EVA M., additional, SAIBIL, FRED, additional, MUKERJI, GEETHA, additional, LOCHNAN, HEATHER A., additional, GILBERT, JEREMY, additional, BAX, KEVIN, additional, LAWSON, MARGARET L., additional, BEATON, MELANIE D., additional, SALOOJEE, NAV A., additional, LOU, OLIVIA, additional, GALLEGO, PATRICIA H., additional, HOULDEN, ROBYN L., additional, ARONSON, RONNIE, additional, KIRSCH, SUSAN E., additional, PATERSON, WILLIAM G., additional, PUNTHAKEE, ZUBIN, additional, and MARCON, MARGARET A., additional

Published
2018
Full Text
View/download PDF

23. Frequency, Severity, and Associations of Gastrointestinal Symptoms in Adults and Children with Type 1 Diabetes

Author

MAHMUD, FARID H., primary, DE MELO, EMILIA NUNES, additional, CLARKE, ANTOINE B., additional, ASSOR, ESTHER, additional, PARIKH, AMISH, additional, ADVANI, ANDREW, additional, PERKINS, BRUCE A., additional, SHAH, BAIJU R., additional, ZUIJDWIJK, CAROLINE S., additional, MCDONALD, CHARLOTTE, additional, MACK, DAVID, additional, KOLTIN, DROR, additional, HSIEH, EUGENE, additional, SZENTGYORGYI, EVA M., additional, SAIBIL, FRED, additional, MUKERJI, GEETHA, additional, LOCHNAN, HEATHER A., additional, GILBERT, JEREMY, additional, BAX, KEVIN, additional, LAWSON, MARGARET L., additional, BEATON, MELANIE D., additional, SALOOJEE, NAV A., additional, LOU, OLIVIA, additional, GALLEGO, PATRICIA H., additional, HOULDEN, ROBYN L., additional, ARONSON, RONNIE, additional, KIRSCH, SUSAN E., additional, PATERSON, WILLIAM G., additional, PUNTHAKEE, ZUBIN, additional, and MARCON, MARGARET A., additional

Published
2018
Full Text
View/download PDF

29. Methotrexate in Combination With Infliximab Is No More Effective Than Infliximab Alone in Patients With Crohn's Disease

Author

Feagan, Brian G., primary, McDonald, John W.D., additional, Panaccione, Remo, additional, Enns, Robert A., additional, Bernstein, Charles N., additional, Ponich, Terry P., additional, Bourdages, Raymond, additional, MacIntosh, Donald G., additional, Dallaire, Chrystian, additional, Cohen, Albert, additional, Fedorak, Richard N., additional, Paré, Pierre, additional, Bitton, Alain, additional, Saibil, Fred, additional, Anderson, Frank, additional, Donner, Allan, additional, Wong, Cindy J., additional, Zou, Guangyong, additional, Vandervoort, Margaret K., additional, Hopkins, Marybeth, additional, and Greenberg, Gordon R., additional

Published
2014
Full Text
View/download PDF

33. How Well IsHelicobacter pyloriTreated in Usual Practice?

Author

Yogeswaran, Kumaresan, primary, Chen, Grant, additional, Cohen, Lawrence, additional, Cooper, Mary Anne, additional, Yong, Elaine, additional, Hsieh, Eugene, additional, Rowsell, Corwyn, additional, Saibil, Fred, additional, and Tinmouth, Jill, additional

Published
2011
Full Text
View/download PDF

35. S1051 Methotrexate for the Prevention of Antibodies to Infliximab in Patients With Crohn's Disease

Author

Feagan, Brian G., primary, McDonald, John W., additional, Panaccione, Remo, additional, Enns, Robert A., additional, Bernstein, Charles N., additional, Ponich, Terry P., additional, Bourdages, Raymond, additional, MacIntosh, Donald G., additional, Dallaire, Chrystian, additional, Cohen, Albert, additional, Fedorak, Richard N., additional, Pare, Pierre, additional, Bitton, Alain, additional, Saibil, Fred, additional, Anderson, Frank, additional, Donner, Allan, additional, Wong, Cindy J., additional, Zou, Guang Yong, additional, Vandervoort, Margaret K., additional, Hopkins, Marybeth, additional, and Greenberg, Gordon R., additional

Published
2010
Full Text
View/download PDF

36. Cyclooxygenase-2 Polymorphisms, Aspirin Treatment, and Risk for Colorectal Adenoma Recurrence—Data from a Randomized Clinical Trial

Author

Barry, Elizabeth L., primary, Sansbury, Leah B., additional, Grau, Maria V., additional, Ali, Iqbal U., additional, Tsang, Shirley, additional, Munroe, David J., additional, Ahnen, Dennis J., additional, Sandler, Robert S., additional, Saibil, Fred, additional, Gui, Jiang, additional, Bresalier, Robert S., additional, McKeown-Eyssen, Gail E., additional, Burke, Carol, additional, and Baron, John A., additional

