Search

In this study, two new phthalocyanines (M = Zn and Co) were synthesized using the (E)-4-(4-(3-(4- (benzyloxy)phenyl)acryloyl)phenoxy)phthalonitrile (3) as ligand prepared from the chemical reaction of 4- nitrophthalonitrile with (E)-3-(4-(benzyloxy)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (2). All compounds were characterized using by 1H-NMR, 13C-NMR, UV–Vis, FT-IR, and MALDI-TOF mass spectra. Singlet oxygen quantum yields of the synthesized compounds, aggregates in different solutions, metal chelating and 2,2- Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging properties were reported.

Gunsel, Armagan/0000-0003-1965-1017; Yarasir, Meryem Nilufer/0000-0002-7327-7137; Gunduz, Bayram/0000-0002-1447-7534; TUZUN, BURAK/0000-0002-0420-2043; BILGICLI, Ahmet Turgut/0000-0002-4144-7357 In this study, the molecular structure of 4-(4-(trifluoromethoxy)phenoxy)phthalonitrile (1) has been elucidated and its supra-molecular dynamics have been revealed by the analysis of single crystal X-ray diffraction measurements. Compound (1) and its copper(ii) phthalocyanine (2) were theoretically calculated with different basis sets. The Gibbs free energy values of copper(ii) phthalocyanine (2) were investigated. The calculated values of IR, NMR and UV-vis spectra for compound (1) and its copper(ii) phthalocyanine (2) were compared with the experimentally obtained values. The surface morphology properties of the compound (2) film for different magnifications were examined with its SEM images. We investigated the optical and optoelectronic parameters of compound (2) for different molarities. Also, we fabricated a diode based on compound (2) and examined its electronic characteristics under darkness, room light and 100 mW cm(-2). Our diode exhibits a photoconductive property. Research Fund of Sakarya UniversitySakarya University [Hzdep-2019-5-19-56] This work was supported by The Research Fund of Sakarya University (Project Number: Hzdep-2019-5-19-56). This research was made possible by TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure).

Removal of strontium has a vital importance for radioactive waste management due to its long half-life. In this context, melamine-styrene based polymer (MSBP) was synthesized and characterized by different spectrophotometric methods. Sr2+ ions were removed from the solution using MSBP sorbent. In this respect, adsorption of Sr(2+)onto melamine-based polymer was studied as a part of pH, amount of adsorbent, initial Sr(2+)concentration, contact time, temperature and particle size. Also, adsorption rate of radioactive strontium was investigated by using LSC (Liquid Scintillation Counter). The adsorption data were fitted to Langmuir, Freundlich and Dubinin-Radushkevich (D-R) isotherm models. MSBP sorbent reached maximum adsorption capacity for Sr2+ as 142.9 mg.g(-1). Thermodynamic parameters such as free energy (Delta G(0)), entropy (Delta S-0) and enthalpy (Delta H-0) of Sr2+ adsorption on MSBP were examined at five different temperatures of 293 K, 303 K, 313 K, 323 K and 333 K. 0 < Delta H-0 values indicated that sorption mechanism presented endothermic feature. 0 > Delta G(0) and 0 < Delta S-0 revealed that Sr2+ adsorption on MSBP occurred spontaneously and irreversible, respectively. Pseudo first and second orders were investigated as a part of kinetic parameters and seen that pseudo second order was much more convenient for adsorption of Sr2+ onto MSBP.

Pure GaAs and GaAs1−xBix alloys with different Bi ratios (1 %, 2.5 %, 3.5 %) fitted with silver contacts were measured with a dielectric spectroscopy device. Dielectric characterization was performed at room temperature in the frequency range of 0.1 Hz to 1 MHz. GaAs exhibits three relaxation regions corresponding to space-charge, dipolar and ionic polarizations in sequence with increasing frequency while GaAs1−xBix samples show only a broad dipolar polarization in the same frequency range. This result proves the filling of the lattice with Bi through making a new bonding reducing the influence of ionic polarization. This finding supports the previous results concerning optical properties of GaAs1−xBix, presented in the literature.

kanmazalp, sibel demir/0000-0002-5896-0966; Dege, Necmi/0000-0003-0660-4721; Ozdemir, Namik/0000-0003-3371-9874; Sen, Pinar/0000-0002-3181-9890 WOS: 000477632400016 PubMed: 31391965 This work presents the synthesis and structural characterization of [4-(1H-benzo[d]imidazol-2-yl) phenoxy]phthalonitrile, a phthalonitrile derivative carrying a benzimidazole moiety. The compound crystallizes as its dimethyl sulfoxide monosolvate, C21H12N4O center dot(CH3)(2)SO. The dihedral angle between the two fused rings in the heterocyclic ring system is 2.11 (1)degrees, while the phenyl ring attached to the imidazole moiety is inclined by 20.7 (1)degrees to the latter. In the crystal structure, adjacent molecules are connected by pairs of weak intermolecular C-H center dot center dot center dot N hydrogen bonds into inversion dimers. N-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds with R-2(1)(7) graph-set motifs are also formed between the organic molecule and the disordered dimethyl sulfoxide solvent [occupancy ratio of 0.623 (5):0.377 (5) for the two sites of the sulfur atom]. Hirshfeld surface analysis and fingerprint plots were used to investigate the intermolecular interactions in the crystalline state. Ondokuz Mayis UniversityOndokuz Mayis University [PYOFEN.1906.19.001] This study was supported by Ondokuz Mayis University under project No. PYOFEN.1906.19.001 (contract No. PYOFEN.1906.19.001).

In the title compound, C—H⋯O hydrogen bonds and weak C—H⋯π inter­actions link adjacent mol­ecules into a three-dimensional supra­molecular network., A novel chalcone, C20H20O, derived from benzyl­idene­tetra­lone, was synthesized via Claissen–Schmidt condensation between tetra­lone and 2,4,6-tri­methyl­benzaldehyde. In the crystal, mol­ecules are linked by C—H⋯O hydrogen bonds, producing R 2 2(20) and R 2 4(12) ring motifs. In addition, weak C—H⋯π and π-stacking inter­actions are observed. The inter­molecular inter­actions were investigated using Hirshfeld surface analysis and two-dimensional fingerprint plots, revealing that the most important contributions for the crystal packing are from H⋯H (66.0%), H⋯C/ C⋯H (22.3%), H⋯O/O⋯H (9.3%), and C⋯C (2.4%) inter­actions. Shape-index plots show π–π stacking inter­actions and the curvedness plots show flat surface patches characteristic of planar stacking.

Dege, Necmi/0000-0003-0660-4721; kanmazalp, sibel demir/0000-0002-5896-0966 WOS: 000477950400008 This work presents the synthesis and characterization of a novel compound, 4-(2-(2-(2-formylphenoxy)ethoxy)ethoxylphthalonitrile as the aldehyde functional group substituted as a phthalonitrile derivative. The spectroscopic properties of the compound were examined through Fourier-transform infrared spectroscopy, Proton nuclear magnetic resonance, Carbon nuclear magnetic resonance, Ultraviolet-visible spectroscopy, Mass spectrometry and elemental analyses. The molecular structure of the compound was also confirmed using X-ray single-crystal data with a theoretical comparative approach. Research Fund of Sakarya UniversitySakarya University [2014-02-04 007] This work was supported by the Research Fund of Sakarya University (project no. 2014-02-04 007).

