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2. Body mass index and complications following major gastrointestinal surgery
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Blanco-Colino R, Lee S, Kamarajah SK, Vasko P, Kuiper SZ, Farina V, Chapman SJ, Drake TM, Gavagna L, Pasquali S, Pata F, Pellino G, de la Rosa-Estadella M, Stellingwerf ME, Stijns RCH, Borrellas A, Golding D, Ngaage M, Van Tol RR, de Groof J, de Wilt H, Bemelman WA, McNamee L, Espin-Basany E, Emre Baki B, Gecim IE, Can Tatar O, Bach S, Bhangu A, Bresges K, Burke J, Claireaux HA, Fearnhead N, Fitzgerald JE, Gallagher S, Glasbey JC, Gundogan B, Harrison EM, Hernon J, Khatri C, Kong CY, Lyons A, Mohan M, Morton D, Pinkney TD, Arezzo A, Foppa C, Morino M, Rubbini M, Selvaggi F, Sensi B, Sica G, Orhalmi J, Naccari P, Sgrò A, Burger BHCM, Fares DA, Spijkerman R, van Elst TR, Wiersema R, Stassen LPS, Rodriguez Garcia R, Özkan BB, Tavuz AI, Demirci ZS, Baki BE, Choi PJ, O'Sullivan H, Salman M, Simioni A, Colombo F, Turati L, Cazzola FE, Gallo G, Perrotta G, Papandrea M, Naccari PM, Menduni N, Rossi E, Chetta N, Romeo F, Giordano F, Randisi B, Curletti G, Kuiper J, Costa A, Marcos Rodrigo A, Sanchez A, Varo Muñoz A, Martinez Rios CE, Aliseda-Jover D, Fernandez Nieto D, Alvarez Reyes I, Dominguez Rodriguez LM, Hernandez Ros MI, Esteban Sinovas O, Bartrina Soler P, Villarejo Campos P, Laguna Román S, Fontanet-Soler S, Raurich-Leandro J, Dominguez-Prieto V, Segura-Sampedro JJ, Alconchel-Gago F, Salazar-García C, Gezen AE, Sahin A, Atasoy H, Yuksek B, Arslan E, Ozmen BB, Sen AY, Erol HI, Ucar E, Aktas MK, Yurdaor SS, Mermer S, Seyhan U, Tosun V, Gunaydin Y, Ekinci ZB, Yazkan Z, Choi J, Yeoh TSL, Jones CS, Venturini S, Saat MI, Loo J, Pike G, Davies SC, Kabariti R, Olivier J, Hurný M, Žebrák R, Machačová A, Schulzová M, Smolák P, Široká M, Palyzová H, Jaroš J, Dušek T, Šimáčková B, Bartoš M, Sotona O, Pös M, Karásek D, Higgins P, Hacking S, Arora E, Coughlan G, Palanivail N, Quill S, Zhang AA, Malak M, Maan DS, Cheema J, Goh AWJ, Shamsul Badrin AK, Guinness F, Howard James N, Neary A, Sebaoui S, Gilroy D, Petrov G, Craven K, MacDonald A, Redmond A, Brennan D, Roche D, O'Dwyer M, Collins P, Edwards S, Doyle J, Tiedt L, Arthurs B, O'Byrne L, Kiely A, Glynn M, Sproule L, Heaney A, Li Hi Shing S, Goh W, Al-Nasser Z, Al-Nasser A, Teh JW, De Boni D, Goldin E, Ciccioli E, Vendramin E, Marchese N, Bruno M, Vinci A, Harder G, Morandi V, Magnoli M, Suppa A, Palmieri A, Martorana M, Sette M, Balagna P, Cruciani C, Corte M, Ciano P, Bagaglini G, Montuori M, Di Benedetto L, Arcudi C, Pezzuto R, Saraceno F, Milana F, Franceschilli M, Rizzi A, Sampietro G, Rampulla V, Bianco F, Boschetti ME, Ghignone F, Bianchini S, Esposto R, Riva L, Riva M, Cannavò M, Arrigo A, Giavarini L, Colombo EM, Trompetto M, Clerico G, Catalano M, Dosa T, El Mabruk M, Barone V, Pallara E, Pasqualoni M, Caudullo G, Mastandrea Bonaviri GN, Muro M, Pistola I, Verardi L, Ferrara D, Gerardi S, Remore LM, Belia F, Del Coco F, Larotonda C, Botrugno EM, Cammarota A, Di Girolami L, Laterza V, Laurino A, Paolo G, Santocchi P, Puccioni C, Truma A, Giardino FR, Giuffrida A, Ripa M, Cautiero R, Patturelli M, Capozzolo A, Selvaggi L, Facchiano A, Milazzo LF, Papazachariou SK, Pattapola V, Anania G, Feo C, Bellinato M, Priani P, Zigiotto D, Troia A, Vable T, Piran G, Targa S, Pulpito S, Tagariello F, Fasano A, Anconelli D, Castiglione F, Tognolo L, Lopez G, Campion A, Tarantino M, Sacco R, Sammarco G, Palmisano S, Giacca M, Rocco I, Bellio G, Favero A, Raimondi P, Pantalone MR, De Nardi P, Notarnicola M, Picciariello A, Licari L, Parinisi Z, Fazzotta S, Ciciliot M, Reggiani L, Mariani F, Aonzo P, Checcacci P, Montanelli P, Guerra F, Skalamera I, Staderini F, Grandi S, Nelli T, de Boer DV, van der Pool AEM, Janssen TL, El-Atmani S, van Verschuer VMT, Poelman M, Dronkers WJ, van Steensel L, Toorenvliet BR, Duinhouwer LE, Vermaas M, Ter Bruggen FFJA, Hogendoorn W, van der Harst E, van Rijckevorsel VAJIM, Bayoumy AB, Lap CR, Gooszen JAH, Abdulrahman N, de Roy van Zuidewijn D, de Groof EJ, Zijlmans JL, van Dalen ASHM, Bos K, Musters GD, Looijen RC, Fliers JM, Oostendorp SE, Mosterd CM, Blonk L, Jurgens J, Ribbink ME, Boom MS, Boersma AM, Hidding E, Schmidt PA, Mensink G, Graus SA, Gastel MDA, Veenker CGH, Van Heumen TM, Slieker FJB, Sedee WJA, Löwensteyn YN, Amelung FJ, de Guerre LEVM, Nota CLMA, Van Dijck WPM, van Wijnbergen JWM, Pronk A, Kip M, van der Zee C, Heiloo S, Muller S, Verboeket B, Oudman TS, Zope S, Gilissen V, Gommers J, Cremers D, Van der Lubbe M, Smet M, Ter Weele K, de Bruin M, Geerlings M, Ter Horst L, Kerimova N, Pesser N, Heesakkers H, de Mees T, de Gooyer JM, Willems L, Gawria L, Bonouvrie D, Harms J, Eggen Y, Hengeveld E, Smeets HJ, Hoffman RPC, Detmers Blom FPN, Van Bruggen D, Steup WH, Gooiker GA, Willems YR, van der Hoeven AC, Vallve-Bernal M, Perez-Gandara B, Perez JL, Caballero Rodriguez E, Perez Febles M, Protti Ruiz GP, Hidalgo Pujol M, Alberti Delgado P, Gil Barrionuevo E, Anabitarte O, Caballero L, Poyato Nuñez FJ, Prado Perez R, de la Portilla de Juan F, Fulgencio Barbarin J, Elorza Echaniz G, Mitxelena Elosegi L, Delgado AT, Marti Gelonch L, Gonzalez Arribas M, De Serra Tejada I, Alberdi San Roman I, de Andres Olabarria U, Fernández-Domper L, Perez Costoya C, Perez Arias H, Fa Binefa M, Becerra Nieves M, Escalona Canal MG, Aldrey I, Vazquez-Gonzalez I, Falcon Cazas A, Amarelo Garcia M, Gonzalez Ruiz AA, Garcia Garrido M, Simon Frapolli V, Martinez Diaz JM, De la Torre Conde C, Rodrigues Silva K, Hernandez Kakauridze S, Lopez Garcia MC, Flores Funes D, Gómez-López de San Román C, San Martín Bragado M, Tejero Pintor FJ, Pando Ruiz B, Sánchez Estébanez E, Roquet Puigneró E, Pla Seró S, Vela Polanco FF, Mirallas Viñas O, Caro Gonzalez MP, Bertelli Puche JL, Gonzalez-Martinez A, Sanchez Cambronero M, Garcia Torres A, Dominguez Jimenez M, de Jesus Rodriguez Perdomo M, Echazarreta-Gallego E, Sánchez-Blasco L, Del Mar López-Cuevas M, Latras-Cortés I, López-Vendrell L, Díaz Padillo A, Mestres Petit N, Cruz Reyes JA, Fernandez C, Posada M, Moratilla Lapeña L, Martin Morales E, Mate-Mate P, Garcia Cruz G, Gorini L, Rubio-Perez I, Soldevila-Verdeguer C, Jiménez-Viñas C, Luehrman A, Sena-Ruiz F, Garcia-Perez JM, Plomer-Sanchez M, Pujol-Cano N, Jimenez-Segovia M, Diaz-Jover P, Pineño-Flores C, Ambrona-Zafra D, Gonzalez-Argente XF, Jiménez-Morillas P, López-Mármol R, Durán-Martínez M, González-Crespo A, Checa Guillen M, Valderrama Pérez A, Claramonte Bellmunt O, Martí Fernández RM, Kasap S, Soylemez ZOBB, Bolat AB, Aydar SEYI, Birgin BZ, Coskun O, Cakir SG, Belibagli ZO, Herken M, Erdem S, Kayacan S, Kelesoglu Y, Moran D, Atalay H, Kucukdiler E, Demirci A, Buyukkasap C, Kuzey A, Emral C, Dogan H, Cok H, Durmaz H, Asma A, Ergul B, Kaya A, Bilicen G, Gunay M, Senturk E, Baskoy L, Besısık HM, Topalan K, Piraliyev E, Danalıoglu AN, Ilbak A, Yıgman S, Kara C, Guzel M, Inci ET, Onsal U, Erel T, Cetin SK, Yekenkurul E, Kasar P, Saglam ZA, Gursoy F, Cetinkaya M, Aktekin H, Bober DN, Mugurtay YS, Koksal G, Celik S, Bektur G, Yildirim R, Ankarali T, Güven H, Yuksel A, Semiz A, Cise S, Tomas K, Ulusahin M, Akbulut F, Tulum H, Bodur S, Isler VC, Pektas AM, Mutlu D, Mericliler M, Tansoker I, Polat ZP, Seyrek N, Beyatli S, Toto OF, Cakaloglu HC, Sapci I, Akpunarli B, Adiyaman C, Kobal BB, Gok Z, Benli S, Turpan M, Kocapinar S, Parimli H, Acar S, Eger M, Yilmaz I, Cengiz U, Yoruk I, Mutlu B, Ulkucu A, Arukan C, Kara B, Gokce K, Calisgan B, Demirci K, Elkatroushi T, Ayaz B, Uzun B, Sivrikaya T, Goksoy B, Eroz E, Celik B, Canbay Torun B, Ekin B, Senay BB, Temiz C, Yilmaz M, Yasar C, Cakir E, Subasi A, Celik K, Aksoy K, Karabulut E, Altintas O, Bali AN, Ciftci E, Babaoglu H, Aljbour A, Aljbour I, Akcaoglu T, Kakil E, Taskin O, Taskin RB, Topal U, Huzmeli E, Caliskan T, Unal AG, Yurekli AM, Sari V, Tutam DN, Celen D, Posteki G, Demirtas B, Yildiz S, Kilic E, Yalcin Y, Kurt A, Gozubuyuk Y, Huseynova S, Cinar S, Calar SN, Kurklu O, Binbuga M, Ceylan C, Yavuz G, Alim YE, Yildirim N, Yilmaz S, Onar D, Aray E, Ozsipahi AC, Koc GE, Yetiskin E, Kocer MD, Ozgencil B, Bahcecioglu B, Hacioglu AD, Bilici O, Cin S, Uzunoglu EC, Cumen EC, Aslan L, Erozgur B, Yildiz SS, Zengin T, Kullac S, Mizan SR, Baykan B, Kopac O, Karabacak U, Aytekin A, Deliktas TS, Buyukkarabacak Y, Uzun O, Karahan B, Turkmen M, Akdogan A, Uctepe F, Bandirmali O, Erdogan P, Demir F, Bozkurt GK, Yilmaz T, Sheikh IMI, Orhan K, Balci B, Keyif MF, Bilgin S, Cantimer E, Yaman S, Akkaya E, Atesavci SN, Arslan U, Asik M, Koksal S, Murtaza MI, Mustafa S, Oun H, Sam ZH, Brogan A, Zaidi R, Quinn K, Taylor F, Pang G, Heath H, Smart NJ, Home J, Mauro D, Noone TM, Fenn J, Sinha A, Lowe R, Hutchings I, Longstaff L, Smith AG, Edwards JA, Alcocer BP, Oakley T, Thomas-Davies M, Hourston GJM, Kankam HKN, Ramana A, Baker C, Endo Y, Wong C, Anderson RGJ, Badran A, Ali A, Myers L, Tippins F, Stanley S, Sandison L, Schofield E, Delf J, Rees S, Anyan-Brown J, Long K, Archer M, Anakwenze V, Goel S, Sharma Khatiwada A, Khan S, Leafe O, Lee J, Embury-Young Y, Edwards L, Hazenberg P, Agrawal M, Guerero D, Britton F, Rejayee M, Mahesh S, Khaing PH, Baldwin