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3. P523 Effectiveness of biological treatments for inflammatory bowel disease in the elderly patients

Author

Suarez Ferrer, C J, primary, Mesonero, F, additional, Caballol, B, additional, Ballester, M P, additional, Baston Rey, I, additional, Castaño Garcia, A, additional, Miranda Bautista, J, additional, Saiz Chumillas, R, additional, Benitez, J M, additional, Sanchez Delgado, L, additional, Lopez-Garcia, A, additional, Rubin de Celix, C, additional, Martin-Arranz, M D, additional, Lopez Sanroman, A, additional, Fernandez-Clotet, A, additional, Merino Murgui, V, additional, Calviño Suarez, C, additional, Florez, P, additional, Lobato Matilla, M E, additional, Sicilia, B, additional, Soto Escribano, P, additional, Maroto Martin, C, additional, Alonso Abreu, I, additional, Melcarne, L, additional, Elena, P G, additional, Iyo, E, additional, Elosua Gonzalez, A, additional, Saiz, E, additional, Hernandez Villalba, L, additional, Perez Galindo, P, additional, Torrealba Medina, L, additional, Monsalve Alonso, S, additional, Olmos Jerez, J A, additional, Dueñas Sadornil, C, additional, and Barreiro-De Acosta, M, additional

Published
2022
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4. P122 Low Risk of new dysplastic lesions during inflammatory bowel disease surveillance with dye-cromoendoscopy: a multicenter population-based retrospective study

Author

Saiz Chumillas, R M, primary, Alba, L, additional, Gonzalez-Lama, Y, additional, Velayos, B, additional, Suarez, P, additional, Maroto-Martin, C, additional, Nuñez, A, additional, Hernandez, L, additional, Relea, L, additional, Fernandez-Salazar, L, additional, Sierra-Ausin, M, additional, Barrio, J, additional, Muñoz, F, additional, Arias, L, additional, and Sicilia, B, additional

Published
2022
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5. P410 Safety of biological drugs for inflammatory bowel disease in elderly patients

Author

Suarez Ferrer, C J, primary, Mesonero, F, additional, Caballol, B, additional, Ballester, M P, additional, Baston Rey, I, additional, Castaño Garcia, A, additional, Miranda Bautista, J, additional, Saiz Chumillas, R, additional, Benitez, J M, additional, Sanchez Delgado, L, additional, Lopez-Garcia, A, additional, Rubin de Celix, C, additional, Lopez Sanroma, A, additional, Martin-Arranz, M D, additional, Fernández-Clotet, A, additional, Merino Murgui, V, additional, Calviño Suárez, C, additional, Florez, P, additional, Lobato matilla, M E, additional, Sicilia, B, additional, Soto Escribano, P, additional, Maroto Martin, C, additional, Alonso Abreu, I, additional, Melcarne, L, additional, Plaza Santos, R, additional, Marques Cami, M, additional, Caballero Mateos, A, additional, Gómez Díez, C, additional, Calafat, M, additional, Alonso Galan, H, additional, Vega Villaamil, P, additional, Castro Senosiain, B, additional, Guerro Moya, A, additional, Rodriguez Diaz, C Y, additional, Spicakova, K, additional, Manceñido Marcos, N, additional, Molina, G, additional, De Castro, L, additional, Mañosa Ciria, M, additional, and Barreiro-De Acosta, M, additional

Published
2022
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6. P481 Profile of elderly patients in which biological drugs are used for the treatment of inflammatory bowel disease

Author

Suarez Ferrer, C J, primary, Mesonero, F, additional, Caballol, B, additional, Ballester, M P, additional, Baston Rey, I, additional, Castaño Garcia, A, additional, Miranda Bautista, J, additional, Saiz Chumillas, R, additional, Benitez, J M, additional, Sanchez Delgado, L, additional, Lopez-Garcia, A, additional, Rubin de Celio, C, additional, Alonso Abreu, I, additional, Melcarne, L, additional, Plaza Santos, R, additional, Marques Cami, M, additional, Caballero Mateos, A, additional, Gomez Diez, C, additional, Calafat, M, additional, Alonso Galan, H, additional, Vega Vilaamil, P, additional, Castro Sensosian, B, additional, Guerro Moya, A, additional, Rodriguez Diaz, C Y, additional, Spicakova, K, additional, Manceñido Marcos, N, additional, Molina, G, additional, De Castro, L, additional, Rodriguez Angulo, A, additional, Cuevas del Campo, L, additional, Rodriguez Grau, M C, additional, Ramirez, F, additional, Gomez Pastrana, B, additional, Gonzalez Partida, I, additional, Botella Mateu, B, additional, Peña Gonzalez, E, additional, Iyo, E, additional, Elosua Gonzalez, A, additional, Mañosa Ciria, M, additional, and Barreiro-De Acosta, M, additional