Published
2009
Full Text
View/download PDF

37. How Well Is Heliobacter pylori Treated?

Author

Yogeswaran, Kumaresan, primary, Chen, Grant, additional, Cohen, Lawrence, additional, Cooper, Mary Anne, additional, Yong, Elaine, additional, Hsieh, Eugene, additional, Rowsell, Corwyn, additional, Saibil, Fred, additional, and Tinmouth, Jill, additional

Published
2008
Full Text
View/download PDF

38. MTHFR Genotype and Colorectal Adenoma Recurrence: Data from a Double-blind Placebo-controlled Clinical Trial

Author

Levine, A. Joan, primary, Wallace, Kristin, additional, Tsang, Shirley, additional, Haile, Robert W., additional, Saibil, Fred, additional, Ahnen, Dennis, additional, Cole, Bernard F., additional, Barry, Elizabeth L., additional, Munroe, David J., additional, Ali, Iqbal U., additional, Ueland, Per, additional, and Baron, John A., additional

Published
2008
Full Text
View/download PDF

39. A Randomized Trial of Methotrexate in Combination With Infliximab for the Treatment of Crohn's Disease

Author

Feagan, Brian, primary, McDonald, John W., additional, Panaccione, Remo, additional, Enns, Robert A., additional, Bernstein, Charles N., additional, Ponich, Terry P., additional, Bourdages, Raymond, additional, MacIntosh, Donald G., additional, Dallaire, Chrystian, additional, Cohen, Albert, additional, Fedorak, Richard, additional, Pare, Pierre, additional, Bitton, Alain, additional, Saibil, Fred, additional, Anderson, Frank, additional, Donner, Allan, additional, Wong, Cindy J., additional, Zou, Guang Yong, additional, Vandervoort, Margaret, additional, Hopkins, Marybeth, additional, and Greenberg, Gordon R., additional

Published
2008
Full Text
View/download PDF

42. The Celiac Disease and Diabetes- Dietary Intervention and Evaluation Trial (CD-DIET) protocol: a randomised controlled study to evaluate treatment of asymptomatic coeliac disease in type 1 diabetes.

Author

Mahmud, Farid H., De Melo, Emilia N., Noordin, Karima, Assor, Esther, Sahota, Kamaljeet, Davies-Shaw, Jolie, Cutz, Ernest, Somers, Gino, Lawson, Margaret, Mack, David R., Gallego, Patricia, McDonald, Charlotte, Beaton, Melanie D., Bax, Kevin, Saibil, Fred, Gilbert, Jeremy, Kirsch, Susan, Perkins, Bruce A., Cino, Maria, and Szentgyorgyi, Eva

Abstract

Introduction: Coeliac disease (CD) is an autoimmune condition characterised by gluten-induced intestinal inflammation, and observed at a 5-10 fold greater prevalence in type 1 diabetes. While universal screening for CD in patients with diabetes is frequently advocated, objective data is limited as to benefits on diabetes control, bone health or quality of life related to the adoption of a gluten-free diet (GFD) in the large proportion of patients with diabetes with asymptomatic CD. The Celiac Disease and Diabetes-Dietary Intervention and Evaluation Trial (CD-DIET) study is a multicenter, randomised controlled trial to evaluate the efficacy and safety of a GFD in patients with type 1 diabetes with asymptomatic CD. Methods and analysis: Children and adults (8-45 years) with type 1 diabetes will be screened for asymptomatic CD. Eligible patients with biopsy-proven CD will be randomly assigned in a 1:1 ratio to treatment with a GFD for 1 year, or continue with a gluten-containing diet. The primary outcome will evaluate the impact of the GFD on change in glycated haemoglobin. Secondary outcomes will evaluate changes in bone mineral density, blood glucose variability and health-related quality of life between GFD-treated and the regular diet group over a 1-year period. The study was initiated in 2012 and has subsequently expanded to multiple paediatric and adult centres in Ontario, Canada. Ethics and dissemination: The findings from this study will provide high-quality evidence as to the impact of GFD treatment on glycaemic control and complications in asymptomatic children and adults with CD and type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

44. A Randomized Trial of Aspirin to Prevent Colorectal Adenomas

Author

Baron, John A., primary, Cole, Bernard F., additional, Sandler, Robert S., additional, Haile, Robert W., additional, Ahnen, Dennis, additional, Bresalier, Robert, additional, McKeown-Eyssen, Gail, additional, Summers, Robert W., additional, Rothstein, Richard, additional, Burke, Carol A., additional, Snover, Dale C., additional, Church, Timothy,/FN> R., additional, Allen, John I., additional, Beach, Michael, additional, Beck, Gerald J., additional, Bond, John H., additional, Byers, Tim, additional, Greenberg, E. Robert, additional, Mandel, Jack S., additional, Marcon, Norman, additional, Mott, Leila A., additional, Pearson, Loretta, additional, Saibil, Fred, additional, and van Stolk, Rosalind U., additional

Published
2003
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results