A, Iyer S, Gaskell P, Adlan A, Cuckow L, Barmayehvar B, Rob T, Ciurleo C, Mural-Krishnan S, Jong N, Carlson S, Abdelgalil R, Goble M, Doshi A, Ogunleye O, Marsh L, Bagley J, Poacher A, Cantelo J, Wylie J, Govil S, Hill F, Beaver D, Urquhart A, Rakhimov I, Raina V, Clifford T, Iorga R, Cartwright E, Harris AJ, Shurovi B, Wadanamby S, Brown E, Bradley C, Ahmad A, Jeyabraba S, Hardaman B, Truss A, Mohamed US, Örhalmi J, Kerin MJ, Reynolds J, Ridgway P, Pietrabissa A, Foschi D, Sgroi G, Rosati G, Benevento A, Coco C, Persiani R, Vasquez G, Messina F, De Manzini N, Innocenti P, Rosati R, Altomare DF, Sartori A, Salamone G, Galleano R, Cianchi F, Wijnhoven BPL, van de Ven AWH, de Vos Tot Nederveen Cappel RJ, de Castro SMM, Meijerink WJHJ, Mulder IM, Acherman YIZ, van Leeuwen BL, Schasfoort RA, Kloppenberg FWH, Wiezer R, Consten ECJ, Van Grevenstein WMU, Schiphorst A, Wijffels N, Uittenbogaart M, Klinkert M, Koppe M, de Hingh I, Konsten J, Polat F, Berends F, Langenhoff B, Zimmerman D, van Engelenburg T, Vries JJM, Baeten CIM, Bastiaansen AJNM, van Geloven A, Khan I, Girones J, Barrera Gomez M, Sanz Ortega G, Duran Muñoz-Cruzado VM, Ruiz Montesinos I, Enriquez-Navascues JM, Portugal Porras V, Baixauli J, Garcia Florez LJ, Alonso Gonçalves S, Parajo A, Sanchez-Guillen L, Lujan Mompean JA, Soria Aledo V, Arenal JJ, Blanco Antona F, Badia JM, Roura J, Garcia Garcia J, Elía-Guedea M, Millan M, Viñas-Salas J, Garcia-Olmo D, Prieto-Nieto MI, Medina-Fernández FJ, Romero-Simó M, Frasson M, Espí Macías A, Tirnaksiz MB, Leventoglu S, Kara E, Taşçı Y, Pehlivan M, Guner A, Ozben V, Agalar C, Albayrak D, Ertekin C, Oncel M, Sakman G, Guler SA, Firat O, Akkucuk S, Ozbalci GS, Sozuer EM, Sengul N, Schizas A, Horgan PG, Singh B, Harikrishnan A, Stechman M, Hayat J, Coyne P, Wilson T, Arun C, Manvydas V, Moroni P, Lo Secco G, Argenti F, Romano F, Calcagno P, Steccanella F, Cisternino G, Bottini C, Realis Luc A, Apicella M, Candilio G, Gubbiotti F, De Luca E, Casagranda B, Decorato A, Aquilino F, Badii B, Rahmee CNS, Kleine E, Yauw S, de Zeeuw S, Aarts E, Teixeira da Silva M, Brueren L, Bokkerink G, Schok T, Graafland M, Gonzalez de Chaves PE, Jimenez-Gomez LM, García Galocha JL, Palos Campos MC, Jimenez Escovar F, Hernandez-Lizoáin JL, Monzonis Hernandez X, Dominguez Sanchez JM, Vives-Rodriguez E, Abrisqueta Carrion J, Beltrán de Heredia J, Padilla Valverde D, Alcazar Montero JA, Córdoba-Díaz de Laspra E, Franco Chacón M, Muriel P, Pastor-Riquelme P, Peinado Iribar B, Alonso Hernandez N, Costa-Navarro D, Martínez Chillarón E, Secilmis E, Bamac E, Koç F, Kayaci Durak M, Bayram S, Ekrem M, Uzun S, Gok AFK, Gorguner F, Yildiz T, Dalci K, Kilinc C, Koç M, Yuksek MA, Ersoy T, Celik E, Parmar E, Abuhussein N, Metcalf P, Atif M, Heywood E, Mayes JW, Kelly M, Mitchell H, Antoniou I, Dean R, Davies N, Trecarten S, Henderson I, Holmes C, Shuttleworth RH, Jindal A, Hughes F, Gouda P, Fleck R, Hanrahan M, Karunakaran P, Chen JH, Sykes MC, Sethi RK, Suresh S, Patel P, Patel M, Varma RK, Mushtaq J, Bolton W, Khan T, Morley R, Favero N, Adams R, Thirumal V, Kennedy ED, Ong KK, Tan YH, Gabriel J, Bakhsh A, Low JYL, Yener A, Paraoan V, Preece R, Tilston TW, Cumber E, Dean S, Ross T, McCance E, Amin H, Satterthwaite L, Clement KD, Gratton R, Mills ED, Chiu SM, Hung G, Rafiq NM, Hayes JDB, Robertson KL, Dynes K, Huang HC, Assadullah S, Duncumb JW, Moon RDC, Poo SX, Mehta JK, Joshi KR, Callan R, Norris JM, Chilvers NJ, Keevil H, Jull P, Mallick S, Elf D, Carr L, Player C, Barton EC, Martin AL, Ratu SG, Roberts EJ, Phan PN, Dyal AR, Rogers JE, Henson AD, Reid NB, Burke D, Culleton G, Lynne S, Mansoor S, Brennan C, Blessed R, Holloway C, Hill A, Goldsmith T, Mackin S, Kim S, Woin E, Brent G, Coffin J, Ziff O, Momoh Z, Debenham R, Ahmed M, Yong CS, Wan JC, Copley HC, Raut P, Chaudhry FI, Nixon G, Dorman C, Tan R, Kanabar S, Canning N, Dolaghan M, Bell N, McMenamin M, Chhabra A, Duke K, Turner L, Patel T, Chew LS, Mirza M, Lunawat S, Oremule B, Ward N, Khan M, Tan ET, Maclennan D, McGregor RJ, Chisholm EG, Griffin EJ, Bell L, Hughes BA, Davies J, Haq H, Ahmed H, Ungcharoen N, Whacha C, Thethi R, Markham RM, Lee AHY, Batt E, Bullock NP, Francescon CT, Davies JE, Shafiq NM, Zhao J, Vivekanantham S, Barai I, Allen JLY, Marshall DC, McIntyre CJ, Wilson HCP, Ashton AJ, Lek C, Behar N, Davis-Hall M, Seneviratne N, Esteve L, Sirakaya M, Ali S, Pope S, Ahn JS, Craig-McQuaide A, Gatfield WA, Leong S, Demetri AM, Kerr AL, Rees C, Loveday J, Liu S, Wijesekera M, Maru D, Attalla M, Smith N, Brown D, Sritharan P, Shah A, Charavanamuttu V, Heppenstall-Harris G, Ng K, Raghvani T, Rajan N, Hulley K, Moody N, Williams M, Cotton A, Sharifpour M, Lwin KN, Bright M, Chitnis AR, Abdelhadi M, Semana AD, Morgan F, Reid R, Dickson J, Anderson L, McMullan R, Ahern N, Asmadi A, Anderson LB, Lua Boon Xuan J, Crozier L, McAleer S, Lees DM, Adebayo AA, Das M, Amphlett AH, Al-Robeye A, Valli A, Khangura J, Winarski A, Woodward H, Gouldthrope C, Turner M, Sasapu K, Tonkins M, Wild JRL, Robinson M, Hardie J, Heminway R, Narramore R, Ramjeeawon N, Hibberd A, Winslow F, Ho W, Chong BF, Lim K, Ho S, Crewdson JA, Singagireson S, Kalra N, Koumpa F, Jhala H, Soon WC, Karia M, Rasiah MG, Xylas D, Gilbert H, Sundar-Singh M, Wills J, Akhtar S, Patel S, Hu L, Brathwaite-Shirley C, Nayee H, Amin O, Rangan T, Turner EJH, McCrann C, Shepherd R, Patel N, Prest-Smith J, Auyoung E, Murtaza A, Coates A, Prys-Jones O, King M, Gaffney S, Dewdney CJ, Nehikhare I, Lavery J, Bassett J, Davies K, Ahmad K, Collins A, Acres M, Egerton C, Cheng K, Chen X, Chan N, Sheldon A, Empey J, Ingram E, Malik A, Johnstone M, Goodier R, Shah JP, Giles JE, Sanders JA, McLure SW, Pal S, Rangedara A, Baker AN, Asbjoernsen CA, Girling C, Gray L, Gauntlett L, Joyner C, Qureshi S, Mogan YP, Ng JCK, Kumar AN, Park JH, Tan D, Choo KP, Raman KP, Buakuma P, Xiao C, Govinden S, Thompson OD, Charalambos MA, Karsan RB, Dogra T, Bullman LM, Dawson PM, Frank AL, Abid H, Tung L, Qureshi U, Tahmina A, Matthews BW, Harris RT, O'Connor A, Mazan K, Iqbal S, Stanger SA, Thompson JD, Sullivan JAL, Uppal E, MacAskill A, Bamgbose FA, Neophytou C, Carroll AF, Rookes CW, Datta U, Dhutia AJ, Rashid S, Ahmed N, Lo T, Bhanderi S, Blore CD, Ahmed S, Shaheen H, Abburu S, Majid S, Abbas Z, Talukdar SS, Burney LJ, Patel JB, Al-Obaedi O, Roberts AW, Mahboob S, Sheth S, Karia P, Prabhudesai A, Kow K, Koysombat K, Wang S, Morrison P, Maheswaran Y, Keane P, Copley PC, Brewster O, Xu GX, Harries P, Wall C, Al-Mousawi A, Bonsu S, Cunha P, Ward T, Paul J, Nadanakumaran K, Tayeh S, Holyoak H, Remedios J, Theodoropoulou K, Luhishi A, Jacob L, Long F, Atayi A, Sarwar S, Parker O, Harvey J, Ross H, Rampal R, Thomas G, Vanmali P, McGowan C, Stein J, Robertson V, Carthew L, Teng V, Fong J, Street AN, Thakker CE, O'Reilly D, Bravo M, Pizzolato A, Khokhar HA, Ryan M, Cheskes L, Carr R, Salih AE, Bassiony S, Yuen R, Chrastek D, Rosen O'Sullivan H, Amajuoyi A, Wang A, Sitta O, Wye J, Qamar MA, Major C, Kaushal A, Morgan C, Petrarca M, Allot R, Verma K, Dutt S, Chilima CP, Peroos S, Kosasih SR, Chin H, Ashken L, Pearse RJ, O'Loughlin RA, Menon A, Singh K, Norton J, Sagar R, Jathanna N, Rothwell L, Watson N, Harding F, Dube P, Khalid H, Punjabi N, Sagmeister M, Gill P, Shahid S, Hudson-Phillips S, George D, Ashwood J, Lewis T, Dhar M, Sangal P, Rhema IA, Kotecha D, Afzal Z, Syeed JA, Prakash E, Jalota P, Herron J, Kimani L, Delport A, Shukla A, Agarwal V, Parthiban S, Thakur H, Cymes W, Rinkoff S, Turnbull JA, Hayat M, Darr S, Khan U, Lim J, Higgins A, Lakshmipathy G, Forte B, Canning E, Jaitley A, Lamont J, Toner E, Ghaffar A, McDowell M, Salmon D, O'Carroll O, Khan A, Kelly ME, Clesham K, Palmer C, Lyons R, Bell A, Chin R, Waldron RM, Trimble A, Cox SE, Ashfaq U, Campbell J, Holliday RBS, McCabe G, Morris F, Priestland R, Vernon OK, Ledsam A, Vaughan R, Lim D, Bakewell ZR, Hughes RK, Koshy RM, Jackson HR, Narayan P, Cardwell AE, Jubainville CL, Arif T, Elliott LE, Gupta V, Bhaskaran G, Odeleye A, Ahmed F, Shah R, Pickard J, Suleman YN, North AS, McClymont LF, Hussain N, Ibrahim I, Ng GS, Wong V, Lim AE, Harris LN, Tharmachandirar T, Mittapalli D, Patel V, Lakhani M, Bazeer HZ, Narwani V, Sandhu KK, Wingfield LR, Gentry S, Adjei H, Bhatti M, Braganza L, Barnes J, Mistry S, Chillarge G, Stokes S, Cleere J, Bucko AM, Meek J, Boxall N, Heywood EG, Wiltshire JJ, Toh C, Ward AE, Shurovi BN, Horth D, Patel BY, Ali B, Spencer T, Axelson T, Kretzmer L, Chhina C, Anandarajah C, Fautz T, Horst C, Thevathasan AA, Ng JQ, Hirst F, Brewer CF, Logan AE, Lockey JW, Forrest PR, Keelty N, Wood AD, Springford LR, Avery P, Schulz TM, Bemand TP, Howells L, Collier H, Khajuria A, Tharakan RG, Parsons S, Buchan AM, McGalliard RJ, Mason JD, Cundy OJ, Li N, Redgrave NA, Watson RP, Pezas TP, Dennis YF, Segall E, Hameed M, Lynch AS, Chamberlain M, Peck FS, Neo YN, Russell G, Elseedawy M, Foster NL, Soo YH, Puan L, Dennis R, Goradia H, Qureshi A, Osman S, Reeves T, Dinsmore L, Marsden M, Lu Q, Pitts-Tucker T, Dunn CE, Walford RA, Heathcote E, Martin R, Pericleous A, Brzyska K, Reid KG, Williams MR, Wetherall N, McAleer E, Thomas D, Kiff R, Milne S, Holmes MJV, Bartlett J, Lucas de