In this study, autonomous Lu-Chen (2002) chaotic system has been implemented on FPGA using Heun numerical algorithm in VHDL 32-bit IQ-Math fixed-point number format for developing embedded chaos-based engineering applications. The core units like multiplier, adder and subtractor units, which are compatible with fixed-point number standart used in FPGA-based design, have been created by IP CORE Generator that developed for Xilinx. The designed system has been simulated and synthesized for the Virtex-6 FPGA chip. The chip statistics obtained from Place&Route processing of FPGA-based system and the phase portraits of the results received from the outputs have been presented. The results obtained from FPGA-based Lu-Chen chaotic oscillator have been compared with the computer-based results and the accuracy of the digital circuit-based design has been certified with the successful results. The maximum operating frequency of designed FPGA-based Lu-Chen chaotic oscillator is 464.688 MHz. The performed FPGA-based Lu-Chen chaotic oscillator presents the highest operating frequency among the others in the literature. Besides, the design provides better results than the other 3D FPGA-based chaotic oscillator structures with respect to FPGA resource utilization. In addition, MSE and RMSE accuracy analyzes were performed on the designed chaotic oscillator. The design provides the highest operating frequency among the others in the literature. In addition, it presents better results than the alternatives with respect to FPGA resource utilization. For this reason, this study demonstrates that hardware-based design of Lu-Chen chaotic system can be used in various chaos-based embedded system applications including cryptography, secure communication and random number generation. (C) 2019 Elsevier B.V. All rights reserved.

Zinc phthalocyanine dyes bearing four sulfonic acid anchoring groups with (A-ZnPc) and without (H-ZnPc) four chloro and eight hexyloxy groups were used as sensitizers for dye-sensitized solar cells (DSSCs). The dyes were investigated in terms of their optical, electrochemical and photovoltaic properties. The presence of these groups in dye A-ZnPc resulted in both red-shifted absorption and decreased dye aggregation, which are beneficial for the improvement of device performance. In the presence of chenodeoxycholic acid (CDCA) as a coadsorbent, the DSSC based on H-ZnPc shows a power conversion efficiency (PCE) of 0.96%, which is improved by [Formula: see text]40% as compared to the device without CDCA. However, the PCE of an A-ZnPc-based device with CDCA slightly enhances from 1.15% (without CDCA) to 1.22%, indicating that the bulky hexyloxy groups with large steric hindrance can effectively suppress aggregation of the adsorbed dye. The results showed that the zinc phthalocyanine dye bearing bulky hexyloxy groups is a promising candidate to construct efficient coadsorbent-free DSSCs.

We report a novel pH-dependent dye-sensitized solar cells by using tannic acid and Fe-tannic acid complex. We have synthesized TiO2 nanoparticles by microwave hydrothermal method, and TiO2 photoanode has been developed via doctor blade technique. The TiO2 nanoparticles and photoanode were characterized by XRD, FE-SEM, Raman and DRS technique. Dye-sensitized solar cells have been assembled by TiO2 photoanode and tannic acid or Fe-tannic acid complex dye as sensitizers at different pH values. The UV–vis absorbance and cyclic voltammetry results for these dyes at different pH values were discussed. The maximum cell efficiency of DSSC based on tannic acid and Fe-tannic acid dyes were 1.56% and 2.95% at pH 7.5, respectively. The cell efficiencies demonstrated decrement above and below pH 7.5, which was explained in detail in this study by suggesting possible reasons. In particular, the Fe-tannic acid structure at the range of pH 6–8 had comparable cell efficiency values compared to synthetic organic dyes. This phenomenon also gave a new way to the use of a novel simple cell with environmental friendly metal complex dye based sensitizers for dye-sensitized solar cells. This study has highlighted the importance of tannic acid and Fe-tannic acid at different pH values for solar cell efficiency. Additionally, the Fe-tannic acid sensitizer is an alternative to synthetic organic dyes and has advantages such as easy synthesis, low cost and abundantly found in nature. © 2018 Elsevier B.V., 2018-12528785-01 Firat University Scientific Research Projects Management Unit: 2016- 50-02-009, This investigation has been supported by the Scientific Research Projects Commission of Sakarya University (Project number: 2016- 50-02-009). Scientific Research Projects Commission of Bulent Ecevit University (Project number: 2018-12528785-01). M.Ö. thanks Turkish Academy of Sciences (TUBA) for partial support. We also would like to thank Mr. Bekir Çakıroğlu for his valuable contributions.

The highly efficient plasmonic photocatalysts have drawn attention with their effective charge carrier separation capabilities and visible light absorption features, which makes them immensely favorable material in the organic contaminants eliminating for wastewater treatment. Thus, the goal of this study is to improve visible light driven plasmonic photocatalysts using Ag/Ag2CrO4 and ZnO. A highly efficient nanoheterojunction structured Ag/Ag2CrO4/ZnO has been prepared by precipitation-photoreduction method and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (ATR-FTIR), electrochemical measurements and UV–vis diffuse reflectance/absorbance spectroscopy (DRS). When photocatalytic efficiencies of ZnO, Ag2CrO4, Ag/Ag2CrO4, Ag2CrO4/ZnO and Ag/Ag2CrO4/ZnO are compared, Ag/Ag2CrO4/ZnO exhibits the best efficiency for the degradation of indigo carmine (IC) under visible-light. The reasons for the highly increased performance of Ag/Ag2CrO4/ZnO may be related to the synergistic effect of Ag/Ag2CrO4 doped on ZnO surface. Thus, the visible light absorption capability of ZnO can be increased and the recombination of charge carriers can be effectively hindered. The nano photocatalyst also showed high stability even after five cycles. Therefore, the Ag/Ag2CrO4/ZnO can be effectively used as active plasmonic photocatalysts under visible light and it exhibits a great potential in removing environmental contamination.

WOS: 000458228500038, This work presents the synthesis of peripherally and non-peripherally tetra-substituted metallophthalocyanines (6-14) containing the 2-(3,4-dimethoxyphenyl)ethanol group. The synthesized compounds were characterized by standard spectroscopy methods. The ligands of the metallophthalocyanines were investigated by quantum chemical calculations. The quantum chemical parameters of these ligands (1 and 2) such as the HOMO, LUMO and chemical hardness were calculated by the B3lyp, HF and M062x methods. The Delta G value of the metal complexes of the ligands were calculated with the obtained results. In addition, photophysical (fluorescence quantum yields) and photochemical (singlet oxygen generation and photodegradation under light irradiation) properties of newly synthesized phthalocyanines were investigated in DMSO solutions, comparatively. (C) 2018 Elsevier Ltd. All rights reserved., Sakarya University [BAP-2017-02-04-013], We thank The Research Fund of Sakarya University (Project no: BAP-2017-02-04-013). This research was made possible by TUBITAK ULAKBIM, High Performance and Grid Computing Center (TR-Grid e-Infrastructure).

