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228 results on '"Sakai, Tomomi"'

10. Artist in Residence for Disclosing the Sensation of Artists : Projecting Arts into the Town

Author

Komatsu, Kayoko, Takemoto, Yutaro, and Sakai, Tomomi

Subjects
KONOSK, アーティストインレジデンス, Artist in residence, 工房このすく, Arts-Based Research
Abstract

application/pdf, This paper has reported some activities in 2021 of ‘Arts-Based Research labo & HANGA studio ‘KOBO KONOSK’’ established in June 2020. Among the various activities, this report focuses in particular on the Artist-in-residence. We have invited three artists to stay and disclose their creative practices. As a result, we found out that projecting art into the region does not mean integrating art activities into the solution of local problems. It is important that both the citizens and the artists themselves undergo a generative transformation by putting themselves in the middle of what happens there.

Published
2023

14. A Study on the Construction of Local Cultural Base Centered on Printmaking Studio

Author

Komatsu, Kayoko, Sakai, Tomomi, and Okanoya, Atsuo

Subjects
KONOSK, Printmaking studio, 版画工房, このすく, Arts-Based Research
Abstract

application/pdf, This paper has reported the process of construction and some activities of ʻArts-Based Research labo & HANGA studio KOBO KONOSK ʼ, which was established in June 2020. The studio is equipped with facilities for copperplate print and silkscreen. The place is used not only for making art but also for several cultural activities, such as art workshop, reading circle, and cultural lectures. This place is characterized by the compound function. It is the alternative place free from a specific function, where we can drop in anytime without hesitation for creative practice or discussion.

Published
2022

23. Feasibility of the Routine Clinical Use of a Multiplex Virus Polymerase Chain Reaction Assay Based on Blood Virus Detection in Hematopoietic Stem Cell-Transplanted Patients

Author

Tsunemine, Hiroko, primary, Sasaki, Miho, additional, Zushi, Yuriko, additional, Saitoh, Toshiharu, additional, Shimizu, Norio, additional, Tomaru, Yasuhiro, additional, Aoyama, Yumi, additional, Yamamoto, Ryusuke, additional, Sakai, Tomomi, additional, Arima, Nobuyoshi, additional, Kodaka, Taiichi, additional, and Takahashi, Takayuki, additional

Published
2022
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44. Trafficking-mediated STING degradation requires sorting to acidified endolysosomes and can be therapeutically targeted to enhance anti-tumor response

Author

Gonugunta, Vijay K, Sakai, Tomomi, Pokatayev, Vladislav, Yang, Kun, Wu, Jianjun, Dobbs, Nicole, and Yan, Nan

Subjects
Lipopolysaccharides, Mice, Knockout, Models, Molecular, Melanoma, Experimental, Gene Expression, Membrane Proteins, rab7 GTP-Binding Proteins, Endosomes, Endoplasmic Reticulum, eye diseases, Article, Protein Structure, Secondary, Tumor Burden, Mice, Inbred C57BL, Mice, Protein Transport, Poly I-C, rab GTP-Binding Proteins, Proteolysis, Animals, Humans, Macrolides, Nucleotides, Cyclic, Lysosomes, Signal Transduction
Abstract

STING is an endoplasmic reticulum (ER)-associated transmembrane protein that turns on and quickly turns off downstream signaling as it translocates from the ER to vesicles. How STING signaling is attenuated during trafficking remains poorly understood. Here, we show that trafficking-mediated STING degradation requires ER exit and function of vacuolar ATPase complex. Late-stage STING vesicles are sorted to Rab7-positive endolysosomes for degradation. Based on analysis of existing structures, we also identified the helix amino acid 281 (aa281)-297 as a motif required for trafficking-mediated STING degradation. Immuno-electron microscopy (EM) reveals the size and clustering of STING vesicles and topology of STING on the vesicle. Importantly, blockade of trafficking-mediated STING degradation using bafilomycin A1 specifically enhanced cyclic guanosine monophosphate (GMP)-AMP (cGAMP)-mediated immune response and anti-tumor effect in mice. Together, our findings provide biochemical and imaging evidence for STING degradation by the lysosome and pinpoint trafficking-mediated STING degradation as a previously unanticipated therapeutic target for enhancing STING signaling in cancer therapy.

Published
2017

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