Carvalho J, Bloomfield T, Tongo F, Bremner RH, Yong N, Atraszkiewicz BA, Mehdi A, Tahir M, Sherliker GXJ, Tear AK, Pandey A, Broyd A, Omer HM, Raphael M, Chaudhry WW, Shahidi S, Jawad AS, Gill CK, Hindle Fisher I, Adeleja I, Clark IJ, Aidoo-Micah GE, Stather PW, Salam GJ, Glover TE, Deas G, Sim NK, Obute RD, Wynell-Mayow WM, Sait MS, Mitha N, de Bernier GL, Siddiqui M, Shaunak R, Wali A, Cuthbert G, Bhudia R, Webb E, Shah S, Ansari N, Perera M, Kelly N, McAllister R, Stanley GH, Keane CP, Shatkar V, Maxwell-Armstrong C, Henderson LA, Maple N, Manson R, Adams RD, Semple E, Mills M, Daoub A, Marsh A, Ramnarine A, Hartley J, Malaj M, Jewell PD, Whatling EA, Hitchen N, Chen M, Goh B, Fern J, Rogers S, Derbyshire L, Robertson DT, Deekonda P, Abid A, Harrison PLM, Aildasani L, Turley H, Sherif MA, Pandey G, Filby JJ, Johnston A, Burke E, Mohamud M, Gohil K, Tsui AY, Singh R, Lim SJ, O'Sullivan K, McKelvey LL, O'Neill S, Roberts HF, Brown FS, Cao Y, Buckle RT, Liew Y, Sii S, Ventre CM, Graham CJ, Filipescu T, Yousif A, Dawar R, Wright A, Peters M, Varley R, Owczarek S, Hartley S, Khattak M, Iqbal A, Ali M, Durrani B, Narang Y, Bethell GS, Horne L, Pinto R, Nicholls K, Kisyov I, Torrance HD, English W, Lakhani SM, Ashraf SF, Venn M, Elangovan V, Kazmi Z, Brecher J, Sukumar S, Mastan A, Mortimer A, Parker J, Boyle J, Elkawafi M, Beckett J, Mohite A, Narain A, Mazumdar E, Sreh A, Hague A, Weinberg D, Fletcher L, Steel M, Shufflebotham H, Masood M, Sinha Y, Jenvey C, Kitt H, Slade R, Craig AR, Deall C, Reakes T, Chervenkoff J, Strange E, O'Bryan M, Murkin C, Joshi D, Bergara T, Naqib S, Wylam D, Scotcher SE, Hewitt CM, Stoddart MT, Kerai A, Trist AJ, Cole SJ, Knight CL, Stevens S, Cooper GE, Ingham R, Dobson J, O'Kane A, Moradzadeh J, Duffy A, Henderson C, Ashraf S, McLaughin C, Hoskins TC, Reehal RS, Bookless LR, McLean RC, Stone EJ, Wright EV, Abdikadir HR, Roberts C, Spence O, Srikantharajah M, Ruiz EM, Matthews JH, Gardner E, Hester E, Naran P, Simpson R, Minhas M, Cornish E, Semnani SA, Rojoa D, Radotra A, Eraifej J, Eparh K, Smith DNE, Mistry BD, Hickling SL, Din W, Liu C, Mithrakumar P, Mirdavoudi V, Rashid M, Mcgenity C, Hussain O, Kadicheeni M, Gardner H, Anim-Addo N, Pearce J, Aslanyan A, Ntala C, Sorah T, Parkin J, Alizadeh M, White A, Edozie F, Johnston J, Kahar A, Navayogaarajah V, Carter D, Khonsari P, Burgess A, Patel B, Kong C, Ponweera A, Cody A, Tan Y, Ng AYL, Croall A, Allan C, Ng S, Raghuvir V, Telfer R, Greenhalgh AD, McKerr CN, Edison MA, Patel BA, Dear K, Hardy MR, Williams P, Hassan S, Sajjad U, O'Neill EM, Lopes S, Healy L, Jamal N, Tan S, Lazenby D, Husnoo SB, Beecroft S, Sarvanandan T, Weston C, Bassam N, Rabinthiran S, Hayat U, Ng L, Varma D, Sukkari M, Mian A, Omar A, Kim JW, Sellathurai J, Mahmood J, O'Connell C, Bose R, Heneghan H, Lalor P, Matheson J, Doherty C, Cullen C, Cooper D, Angelov S, Drislane C, Smith ACD, Kreibich A, Palkhi E, Durr A, Lotfallah A, Gold D, Mckean E, Dhanji A, Anilkumar A, Thacoor A, Siddiqui ZH, Lim S, Piquet A, Anderson SM, McCormack DR, Gulati J, Ibrahim A, Murray SE, Walsh SL, McGrath A, Ziprin P, Chua EY, Lou CN, Bloomer J, Paine HR, Osei-Kuffour D, White CJ, Szczap A, Gokani S, Patel K, Malys MK, Reed A, Torlot GE, Cumber EM, Charania A, Ahmad S, Varma N, Cheema H, Austreng L, Petra H, Chaudhary M, Zegeye MI, Cheung F, Coffey D, Heer RS, Singh S, Seager E, Cumming S, Suresh RS, Verma S, Ptacek IB, Gwozdz AM, Yang T, Khetarpal AA, Shumon S, Fung TMP, Leung W, Kwang P, Chew L, Loke W, Curran A, Chan C, McGarrigle C, Mohan K, Cullen S, Wong E, Toale C, Collins D, Keane N, Traynor BP, Shanahan D, Yan A, Jafree DJ, Topham C, Mitrasinovic S, Omara S, Bingham G, Lykoudis PM, Miranda BH, Whitehurst K, Kumaran G, Devabalan Y, Aziz H, Shoa M, Dindyal S, Yates JA, Bernstein I, Rattan G, Coulson R, Stezaker S, Isaac A, Salem M, McBride A, McFarlane H, Yow L, MacDonald J, Bartlett RD, Turaga S, White U, Liew W, Yim N, Ang A, Simpson A, McAuley D, Craig E, Murphy L, Shepherd P, Kee JY, Abdulmajid A, Chung A, Warwick HL, Livesey A, Holton P, Theodoreson MD, Jenkin SL, Turner J, Entwisle JH, Marchal ST, O'Connor S, Blege HK, Aithie JM, Sabine LM, Stewart GE, Jackson S, Kishore A, Lankage CM, Acquaah F, Joyce HL, McKevitt KL, Coffey CJ, Fawaz AS, Dolbec KS, O'Sullivan DA, Geraghty JM, Lim E, Bolton L, FitzPatrick D, Robinson C, Ramtoola T, Collinson S, Grundy L, McEnhill PM, Harbhajan Singh GS, Loughran D, Golding DM, Keeling RE, Williams RP, Whitham RDJ, Yoganathan S, Nachiappan R, Egan RJ, Owasil R, Kwan ML, He A, Goh RW, Bhome R, Wilson H, Teoh PJ, Raji K, Jayakody N, Matthams J, Chong J, Luk CY, Greig RJ, Trail M, Charalambous G, Rocke AS, Gardiner N, Bulley F, Warren N, Brennan E, Fergurson P, Wilson R, Whittingham H, Brown EJ, Khanijau R, Gandhi K, Morris S, Boulton AJ, Chandan N, Barthorpe AE, Maamari R, Sandhu S, McCann M, Higgs L, Balian V, Reeder C, Diaper C, Sale T, Ali H, Archer CH, Clarke AK, Heskin J, Hurst PC, Farmer JD, O'Flynn LD, Doan L, Shuker BA, Stott GD, Vithanage NA, Hoban KA, Nesargikar PN, Kennedy HR, Grossart CM, Tan ESM, Roy CSD, Sim P, Leslie KE, Sim D, Abul MH, Cody N, Tay AY, Woon E, Sng S, Mah J, Robson J, Shakweh E, Wing VC, Mills H, Li MM, Barrow TR, Balaji S, Jordan HEM, Phillips C, Naveed H, Hirani S, Tai A, Ratnakumaran R, Sahathevan A, Shafi AMA, Seedat M, Weaver R, Batho A, Punj R, Selvachandran H, Bhatt N, Botchey S, Khonat Z, Brennan K, Morrison CJ, Devlin E, Linton A, Galloway E, McGarvie S, Ramsay N, McRobbie HD, Whewell H, Dean W, Nelaj S, Eragat M, Mishra A, Kane T, Zuhair M, Wells M, Wilkinson D, Woodcock N, Sun E, Aziz N, Abd Ghaffar MK, Bath MF, Nepogodiev D., Blanco-Colino, R, Lee, S, Kamarajah, Sk, Vasko, P, Kuiper, Sz, Farina, V, Chapman, Sj, Drake, Tm, Gavagna, L, Pasquali, S, Pata, F, Pellino, G, de la Rosa-Estadella, M, Stellingwerf, Me, Stijns, Rch, Borrellas, A, Golding, D, Ngaage, M, Van Tol, Rr, de Groof, J, de Wilt, H, Bemelman, Wa, Mcnamee, L, Espin-Basany, E, Emre Baki, B, Gecim, Ie, Can Tatar, O, Bach, S, Bhangu, A, Bresges, K, Burke, J, Claireaux, Ha, Fearnhead, N, Fitzgerald, Je, Gallagher, S, Glasbey, Jc, Gundogan, B, Harrison, Em, Hernon, J, Khatri, C, Kong, Cy, Lyons, A, Mohan, M, Morton, D, Pinkney, Td, Arezzo, A, Foppa, C, Morino, M, Rubbini, M, Selvaggi, F, Sensi, B, Sica, G, Orhalmi, J, Naccari, P, Sgrò, A, Burger, Bhcm, Fares, Da, Spijkerman, R, van Elst, Tr, Wiersema, R, Stassen, Lp, Rodriguez Garcia, R, Özkan, Bb, Tavuz, Ai, Demirci, Z, Baki, Be, Choi, Pj, O'Sullivan, H, Salman, M, Simioni, A, Colombo, F, Turati, L, Cazzola, Fe, Gallo, G, Perrotta, G, Papandrea, M, Naccari, Pm, Menduni, N, Rossi, E, Chetta, N, Romeo, F, Giordano, F, Randisi, B, Curletti, G, Kuiper, J, Costa, A, Marcos Rodrigo, A, Sanchez, A, Varo Muñoz, A, Martinez Rios, Ce, Aliseda-Jover, D, Fernandez Nieto, D, Alvarez Reyes, I, Dominguez Rodriguez, Lm, Hernandez Ros, Mi, Esteban Sinovas, O, Bartrina Soler, P, Villarejo Campos, P, Laguna Román, S, Fontanet-Soler, S, Raurich-Leandro, J, Dominguez-Prieto, V, Segura-Sampedro, Jj, Alconchel-Gago, F, Salazar-García, C, Gezen, Ae, Sahin, A, Atasoy, H, Yuksek, B, Arslan, E, Ozmen, Bb, Sen, Ay, Erol, Hi, Ucar, E, Aktas, Mk, Yurdaor, S, Mermer, S, Seyhan, U, Tosun, V, Gunaydin, Y, Ekinci, Zb, Yazkan, Z, Choi, J, Yeoh, Tsl, Jones, C, Venturini, S, Saat, Mi, Loo, J, Pike, G, Davies, Sc, Kabariti, R, Olivier, J, Hurný, M, Žebrák, R, Machačová, A, Schulzová, M, Smolák, P, Široká, M, Palyzová, H, Jaroš, J, Dušek, T, Šimáčková, B, Bartoš, M, Sotona, O, Pös, M, Karásek, D, Higgins, P, Hacking, S, Arora, E, Coughlan, G, Palanivail, N, Quill, S, Zhang, Aa, Malak, M, Maan, D, Cheema, J, Goh, Awj, Shamsul Badrin, Ak, Guinness, F, Howard James, N, Neary, A, Sebaoui, S, Gilroy, D, Petrov, G, Craven, K, Macdonald, A, Redmond, A, Brennan, D, Roche, D, O'Dwyer, M, Collins, P, Edwards, S, Doyle, J, Tiedt, L, Arthurs, B, O'Byrne, L, Kiely, A, Glynn, M, Sproule, L, Heaney, A, Li Hi Shing, S, Goh, W, Al-Nasser, Z, Al-Nasser, A, Teh, Jw, De Boni, D, Goldin, E, Ciccioli, E, Vendramin, E, Marchese, N, Bruno, M, Vinci, A, Harder, G, Morandi, V, Magnoli, M, Suppa, A, Palmieri, A, Martorana, M, Sette, M, Balagna, P, Cruciani, C, Corte, M, Ciano, P, Bagaglini, G, Montuori, M, Di Benedetto, L, Arcudi, C, Pezzuto, R, Saraceno, F, Milana, F, Franceschilli, M, Rizzi, A, Sampietro, G, Rampulla, V, Bianco, F, Boschetti, Me, Ghignone, F, Bianchini, S, Esposto, R, Riva, L, Riva, M, Cannavò, M, Arrigo, A, Giavarini, L, Colombo, Em, Trompetto, M, Clerico, G, Catalano, M, Dosa, T, El Mabruk, M, Barone, V, Pallara, E, Pasqualoni, M, Caudullo, G, Mastandrea Bonaviri, Gn, Muro, M, Pistola, I, Verardi, L, Ferrara, D, Gerardi, S, Remore, Lm, Belia, F, Del Coco, F, Larotonda, C, Botrugno, Em, Cammarota, A, Di Girolami, L, Laterza, V, Laurino, A, Paolo, G, Santocchi, P, Puccioni, C, Truma, A, Giardino, Fr, Giuffrida, A, Ripa, M, Cautiero, R, Patturelli, M, Capozzolo, A, Selvaggi, L, Facchiano, A, Milazzo, Lf, Papazachariou, Sk, Pattapola, V, Anania, G, Feo, C, Bellinato, M, Priani, P, Zigiotto, D, Troia, A, Vable, T, Piran, G, Targa, S, Pulpito, S, Tagariello, F, Fasano, A, Anconelli, D, Castiglione, F, Tognolo, L, Lopez, G, Campion, A, Tarantino, M, Sacco, R, Sammarco, G, Palmisano, S, Giacca, M, Rocco, I, Bellio, G, Favero, A, Raimondi, P, Pantalone, Mr, De