Published
2022
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7. P338 effectiveness and safety of biological therapies in elderly inflammatory bowel diseases patients results from a multi center study of Geteccu

Author

Suarez Ferrer, C J, primary, Mesonero, F, additional, Caballol, B, additional, Saiz Chumillas, R, additional, Bastón-Rey, I, additional, Rubin de Celix, C, additional, Melcarne, L, additional, Caballero Mateos, A, additional, Calafat, M, additional, Alonso Galan, H, additional, Vega Villaamil, P, additional, Castro Senosiain, B, additional, Rodriguez Diaz, C Y, additional, Plaza Santos, R, additional, Marques Cami, M, additional, Rodriguez Grau, M C, additional, Ramirez, F, additional, Lopez-García, A, additional, Gomez Pastrana, B, additional, Gonzalez Partida, I, additional, Botella Mateu, B, additional, Cuevas del Campo, L, additional, Gonzalez Peña, E, additional, Iyo, E, additional, Elosua Gonzalez, A, additional, Sainz, E, additional, Hernandez, L, additional, Perez Galindo, P, additional, Rueda Garcia, J L, additional, Martin-Arranz, M D, additional, Lopez Sanroman, A, additional, Fernandez-Clotet, A, additional, Sicilia, B, additional, Calviño Suárez, C, additional, Mañosa Ciria, M, additional, and Barreiro-De Acosta, M, additional

Published
2021
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9. Effectiveness of biological treatments for inflammatory bowel disease in the elderly patients

Author

Suarez Ferrer, C. J., Mesonero, F., Caballol, B., Maria Pilar Ballester, Baston Rey, I., Castano Garcia, A., Miranda Bautista, J., Saiz Chumillas, R., Benitez, J. M., Sanchez Delgado, L., Lopez-Garcia, A., Rubin Celix, C., Martin-Arranz, M. D., Lopez Sanroman, A., Fernandez-Clotet, A., Merino Murgui, V., Calvino Suarez, C., Florez, P., Lobato Matilla, M. E., Sicilia, B., Soto Escribano, P., Maroto Martin, C., Alonso Abreu, I., Melcarne, L., Elena, P. G., Iyo, E., Elosua Gonzalez, A., Saiz, E., Hernandez Villalba, L., Perez Galindo, P., Torrealba Medina, L., Monsalve Alonso, S., Olmos Jerez, J. A., Duenas Sadornil, C., and Barreiro-De Acosta, M.

10. Profile of elderly patients in which biological drugs are used for the treatment of inflammatory bowel disease

Author

Suarez Ferrer, C. J., Mesonero, F., Caballol, B., Maria Pilar Ballester, Baston Rey, I., Castano Garcia, A., Miranda Bautista, J., Saiz Chumillas, R., Benitez, J. M., Sanchez Delgado, L., Lopez-Garcia, A., Rubin Celio, C., Alonso Abreu, I., Melcarne, L., Plaza Santos, R., Marques Cami, M., Caballero Mateos, A., Gomez Diez, C., Calafat, M., Alonso Galan, H., Vega Vilaamil, P., Castro Sensosian, B., Guerro Moya, A., Rodriguez Diaz, C. Y., Spicakova, K., Mancenido Marcos, N., Molina, G., Castro, L., Rodriguez Angulo, A., Cuevas Del Campo, L., Rodriguez Grau, M. C., Ramirez, F., Gomez Pastrana, B., Gonzalez Partida, I., Botella Mateu, B., Pena Gonzalez, E., Iyo, E., Elosua Gonzalez, A., Manosa Ciria, M., and Barreiro-De Acosta, M.

11. Efficacy and safety of biological treatment for inflammatory bowel disease in elderly patients: Results from a GETECCU cohort.