In the present work, novel double-decker samarium(III), europium(III), and ytterbium (III) phthalocyanines (SmPc2, EuPc2, and YbPc2) bearing 4-(hydroxyethyl)phenoxy moieties have been synthesized and their electrochemical redox, spectroelectrochemical, and electrocolorimetric properties of the complexes have been inquired comparatively in two different non-aqueous solution. All complexes were observed to expose a series of usually reversible phthalocyanine ring-based one-electron reduction and oxidation processes. The effect of the size of rare earth metal ion was clearly reflected as the modest shift in half-wave potentials. Enriched electron transfer processes of the complexes and the interaction between the electrochemically generated anionic and cationic species caused distinct spectral and color changes, identified with in-situ spectroelectrochemical and in-situ electrocolorimetric measurements in solution medium. Spectroelectrochemical and electrocolorimetric measurements of the complexes were also performed in the solid state as the Langmuir-Blodgett film on an indium tin oxide glass in order to understand their technological applicability in electrochromic devices as color changing material. Comparative evaluation of these measurements suggested that Langmuir-Blodgett films of SmPc2 and EuPc illustrate highly reversible distinct color change from green to purple with satisfying electrochromic performance for electrochromic device applications. (c) 2019 The Electrochemical Society.

The synthesis, photophysical, singlet oxygen generation, electrochemical and photovoltaic properties of peripheral and axial 1,2,3-triazole group substituted zinc and silicon phthalocyanine complexes with strong absorption in the visible region were described. All novel complexes have been characterized by spectroscopic and electrochemical techniques. All the new compounds are highly soluble in most common organic solvents. The electronic absorption and fluorescence spectral properties of complexes 4 and 5 are investigated. The effects of the triazole group, different metal centers and position of the substituent on the photophysical, electrochemical and photovoltaic properties of the new phthalocyanines were also investigated for the first time in this work. According to the fluorescence measurements, the axially substituted silicon complex (5) showed higher fluorescence quantum yield (phi(F) = 0.28) than the peripherally substituted zinc complex (4). In addition, quantum yields for singlet oxygen generation (phi = 0.32 for silicon complex (4) and phi = 0.76 for zinc complex (5) in DMSO) were obtained. Electrochemical studies show that complex 5 is present in non-aggregated form as a result of steric hindrance of the axial groups; the LUMO level of this complex is slightly more negative than the conduction band of TiO2 and electron injection might be less effective. Therefore, the power conversion efficiency of 1.30% for a complex 4 based dye-sensitized solar cell (DSSC) is higher than complex 5 (0.90%). Consequently, these zinc and silicon complexes are promising candidates not only for photodynamic therapy but also solar power conversion.

In an extension of the research on the nucleophilic substitution reactions of hexachlorocyclotriphosphazene (1) with linear aliphatic primary diamines, NH2-(CH2)(n) -NH2 (n = 3, 5, 6 and 8) are surveyed. In the presence of pyridine, NaH and in excess of the used amine as base, at 0 degrees C and room temperature, we subjected the reactions of 1, to a systematic reinvestigation with aliphatic propane-1,3-, pentane-1,5-, hexane-1,6- and octane-1,8-diamines (2, 3, 4 and 5 respectively) and we isolated a total of 18 compounds which include examples of all four structural types (open chain, spiro, ansa and the bino derivatives). The novel synthesized open chain (6), mono-ansa (8a), spiro-ansa (10), single-bridged (12a), double-bridged (13a) and tri-bridged (14a) cyclophosphazene derivatives are reported for the first time. The synthesized compounds are characterized by elemental analysis, MS, FT-IR, H-1 and P-31 NMR spectroscopy. Spectroscopic data, product types and the relative yields are compared with those of the previously reported cyclophosphazene derivatives derived from di-functional nucleophilic reagents. (C) 2019 Elsevier B.V. All rights reserved.

Guzel, Emre/0000-0002-1142-3936; cavus, Muhammet Serdar/0000-0002-3721-0883; Bakir, Temel Kan/0000-0002-7447-1468 WOS: 000501486700069 In this study, peripherally tetra 2-mercaptobenzimidazole group substituted cobalt and indium phthalocyanine complexes (2 and 3) were prepared from 4-(benzo[d]imidazole-2-ylthio)phthalonitrile (1) for the first time. Antioxidant behaviors and theoretical calculations of benzimidazole-substituted metallophthalocyanines are presented. The structures of these compounds were determined by the spectroscopic methods (IR, H-1 NMR, UV-Vis and mass spectroscopies) and elemental analysis. Antioxidant activities of the compounds (1-3) were measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Antioxidant activity was followed by 1 > 3 > 2 > Trolox. In addition, density functional theory (DFT) calculations were carried out to determine the stable electronic structure, charge density distributions, FMO energy eigenvalues, and electronegativity of the ligand (1) and complexes (2 and 3). NBO and QTAIM analysis were performed to investigate the relationship between the electronic properties and antioxidant activity of the compounds. (C) 2019 Elsevier B.V. All rights reserved.

In this study, as a novel design with the collaboration of a fluorene and sulfide-based copolymer for Li-ion battery application is presented. Polyfluorene-co-polydisulfide is prepared with desired functional groups to yield a conductivity and good adhesion. These critical and important features are performed by preparing polymers with proper functional groups. The preparation process is accomplished via Suzuki coupling process under Pd catalyst by combining separately synthesized 4,4 '-dibromodiphenyl disulfide in combination with 9,9-dioctylfluorene-2,7-bis(trimethylborate). The fully obtained capacity of the silicon particles, that is, at C/10 with the capacity of 1250 mAh g(-1) after the 500th cycle, approves the good performance by preserving capacity stability till 600th cycles. The designed and synthesized polymer binder with different functionalities and carbon nanotube additive show better characteristics such as conductivity, high polarity, and binding adhesion. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48303.

Carvacrol, as a natural product used for many years in the treatment of various diseases, therefore it was chosen as the starting compound for this study. Novel carvacrol based new oxypropanolamine derivatives were synthesized and characterized by spectroscopic methods. All new compounds were tested as metabolic enzyme inhibitory agents. Their clinical usage of carvacrol has been established as diuretics, antiepileptics, and anti-glaucoma factors, in the management of gastric, duodenal ulcers, mountain sickness, osteoporosis, idiopathic intracranial hypertension, or neurological disorders. The in vitro anti-hyperglycemic screening results showed that the compound 3d exhibits the maximum inhibitory effect against alpha-glycosidase enzyme (IC50: 904.10 nM). In addition, the compounds 3d (IC50: 29.74 nM and 23.64 nM) and 3e (IC50: 31.28 nM and 26.11 nM) were found to have a significant response to inhibit carbonic anhydrase I, and II isoenzymes (hCA I and II), respectively. The novel carvacrol based oxypropanolamine compounds were effective inhibitors of the hCA I and II isozymes, and acetylcholinesterase with Ki values in the range of 27.18-44.84 nM for hCA I, 25.62-38.71 nM for hCA II, and 99.83-146.25 nM for AChE, respectively. (C) 2019 Elsevier B.V. All rights reserved.y