Nardi, P, Notarnicola, M, Picciariello, A, Licari, L, Parinisi, Z, Fazzotta, S, Ciciliot, M, Reggiani, L, Mariani, F, Aonzo, P, Checcacci, P, Montanelli, P, Guerra, F, Skalamera, I, Staderini, F, Grandi, S, Nelli, T, de Boer, Dv, van der Pool, Aem, Janssen, Tl, El-Atmani, S, van Verschuer, Vmt, Poelman, M, Dronkers, Wj, van Steensel, L, Toorenvliet, Br, Duinhouwer, Le, Vermaas, M, Ter Bruggen, Ffja, Hogendoorn, W, van der Harst, E, van Rijckevorsel, Vajim, Bayoumy, Ab, Lap, Cr, Gooszen, Jah, Abdulrahman, N, de Roy van Zuidewijn, D, de Groof, Ej, Zijlmans, Jl, van Dalen, Ashm, Bos, K, Musters, Gd, Looijen, Rc, Fliers, Jm, Oostendorp, Se, Mosterd, Cm, Blonk, L, Jurgens, J, Ribbink, Me, Boom, M, Boersma, Am, Hidding, E, Schmidt, Pa, Mensink, G, Graus, Sa, Gastel, Mda, Veenker, Cgh, Van Heumen, Tm, Slieker, Fjb, Sedee, Wja, Löwensteyn, Yn, Amelung, Fj, de Guerre, Levm, Nota, Clma, Van Dijck, Wpm, van Wijnbergen, Jwm, Pronk, A, Kip, M, van der Zee, C, Heiloo, S, Muller, S, Verboeket, B, Oudman, T, Zope, S, Gilissen, V, Gommers, J, Cremers, D, Van der Lubbe, M, Smet, M, Ter Weele, K, de Bruin, M, Geerlings, M, Ter Horst, L, Kerimova, N, Pesser, N, Heesakkers, H, de Mees, T, de Gooyer, Jm, Willems, L, Gawria, L, Bonouvrie, D, Harms, J, Eggen, Y, Hengeveld, E, Smeets, Hj, Hoffman, Rpc, Detmers Blom, Fpn, Van Bruggen, D, Steup, Wh, Gooiker, Ga, Willems, Yr, van der Hoeven, Ac, Vallve-Bernal, M, Perez-Gandara, B, Perez, Jl, Caballero Rodriguez, E, Perez Febles, M, Protti Ruiz, Gp, Hidalgo Pujol, M, Alberti Delgado, P, Gil Barrionuevo, E, Anabitarte, O, Caballero, L, Poyato Nuñez, Fj, Prado Perez, R, de la Portilla de Juan, F, Fulgencio Barbarin, J, Elorza Echaniz, G, Mitxelena Elosegi, L, Delgado, At, Marti Gelonch, L, Gonzalez Arribas, M, De Serra Tejada, I, Alberdi San Roman, I, de Andres Olabarria, U, Fernández-Domper, L, Perez Costoya, C, Perez Arias, H, Fa Binefa, M, Becerra Nieves, M, Escalona Canal, Mg, Aldrey, I, Vazquez-Gonzalez, I, Falcon Cazas, A, Amarelo Garcia, M, Gonzalez Ruiz, Aa, Garcia Garrido, M, Simon Frapolli, V, Martinez Diaz, Jm, De la Torre Conde, C, Rodrigues Silva, K, Hernandez Kakauridze, S, Lopez Garcia, Mc, Flores Funes, D, Gómez-López de San Román, C, San Martín Bragado, M, Tejero Pintor, Fj, Pando Ruiz, B, Sánchez Estébanez, E, Roquet Puigneró, E, Pla Seró, S, Vela Polanco, Ff, Mirallas Viñas, O, Caro Gonzalez, Mp, Bertelli Puche, Jl, Gonzalez-Martinez, A, Sanchez Cambronero, M, Garcia Torres, A, Dominguez Jimenez, M, de Jesus Rodriguez Perdomo, M, Echazarreta-Gallego, E, Sánchez-Blasco, L, Del Mar López-Cuevas, M, Latras-Cortés, I, López-Vendrell, L, Díaz Padillo, A, Mestres Petit, N, Cruz Reyes, Ja, Fernandez, C, Posada, M, Moratilla Lapeña, L, Martin Morales, E, Mate-Mate, P, Garcia Cruz, G, Gorini, L, Rubio-Perez, I, Soldevila-Verdeguer, C, Jiménez-Viñas, C, Luehrman, A, Sena-Ruiz, F, Garcia-Perez, Jm, Plomer-Sanchez, M, Pujol-Cano, N, Jimenez-Segovia, M, Diaz-Jover, P, Pineño-Flores, C, Ambrona-Zafra, D, Gonzalez-Argente, Xf, Jiménez-Morillas, P, López-Mármol, R, Durán-Martínez, M, González-Crespo, A, Checa Guillen, M, Valderrama Pérez, A, Claramonte Bellmunt, O, Martí Fernández, Rm, Kasap, S, Soylemez, Zobb, Bolat, Ab, Aydar, Seyi, Birgin, Bz, Coskun, O, Cakir, Sg, Belibagli, Zo, Herken, M, Erdem, S, Kayacan, S, Kelesoglu, Y, Moran, D, Atalay, H, Kucukdiler, E, Demirci, A, Buyukkasap, C, Kuzey, A, Emral, C, Dogan, H, Cok, H, Durmaz, H, Asma, A, Ergul, B, Kaya, A, Bilicen, G, Gunay, M, Senturk, E, Baskoy, L, Besısık, Hm, Topalan, K, Piraliyev, E, Danalıoglu, An, Ilbak, A, Yıgman, S, Kara, C, Guzel, M, Inci, Et, Onsal, U, Erel, T, Cetin, Sk, Yekenkurul, E, Kasar, P, Saglam, Za, Gursoy, F, Cetinkaya, M, Aktekin, H, Bober, Dn, Mugurtay, Y, Koksal, G, Celik, S, Bektur, G, Yildirim, R, Ankarali, T, Güven, H, Yuksel, A, Semiz, A, Cise, S, Tomas, K, Ulusahin, M, Akbulut, F, Tulum, H, Bodur, S, Isler, Vc, Pektas, Am, Mutlu, D, Mericliler, M, Tansoker, I, Polat, Zp, Seyrek, N, Beyatli, S, Toto, Of, Cakaloglu, Hc, Sapci, I, Akpunarli, B, Adiyaman, C, Kobal, Bb, Gok, Z, Benli, S, Turpan, M, Kocapinar, S, Parimli, H, Acar, S, Eger, M, Yilmaz, I, Cengiz, U, Yoruk, I, Mutlu, B, Ulkucu, A, Arukan, C, Kara, B, Gokce, K, Calisgan, B, Demirci, K, Elkatroushi, T, Ayaz, B, Uzun, B, Sivrikaya, T, Goksoy, B, Eroz, E, Celik, B, Canbay Torun, B, Ekin, B, Senay, Bb, Temiz, C, Yilmaz, M, Yasar, C, Cakir, E, Subasi, A, Celik, K, Aksoy, K, Karabulut, E, Altintas, O, Bali, An, Ciftci, E, Babaoglu, H, Aljbour, A, Aljbour, I, Akcaoglu, T, Kakil, E, Taskin, O, Taskin, Rb, Topal, U, Huzmeli, E, Caliskan, T, Unal, Ag, Yurekli, Am, Sari, V, Tutam, Dn, Celen, D, Posteki, G, Demirtas, B, Yildiz, S, Kilic, E, Yalcin, Y, Kurt, A, Gozubuyuk, Y, Huseynova, S, Cinar, S, Calar, Sn, Kurklu, O, Binbuga, M, Ceylan, C, Yavuz, G, Alim, Ye, Yildirim, N, Yilmaz, S, Onar, D, Aray, E, Ozsipahi, Ac, Koc, Ge, Yetiskin, E, Kocer, Md, Ozgencil, B, Bahcecioglu, B, Hacioglu, Ad, Bilici, O, Cin, S, Uzunoglu, Ec, Cumen, Ec, Aslan, L, Erozgur, B, Zengin, T, Kullac, S, Mizan, Sr, Baykan, B, Kopac, O, Karabacak, U, Aytekin, A, Deliktas, T, Buyukkarabacak, Y, Uzun, O, Karahan, B, Turkmen, M, Akdogan, A, Uctepe, F, Bandirmali, O, Erdogan, P, Demir, F, Bozkurt, Gk, Yilmaz, T, Sheikh, Imi, Orhan, K, Balci, B, Keyif, Mf, Bilgin, S, Cantimer, E, Yaman, S, Akkaya, E, Atesavci, Sn, Arslan, U, Asik, M, Koksal, S, Murtaza, Mi, Mustafa, S, Oun, H, Sam, Zh, Brogan, A, Zaidi, R, Quinn, K, Taylor, F, Pang, G, Heath, H, Smart, 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AII - Infectious diseases, AII - Inflammatory diseases, ANS - Neuroinfection & -inflammation, APH - Quality of Care, AII - Amsterdam institute for Infection and Immunity, Paediatric Infectious Diseases / Rheumatology / Immunology, ACS - Pulmonary hypertension & thrombosis, ACS - Heart failure & arrhythmias, Blanco-Colino R, Lee S, Kamarajah SK, Vasko P, Kuiper SZ, Farina V, Chapman SJ, Drake TM, Gavagna L, Pasquali S, Pata F, Pellino G, de la Rosa-Estadella M, Stellingwerf ME, Stijns RCH, Borrellas A, Golding D, Ngaage M, Van Tol RR, de Groof J, de Wilt H, Bemelman WA, McNamee L, Espin-Basany E, Emre Baki B, Gecim IE, Can Tatar O, Bach S, Bhangu A, Bresges K, Burke J, Claireaux HA, Fearnhead N, Fitzgerald JE, Gallagher S, Glasbey JC, Gundogan B, Harrison EM, Hernon J, Khatri C, Kong CY, Lyons A, Mohan M, Morton D, Pinkney TD, Arezzo A, Foppa C, Morino M, Rubbini M, Selvaggi F, Sensi B, Sica G, Orhalmi J, Naccari P, Sgrò A, Burger BHCM, Fares DA, Spijkerman R, van Elst TR, Wiersema R, 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Sharifpour M, Lwin KN, Bright M, Chitnis AR, Abdelhadi M, Semana AD, Morgan F, Reid R, Dickson J, Anderson L, McMullan R, Ahern N, Asmadi A, Anderson LB, Lua Boon Xuan J, Crozier L, McAleer S, Lees DM, Adebayo AA, Das M, Amphlett AH, Al-Robeye A, Valli A, Khangura J, Winarski A, Woodward H, Gouldthrope C, Turner M, Sasapu K, Tonkins M, Wild JRL, Robinson M, Hardie J, Heminway R, Narramore R, Ramjeeawon N, Hibberd A, Winslow F, Ho W, Chong BF, Lim K, Ho S, Crewdson JA, Singagireson S, Kalra N, Koumpa F, Jhala H, Soon WC, Karia M, Rasiah MG, Xylas D, Gilbert H, Sundar-Singh M, Wills J, Akhtar S, Patel S, Hu L, Brathwaite-Shirley C, Nayee H, Amin O, Rangan T, Turner EJH, McCrann C, Shepherd R, Patel N, Prest-Smith J, Auyoung E, Murtaza A, Coates A, Prys-Jones O, King M, Gaffney S, Dewdney CJ, Nehikhare I, Lavery J, Bassett J, Davies K, Ahmad K, Collins A, Acres M, Egerton C, Cheng K, Chen X, Chan N, Sheldon A, Empey J, Ingram E, Malik A, Johnstone M, Goodier R, Shah JP, Giles JE, Sanders JA, McLure SW, Pal S, Rangedara A, Baker AN, Asbjoernsen CA, Girling C, Gray L, Gauntlett L, Joyner C, Qureshi S, Mogan YP, Ng JCK, Kumar AN, Park JH, Tan D, Choo KP, Raman KP, Buakuma P, Xiao C, Govinden S, Thompson OD, Charalambos MA, Karsan RB, Dogra T, Bullman LM, Dawson PM, Frank AL, Abid H, Tung L, Qureshi U, Tahmina A, Matthews BW, Harris RT, O'Connor A, Mazan K, Iqbal S, Stanger SA, Thompson JD, Sullivan JAL, Uppal E, MacAskill A, Bamgbose FA, Neophytou C, Carroll AF, Rookes CW, Datta U, Dhutia AJ, Rashid S, Ahmed N, Lo T, Bhanderi S, Blore CD, Ahmed S, Shaheen H, Abburu S, Majid S, Abbas Z, Talukdar SS, Burney LJ, Patel JB, Al-Obaedi O, Roberts AW, Mahboob S, Sheth S, Karia P, Prabhudesai A, Kow K, Koysombat K, Wang S, Morrison P, Maheswaran Y, Keane P, Copley PC, Brewster O, Xu GX, Harries P, Wall C, Al-Mousawi A, Bonsu S, Cunha P, Ward T, Paul J, Nadanakumaran K, Tayeh S, Holyoak H, Remedios J, Theodoropoulou K, Luhishi A, Jacob L, Long F, Atayi A, Sarwar S, Parker O, Harvey J, Ross H, Rampal R, Thomas G, Vanmali P, McGowan C, Stein J, Robertson V, Carthew L, Teng V, Fong J, Street AN, Thakker CE, O'Reilly D, Bravo M, Pizzolato A, Khokhar HA, Ryan M, Cheskes L, Carr R, Salih AE, Bassiony S, Yuen R, Chrastek D, Rosen O'Sullivan H, Amajuoyi A, Wang A, Sitta O, Wye J, Qamar MA, Major C, Kaushal A, Morgan C, Petrarca M, Allot R, Verma K, Dutt S, Chilima CP, Peroos S, Kosasih SR, Chin H, Ashken L, Pearse RJ, O'Loughlin