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2. Farmasötik teknoloji I

Author

editörler Prof. Dr. Özgen Özer, Prof. Dr. Işık Özgüney, yazarlar Prof. Dr. Gökhan Ertan, Prof. Dr. Levent Kırılmaz, Prof. Dr. Esra Baloğlu, Prof. Dr. Yeşim Karasulu, Prof. Dr. Ferhan Sevgi, Prof. Dr. Ercüment Karasulu, Doç. Dr. Mine Özyazıcı, Doç. Dr. Sinem Yaprak Karavana, Doç. Dr. Evren Homan Gökçe, Doç. Dr. İpek Eroğlu, Doç. Dr. E. Öykü Çetin Uyanıkgil, Yard. Doç. Dr. Mesut Arıcı, Arş. Gör. Dr. Aysu Yurdasiper, Arş. Gör. Dr. Zeynep Şenyiğit, Arş. Gör. Dr. Sakine Tuncay Tanrıverdi, Arş. Gör. Dr. Gülbeyaz Yıldız Türkyılmaz, Arş. Gör. Dr. Seda Rençber, Arş. Gör. Erkan Azizoğlu, Arş. Gör. Gülçin Arslan Azizoğlu, editörler Prof. Dr. Özgen Özer, Prof. Dr. Işık Özgüney, yazarlar Prof. Dr. Gökhan Ertan, Prof. Dr. Levent Kırılmaz, Prof. Dr. Esra Baloğlu, Prof. Dr. Yeşim Karasulu, Prof. Dr. Ferhan Sevgi, Prof. Dr. Ercüment Karasulu, Doç. Dr. Mine Özyazıcı, Doç. Dr. Sinem Yaprak Karavana, Doç. Dr. Evren Homan Gökçe, Doç. Dr. İpek Eroğlu, Doç. Dr. E. Öykü Çetin Uyanıkgil, Yard. Doç. Dr. Mesut Arıcı, Arş. Gör. Dr. Aysu Yurdasiper, Arş. Gör. Dr. Zeynep Şenyiğit, Arş. Gör. Dr. Sakine Tuncay Tanrıverdi, Arş. Gör. Dr. Gülbeyaz Yıldız Türkyılmaz, Arş. Gör. Dr. Seda Rençber, Arş. Gör. Erkan Azizoğlu, and Arş. Gör. Gülçin Arslan Azizoğlu

Published
2020

3. Farmasötik teknoloji pratik el kitabı I-II-II-IV

Author

editör Özgen Özer, yazarlar Prof. Dr. Gökhan Ertan, Prof. Dr. Levent Kırılmaz, Prof. Dr. Esra Baloğlu, Prof. Dr. Yeşim Karasulu, Prof. Dr. Ferhan Sevgi, Prof. Dr. Ercüment Karasulu, Prof. Dr. Işık Özgüney, Doç. Dr. Mine Özyazıcı, Doç. Dr. Sinem Yaprak Karavana, Doç. Dr. Evren Homan Gökçe, Doç. Dr. E. Öykü Çetin Uyanıkgil, Doç. Dr. İpek Eroğlu, Yrd. Doç. Dr. Mesut Arıcı, Arş. Gör. Dr. Aysu Yurdasiper, Arş. Gör. Dr. Zeynep Şenyiğit, Arş. Gör. Dr. Sakine Tuncay Tanrıverdi, Arş. Gör. Dr. Gülbeyaz Yıldız Türkyılmaz, Arş. Gör. Dr. Seda Rençber, Arş. Gör. Erkan Azizoğlu, Arş. Gör. Gülçin Arslan Azizoğlu, Arş. Gör. Betül Rümeysa Temel, editör Özgen Özer, yazarlar Prof. Dr. Gökhan Ertan, Prof. Dr. Levent Kırılmaz, Prof. Dr. Esra Baloğlu, Prof. Dr. Yeşim Karasulu, Prof. Dr. Ferhan Sevgi, Prof. Dr. Ercüment Karasulu, Prof. Dr. Işık Özgüney, Doç. Dr. Mine Özyazıcı, Doç. Dr. Sinem Yaprak Karavana, Doç. Dr. Evren Homan Gökçe, Doç. Dr. E. Öykü Çetin Uyanıkgil, Doç. Dr. İpek Eroğlu, Yrd. Doç. Dr. Mesut Arıcı, Arş. Gör. Dr. Aysu Yurdasiper, Arş. Gör. Dr. Zeynep Şenyiğit, Arş. Gör. Dr. Sakine Tuncay Tanrıverdi, Arş. Gör. Dr. Gülbeyaz Yıldız Türkyılmaz, Arş. Gör. Dr. Seda Rençber, Arş. Gör. Erkan Azizoğlu, Arş. Gör. Gülçin Arslan Azizoğlu, and Arş. Gör. Betül Rümeysa Temel