Fosil polen analizleri göl çökelleri, turbalıklar, akarsu ve deniz sedimanları, buzullar, linyitler ve taş kömürleri gibi çeşitli ortamlardan elde edilen polenlerin_x000D_ araştırılmasını kapsamaktadır. Kuvaterner dönemine ait palinolojik çalışmaların önemli veri kaynaklarından biri de göllerdir. Araştırma alanı olarak seçilen_x000D_ Akgöl, Sakarya ilinde, Ferizli ilçesinin Gölkent mahallesinde bulunmaktadır. Gölün yüzölçümü 3,5 km2_x000D_ ve maksimum derinliği 8 m’dir. Bu çalışmanın amacı:_x000D_ gölün dip sedimanlarında fosil polen analizleri yaparak gölün çevresinde son 1000 yılda meydana gelen vejetasyon değişimlerini ortaya çıkarmaktır._x000D_ Akgöl’den karot alımında İTÜ EMCOL Araştırma Uygulama Merkezi’nin 4x4 m. platformlu piston karotiyeri kullanılmıştır. İstanbul Üniversitesi-Cerrahpaşa,_x000D_ Orman Fakültesi Orman Botaniği Anabilim Dalında bulunan Palinoloji Laboratuvarı’na getirilen karot üzerinde her 5 cm’de bir 2 cm3_x000D_ lük sediman örnekleri_x000D_ alınmıştır. Bu örneklerde “klasik yönteme” göre fosil polen analizi yapılmıştır. Hazırlanan polen preparatlarında her bir bitki taksonu için polen yüzdesi_x000D_ değerleri hesaplanmış, odunsu ve otsu taksonlara ait yüzde grafikleri TILIA adlı programda çizilmiştir. Polen diyagramından elde edilen ilk bulgulara göre;_x000D_ Akgöl ve çevresinde son 1000 yılda yaprak döken orman vejetasyonu hâkimdir. Bu doğal orman varlığının içine son yıllarda Gymnospermae taksonlarından_x000D_ sahil çamları da dikim yoluyla getirilmiştir. Fossil pollen analyzes include research of pollen grains from various environments such as lake sediments, peatland, river and marine sediments, glaciers,_x000D_ lignite and coal. Lakes are one of the important data sources for Quaternary palynological studies. Akgöl, which is selected as a research area, is located in Gölkent district of the Ferizli township in the provincial city of Sakarya. Its surface area is 3.5 km2_x000D_ and its maximum depth is 8 meters. The aim of this study_x000D_ was to investigate vegetation changes around Akgöl in the last 1000 years using fossil pollen analysis in the bottom sediments of the lake. The Piston corer_x000D_ of ITU EMCOL Research Centre was used for recovering sediment cores from Akgöl. Sediment samples of 2 cm3_x000D_ were collected every 5 centimeters on one_x000D_ of the cores at the Palynology Laboratory of IUC. Fossil pollen analysis was performed according to the “classical method”. The pollen percentage values_x000D_ were calculated for each plant taxa and relative abundance graphs were plotted in the TILIA program. According to preliminary results of the pollen_x000D_ diagram; deciduous forest vegetation has been predominant in the last 1000 years around Akgöl. Maritime pine was introduced into this natural forest by_x000D_ plantation in the recent years

It is well observed that cryptographic applications have great challenges in guaranteeing high security as well as high throughput. Artificial neural network (ANN)-based chaotic true random number generator (TRNG) structure has not been unprecedented in current literature. This paper provides a novel type of high-speed TRNG based on chaos and ANN implemented in a Xilinx field-programmable gate array (FPGA) chip. The paper consists of two main parts. In the first part, chaos analyses of Pehlivan-Uyaroglu_2010 chaotic system (PUCS) have been accomplished to prove that PUCS operates in chaotic regime. So PUCS can be an efficient alternative to the entropy source for classical TRNGs. In the second part, the hardware design of the proposed TRNG has been created using VHDL in Xilinx platform. As a result, the implemented TRNG offers throughput up to 115.794 Mbps. Besides, the generated random numbers have been tested with the FIPS 140-1 and NIST 800.22 test suites. The high quality of generated true random numbers have been confirmed by passing all randomness tests. The results have shown that the proposed system can provide not only high throughput but also high quality random bit sequences for a wide variety of embedded cryptographic applications. Sakarya University Scientific Research Projects Commission PresidencySakarya University [2015-50-02-027] Sakarya University Scientific Research Projects Commission Presidency, Grant/Award Number: 2015-50-02-027, 2017

Türe, Sedat (Bilecik, Author) Gurbanov, Rafıg (Bilecik, Author) The reactions of hexachlorocyclotriphosphazatriene, N3P3Cl6 (1) with 2-mercaptoethanol, 2-HS-CH2-CH2-OH (2), in (1:1, 1:2 and 1:3) mole ratios, in excess of NaH, in THF and diethylether solutions yield a total of 6 novel products: one mono spiro, N3P3Cl4[O-CH2-CH2-S] (3); one mono-substituted open chain, N3P3Cl5[S-CH2-CH2-OH] (4); one dispiro, N3P3Cl2[O-CH2-CH2-S](2) (5); one tri-substituted open chain, N3P3Cl3[S-CH2-CH2-OH](3) (6); one tris-spiro, N3P3[O-CH2-CH2-S](3) (7) and one disubstituted open chain, N3P3Cl4[S-CH2-CH2-OH](2) (8) derivatives. The spiro products (3, 5 and 7) are formed as the major products in this system and all of the synthesized compounds are found to be stable at room temperature. The structures of the derived compounds were elucidated by elemental analysis, TLC-MS, P-31 and H-1 NMR spectral data. For evaluation of melting behavior of derivatives (6) and (7), thermal transition peaks and their corresponding enthalpies were determined via DSC technique. Bilecik Şeyh Edebali Üniversitesi Bilimsel Araştırma Projesi - BAP - 2016-01.BŞEÜ.04-02. Bilecik Seyh Edebali University Scientific Research Project - BAP - 2016-01.BŞEÜ.04-02. WOS:000452036700009 Q3 Q4

In the present study, (3aR,7aS)-1,3,3a,4,7,7a-hexahydroisobenzofuran was submitted to photooxygenation and two isomeric hydroperoxides were successfully obtained. Without any further purification, reduction of the hydroperoxides with titanium tetraisopropoxide catalyzed by dimethyl sulfide gave two alcohol isomers in high yields. After acetylation of alcohol with Ac2O in pyridine, epoxidation reaction of formed monoacetates with m-CPBA, then chromatographed and followed by hydrolysis of the acetate groups with NH3 in CH3OH resulted in the formation of epoxy alcohol isomers respectively. These epoxy alcohol isomers were subjected to trans-dihydroxylation reaction with acid (H2SO4) in the presence of water to afford triols. Acetylation of the free hydroxyl groups produced benzofuran triacetates in high yields. Ring-opening reaction of furan triacetates with sulfamic acid catalyzed in the presence of acetic acid/acetic anhydrate and subsequently hydrolysis of the acetate groups with ammonia gave the targeted cyclohexane carbasugar-based pentols. All products were separated and purified by chromatographic and crystallographic methods. Structural analyses of all compounds were conducted by spectral techniques including NMR and X-ray analyses. The biological inhibition activity of the target compounds was tested against glycosidase enzymes, α- and β-glucosidase.

