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671 results on '"Sakai, Takahiro"'

1. Association between complete revascularization of the coronary artery and clinical outcomes in peripheral artery disease: a sub-analysis of the I-PAD Nagano registry

Author

Kato, Tamon, Ueki, Yasushi, Minamisawa, Masatoshi, Miura, Takashi, Oyama, Yushi, Hashizume, Naoto, Yokota, Daisuke, Taki, Minami, Senda, Keisuke, Okina, Yoshiteru, Wakabayashi, Tadamasa, Fujimori, Koki, Karube, Kenichi, Sakai, Takahiro, Nomi, Hidetomo, Yui, Hisanori, Kanzaki, Yusuke, Machida, Keisuke, Maruyama, Shusaku, Nagae, Ayumu, Saigusa, Tatsuya, Ebisawa, Soichiro, Okada, Ayako, Motoki, Hirohiko, and Kuwahara, Koichiro

Published
2023
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3. Impact of hyper-polypharmacy due to non-cardiovascular medications on long-term clinical outcomes following endovascular treatment for lower limb artery disease: A sub-analysis of the I-PAD Nagano registry

Author

Kato, Tamon, Minamisawa, Masatoshi, Miura, Takashi, Kanai, Masafumi, Oyama, Yushi, Hashizume, Naoto, Yokota, Daisuke, Taki, Minami, Senda, Keisuke, Nishikawa, Ken, Wakabayashi, Tadamasa, Fujimori, Koki, Karube, Kenichi, Sakai, Takahiro, Inoue, Minami, Yoda, Hidetsugu, Sunohara, Daisuke, Okina, Yoshiteru, Nomi, Hidetomo, Kanzaki, Yusuke, Machida, Keisuke, Kashiwagi, Daisuke, Ueki, Yasushi, Saigusa, Tatsuya, Ebisawa, Soichiro, Okada, Ayako, Motoki, Hirohiko, and Kuwahara, Koichiro

Published
2024
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9. Relaxing RGV Scheduling Problem for Approximate Assessment of Transportation Rate

Author

Suginouchi, Shota, Honda, Kazuki, Hattori, Tomoya, Sakai, Takahiro, Mizuyama, Hajime, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Goedicke, Michael, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Tröltzsch, Fredi, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Reis, Ricardo, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Kim, Duck Young, editor, von Cieminski, Gregor, editor, and Romero, David, editor

Published
2022
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16. A single institutional clinical outcome for stages III and IV ovarian cancer patients treated with dose‐dense TC therapy in the frontline or first platinum‐sensitive relapse setting.

Author

Sueoka, Kotaro, Kajimura, Takuya, Sakai, Takahiro, Tamehisa, Tetsuro, Okada, Maki, Tamura, Isao, Taketani, Toshiaki, and Sugino, Norihiro

Subjects
PATIENT safety, RESEARCH funding, CANCER relapse, OVARIAN tumors, ANTINEOPLASTIC agents, CARBOPLATIN, RETROSPECTIVE studies, DESCRIPTIVE statistics, TREATMENT effectiveness, DRUG efficacy, MEDICAL records, ACQUISITION of data, PACLITAXEL, TUMOR classification, PROGRESSION-free survival, EVALUATION
Abstract

Aim: Dose‐dense paclitaxel /carboplatin (ddTC) therapy was shown to be more effective against ovarian cancer than conventional tri‐weekly TC in the JGOG3016 study. However, two phase III studies performed after JGOG3016 did not show the same positive results. Because we have been using ddTC in the frontline or first platinum‐sensitive relapse of ovarian cancer, we investigated the clinical outcome of the patients treated with ddTC. Methods: We retrospectively examined the response rate (RR), progression free survival (PFS) and adverse events of the patients who were treated with ddTC for stage III and IV epithelial ovarian, tubal and peritoneal cancer from January 2012 to December 2018. Results: We analyzed 50 patients for frontline treatment and 11 patients for first platinum‐sensitive relapse treatment, excluding those receiving maintenance therapy. Among the patients that received frontline ddTC treatment, RR was 82.9% for those in a neo‐adjuvant chemotherapy (NACT) setting and 85.0% for those in an adjuvant setting. The median progression‐free survival (PFS) was 20 months after initial therapy. Among 31 cases that achieved remission by frontline surgery and the following ddTC, 22 had a platinum‐sensitive relapse. RR of 11 patients treated with ddTC therapy alone for the first platinum‐sensitive relapse was 81.8%, and the median PFS of these patients was 22 months after the first recurrence. Conclusions: ddTC therapy for advanced ovarian cancer achieved high response rates in all settings (NACT, adjuvant or platinum‐sensitive relapse). ddTC therapy was effective for improving the prognosis of patients with stages III and IV of ovarian cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Prognostic ability of mid-term worsening renal function after percutaneous coronary intervention: findings from the SHINANO registry