RA, Menon A, Singh K, Norton J, Sagar R, Jathanna N, Rothwell L, Watson N, Harding F, Dube P, Khalid H, Punjabi N, Sagmeister M, Gill P, Shahid S, Hudson-Phillips S, George D, Ashwood J, Lewis T, Dhar M, Sangal P, Rhema IA, Kotecha D, Afzal Z, Syeed JA, Prakash E, Jalota P, Herron J, Kimani L, Delport A, Shukla A, Agarwal V, Parthiban S, Thakur H, Cymes W, Rinkoff S, Turnbull JA, Hayat M, Darr S, Khan U, Lim J, Higgins A, Lakshmipathy G, Forte B, Canning E, Jaitley A, Lamont J, Toner E, Ghaffar A, McDowell M, Salmon D, O'Carroll O, Khan A, Kelly ME, Clesham K, Palmer C, Lyons R, Bell A, Chin R, Waldron RM, Trimble A, Cox SE, Ashfaq U, Campbell J, Holliday RBS, McCabe G, Morris F, Priestland R, Vernon OK, Ledsam A, Vaughan R, Lim D, Bakewell ZR, Hughes RK, Koshy RM, Jackson HR, Narayan P, Cardwell AE, Jubainville CL, Arif T, Elliott LE, Gupta V, Bhaskaran G, Odeleye A, Ahmed F, Shah R, Pickard J, Suleman YN, North AS, McClymont LF, Hussain N, Ibrahim I, Ng GS, Wong V, Lim AE, Harris LN, Tharmachandirar T, Mittapalli D, Patel V, Lakhani M, Bazeer HZ, Narwani V, Sandhu KK, Wingfield LR, Gentry S, Adjei H, Bhatti M, Braganza L, Barnes J, Mistry S, Chillarge G, Stokes S, Cleere J, Bucko AM, Meek J, Boxall N, Heywood EG, Wiltshire JJ, Toh C, Ward AE, Shurovi BN, Horth D, Patel BY, Ali B, Spencer T, Axelson T, Kretzmer L, Chhina C, Anandarajah C, Fautz T, Horst C, Thevathasan AA, Ng JQ, Hirst F, Brewer CF, Logan AE, Lockey JW, Forrest PR, Keelty N, Wood AD, Springford LR, Avery P, Schulz TM, Bemand TP, Howells L, Collier H, Khajuria A, Tharakan RG, Parsons S, Buchan AM, McGalliard RJ, Mason JD, Cundy OJ, Li N, Redgrave NA, Watson RP, Pezas TP, Dennis YF, Segall E, Hameed M, Lynch AS, Chamberlain M, Peck FS, Neo YN, Russell G, Elseedawy M, Foster NL, Soo YH, Puan L, Dennis R, Goradia H, Qureshi A, Osman S, Reeves T, Dinsmore L, Marsden M, Lu Q, Pitts-Tucker T, Dunn CE, Walford RA, Heathcote E, Martin R, Pericleous A, Brzyska K, Reid KG, Williams MR, Wetherall N, McAleer E, Thomas D, Kiff R, Milne S, Holmes MJV, Bartlett J, Lucas de Carvalho J, Bloomfield T, Tongo F, Bremner RH, Yong N, Atraszkiewicz BA, Mehdi A, Tahir M, Sherliker GXJ, Tear AK, Pandey A, Broyd A, Omer HM, Raphael M, Chaudhry WW, Shahidi S, Jawad AS, Gill CK, Hindle Fisher I, Adeleja I, Clark IJ, Aidoo-Micah GE, Stather PW, Salam GJ, Glover TE, Deas G, Sim NK, Obute RD, Wynell-Mayow WM, Sait MS, Mitha N, de Bernier GL, Siddiqui M, Shaunak R, Wali A, Cuthbert G, Bhudia R, Webb E, Shah S, Ansari N, Perera M, Kelly N, McAllister R, Stanley GH, Keane CP, Shatkar V, Maxwell-Armstrong C, Henderson LA, Maple N, Manson R, Adams RD, Semple E, Mills M, Daoub A, Marsh A, Ramnarine A, Hartley J, Malaj M, Jewell PD, Whatling EA, Hitchen N, Chen M, Goh B, Fern J, Rogers S, Derbyshire L, Robertson DT, Deekonda P, Abid A, Harrison PLM, Aildasani L, Turley H, Sherif MA, Pandey G, Filby JJ, Johnston A, Burke E, Mohamud M, Gohil K, Tsui AY, Singh R, Lim SJ, O'Sullivan K, McKelvey LL, O'Neill S, Roberts HF, Brown FS, Cao Y, Buckle RT, Liew Y, Sii S, Ventre CM, Graham CJ, Filipescu T, Yousif A, Dawar R, Wright A, Peters M, Varley R, Owczarek S, Hartley S, Khattak M, Iqbal A, Ali M, Durrani B, Narang Y, Bethell GS, Horne L, Pinto R, Nicholls K, Kisyov I, Torrance HD, English W, Lakhani SM, Ashraf SF, Venn M, Elangovan V, Kazmi Z, Brecher J, Sukumar S, Mastan A, Mortimer A, Parker J, Boyle J, Elkawafi M, Beckett J, Mohite A, Narain A, Mazumdar E, Sreh A, Hague A, Weinberg D, Fletcher L, Steel M, Shufflebotham H, Masood M, Sinha Y, Jenvey C, Kitt H, Slade R, Craig AR, Deall C, Reakes T, Chervenkoff J, Strange E, O'Bryan M, Murkin C, Joshi D, Bergara T, Naqib S, Wylam D, Scotcher SE, Hewitt CM, Stoddart MT, Kerai A, Trist AJ, Cole SJ, Knight CL, Stevens S, Cooper GE, Ingham R, Dobson J, O'Kane A, Moradzadeh J, Duffy A, Henderson C, Ashraf S, McLaughin C, Hoskins TC, Reehal RS, Bookless LR, McLean RC, Stone EJ, Wright EV, Abdikadir HR, Roberts C, Spence O, Srikantharajah M, Ruiz EM, Matthews JH, Gardner E, Hester E, Naran P, Simpson R, Minhas M, Cornish E, Semnani SA, Rojoa D, Radotra A, Eraifej J, Eparh K, Smith DNE, Mistry BD, Hickling SL, Din W, Liu C, Mithrakumar P, Mirdavoudi V, Rashid M, Mcgenity C, Hussain O, Kadicheeni M, Gardner H, Anim-Addo N, Pearce J, Aslanyan A, Ntala C, Sorah T, Parkin J, Alizadeh M, White A, Edozie F, Johnston J, Kahar A, Navayogaarajah V, Carter D, Khonsari P, Burgess A, Patel B, Kong C, Ponweera A, Cody A, Tan Y, Ng AYL, Croall A, Allan C, Ng S, Raghuvir V, Telfer R, Greenhalgh AD, McKerr CN, Edison MA, Patel BA, Dear K, Hardy MR, Williams P, Hassan S, Sajjad U, O'Neill EM, Lopes S, Healy L, Jamal N, Tan S, Lazenby D, Husnoo SB, Beecroft S, Sarvanandan T, Weston C, Bassam N, Rabinthiran S, Hayat U, Ng L, Varma D, Sukkari M, Mian A, Omar A, Kim JW, Sellathurai J, Mahmood J, O'Connell C, Bose R, Heneghan H, Lalor P, Matheson J, Doherty C, Cullen C, Cooper D, Angelov S, Drislane C, Smith ACD, Kreibich A, Palkhi E, Durr A, Lotfallah A, Gold D, Mckean E, Dhanji A, Anilkumar A, Thacoor A, Siddiqui ZH, Lim S, Piquet A, Anderson SM, McCormack DR, Gulati J, Ibrahim A, Murray SE, Walsh SL, McGrath A, Ziprin P, Chua EY, Lou CN, Bloomer J, Paine HR, Osei-Kuffour D, White CJ, Szczap A, Gokani S, Patel K, Malys MK, Reed A, Torlot GE, Cumber EM, Charania A, Ahmad S, Varma N, Cheema H, Austreng L, Petra H, Chaudhary M, Zegeye MI, Cheung F, Coffey D, Heer RS, Singh S, Seager E, Cumming S, Suresh RS, Verma S, Ptacek IB, Gwozdz AM, Yang T, Khetarpal AA, Shumon S, Fung TMP, Leung W, Kwang P, Chew L, Loke W, Curran A, Chan C, McGarrigle C, Mohan K, Cullen S, Wong E, Toale C, Collins D, Keane N, Traynor BP, Shanahan D, Yan A, Jafree DJ, Topham C, Mitrasinovic S, Omara S, Bingham G, Lykoudis PM, Miranda BH, Whitehurst K, Kumaran G, Devabalan Y, Aziz H, Shoa M, Dindyal S, Yates JA, Bernstein I, Rattan G, Coulson R, Stezaker S, Isaac A, Salem M, McBride A, McFarlane H, Yow L, MacDonald J, Bartlett RD, Turaga S, White U, Liew W, Yim N, Ang A, Simpson A, McAuley D, Craig E, Murphy L, Shepherd P, Kee JY, Abdulmajid A, Chung A, Warwick HL, Livesey A, Holton P, Theodoreson MD, Jenkin SL, Turner J, Entwisle JH, Marchal ST, O'Connor S, Blege HK, Aithie JM, Sabine LM, Stewart GE, Jackson S, Kishore A, Lankage CM, Acquaah F, Joyce HL, McKevitt KL, Coffey CJ, Fawaz AS, Dolbec KS, O'Sullivan DA, Geraghty JM, Lim E, Bolton L, FitzPatrick D, Robinson C, Ramtoola T, Collinson S, Grundy L, McEnhill PM, Harbhajan Singh GS, Loughran D, Golding DM, Keeling RE, Williams RP, Whitham RDJ, Yoganathan S, Nachiappan R, Egan RJ, Owasil R, Kwan ML, He A, Goh RW, Bhome R, Wilson H, Teoh PJ, Raji K, Jayakody N, Matthams J, Chong J, Luk CY, Greig RJ, Trail M, Charalambous G, Rocke AS, Gardiner N, Bulley F, Warren N, Brennan E, Fergurson P, Wilson R, Whittingham H, Brown EJ, Khanijau R, Gandhi K, Morris S, Boulton AJ, Chandan N, Barthorpe AE, Maamari R, Sandhu S, McCann M, Higgs L, Balian V, Reeder C, Diaper C, Sale T, Ali H, Archer CH, Clarke AK, Heskin J, Hurst PC, Farmer JD, O'Flynn LD, Doan L, Shuker BA, Stott GD, Vithanage NA, Hoban KA, Nesargikar PN, Kennedy HR, Grossart CM, Tan ESM, Roy CSD, Sim P, Leslie KE, Sim D, Abul MH, Cody N, Tay AY, Woon E, Sng S, Mah J, Robson J, Shakweh E, Wing VC, Mills H, Li MM, Barrow TR, Balaji S, Jordan HEM, Phillips C, Naveed H, Hirani S, Tai A, Ratnakumaran R, Sahathevan A, Shafi AMA, Seedat M, Weaver R, Batho A, Punj R, Selvachandran H, Bhatt N, Botchey S, Khonat Z, Brennan K, Morrison CJ, Devlin E, Linton A, Galloway E, McGarvie S, Ramsay N, McRobbie HD, Whewell H, Dean W, Nelaj S, Eragat M, Mishra A, Kane T, Zuhair M, Wells M, Wilkinson D, Woodcock N, Sun E, Aziz N, Abd Ghaffar MK., Nepogodiev, Dmitri, Rosati, Riccardo, Nepogodiev, D., and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
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Male ,obesity ,Multivariate analysis ,Gastrointestinal Diseases ,IMPACT ,Settore MED/18 - CHIRURGIA GENERALE ,Body mass index ,Body weight ,Digestive tract ,Gastrointestinal tract ,Obesity ,Postoperative complications ,Gastroenterology ,digestive tract ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Risk Factors ,Medicine ,Prospective Studies ,Prospective cohort study ,Aged ,Europe ,Female ,Gastrointestinal Neoplasms ,Humans ,Middle Aged ,Postoperative Complications ,Body Mass Index ,OUTCOMES ,body mass index ,body weight ,gastrointestinal tract ,030220 oncology & carcinogenesis ,Meta-analysis ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Cohort ,030211 gastroenterology & hepatology ,Cohort study ,medicine.medical_specialty ,Malignancy ,NO ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,business.industry ,postoperative complications ,MORTALITY ,medicine.disease ,Settore MED/18 ,Surgery ,Postoperative complication ,Postoperative Complications, Obesity, Digestive Tract, Gastrointestinal Tract, Body Mass Index, Body Weight ,business - Abstract
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
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- 2018
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3. MULTIMODAL TREATMENT OF CHYLOUS FISTULA. A RETROSPECTIVE CASE-CONTROL STUDY.