In this study, we have analyzed the effect a newly synthesized water-soluble alpha tetra-substituted zinc phthalocyanine (Pc) compound on superoxide dismutase (SOD), ascorbate peroxidase (APX) and glutathione reductase (GR) activities and biomass accumulation in the Arthrospira platensis-M2 strain to test whether this compound could be used as an algaecide or not. We found that lower concentrations (3 μg mL[Formula: see text] and 6 μg mL[Formula: see text] of Pc compound were not toxic to algae cells, as indicated by enduring biomass accumulation during the study (7 days). Higher Pc concentrations, however, were toxic and inhibited biomass accumulation. This inhibition appeared on the fourth day and persisted during the study. At higher Pc concentrations, SOD activity decreased significantly, but APX and GR activity were not affected. These results may show that Pc applications did not cause the accumulation of reactive oxygen species in Arthrospira platensis-M2 cells. Our result suggests that higher Pc concentrations did not cause oxidative stress but biomass accumulation inhibited, possibly due to some different toxicity mechanism(s), which should be carried out in the future studies. As a result, we may offer use of this compound as a means to keep under control algal populations in natural environments.

In this study, a protease enzyme was purified from strawberry by using Sepharose-4B-L-tyrosine-p-amino benzoic acid affinity chromatography. The molecular weight of pure protease was determined 65.8 kDa by SDS-PAGE. The single band observed on the gel showed that the enzyme had a single polypeptide chain and was successfully purified. Purification of the protease by the chromatographic method resulted in a 395.6-fold increase in specific activity (3600 U/mg). Optimum pH and temperature for the enzyme were 6 and 40 degrees C, respectively. The protease was stable at a wide temperature range of 40 to 70 degrees C and a pH range of 3.0 to 9.0. Co2+ ions stimulated protease activity very strongly. Cu2+, Hg2+, Cd2+ and Mn2+ ions significantly inhibited protease activity. While 2-propanol completely inhibited the enzyme, the enzyme maintained its activity better in the presence of ethanol and methanol. The strawberry protease showed the highest specificity towards hemoglobin among all the natural substrates tested. The specificity of the enzyme towards synthetic substrates was also investigated and it was concluded that it has broad substrate specificity. The obtained results indicated that this purified protease was highly-likely a serine protease and its activity was significantly affected by the presence of metal ions. (C) 2018 Published by Elsevier B.V.

In this paper, a cloud point extraction (CPE) method is described and inorganic antimony species were determined by using an inductively coupled plasma optic emission spectrometer coupled to an ultrasonic nebulizer (USN-ICPOES). Dithizone complexed Sb(III) species were trapped in the micelle front the aqueous phase using the Triton X-114 surfactant with an increase in temperature. After centrifugation and phase separation, the surfactant-rich phase was dissolved with 2 M HNO3 and measured in the USN-ICP-OES. Indium (In) was used as an internal standard in order to reduce noise and random systematic errors. The effects of phi, surfactant concentration, ligand concentration, heating time, temperature, and interfering ions were optimized. The effects of the rate of foreign ions and their species, as well as the parameters such as pH, surfactant concentration, ligand concentration, heating time and temperature, were optimized. In the proposed method, Sb(V) was reduced to Sb(III) with L-cysteine for the determination of total antimony. For Sb(III), the determined 1.01) value was 0.04 mu g with an RSD of 2.59% (n=12) [pH = 4, 0.04 mu g mol L-1 dithizone, and 0.06% (w/v) Triton X-114]. The developed method was applied to the analysis of real water and fruit juices, and validated using a certified reference material.

We report the highly soluble axially disubstituted 4-(methoxymethyl) phenol silicon (IV) (1) phthalocyanine which was synthesized by the reaction of silicon phthalocyanine dichloride (SiPcCl2) with 4-(methoxymethyl)phenol. UV–Vis, FT-IR, 1H, 13C, NMR and mass spectrometry were used to characterize SiPc (1). Fluorescence quantum yield (spectral and photophysical) characteristics of SiPc (1) were investigated for various solvents. The obtained spectral and photophysical results indicated that the fluorescence quantum yields (?F) of SiPc (1) are both lower than unsubstituted ZnPc and SiPcCl2 in the solvents used which is not typical of silicon-phthalocyanines. The effects on optoelectronic and spectral properties of SiPc (1) of solvents and concentrations were investigated in detail. We obtained absorption band edge, maximum peak of absorbance, molar and mass extinction coefficients, refractive index, optical band gap, optical and electrical conductance of SiPc (1) for different solvents and concentrations. We obtained the refractive index values of SiPc (1) with many relationships. Also, we investigated the angles of incidence and refraction of SiPc (1). SiPc (1) exhibited semiconductor behavior in terms of optical band gap and can be used for photonic applications. Graphical Abstract: [Figure not available: see fulltext.]. © 2018, Springer Science+Business Media B.V., part of Springer Nature. BAP-2017-02-04-013 Acknowledgement We thank The Research Fund of Sakarya University (Project No: BAP-2017-02-04-013).

The new peripherally tetra-substituted metallophthalocyanines (MPcs, M=Zn, Co, Ni) bearing the chalcone, (E)-3-(4-hydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, for dye-sensitized solar cells (DSSCs) were synthesized. FT-IR, H-1 NMR, C-13 NMR, and UV-Vis spectroscopy techniques were utilized for characterization of all the MPcs. Electrochemical, optical and photovoltaic properties of all the MPcs as sensitizers were examined. Electrochemical studies reveal that while the ZnPc (4) and NiPc (6) give only Pc ring-based redox reactions, the CoPc (5) shows redox reactions based on both the central metal and the ring due to the metal 3d orbitals lying between the Pc HOMO and LUMO. The DSSC based on 5 gave the lowest power conversion efficiency (0.51%), perhaps due to the presence of a redox active central metal ion in the core of the complex, which results in a decrease electron transfer in the device. However, cells based on the other complexes including redox inactive central metal ions, which cannot reduce electron transfer, showed reasonable power conversion efficiencies of 1.27% and 1.11% for 4 and 6, respectively. The slight difference between the efficiencies can be attributed to higher molar extinction coefficient and narrower band gap of 4 than 6, which ensure a higher photocurrent and broader light absorption in the visible region.

Novel magnetically separable nanocomposite photocatalyst Ag3PO4/ZnO/Fe3O4, prepared by the coprecipitation and microwave assisted hydrothermal synthesis, was first investigated as the photocatalyst for congo red degradation under visible light. The nano photocatalysts were systematically characterized with by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (ATR-FTIR), vibrational sample magnetometer (VSM) measurements and UV–vis diffuse reflectance/absorbance spectroscopy (DRS). The nanocomposite Ag3PO4/ZnO/Fe3O4 showed enhanced photocatalytic activity compared with ZnO, ZnO/Fe3O4, Ag3PO4 and Ag3PO4/ZnO under the same conditions. The reasons for the highly increased activity of Ag3PO4/ZnO/Fe3O4 are that it allows more visible light absorption and efficient delaying the recombination of charge carriers. Also, the degradation efficiency for congo red is about 97.0% for the Ag3PO4/ZnO/Fe3O4 nanocomposite in the 90 min. At the end of the successful degradation process, the obtained magnetic photocatalyst was effectively separated from the suspension by applying external magnetic field.