Author

Suárez Ferrer C, Mesonero Gismero F, Caballol B, Ballester MP, Bastón Rey I, Castaño García A, Miranda Bautista J, Saiz Chumillas R, Benitez JM, Sanchez-Delgado L, López-García A, Rubin de Celix C, Alonso Abreu I, Melcarne L, Plaza Santos R, Marques-Camí M, Caballero Mateos A, Gómez Díez C, Calafat M, Galan HA, Vega Vilaamil P, Castro Senosiain B, Guerro Moya A, Rodriguez Diaz CY, Spicakova K, Manceñido Marcos N, Molina G, de Castro Parga L, Rodriguez Angulo A, Cuevas Del Campo L, Rodriguez Grau MDC, Ramirez F, Gomez Pastrana B, Gonzalez Partida I, Botella Mateu B, Peña Gonzalez E, Iyo E, Elosua Gonzalez A, Sainz Arnau E, Hernandez Villalba L, Perez Galindo P, Torrealba Medina L, Monsalve Alonso S, Olmos Perez JA, Dueñas Sadornil C, Garcia Ramirez L, Martín-Arranz MD, López Sanroman A, Fernández A, Merino Murgui V, Calviño Suárez C, Flórez-Diez P, Lobato Matilla ME, Sicilia B, Soto Escribano P, Maroto Martin C, Mañosa M, and Barreiro-De Acosta M

Subjects
Humans, Aged, Male, Female, Retrospective Studies, Treatment Outcome, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal adverse effects, Aged, 80 and over, Adalimumab therapeutic use, Adalimumab adverse effects, Ustekinumab therapeutic use, Ustekinumab adverse effects, Antibodies, Monoclonal, Humanized therapeutic use, Antibodies, Monoclonal, Humanized adverse effects, Biological Therapy adverse effects, Remission Induction, Inflammatory Bowel Diseases drug therapy
Abstract

Introduction: Biological therapies used for the treatment of inflammatory bowel disease (IBD) have shown to be effective and safe, although these results were obtained from studies involving mostly a young population, who are generally included in clinical trials. The aim of our study was to determine the efficacy and safety of the different biological treatments in the elderly population., Methods: Multicenter study was carried out in the GETECCU group. Patients diagnosed with IBD and aged over 65 years at the time of initiating biological therapy (infliximab, adalimumab, golimumab, ustekinumab or vedolizumab) were retrospectively included. Among the patients included, clinical response was assessed after drug induction (12 weeks of treatment) and at 52 weeks. Patients' colonoscopy data in week 52 were assessment, where available. Regarding complications, development of oncological events during follow-up and infectious processes occurring during biological treatment were collected (excluding bowel infection by cytomegalovirus)., Results: A total of 1090 patients were included. After induction, at approximately 12-14 weeks of treatment, 419 patients (39.6%) were in clinical remission, 502 patients (47.4%) had responded without remission and 137 patients (12.9%) had no response. At 52 weeks of treatment 442 patients (57.1%) had achieved clinical remission, 249 patients had responded without remission (32.2%) and 53 patients had no response to the treatment (6.8%). Before 52 weeks, 129 patients (14.8%) had discontinued treatment due to inefficacy, this being significantly higher (p<0.0001) for Golimumab - 9 patients (37.5%) - compared to the other biological treatments analyzed. With respect to tumor development, an oncological event was observed in 74 patients (6.9%): 30 patients (8%) on infliximab, 23 (7.14%) on adalimumab, 3 (11.1%) on golimumab, 10 (6.4%) on ustekinumab, and 8 (3.8%) on vedolizumab. The incidence was significantly lower (p=0.04) for the vedolizumab group compared to other treatments. As regards infections, these occurred in 160 patients during treatment (14.9%), with no differences between the different biologicals used (p=0.61): 61 patients (19.4%) on infliximab, 39 (12.5%) on adalimumab, 5 (17.8%) on golimumab, 22 (14.1%) on ustekinumab, and 34 (16.5%) on vedolizumab., Conclusions: Biological drug therapies have response rates in elderly patients similar to those described in the general population, Golimumab was the drug that was discontinued most frequently due to inefficacy. In our experience, tumor development was more frequent in patients who used anti-TNF therapies compared to other targets, although its incidence was generally low and that this is in line with younger patients based on previous literature., (Copyright © 2024 Elsevier España, S.L.U. All rights reserved.)

Published
2024
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