Author

Okina, Yoshiteru, Miura, Takashi, Senda, Keisuke, Taki, Minami, Kobayashi, Masanori, Kanai, Masafumi, Okuma, Yukari, Yanagisawa, Takashi, Hashizume, Naoto, Otagiri, Kyuhachi, Shoin, Kyoko, Watanabe, Noboru, Ebisawa, Soichiro, Karube, Kenichi, Nakajima, Hiroyuki, Saigusa, Tatsuya, Miyashita, Yusuke, Kashiwagi, Daisuke, Machida, Keisuke, Abe, Naoyuki, Tachibana, Takahiro, Kanzaki, Yusuke, Maruyama, Takuya, Nomi, Hidetomo, Sakai, Takahiro, Yui, Hisanori, Mochidome, Tomoaki, Kobayashi, Takahiro, Kasai, Toshio, Ikeda, Uichi, and Kuwahara, Koichiro

Published
2021
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22. Validation and Comparison of the Prognosis Predicting Ability of Inflammation-Based Scores Following Endovascular Treatment for Peripheral Artery Disease.

Author

Itagaki, Tadashi, Ebisawa, Soichiro, Kato, Tamon, Miura, Takashi, Oyama, Yushi, Hashizume, Naoto, Yokota, Daisuke, Taki, Minami, Senda, Keisuke, Okina, Yoshiteru, Wakabayashi, Tadamasa, Fujimori, Kouki, Karube, Kenichi, Sakai, Takahiro, Nomoto, Fumika, Takamatsu, Toshifumi, Tanaka, Kiu, Mochidome, Tomoaki, Saigusa, Tatsuya, and Motoki, Hirohiko

Subjects
PERIPHERAL vascular disease treatment, PREDICTION models, ENDOVASCULAR surgery, TREATMENT effectiveness, RESEARCH methodology, INFLAMMATION, COMPARATIVE studies
Abstract

We assessed the prognostic ability of several inflammation-based scores and compared their long-term outcomes in patients with peripheral artery disease (PAD) following endovascular treatment (EVT). We included 278 patients with PAD who underwent EVT and classified them according to their inflammation-based scores (Glasgow prognostic score [GPS], modified GPS [mGPS], platelet to lymphocyte ratio [PLR], prognostic index [PI], and prognostic nutritional index [PNI]). Major adverse cardiovascular events (MACE) at 5 years were examined, and C-statistics in each measure were calculated to compare their MACE predictive ability. During the follow-up period, 96 patients experienced MACE. Kaplan–Meier analysis showed that higher scores of all measures were associated with a higher MACE incidence. Multivariate Cox proportional hazard analysis showed that GPS 2, mGPS 2, PLR 1, and PNI 1, compared with GPS 0, mGPS 0, PLR 0, and PNI 0, were associated with an increased risk of MACE. C-statistics for MACE for PNI (.683) were greater than those for GPS (.635, P =.021), mGPS (.580, P =.019), PLR (.604, P =.024), and PI (.553, P <.001). PNI is associated with MACE risk and has a better prognosis-predicting ability than other inflammation-scoring models for patients with PAD following EVT. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Validation and Comparison of the Prognosis Predicting Ability of Inflammation-Based Scores Following Endovascular Treatment for Peripheral Artery Disease