The content of this work is based on the introduction of the salicylhydrazone-zinc complexes into the phthalocyanine core. The reaction of the salicylhydrazone substituted ZnPc (1) with the related zinc(II) salt in basic conditions in DMF yielded bis[bis(salicyhydrazone)phenoxy)zinc(II)] phthalocyaninato zinc(II) (5) in which two salicylhydrazone-Zn complexes are linked through oxygen bridges to the macrocyclic core as three-nuclear complex. The novel compound synthesized in this study was fully characterized by general spectroscopic techniques such as FT-IR, UV-vis, 1H NMR, 13C NMR, elemental analysis and mass spectroscopy. In addition, spectral, photophysical (fluorescence quantum yields), and photochemical (generation of singlet oxygen and photo stability under light irradiation) properties of newly synthesized phthalocyanine (5) and the starting Pcs molecules used to obtain this molecule were investigated in DMSO solutions, comparatively.

Gencer, Nahit/0000-0001-7092-8857; WOS: 000422674700030 A series of novel tetrahydroquinoline derivatives containing urea moiety was synthesized and their invitro inhibitory effects on the human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were evaluated by using the CO2 hydration method. All the synthesized compounds exhibited inhibitory activity against both hCA I and hCA II with 1-(4-fluorophenyl)-3-(4-(4-p-tolyl-5,6,7,8-tetrahydroquinolin-2-yl)phenyl)urea (7k, IC50 value of 5.28M and 5.51M, against hCA I and hCA II, respectively) as the strongest inhibitor in this study. Structure-activity relationships were also investigated. The results showed that most of synthesized compounds have a higher inhibitory activity against hCA I than hCA II. Also the substituents, containing two or more pairs of non-bonding electrons, generally increased the hCA I and II inhibitory activity. Furthermore, some electronic parameters such as the highest occupied molecular orbital and the lowest unoccupied molecular orbital (HOMO-LUMO) energy levels, electron affinity, total energy and dipole moments of the best inhibitors (7b, 7h and 7k) in this study were also calculated by using Gaussian software. The results revealed that HOMO-LUMO energy differences, total energy, chemical hardness and dipole moment of 7b, 7h and 7k showed a linear relationship with increasing inhibitory activity. Gaziosmanpasa University Scientific Research ProjectGaziosmanpasa University [2011/34] This work was supported by Gaziosmanpasa University Scientific Research Project (Project No: 2011/34).

This paper reports on the synthesis and characterization of a non-peripherally tetra-substituted copper phthalocyanine containing a 4-(trifluoromethylthio)phenoxy group. The synthesized compounds have been characterized using elemental analysis, FTIR, 1H NMR, 13C NMR, MALDI-TOF, SEM and UV-vis spectral data. The crystal structure of 3-(4-(trifluoromethylthio)phenoxy)phthalonitrile (1) was confirmed by single-crystal X-ray diffraction. The crystallographic information file (cif) was uploaded to the data center with CCDC 1538643. We investigated the UV-vis spectra, band edge, band gap, refractive indices, dispersion, sensing, conductance and dielectric properties. The surface morphological properties of the Cu(ii)Pc (2) film were investigated under different conditions. © 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. BAP-2017-02-04-013 We thank The Research Fund of Sakarya University (Project no: BAP-2017-02-04-013).

An ESI ion trap mass spectrometer was designed for high-throughput and rapid mass analysis of large bioparticles. Mass calibration of the instrument was performed using commercially available polystyrene (PS) microparticles with a size comparable to cancer cells. Different sites of MCF-7 breast cancer cells (8 to 15 mu m) were used in this study. The masses of different cancer cells were measured. This system allows for the analysis of all types of particles.

The incubations of androst-4-ene-3,17-dione with Aspergillus candidus MRC 200634, Aspergillus tamarii MRC 72400, Aspergillus wentii MRC 200316 and Mucor hiemalis MRC 70325 for 5 days are reported. A. candidus MRC 200634 mainly hydroxylated androst-4-ene-3,17-dione at C-11 alpha, C-15 alpha and C-15 beta whilst A. wentii MRC 200316 hydroxylated it mainly at C-6 beta. A. tamarii MRC 72400 showed predominately a Baeyer-Villiger monooxygenase activity. M. hiemalis MRC 70325 hydroxylated the substrate at C-14 alpha and reduced most of it at C-17.

The synthesis and characterization of peripherally tetra 4-(methylthio)phenoxy substituted metal-free(2), Zn(II) (3) and Co(II) (4) phthalocyanine derivatives were reported. These newly synthesized phthalocyanine derivatives showed the enhanced solubility in organic solvents and they were characterized by a combination of elemental analysis, FTIR, H-1 NMR, C-13 NMR, UV-vis and MALDI-TOF/MS spectral data. Their aggregation properties were investigated in THE by UV-vis and fluorescence. These metal-free and metallophthalocyanine compounds were also evaluated for their total antioxidant abilities by using three different antioxidant methods such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, ferrous ion chelating and reducing power activity. All tested compounds showed radical scavenging activity. The highest radical scavenging activity was found from cobalt phthalocyanine (4) compound respectively. IC50 values of the compounds and standards (BHT and Trolox) were also determined. The results showed that the compound 4 had the highest antioxidant activity among all tested compounds including standards. The tested phthalocyanine compounds had ferrous ion chelating activity. In addition, they showed very high reducing power. All tested compounds had higher reducing power than the standards such as ascorbic acid and BHT. The present study shows that the synthesized tetra phthalocyanine [M: 2H(2), Zn(II)(3), Co(lI)(4)] with four peripheral 4-(methylthio) phenoxy compounds have the effective antioxidant properties that can be used as antioxidant agents. (C) 2017 Elsevier B.V. All rights reserved.

This study covers the functional complexes of tetrakis [4-(salicyhydrazone)phenoxy)] phthalocyaninato cobalt (II) (5) which was the macro molecular Schiff base ligand and synthesized through a multistep reaction sequence starting first with the cyclotetramerization of 4-[4-(1,3-Dioxolan-2-yl)phenoxy]-phthalonitrile (2). Then, the de-protection of tetra acetal groups of Tetrakis[4-(1,3-dioxolan-2-yl)phenoxy)]phthalocyaninato cobalt (II) (3) to the aldehyde functionality in acetic acid/FeCl3 system to yield the Tetrakis(4-formylphenoxy)phthalocyaninato cobalt(II) (4) and then its condensation with salicylhydrazide gave to 5. Finally, CoPc-bis(salicyhydrazone)phenoxy)manganese (III) (6), CoPc-bis(salicyhydrazone) phenoxy)cobalt(III) (7) and CoPc-bis (salicyhydrazone)phenoxy) nickel(II) (8) were synthesized using with the related MnCl2·4H2O, CoCl2·6H2O, Ni(CH3COO)2 salt in basic conditions in DMF. FT-IR, UV–Vis, MS spectra and elemental analysis were applied to characterize to prepared compounds. The bleaching performances of the prepared phthalocyanine compounds (3–8) were examined by the degradation of Morin as the hydrophilic dye which characterized the wine stains on the fabrics. Progress of the degradations in the catalysts (3–8)/H2O2 combination in basic aqueous solution conditions was investigated by using online spectrophotometric method (OSM). It was found that the prepared catalysts showed better bleaching performance at 25 °C than to that of tetraacetylethylenediamine (TAED) bleach activator commercially used in powder detergent formulations.

