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3. Development of Dry Powder Inhaler Containing Prothionamide-PLGA Nanoparticles Optimized Through Statistical Design: In-vivo Study

Author

Saisivam Srinivasan, Monalisha Debnath, and Sujit Kumar Debnath

Subjects
Materials science, Statistical design, Nanotechnology, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Box–Behnken design, Dry-powder inhaler, 0104 chemical sciences, Plga nanoparticles, 010404 medicinal & biomolecular chemistry, PLGA, chemistry.chemical_compound, chemistry, In vivo, Prothionamide, medicine, 0210 nano-technology, Biomedical engineering, medicine.drug
Abstract

Objective:The objective of the present work was to formulate Prothionamide (PTH) nanoparticles using Poly lactic co-glycolic acid (PLGA), optimized by Box-Behnken Design and further modification to dry powder inhaler followed byin-vivostudy.Methods:Poly-lactic co-gycolic acid (PLGA), a biodegradable polymer was used to coat Prothionamide by solvent evaporation technique. Formulation was optimized using Box-Behnken Design. Response surface curve and desirability factors helped in the selection of optimum formulation of PTH nanoparticles. Dry powder inhaler was prepared by adding inhalable grade lactose to optimize PTH nanoparticles. Mass median aerodynamic diameter (MMAD) was carried out using Andersen Cascade Impactor (ACI) to demonstrate its suitability in the pulmonary administration.In-vitrodrug release of dry powder inhaler was carried out in simulated lungs fluid. Correlationin-vitrotoin-vivowas established after performing animal experiment.Results:FTIR study reveals no chemical interaction between PTH, lactose and PLGA as the principle peaks was retained with same intensity in the physical mixture. Scanning electron microscope showed the spherical shape and aerodynamic particle size was found to be 1.69µm. Drug release study showed initial burst release followed by zero order release.In-vivomodel confirmed the presence of PTH after 24h. Aerodynamic particle size and the release profile revealed the suitability of PTH loaded nanoparticles containing dry powder inhaler for the pulmonary administration.Conclusion:Prepared DPI containing PTH nanoparticles can improve in the management of tuberculosis by increasing PTH residency in the lungs tissue for prolong period of time.

Published
2017

6. FLOATING MATRIX TABLET OF LOSARTAN POTASSIUM BY USING HYDROPHILIC SWELLING POLYMER AND NATURAL GUM.

Author

ULLA, Mohamed Rahamath and SAISIVAM, Srinivasan

Subjects
*LOSARTAN, *DRUG tablets, *BIOAVAILABILITY, *BIOGEOCHEMICAL residence time, *SODIUM bicarbonate, *GAS compressors
Abstract

The main purpose of this study was to prepare the losarían potassium controlled release floating tablets by using effervescent technique to extent the gastric residence time and enhance its bioavailability. The floating matrix tablets were prepared by using different proportion of polymers such as hydroxypropylmethylcellulose, karaya gum and sodium bicarbonate used as gas generating agent, by direct compression technique. Before compression the particulate matter of the series of formulations were evaluated for various micromeritic properties. The prepared floating tablets were evaluated for weight uniformity, drug content uniformity, friability, hardness, floating characteristics such as floating lag time, total floating time, water uptake studies, compatibility studies of drug with polymers and in vitro drug release. The mathematical models were also used to investigate the principle release mechanism of drug release. The results showed that all prepared floating tablet were have excellent swelling, floating capabilities with short floating lag time within 100 seconds and maintain controlled release up to 12 hours. [ABSTRACT FROM AUTHOR]

Published
2013

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