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Dalci, K., Gumus, S., Saritas, A. G., Onan, H. B., Akcam, A. T., Ulku, A., and Sakman, G.
- Abstract
Chylous fistulas (CF) are rare surgical complications and there is no standard treatment. This study presents the treatment modalities performed on patients who developed CF over a 10-year period. During the observation period, CF developed in 29 patients, 16 of whom were women. The mean age was 55.76± 13.48. Lymphatic duct injury was mostly seen in the abdomen (58.6%) and the most common reason was nephrectomy (20.7%). Extended lymphatic dissection due to malignancy was performed in 82.7% of all cases. Chylous leakage started postoperatively on 3.78±3.94 days (range: 1-19 days). Fasting, total parenteral nutrition (TPN), and somatostatin treatment were applied to all patients, and 75.8% of the fistulas were resolved completely with medical treatment. Surgical ligation of the lymphatic canal was performed in 7 patients. One was not successful and underwent percutaneous embolization of the thoracic lymphatic leakage cavity. All fistulas were resolved in 18.18±10.4 days. The resolution time and hospital stay were significantly higher in thoracic fistulas (p=0.017; p=0.003, respectively). In addition, malignant cases had longer resolution time (32.40±28.72 vs 16.27±11.25, p=0.036) and hospital stay (35.0±29.74 vs 16.25±14.05p= 0.002 respectively) than non-malignant. There was no chylothorax, chylous ascites, or recurrence at 20.55±22.88 months follow-up. Treatment of CF with fasting, TPN, and somatostatin somatostatin analogs are effective. Other interventions such as surgical ligation with or without fibrin glue and interventional radiology treatments may be considered when conservative treatments fail. [ABSTRACT FROM AUTHOR]
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- 2023
4. Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options
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Ağcaoğlu, Orhan (ORCID 0000-0003-1617-3953 & YÖK ID175476); Alagöl, Faruk; Deyneli, Oğuzhan (ORCID 0000-0001-6582-7031 & YÖK ID 171914); Yazıcı, Dilek (ORCID 0000-0001-5603-0004 & YÖK ID 179659); Tezelman, Serdar, Sezer, A.; Makay, O.; Erdoğan, M. F.; Bayram, F.; Güldiken, S.; Raffaelli, M.; Sönmez, Y. A.; Lee, Y.-S.; Vamvakidis, K.; Mihai, R.; Duh, Q.-Y.; Akıncı, B.; Almquist, M.; Barczynski, M.; Bayraktaroğlu, T.; Berber, E.; Bukey, Y.; Çakmak, G. K.; Cantürk, N. Z.; Cantürk, Z.; Çelik, M.; Çelik O.; Ceyhan, B. O.; Cherenko, S.; Clerici, T.; Coombes, D. S.; Demircan, O.; Dionigi, G.; Emre, A. U.; Erbil, Y.; Filiz, A. I.; Gozu, H. I.; Gürdal, S. O.; Gürleyik, G.; Hacıyanlı, M.; Kebudi, A.; Kim, S.; Koutelidakis, G.; Kuru, B.; Mert, M.; Oruk, G. G.; Özbaş, S.; Palazzo, F.; Pandev, R.; Riss, P.; Sabuncu, T.; Şahin, I.; Sakman, G.; Saygılı, F.; Şenyürek, Y. G.; Sleptsov, I.; Van Slycke, S.; Teksöz, S.; Terzioğlu, T.; Tunca, F.; Uğurlu, M. U.; Uludağ, M.; Villar-del-Moral, J.; Vriens, M., School of Medicine, Ağcaoğlu, Orhan (ORCID 0000-0003-1617-3953 & YÖK ID175476); Alagöl, Faruk; Deyneli, Oğuzhan (ORCID 0000-0001-6582-7031 & YÖK ID 171914); Yazıcı, Dilek (ORCID 0000-0001-5603-0004 & YÖK ID 179659); Tezelman, Serdar, Sezer, A.; Makay, O.; Erdoğan, M. F.; Bayram, F.; Güldiken, S.; Raffaelli, M.; Sönmez, Y. A.; Lee, Y.-S.; Vamvakidis, K.; Mihai, R.; Duh, Q.-Y.; Akıncı, B.; Almquist, M.; Barczynski, M.; Bayraktaroğlu, T.; Berber, E.; Bukey, Y.; Çakmak, G. K.; Cantürk, N. Z.; Cantürk, Z.; Çelik, M.; Çelik O.; Ceyhan, B. O.; Cherenko, S.; Clerici, T.; Coombes, D. S.; Demircan, O.; Dionigi, G.; Emre, A. U.; Erbil, Y.; Filiz, A. I.; Gozu, H. I.; Gürdal, S. O.; Gürleyik, G.; Hacıyanlı, M.; Kebudi, A.; Kim, S.; Koutelidakis, G.; Kuru, B.; Mert, M.; Oruk, G. G.; Özbaş, S.; Palazzo, F.; Pandev, R.; Riss, P.; Sabuncu, T.; Şahin, I.; Sakman, G.; Saygılı, F.; Şenyürek, Y. G.; Sleptsov, I.; Van Slycke, S.; Teksöz, S.; Terzioğlu, T.; Tunca, F.; Uğurlu, M. U.; Uludağ, M.; Villar-del-Moral, J.; Vriens, M., and School of Medicine
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NA
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- 2021
5. Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
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Blanco-Colino, R., Lee, S., Kamarajah, S. K., Vasko, P., Kuiper, S. Z., Farina, V., Chapman, S. J., Drake, T. M., Gavagna, L., Pasquali, S., Pata, F., Pellino, G., de la Rosa-Estadella, M., Stellingwerf, M. E., Stijns, R. C. H., Borrellas, A., Golding, D., Ngaage, M., Van Tol, R. R., de Groof, J., de Wilt, H., Bemelman, W. A., Mcnamee, L., Espin-Basany, E., Emre Baki, B., Gecim, I. E., Can Tatar, O., Bach, S., Bhangu, A., Bresges, K., Burke, J., Claireaux, H. A., Fearnhead, N., Fitzgerald, J. E., Gallagher, S., Glasbey, J. C., Gundogan, B., Harrison, E. M., Hernon, J., Khatri, C., Kong, C. Y., Lyons, A., Mohan, M., Morton, D., Pinkney, T. D., Arezzo, A., Foppa, C., Morino, M., Rubbini, M., Selvaggi, F., Sensi, B., Sica, G., Orhalmi, J., Naccari, P., Sgro, A., Burger, B. H. C. M., Fares, D. A., Spijkerman, R., van Elst, T. R., Wiersema, R., Stassen, L. P. S., Rodriguez Garcia, R., Ozkan, B. B., Tavuz, A. I., Demirci, Z. S., Baki, B. E., Choi, P. J., O'Sullivan, H., Salman, M., Simioni, A., Colombo, F., Turati, L., Cazzola, F. E., Gallo, G., Perrotta, G., Papandrea, M., Naccari, P. M., Menduni, N., Rossi, E., Chetta, N., Romeo, F., Giordano, F., Randisi, B., Curletti, G., Kuiper, J., Costa, A., Marcos Rodrigo, A., Sanchez, A., Varo Munoz, A., Martinez Rios, C. E., Aliseda-Jover, D., Fernandez Nieto, D., Alvarez Reyes, I., Dominguez Rodriguez, L. M., Hernandez Ros, M. I., Esteban Sinovas, O., Bartrina Soler, P., Villarejo Campos, P., Laguna Roman, S., Fontanet-Soler, S., Raurich-Leandro, J., Dominguez-Prieto, V., Segura-Sampedro, J. J., Alconchel-Gago, F., Salazar-Garcia, C., Gezen, A. E., Sahin, A., Atasoy, H., Yuksek, B., Arslan, E., Ozmen, B. B., Sen, A. Y., Erol, H. I., Ucar, E., Aktas, M. K., Yurdaor, S. S., Mermer, S., Seyhan, U., Tosun, V., Gunaydin, Y., Ekinci, Z. B., Yazkan, Z., Choi, J., Yeoh, T. S. L., Jones, C. S., Venturini, S., Saat, M. I., Loo, J., Pike, G., Davies, S. C., Kabariti, R., Olivier, J., Hurny, M., Zebrak, R., Machacova, A., Schulzova, M., Smolak, P., Siroka, M., Palyzova, H., Jaros, J., Dusek, T., Simackova, B., Bartos, M., Sotona, O., Pos, M., Karasek, D., Higgins, P., Hacking, S., Arora, E., Coughlan, G., Palanivail, N., Quill, S., Zhang, A. A., Malak, M., Maan, D. S., Cheema, J., Goh, A. W. J., Shamsul Badrin, A. K., Guinness, F., Howard James, N., Neary, A., Sebaoui, S., Gilroy, D., Petrov, G., Craven, K., Macdonald, A., Redmond, A., Brennan, D., Roche, D., O'Dwyer, M., Collins, P., Edwards, S., Doyle, J., Tiedt, L., Arthurs, B., O'Byrne, L., Kiely, A., Glynn, M., Sproule, L., Heaney, A., Li Hi Shing, S., Goh, W., Al-Nasser, Z., Al-Nasser, A., Teh, J. W., De Boni, D., Goldin, E., Ciccioli, E., Vendramin, E., Marchese, N., Bruno, M., Vinci, A., Harder, G., Morandi, V., Magnoli, M., Suppa, A., Palmieri, A., Martorana, M., Sette, M., Balagna, P., Cruciani, C., Corte, M., Ciano, P., Bagaglini, G., Montuori, M., Di Benedetto, L., Arcudi, C., Pezzuto, R., Saraceno, F., Milana, F., Franceschilli, M., Rizzi, A., Sampietro, G., Rampulla, V., Bianco, F., Boschetti, M. E., Ghignone, F., Bianchini, S., Esposto, R., Riva, L., Riva, M., Cannavo, M., Arrigo, A., Giavarini, L., Colombo, E. M., Trompetto, M., Clerico, G., Catalano, M., Dosa, T., El Mabruk, M., Barone, V., Pallara, E., Pasqualoni, M., Caudullo, G., Mastandrea Bonaviri, G. N., Muro, M., Pistola, I., Verardi, L., Ferrara, D., Gerardi, S., Remore, L. M., Belia, F., Del Coco, F., Larotonda, C., Botrugno, E. M., Cammarota, A., Di Girolami, L., Laterza, V., Laurino, A., Paolo, G., Santocchi, P., Puccioni, C., Truma, A., Giardino, F. R., Giuffrida, A., Ripa, M., Cautiero, R., Patturelli, M., Capozzolo, A., Selvaggi, L., Facchiano, A., Milazzo, L. F., Papazachariou, S. K., Pattapola, V., Anania, G., Feo, C., Bellinato, M., Priani, P., Zigiotto, D., Troia, A., Vable, T., Piran, G., Targa, S., Pulpito, S., Tagariello, F., Fasano, A., Anconelli, D., Castiglione, F., Tognolo, L., Lopez, G., Campion, A., Tarantino, M., Sacco, R., Sammarco, G., Palmisano, S., Giacca, M., Rocco, I., Bellio, G., Favero, A., Raimondi, P., Pantalone, M. R., De Nardi, P., Notarnicola, M., Picciariello, A., Licari, L., Parinisi, Z., Fazzotta, S., Ciciliot, M., Reggiani, L., Mariani, F., Aonzo, P., Checcacci, P., Montanelli, P., Guerra, F., Skalamera, I., Staderini, F., Grandi, S., Nelli, T., de Boer, D. V., van der Pool, A. E. M., Janssen, T. L., El-Atmani, S., van Verschuer, V. M. T., Poelman, M., Dronkers, W. J., van Steensel, L., Toorenvliet, B. R., Duinhouwer, L. E., Vermaas, M., Ter Bruggen, F. F. J. A., Hogendoorn, W., van der Harst, E., van Rijckevorsel, V. A. J. I. M., Bayoumy, A. B., Lap, C. R., Gooszen, J. A. H., Abdulrahman, N., de Roy van Zuidewijn, D., de Groof, E. J., Zijlmans, J. L., van