Author

Itagaki, Tadashi, primary, Ebisawa, Soichiro, additional, Kato, Tamon, additional, Miura, Takashi, additional, Oyama, Yushi, additional, Hashizume, Naoto, additional, Yokota, Daisuke, additional, Taki, Minami, additional, Senda, Keisuke, additional, Okina, Yoshiteru, additional, Wakabayashi, Tadamasa, additional, Fujimori, Kouki, additional, Karube, Kenichi, additional, Sakai, Takahiro, additional, Nomoto, Fumika, additional, Takamatsu, Toshifumi, additional, Tanaka, Kiu, additional, Mochidome, Tomoaki, additional, Saigusa, Tatsuya, additional, Motoki, Hirohiko, additional, Kasai, Toshio, additional, Ikeda, Uichi, additional, and Kuwahara, Koichiro, additional

Published
2023
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38. Study on Integrated Synthesis of Dimeric Pyranonaphthoquinones: Preparation of Versatile Synthetic Intermediate and Conversion into ent -Hemi-actinorhodin and ent -Hemi-γ-actinorhodin.

Author

Ando, Yoshio, Maturi, Mark M., Hoshino, Taiju, Tanaka, Nozomi, Sakai, Takahiro, Ohmori, Ken, and Suzuki, Keisuke

Subjects
METHOXY group, STEREOCHEMISTRY, PYRAN, ENANTIOMERIC purity, APROTIC solvents, HEMICELLULOSE
Abstract

Keywords: stereoselective synthesis; pyranonaphthoquinone; naphthazarin; natural product; oxidative lactonization EN stereoselective synthesis pyranonaphthoquinone naphthazarin natural product oxidative lactonization 2011 2016 6 10/09/23 20231024 NES 231024 Graph We have been studying the synthesis of dimeric pyranonaphthoquinones, [1] -naphthocyclinone ( B 1 b ), [5] actinorhodin ( B 2 b ), [10][65] and -actinorhodin ( B 3 b ), [65] antibiotics of historical importance in polyketide biosynthesis (Figure 1). In planning the synthesis of B 9 b , we sought for the robustness of the skeletal assembly, because our previously developed two routes had problems, one of which was the scalability of the substrate synthesis, [1] and the other was the imperfect enantiocontrol. Further elaboration of B 9 b was studied, which not only provided useful information for the dimer synthesis, but also allowed us to complete the syntheses of I ent i -hemi-actinorhodin ( I ent i - B 8 b ) and I ent i -hemi- -actinorhodin ( B 12 b ). Recent studies on the actinorhodin biosynthesis revealed that the monomer unit undergoes hydroxylation at C6, and hemi-actinorhodin ( B 8 b ), thus generated, serves as the substrate for enzyme-mediated dimerization (Scheme 1). [Extracted from the article]

Published
2023
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42. Abstract 17259: Impact of Older Age (>80 Years) and Gender on Long-Term Outcomes in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention

Author

Yui, Hisanori, Otagiri, Kyuhachi, Miura, Takashi, Abe, Naoyuki, Hisatsugu, Yuzo, Kashiwagi, Daisuke, Machida, Keisuke, Tachibana, Takahiro, Yanagisawa, Takashi, Hashizume, Naoto, Kobayashi, Takahiro, Katoh, Tamon, Karube, Kenichi, Kanai, Masafumi, Nakamura, Chie, Sakai, Takahiro, Takeuchi, Takahiro, and Kitabayashi, Hiroshi

Published
2017

48. Impact of Ambulation Status in Patients with End-stage Renal Disease on Hemodialysis due to Diabetic Nephropathy : The PREDICT Study

Author

Kato, Tamon, Miyashita, Yusuke, Sone, Hidenao, Mizukami, Tetsutaro, Kanno, Yutaka, Oguchi, Tomomasa, Yokota, Daisuke, Shiotsuki, Noriyo, Mizukami, Etsuko, Terashima, Masuo, Aruga, Masakazu, Yui, Hisanori, Maruyama, Shusaku, Kobayashi, Hideki, Kashiwagi, Daisuke, Nagae, Ayumu, Sakai, Takahiro, Saigusa, Tatsuya, Ebisawa, Soichiro, Okada, Ayako, Motoki, Hirohiko, and Kuwahara, Koichiro

Subjects
critical limb ischemia, hemodialysis, ambulatory status, prognosis
Abstract

Article, 信州医学雑誌 68(3): 131-138(2020)

Published
2020

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