In this study, magnetic characteristic was added to activated carbon (AC) obtained by ZnCl2 activation of acorn shell. The produced magnetic AC (Fe-AC) was used effectively for the removal of methylene blue (MB) from aqueous solution. The effects of different batch parameters such as adsorbent dosage (0.05-0.2 g/100 mL), initial pH (3-9), temperature (298-318 K), initial dyestuff concentration (50-250 mg/L) and contact time (5-60 min) on the adsorption process were examined. The structural and chemical characterization of the synthesized AC and Fe-AC adsorbents were carried out by using various analytical techniques such as XRD, SEM/EDS, FT-IR and BET analysis techniques. The MB concentration in the solution was determined by UV-VIS spectrophotometer. From the Langmuir isotherm model, the maximum adsorption capacity was found as 330.0 and 357.1 mg/g for AC and Fe-AC adsorbents at 298K, respectively. The investigations on the effect of the temperature and calculated thermodynamic parameters exposed the endothermic nature of the adsorption process under the studied temperature range. The adsorption/desorption cycling test indicated that the prepared Fe-AC adsorbent had good reusability performance especially up to fourth cycle. Additionally, by considering all results it was concluded that the produced AC and Fe-AC adsorbents as novel adsorbents offer a great promise for the cleaning of MB dyestuff from aqueous solutions because of the advantage of their producibility from a cheap source, high adsorption capacity and fast uptake feasibility (C) 2017 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

The ZnO and different noble and transition metals (Ni, Mn, Fe and Ag) doped ZnO (M/ZnO) nanostructures were synthesized by hydrothermal method. The ZnO and M/ZnO photocatalysts were characterized by Xray diffraction (XRD), field emission scanning electron microscopy (FESEM), fourier transform infrared (FTIR) and UV-vis spectrophotometry. The obtained XRD and FESEM results confirmed the well dispersion of Ni and Ag nanoparticles and highly agglomerated Mn and Fe nanoparticles on the surface of ZnO nanostructures. The optical band gap value was calculated as 3.24, 3.15, 3.10, 3.05 and 3.00 eV from UV-vis diffuse reflectance spectra of ZnO, Ag/ZnO, Ni/ZnO, Fe/ZnO and Mn/ZnO photocatalysts, respectively. The results of the photocatalytic degradation of tartrazine in aqueous solutions under the UV-light showed that Ni/ZnO exhibited higher photocatalytic activity than the other ones. Mn/ZnO demonstrated the lowest photocatalytic activity among the synthesized photocatalysts. Thus, Ni and Ag exhibited synergistic effect while Fe and Mn exhibited antagonistic effect on the ZnO photocatalytic activity. The maximum degradation rate of tartrazine was obtained to be 98.2% in the 60 min using Ni/ZnO. The plausible mechanisms were proposed and discussed for the enhanced or decreased photocatalytic activities resulting from different metals doped ZnO. (C) 2017 Elsevier B.V. All rights reserved.

Hierarchical bundle-like ZnO nanorod arrays (BNRs) were synthesized by a one-pot hydrothermal method based on two consecutive temperature steps for cascade CdS/CdSe and ternary CdS1-xSex alloy quantum dot-sensitized solar cells (QDSSCs) as photoanode. The CdS/CdSe and CdS1-xSex QDs were deposited on the surface of the ZnO BNRs by conventional and modified successive ionic-layer adsorption and reaction (SILAR) methods, respectively. Using the ZnO BNRs/CdS/CdSe photoanode, the power conversion efficiency reaches 2.08%, which is 1.8 times higher than that of pristine ZnO nanorods/CdS/CdSe photoanode, while by applying ZnO BNRs/CdS1-xSex, the power conversion efficiency improves 2.52%. The remarkably improved photovoltaic performance is mainly derived from the bundle-like nanorod arrays structure, which increases the QDs loading amount and the scattering effect for light absorption, and the appropriate conduction band energy, sufficient Se amount and well coverage of the ternary CdS1-xSex QDs result in enhanced photogenerated electron injection, high light absorption and reduced recombination, respectively. As a result, ZnO BNRs/CdS1-xSex combination can significantly improve performance of QDSSCs. (C) 2016 Elsevier B.V. All rights reserved.

The catalytic activity of 1,3,5-triazine-pentaethylenehexamine (TAPEHA) polymer-supported Pd nanoparticles was investigated in the reduction of nitro arenes to the corresponding amines by NaBH$_{4}$ or N$_{2}$H$_{4}$.H$_{2}$O. Optimized reaction conditions for both systems were successfully tested on 20 nitroarenes with different characteristics. Considerably high yields (80%-98% in NaBH$_{4}$ and 85%-98% in N$_{2}$H$_{4})$ were obtained in a short time and at ambient temperature. In addition to these methods being selective against other reducible functionalities such as -CN, -Br, -Cl, and -I, the catalyst can be recovered easily and reused more than ten times.

Incubation of epiandrosterone with Aspergillus sydowii MRC 200653 afforded ten metabolites. The fungal dehydrogenation of epiandrosterone is reported for the first time. The formation of the major metabolite, 6 beta-hydroxyandrost-4-ene-3,17-dione, involved first dehydrogenation to give a 4-ene and then hydroxylation at C-6 beta. Small amounts of the substrate were hydroxylated at C-1 alpha, C-7 alpha, C-7 beta and C-11 alpha.

Heterocyclic compounds are of particular importance among pharmacologically active compounds. In this study, some piperonyl-based 4-thiazolidinone derivatives (2a-i) were synthesized and characterized by spectroscopic assays. All molecules were tested as enzyme inhibitory factors. These compounds were effective inhibitors of the enzymes acetylcholinesterase (AChE), alpha-glycosidase (alpha-Gly), and the human carbonic anhydrase I and II isoforms (hCA I and II), with K-i values in the range of 8.90-66.51 nM for alpha-Gly, 94.8-289.5 nM for hCA I, 106.3-304.6 nM for hCA II, and 0.55-2.36 nM for AChE. The synthesized molecules were also studied theoretically. Molecular docking calculations were performed to investigate the interaction between the target protein and molecules. CA inhibitor compounds have been clinically used for almost 60 years as antiglaucoma and diuretic drugs. The inhibition of the AChE enzyme results in the blockage of ACh hydrolysis. On the contrary, the design of inhibitor compounds or/and modulators for AChE is of major interest as it is one of the most popular tools to prevent Alzheimer's disease.

Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with K-i values in the range of 0.80 +/- 0.24-3.52 +/- 1.01 mu M for hCA I, 1.08 +/- 0.15-3.64 +/- 0.92 mu M for hCA II, 5.18 +/- 0.84-12.46 +/- 2.08 mu M for alpha-glycosidase, and 11.33 +/- 2.83-32.81 +/- 9.73 mu M for AChE, respectively.