Dalen, A. S. H. M., Bos, K., Musters, G. D., Looijen, R. C., Fliers, J. M., Oostendorp, S. E., Mosterd, C. M., Blonk, L., Jurgens, J., Ribbink, M. E., Boom, M. S., Boersma, A. M., Hidding, E., Schmidt, P. A., Mensink, G., Graus, S. A., Gastel, M. D. A., Veenker, C. G. H., Van Heumen, T. M., Slieker, F. J. B., Sedee, W. J. A., Lowensteyn, Y. N., Amelung, F. J., de Guerre, L. E. V. M., Nota, C. L. M. A., Van Dijck, W. P. M., van Wijnbergen, J. W. M., Pronk, A., Kip, M., van der Zee, C., Heiloo, S., Muller, S., Verboeket, B., Oudman, T. S., Zope, S., Gilissen, V., Gommers, J., Cremers, D., Van der Lubbe, M., Smet, M., Ter Weele, K., de Bruin, M., Geerlings, M., Ter Horst, L., Kerimova, N., Pesser, N., Heesakkers, H., de Mees, T., de Gooyer, J. M., Willems, L., Gawria, L., Bonouvrie, D., Harms, J., Eggen, Y., Hengeveld, E., Smeets, H. J., Hoffman, R. P. C., Detmers Blom, F. P. N., Van Bruggen, D., Steup, W. H., Gooiker, G. A., Willems, Y. R., van der Hoeven, A. C., Vallve-Bernal, M., Perez-Gandara, B., Perez, J. L., Caballero Rodriguez, E., Perez Febles, M., Protti Ruiz, G. P., Hidalgo Pujol, M., Alberti Delgado, P., Gil Barrionuevo, E., Anabitarte, O., Caballero, L., Poyato Nunez, F. J., Prado Perez, R., de la Portilla de Juan, F., Fulgencio Barbarin, J., Elorza Echaniz, G., Mitxelena Elosegi, L., Delgado, A. T., Marti Gelonch, L., Gonzalez Arribas, M., De Serra Tejada, I., Alberdi San Roman, I., de Andres Olabarria, U., Fernandez-Domper, L., Perez Costoya, C., Perez Arias, H., Fa Binefa, M., Becerra Nieves, M., Escalona Canal, M. G., Aldrey, I., Vazquez-Gonzalez, I., Falcon Cazas, A., Amarelo Garcia, M., Gonzalez Ruiz, A. A., Garcia Garrido, M., Simon Frapolli, V., Martinez Diaz, J. M., De la Torre Conde, C., Rodrigues Silva, K., Hernandez Kakauridze, S., Lopez Garcia, M. C., Flores Funes, D., Gomez-Lopez de San Roman, C., San Martin Bragado, M., Tejero Pintor, F. J., Pando Ruiz, B., Sanchez Estebanez, E., Roquet Puignero, E., Pla Sero, S., Vela Polanco, F. F., Mirallas Vinas, O., Caro Gonzalez, M. P., Bertelli Puche, J. L., Gonzalez-Martinez, A., Sanchez Cambronero, M., Garcia Torres, A., Dominguez Jimenez, M., de Jesus Rodriguez Perdomo, M., Echazarreta-Gallego, E., Sanchez-Blasco, L., Del Mar Lopez-Cuevas, M., Latras-Cortes, I., Lopez-Vendrell, L., Diaz Padillo, A., Mestres Petit, N., Cruz Reyes, J. A., Fernandez, C., Posada, M., Moratilla Lapena, L., Martin Morales, E., Mate-Mate, P., Garcia Cruz, G., Gorini, L., Rubio-Perez, I., Soldevila-Verdeguer, C., Jimenez-Vinas, C., Luehrman, A., Sena-Ruiz, F., Garcia-Perez, J. M., Plomer-Sanchez, M., Pujol-Cano, N., Jimenez-Segovia, M., Diaz-Jover, P., Pineno-Flores, C., Ambrona-Zafra, D., Gonzalez-Argente, X. F., Jimenez-Morillas, P., Lopez-Marmol, R., Duran-Martinez, M., Gonzalez-Crespo, A., Checa Guillen, M., Valderrama Perez, A., Claramonte Bellmunt, O., Marti Fernandez, R. M., Kasap, S., Soylemez, Z. O. B. B., Bolat, A. B., Aydar, S. E. Y. I., Birgin, B. Z., Coskun, O., Cakir, S. G., Belibagli, Z. O., Herken, M., Erdem, S., Kayacan, S., Kelesoglu, Y., Moran, D., Atalay, H., Kucukdiler, E., Demirci, A., Buyukkasap, C., Kuzey, A., Emral, C., Dogan, H., Cok, H., Durmaz, H., Asma, A., Ergul, B., Kaya, A., Bilicen, G., Gunay, M., Senturk, E., Baskoy, L., Besisik, H. M., Topalan, K., Piraliyev, E., Danalioglu, A. N., Ilbak, A., Yigman, S., Kara, C., Guzel, M., Inci, E. T., Onsal, U., Erel, T., Cetin, S. K., Yekenkurul, E., Kasar, P., Saglam, Z. A., Gursoy, F., Cetinkaya, M., Aktekin, H., Bober, D. N., Mugurtay, Y. S., Koksal, G., Celik, S., Bektur, G., Yildirim, R., Ankarali, T., Guven, H., Yuksel, A., Semiz, A., Cise, S., Tomas, K., Ulusahin, M., Akbulut, F., Tulum, H., Bodur, S., Isler, V. C., Pektas, A. M., Mutlu, D., Mericliler, M., Tansoker, I., Polat, Z. P., Seyrek, N., Beyatli, S., Toto, O. F., Cakaloglu, H. C., Sapci, I., Akpunarli, B., Adiyaman, C., Kobal, B. B., Gok, Z., Benli, S., Turpan, M., Kocapinar, S., Parimli, H., Acar, S., Eger, M., Yilmaz, I., Cengiz, U., Yoruk, I., Mutlu, B., Ulkucu, A., Arukan, C., Kara, B., Gokce, K., Calisgan, B., Demirci, K., Elkatroushi, T., Ayaz, B., Uzun, B., Sivrikaya, T., Goksoy, B., Eroz, E., Celik, B., Canbay Torun, B., Ekin, B., Senay, B. B., Temiz, C., Yilmaz, M., Yasar, C., Cakir, E., Subasi, A., Celik, K., Aksoy, K., Karabulut, E., Altintas, O., Bali, A. N., Ciftci, E., Babaoglu, H., Aljbour, A., Aljbour, I., Akcaoglu, T., Kakil, E., Taskin, O., Taskin, R. B., Topal, U., Huzmeli, E., Caliskan, T., Unal, A. G., Yurekli, A. M., Sari, V., Tutam, D. N., Celen, D., Posteki, G., Demirtas, B., Yildiz, S., Kilic, E., Yalcin, Y., Kurt, A., Gozubuyuk, Y., Huseynova, S., Cinar, S., Calar, S. N., Kurklu, O., Binbuga, M., Ceylan, C., Yavuz, G., Alim, Y. E., Yildirim, N., Yilmaz, S., Onar, D., Aray, E., Ozsipahi, A. C., Koc, G. E., Yetiskin, E., Kocer, M. D., Ozgencil, B., Bahcecioglu, B., Hacioglu, A. D., Bilici, O., Cin, S., Uzunoglu, E. C., Cumen, E. C., Aslan, L., Erozgur, B., Yildiz, S. S., Zengin, T., Kullac, S., Mizan, S. R., Baykan, B., Kopac, O., Karabacak, U., Aytekin, A., Deliktas, T. S., Buyukkarabacak, Y., Uzun, O., Karahan, B., Turkmen, M., Akdogan, A., Uctepe, F., Bandirmali, O., Erdogan, P., Demir, F., Bozkurt, G. K., Yilmaz, T., Sheikh, I. M. I., Orhan, K., Balci, B., Keyif, M. F., Bilgin, S., Cantimer, E., Yaman, S., Akkaya, E., Atesavci, S. N., Arslan, U., Asik, M., Koksal, S., Murtaza, M. I., Mustafa, S., Oun, H., Sam, Z. H., Brogan, A., Zaidi, R., Quinn, K., Taylor, F., Pang, G., Heath, H., Smart, N. J., Home, J., Mauro, D., Noone, T. M., Fenn, J., Sinha, A., Lowe, R., Hutchings, I., Longstaff, L., Smith, A. G., Edwards, J. A., Alcocer, B. P., Oakley, T., Thomas-Davies, M., Hourston, G. J. M., Kankam, H. K. N., Ramana, A., Baker, C., Endo, Y., Wong, C., Anderson, R. G. J., Badran, A., Ali, A., Myers, L., Tippins, F., Stanley, S., Sandison, L., Schofield, E., Delf, J., Rees, S., Anyan-Brown, J., Long, K., Archer, M., Anakwenze, V., Goel, S., Sharma Khatiwada, A., Khan, S., Leafe, O., Lee, J., Embury-Young, Y., Edwards, L., Hazenberg, P., Agrawal, M., Guerero, D., Britton, F., Rejayee, M., Mahesh, S., Khaing, P. H., Baldwin, A., Iyer, S., Gaskell, P., Adlan, A., Cuckow, L., Barmayehvar, B., Rob, T., Ciurleo, C., Mural-Krishnan, S., Jong, N., Carlson, S., Abdelgalil, R., Goble, M., Doshi, A., Ogunleye, O., Marsh, L., Bagley, J., Poacher, A., Cantelo, J., Wylie, J., Govil, S., Hill, F., Beaver, D., Urquhart, A., Rakhimov, I., Raina, V., Clifford, T., Iorga, R., Cartwright, E., Harris, A. J., Shurovi, B., Wadanamby, S., Brown, E., Bradley, C., Ahmad, A., Jeyabraba, S., Hardaman, B., Truss, A., Mohamed, U. S., Kerin, M. J., Reynolds, J., Ridgway, P., Pietrabissa, A., Foschi, D., Sgroi, G., Rosati, G., Benevento, A., Coco, Claudio, Persiani, Roberto, Vasquez, G., Messina, F., De Manzini, N., Innocenti, P., Rosati, R., Altomare, D. F., Sartori, A., Salamone, G., Galleano, R., Cianchi, F., Wijnhoven, B. P. L., van de Ven, A. W. H., de Vos Tot Nederveen Cappel, R. J., de Castro, S. M. M., Meijerink, W. J. H. J., Mulder, I. M., Acherman, Y. I. Z., van Leeuwen, B. L., Schasfoort, R. A., Kloppenberg, F. W. H., Wiezer, R., Consten, E. C. J., Van Grevenstein, W. M. U., Schiphorst, A., Wijffels, N., Uittenbogaart, M., Klinkert, M., Koppe, M., de Hingh, I., Konsten, J., Polat, F., Berends, F., Langenhoff, B., Zimmerman, D., van Engelenburg, T., Vries, J. J. M., Baeten, C. I. M., Bastiaansen, A. J. N. M., van Geloven, A., Khan, I., Girones, J., Barrera Gomez, M., Sanz Ortega, G., Duran Munoz-Cruzado, V. M., Ruiz Montesinos, I., Enriquez-Navascues, J. M., Portugal Porras, V., Baixauli, J., Garcia Florez, L. 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S., Kleine, E., Yauw, S., de Zeeuw, S., Aarts, E., Teixeira da Silva, M., Brueren, L., Bokkerink, G., Schok, T., Graafland, M., Gonzalez de Chaves, P. E., Jimenez-Gomez, L. M., Garcia Galocha, J. L., Palos Campos, M. C., Jimenez Escovar, F., Hernandez-Lizoain, J. L., Monzonis Hernandez, X., Dominguez Sanchez, J. M., Vives-Rodriguez, E., Abrisqueta Carrion, J., Beltran de Heredia, J., Padilla Valverde, D., Alcazar Montero, J. A., Cordoba-Diaz de Laspra, E., Franco Chacon, M., Muriel, P., Pastor-Riquelme, P., Peinado Iribar, B., Alonso Hernandez, N., Costa-Navarro, D., Martinez Chillaron, E., Secilmis, E., Bamac, E., Koc, F., Kayaci Durak, M., Bayram, S., Ekrem, M., Uzun, S., Gok, A. F. K., Gorguner, F., Yildiz, T., Dalci, K., Kilinc, C., Koc, M., Yuksek, M. A., Ersoy, T., Celik, E., Parmar, E., Abuhussein, N., Metcalf, P., Atif, M., Heywood, E., Mayes, J. W., Kelly, M., Mitchell, H., Antoniou, I., Dean, R., Davies, N., Trecarten, S., Henderson, I., Holmes, C., Shuttleworth, R. H., Jindal, A., Hughes, F., Gouda, P., Fleck, R., Hanrahan, M., Karunakaran, P., Chen, J. H., Sykes, M. C., Sethi, R. K., Suresh, S., Patel, P., Patel, M., Varma, R. K., Mushtaq, J., Bolton, W., Khan, T., Morley, R., Favero, N., Adams, R., Thirumal, V., Kennedy, E. D., Ong, K. K., Tan, Y. H., Gabriel, J., Bakhsh, A., Low, J. Y. L., Yener, A., Paraoan, V., Preece, R., Tilston, T. W., Cumber, E., Dean, S., Ross, T., Mccance, E., Amin, H., Satterthwaite, L., Clement, K. D., Gratton, R., Mills, E. D., Chiu, S. M., Hung, G., Rafiq, N. M., Hayes, J. D. B., Robertson, K. L., Dynes, K., Huang, H. C., Assadullah, S., Duncumb, J. W., Moon, R. D. C., Poo, S. X., Mehta, J. K., Joshi, K. R., Callan, R., Norris, J. M., Chilvers, N. J., Keevil, H., Jull, P., Mallick, S., Elf, D., Carr, L., Player, C., Barton, E. C., Martin, A. L., Ratu, S. G., Roberts, E. J., Phan, P. N., Dyal, A. R., Rogers, J. E., Henson, A. D., Reid, N. B., Burke, D., Culleton, G., Lynne, S., Mansoor, S., Brennan, C., Blessed, R., Holloway, C., Hill, A., Goldsmith, T., Mackin, S., Kim, S., Woin, E., Brent, G., Coffin, J., Ziff, O., Momoh, Z., Debenham, R., Ahmed, M., Yong, C. S., Wan, J. C., Copley, H. C., Raut, P., Chaudhry, F. I., Nixon, G., Dorman, C., Tan, R., Kanabar, S., Canning, N., Dolaghan, M., Bell, N., Mcmenamin, M., Chhabra, A., Duke, K., Turner, L., Patel, T., Chew, L. S., Mirza, M., Lunawat, S., Oremule, B., Ward, N., Khan, M., Tan, E. T., Maclennan, D., Mcgregor, R. J., Chisholm, E. G., Griffin, E. J., Bell, L., Hughes, B. A., Davies, J., Haq, H., Ahmed, H., Ungcharoen, N., Whacha, C., Thethi, R., Markham, R. M., Lee, A. H. Y., Batt, E., Bullock, N. P., Francescon, C. T., Davies, J. E., Shafiq, N. M., Zhao, J., Vivekanantham, S., Barai, I., Allen, J. L. Y., Marshall, D. C., Mcintyre, C. J., Wilson, H. C. P., Ashton, A. 