Published
2020

4. A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers

Author

Özgen Özer, Evren Gökçe, Eleonora Dellera, M. Cristina Bonferoni, Sakine Tuncay-Tanrıverdi, Emrah Korkmaz, Giuseppina Sandri, and Ege Üniversitesi

Subjects
Medicine (General), Materials science, Biocompatibility, Ubiquinone, Administration, Topical, Skin Absorption, Cytotoxicity, Dispersity, Solid lipid nanoparticles, Biophysics, Pharmaceutical Science, Bioengineering, Pharmacology, Antioxidants, Cell Line, Biomaterials, chemistry.chemical_compound, R5-920, Nanocapsules, International Journal of Nanomedicine, Drug Discovery, Solid lipid nanoparticle, Zeta potential, Humans, Original Research, Coenzyme Q10, Liposome, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Organic Chemistry, General Medicine, Fibroblasts, Lipids, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, chemistry, Liposomes, Particle size, InformationSystems_MISCELLANEOUS, Antioxidant, Homogenization (biology)
Abstract

PubMed ID: 23055723, Background: The effective delivery of coenzyme Q10 (Q10) to the skin has several benefits in therapy for different skin pathologies. However, the delivery of Q10 to deeper layers of skin is challenging due to low aqueous solubility of Q10. Liposomes and solid lipid nanoparticles (SLN) have many advantages to accomplish the requirements in topical drug delivery. This study aims to evaluate the influence of these nanosystems on the effective delivery of Q10 into the skin. Methods: Q10-loaded liposomes (LIPO-Q10) and SLNs (SLN-Q10) were prepared by thin film hydration and high shear homogenization methods, respectively. Particle size (PS), polydispersity index (PI), zeta potential (ZP), and drug entrapment efficiency were determined. Differential scanning calorimetry analysis and morphological transmission electron microscopy (TEM) examination were conducted. Biocompatibility/cytotoxicity studies of Q10-loaded nanosystems were performed by means of cell culture (human fibroblasts) under oxidative conditions. The protective effect of formulations against production of reactive oxygen species were comparatively evaluated by cytofluorometry studies. Results: PS of uniform SLN-Q10 and LIPO-Q10 were determined as 152.4 ± 7.9 nm and 301.1 ± 8.2 nm, respectively. ZPs were -13.67 ± 1.32 mV and -36.6 ± 0.85 mV in the same order. The drug entrapment efficiency was 15% higher in SLN systems. TEM studies confirmed the colloidal size. SLN-Q10 and LIPO-Q10 showed biocompatibility towards fibroblasts up to 50 µM of Q10, which was determined as suitable for cell proliferation. The mean fluorescence intensity % depending on ROS production determined in cytofluorometric studies could be listed as Q10 ? SLN-Q10 > LIPO-Q10. Conclusion: The LIPO-Q10 system was able to enhance cell proliferation. On the contrary, SLN-Q10 did not show protective effects against ROS accumulation. As a conclusion, liposomes seem to have advantages over SLN in terms of effective delivery of Q10 to skin for antioxidant purposes. © 2012 Gokce et al, publisher and licensee Dove Medical Press Ltd.

Published
2012

5. List of contributors

Author

Saket Asati, Silki Chandel, Marco V. Chaud, Jaime Conceição, Juliana Cordeiro, Sandipan Dasgupta, Supriya Datta, Sanjay Dey, Marilene Estanqueiro, Joana F. Fangueiro, Agnieszka Feliczak-Guzik, Evren H. Gökçe, M. Helena Amaral, Priyanka Jain, Alicja Kapuścińska, Susmitha Kasina, Ranjot Kaur, Nicola Lionetti, Shikha Lohan, Bhaskar Mazumder, S. Narasimha Murthy, Arun Nanda, Sanju Nanda, Izabela Nowak, Anna Olejnik, Özgen Özer, Yasvant V. Pathak, Madhulika Pradhan, Abhay Raizaday, Luigi Rigano, Patrícia Severino, Neha Sharma, Ranjita Shegokar, Shikha Shrivastava, Amélia M. Silva, Bhupinder Singh, Deependra Singh, Manju Rawat Singh, Thakur Gurjeet Singh, Vandana Soni, José M. Sousa Lobo, Eliana B. Souto, Sakine Tuncay Tanrıverdi, Agata Wawrzynczak, Hemant K.S. Yadav, Evren Algın Yapar, and Aleksandra Zielińska

Published
2016
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