In this study, novel phthalonitrile derivatives (1 and 2) and their peripherally and non-peripherally tetra (4-isopropylbenzyl)oxy-substituted zinc and chloroindium phthalocyanine complexes (3-6) have been prepared for the first time. The synthesized phthalonitrile derivatives and phthalocyanine complexes were characterized spectroscopically. Not only the chloroindium phthalocyanines but also zinc phthalocyanines are essentially free from aggregation in THF at the studied micromolar concentration. The purpose is to compare the effects of two types of substitution on the phthalocyanines to be used as sensitizers in photodynamic therapy (PDT). Photophysical and photochemical properties of all phthalocyanines are investigated and the results showed that the peripheral phthalocyanines more effectively photooxidize DPBF through singlet oxygen. The photochemical results showed that both ZnPc (3 and 5) and InPc (4 and 6) can be used as sensitizers in PDT because of their very high singlet oxygen quantum yields (range from 0.80 to 0.97).

WOS: 000457586700007, PubMed ID: 30600535, The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)ethoxy)phthalonitrile (2) and its soluble aminopyrazole-substituted peripheral metallo (Mn, Co, and Ni)-phthalocyanine complexes (3-5) are reported for the first time. The synthesized compounds and phthalocyanine complexes were characterized spectroscopically. The new phthalonitrile derivative (2) and its peripheral metallophthalocyanine complexes (3-5) were found to be effective inhibitors of alpha-glycosidase, acetylcholinesterase (AChE), human carbonic anhydrase I and II isoforms (hCA I and II), and butyrylcholinesterase (BChE) with K-i values in the range of 1.55 +/- 0.47 to 10.85 +/- 3.43 nM for alpha-glycosidase, 8.44 +/- 0.32 to 21.31 +/- 7.91 nM for hCA I, 11.73 +/- 2.82 to 31.03 +/- 4.81 nM for hCA II, 101.62 +/- 26.58 to 326.54 +/- 89.67 nM for AChE, and 68.68 +/- 11.15 to 109.53 +/- 19.55 nM for BChE. This is the first study of peripherally substituted phthalocyanines containing an aminopyrazole group as potential carbonic anhydrase enzyme inhibitor. Also, the antimicrobial activities of the synthesized compounds were evaluated against six microorganisms (four bacteria and two Candida species) using the broth microdilution method. The gram-positive bacteria were detected to be more sensitive than gram-negative bacteria and yeasts in the synthesized compounds., Sakarya University [2012-02-04-036], Sakarya University, Grant number: 2012-02-04-036

Polyphenol oxidase (Tyrosinase, PPO) has received considerable attention, since it is the key enzyme in melanin biosynthesis. In this study, we investigated prepared novel carbazole-containing pyridopyrimidine-substituted with urea and thiourea derivatives and their PPO activities on the diphenolase activity of banana tyrosinase. The structures of the compounds synthesized were confirmed by 1 H NMR, 13 C NMR, FTIR and elemental analysis. PPO enzyme was purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-amino benzoic acid. For evaluating the enzyme activity, the synthesised compounds were subjected to tyrosinase inhibition assay using catechol as substrate. While some of the compounds (6, 7, 8f, 8h, 8i, 8j) showed enzyme inhibitor effect, some of them (8a, 8b, 8c, 8d, 8e, 8g, 8k) activated the PPO enzyme activity. Gaussian software was used for the molecular calculations to explain the results for the prepared compounds.

A new photosensitizer, PCA-ZnPc-2, was synthesized through the asymmetric functionalization of phthalocyanine ring with a pyrazole-3-carboxylic acid as the electron-withdrawing and anchoring group and six hexylsulfanyl as the bulky electron-donating groups. PCA-ZnPc-2 was tested in dye-sensitized solar cells (DSSCs) and its performance was compared with PCA-ZnPc-1. It was found that PCA-ZnPc-2 has higher electron-donating ability which is favorable for light harvesting and suppress the dye aggregation on TiO2 when compared to PCA-ZnPc-1. Also, the new photosensitizer was used in dye-sensitized photoelectrochemical cells for hydrogen production under visible irradiation. The results show that PCA-ZnPc-2 is a promising photosensitizer to harvest the red/near-IR regions.

Guzel, Emre/0000-0002-1142-3936 WOS: 000484115800009 Electron-donating bromobenzenesulfanyl-group-substituted phthalonitrile derivative (1) and its novel non-peripherally tetra-substituted metal-free, indium and zinc phthalocyanine complexes (2-4) have been prepared for the first time. The chemical structures of this new phthalonitrile and its phthalocyanine derivatives were characterized by UV-vis, FT-IR, NMR, and MALDI-TOF mass spectrometry. The introduction of this electron-donating sulfanyl type of non-peripheral substituent accounts for a remarkable red shift of the phthalocyanine Q band to approximately 730 nm. Photophysical and photochemical properties of the novel functional complexes were also examined as photosensitizers for PDT applications. Research Fund of the Sakarya UniversitySakarya University [2017-02-04-009] This work was supported by the Research Fund of the Sakarya University (Project No: 2017-02-04-009).

WOS: 000472604800003 In this study simultaneous analysis of seven different anions (Fluoride, Chloride, Bromide, Nitrite, Nitrate, Phosphate, and Sulfate) in13 different water samples collected from Sakarya/Turkey and it was conducted with ion chromatography method. Analyzes were performed simultaneously using the ion chromatography method. Some validation tests and the optimum conditions for the determination of anions were studied. The analysis of anions was accomplished by the dilution of the sample injection device. Samples were used to adjust the terms of the device and the results were recorded. Ion chromatography (IC) is now considered as an excellent technique for the analysis of ions in many samples.

Peroxidase (POD) was extracted from kiwano (Cucumis metuliferus) and purified for the first time using three-phase partitioning (TPP). The POD was purified 4.47-fold with 138.78% recovery of enzyme activity. In the sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis, the POD showed a molecular weight of approximately 38 kDa. The optimum pH and temperature were found to be in the range of 4.0-7.5 and 30 degrees C- 40 degrees C, respectively, for substrates. The maximum substrate specificity was observed using caffeic acid (K-m = 0.03 mM) as the substrate. Seven inhibitors were investigated, of which KCN was the strongest inhibitor. Tests were performed for identifying various metal ions, of which Fe2+ was the most effective inhibitor and Hg2+ was the strongest activator. All tested organic solvents inhibited the POD activity. The optimum ionic strength of POD was found in 4 mM NaCl. The POD had a high salt tolerance with an enhancement of approximately 12%-20% enzyme activity after 2 h incubation in NaCl. Enzyme storage stability led to decrease in the POD activity by 84% at room temperature after 400 h, 83% at +4 degrees C after 60 days, and 73% at -20 degrees C after 135 days. To our knowledge, the present study is the first to report the purification and characterization of the POD extracted from kiwano, which could be useful in potential applications.

Two different silica samples with different particle size distributions (Silica-I: 40-63m, Silica-II: 90% below