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F., Lim, K., Ho, S., Crewdson, J. A., Singagireson, S., Kalra, N., Koumpa, F., Jhala, H., Soon, W. C., Karia, M., Rasiah, M. G., Xylas, D., Gilbert, H., Sundar-Singh, M., Wills, J., Akhtar, S., Patel, S., Hu, L., Brathwaite-Shirley, C., Nayee, H., Amin, O., Rangan, T., Turner, E. J. H., Mccrann, C., Shepherd, R., Patel, N., Prest-Smith, J., Auyoung, E., Murtaza, A., Coates, A., Prys-Jones, O., King, M., Gaffney, S., Dewdney, C. J., Nehikhare, I., Lavery, J., Bassett, J., Davies, K., Ahmad, K., Collins, A., Acres, M., Egerton, C., Cheng, K., Chen, X., Chan, N., Sheldon, A., Empey, J., Ingram, E., Malik, A., Johnstone, M., Goodier, R., Shah, J. P., Giles, J. E., Sanders, J. A., Mclure, S. W., Pal, S., Rangedara, A., Baker, A. N., Asbjoernsen, C. A., Girling, C., Gray, L., Gauntlett, L., Joyner, C., Qureshi, S., Mogan, Y. P., Ng, J. C. K., Kumar, A. N., Park, J. H., Tan, D., Choo, K. P., Raman, K. P., Buakuma, P., Xiao, C., Govinden, S., Thompson, O. D., Charalambos, M. A., Karsan, R. B., Dogra, T., Bullman, L. M., Dawson, P. M., Frank, A. L., Abid, H., Tung, L., Qureshi, U., Tahmina, A., Matthews, B. W., Harris, R. T., O'Connor, A., Mazan, K., Iqbal, S., Stanger, S. A., Thompson, J. D., Sullivan, J. A. L., Uppal, E., Macaskill, A., Bamgbose, F. A., Neophytou, C., Carroll, A. F., Rookes, C. W., Datta, U., Dhutia, A. J., Rashid, S., Ahmed, N., Lo, T., Bhanderi, S., Blore, C. D., Ahmed, S., Shaheen, H., Abburu, S., Majid, S., Abbas, Z., Talukdar, S. S., Burney, L. J., Patel, J. B., Al-Obaedi, O., Roberts, A. W., Mahboob, S., Sheth, S., Karia, P., Prabhudesai, A., Kow, K., Koysombat, K., Wang, S., Morrison, P., Maheswaran, Y., Keane, P., Copley, P. C., Brewster, O., Xu, G. X., Harries, P., Wall, C., Al-Mousawi, A., Bonsu, S., Cunha, P., Ward, T., Paul, J., Nadanakumaran, K., Tayeh, S., Holyoak, H., Remedios, J., Theodoropoulou, K., Luhishi, A., Jacob, L., Long, F., Atayi, A., Sarwar, S., Parker, O., Harvey, J., Ross, H., Rampal, R., Thomas, G., Vanmali, P., Mcgowan, C., Stein, J., Robertson, V., Carthew, L., Teng, V., Fong, J., Street, A. N., Thakker, C. E., O'Reilly, D., Bravo, M., Pizzolato, A., Khokhar, H. A., Ryan, M., Cheskes, L., Carr, R., Salih, A. E., Bassiony, S., Yuen, R., Chrastek, D., Rosen O'Sullivan, H., Amajuoyi, A., Wang, A., Sitta, O., Wye, J., Qamar, M. A., Major, C., Kaushal, A., Morgan, C., Petrarca, M., Allot, R., Verma, K., Dutt, S., Chilima, C. P., Peroos, S., Kosasih, S. R., Chin, H., Ashken, L., Pearse, R. J., O'Loughlin, R. 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E., Jubainville, C. L., Arif, T., Elliott, L. E., Gupta, V., Bhaskaran, G., Odeleye, A., Ahmed, F., Shah, R., Pickard, J., Suleman, Y. N., North, A. S., Mcclymont, L. F., Hussain, N., Ibrahim, I., Ng, G. S., Wong, V., Lim, A. E., Harris, L. N., Tharmachandirar, T., Mittapalli, D., Patel, V., Lakhani, M., Bazeer, H. Z., Narwani, V., Sandhu, K. K., Wingfield, L. R., Gentry, S., Adjei, H., Bhatti, M., Braganza, L., Barnes, J., Mistry, S., Chillarge, G., Stokes, S., Cleere, J., Bucko, A. M., Meek, J., Boxall, N., Heywood, E. G., Wiltshire, J. J., Toh, C., Ward, A. E., Shurovi, B. N., Horth, D., Patel, B. Y., Ali, B., Spencer, T., Axelson, T., Kretzmer, L., Chhina, C., Anandarajah, C., Fautz, T., Horst, C., Thevathasan, A. A., Ng, J. Q., Hirst, F., Brewer, C. F., Logan, A. E., Lockey, J. W., Forrest, P. R., Keelty, N., Wood, A. D., Springford, L. R., Avery, P., Schulz, T. M., Bemand, T. P., Howells, L., Collier, H., Khajuria, A., Tharakan, R. G., Parsons, S., Buchan, A. M., Mcgalliard, R. 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M., Gavagna, L., Pasquali, S., Pata, F., Pellino, G., de la Rosa-Estadella, M., Stellingwerf, M. E., Stijns, R. C. H., Borrellas, A., Golding, D., Ngaage, M., Van Tol, R. R., de Groof, J., de Wilt, H., Bemelman, W. A., Mcnamee, L., Espin-Basany, E., Emre Baki, B., Gecim, I. E., Can Tatar, O., Bach, S., Bhangu, A., Bresges, K., Burke, J., Claireaux, H. A., Fearnhead, N., Fitzgerald, J. E., Gallagher, S., Glasbey, J. C., Gundogan, B., Harrison, E. M., Hernon, J., Khatri, C., Kong, C. Y., Lyons, A., Mohan, M., Morton, D., Pinkney, T. D., Arezzo, A., Foppa, C., Morino, M., Rubbini, M., Selvaggi, F., Sensi, B., Sica, G., Orhalmi, J., Naccari, P., Sgro, A., Burger, B. H. C. M., Fares, D. A., Spijkerman, R., van Elst, T. R., Wiersema, R., Stassen, L. P. S., Rodriguez Garcia, R., Ozkan, B. B., Tavuz, A. I., Demirci, Z. S., Baki, B. E., Choi, P. J., O'Sullivan, H., Salman, M., Simioni, A., Colombo, F., Turati, L., Cazzola, F. E., Gallo, G., Perrotta, G., Papandrea, M., Naccari, P. 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M., De la Torre Conde, C., Rodrigues Silva, K., Hernandez Kakauridze, S., Lopez Garcia, M. C., Flores Funes, D., Gomez-Lopez de San Roman, C., San Martin Bragado, M., Tejero Pintor, F. J., Pando Ruiz, B., Sanchez Estebanez, E., Roquet Puignero, E., Pla Sero, S., Vela Polanco, F. F., Mirallas Vinas, O., Caro Gonzalez, M. P., Bertelli Puche, J. L., Gonzalez-Martinez, A., Sanchez Cambronero, M., Garcia Torres, A., Dominguez Jimenez, M., de Jesus Rodriguez Perdomo, M., Echazarreta-Gallego, E., Sanchez-Blasco, L., Del Mar Lopez-Cuevas, M., Latras-Cortes, I., Lopez-Vendrell, L., Diaz Padillo, A., Mestres Petit, N., Cruz Reyes, J. A., Fernandez, C., Posada, M., Moratilla Lapena, L., Martin Morales, E., Mate-Mate, P., Garcia Cruz, G., Gorini, L., Rubio-Perez, I., Soldevila-Verdeguer, C., Jimenez-Vinas, C., Luehrman, A., Sena-Ruiz, F., Garcia-Perez, J. M., Plomer-Sanchez, M., Pujol-Cano, N., Jimenez-Segovia, M., Diaz-Jover, P., Pineno-Flores, C., Ambrona-Zafra, D., Gonzalez-Argente, X. F., Jimenez-Morillas, P., Lopez-Marmol, R., Duran-Martinez, M., Gonzalez-Crespo, A., Checa Guillen, M., Valderrama Perez, A., Claramonte Bellmunt, O., Marti Fernandez, R. M., Kasap, S., Soylemez, Z. O. B. B., Bolat, A. B., Aydar, S. E. Y. I., Birgin, B. Z., Coskun, O., Cakir, S. G., Belibagli, Z. O., Herken, M., Erdem, S., Kayacan, S., Kelesoglu, Y., Moran, D., Atalay, H., Kucukdiler, E., Demirci, A., Buyukkasap, C., Kuzey, A., Emral, C., Dogan, H., Cok, H., Durmaz, H., Asma, A., Ergul, B., Kaya, A., Bilicen, G., Gunay, M., Senturk, E., Baskoy, L., Besisik, H. M., Topalan, K., Piraliyev, E., Danalioglu, A. N., Ilbak, A., Yigman, S., Kara, C., Guzel, M., Inci, E. T., Onsal, U., Erel, T., Cetin, S. K., Yekenkurul, E., Kasar, P., Saglam, Z. A., Gursoy, F., Cetinkaya, M., Aktekin, H., Bober, D. N., Mugurtay, Y. S., Koksal, G., Celik, S., Bektur, G., Yildirim, R., Ankarali, T., Guven, H., Yuksel, A., Semiz, A., Cise, S., Tomas, K., Ulusahin, M., Akbulut, F., Tulum, H., Bodur, S., Isler, V. C., Pektas, A. M., Mutlu, D., Mericliler, M., Tansoker, I., Polat, Z. P., Seyrek, N., Beyatli, S., Toto, O. F., Cakaloglu, H. C., Sapci, I., Akpunarli, B., Adiyaman, C., Kobal, B. B., Gok, Z., Benli, S., Turpan, M., Kocapinar, S., Parimli, H., Acar, S., Eger, M., Yilmaz, I., Cengiz, U., Yoruk, I., Mutlu, B., Ulkucu, A., Arukan, C., Kara, B., Gokce, K., Calisgan, B., Demirci, K., Elkatroushi, T., Ayaz, B., Uzun, B., Sivrikaya, T., Goksoy, B., Eroz, E., Celik, B., Canbay Torun, B., Ekin, B., Senay, B. B., Temiz, C., Yilmaz, M., Yasar, C., Cakir, E., Subasi, A., Celik, K., Aksoy, K., Karabulut, E., Altintas, O., Bali, A. N., Ciftci, E., Babaoglu, H., Aljbour, A., Aljbour, I., Akcaoglu, T., Kakil, E., Taskin, O., Taskin, R. B., Topal, U., Huzmeli, E., Caliskan, T., Unal, A. G., Yurekli, A. M., Sari, V., Tutam, D. N., Celen, D., Posteki, G., Demirtas, B., Yildiz, S., Kilic, E., Yalcin, Y., Kurt, A., Gozubuyuk, Y., Huseynova, S., Cinar, S., Calar, S. N., Kurklu, O., Binbuga, M., Ceylan, C., Yavuz, G., Alim, Y. E., Yildirim, N., Yilmaz, S., Onar, D., Aray, E., Ozsipahi, A. C., Koc, G. E., Yetiskin, E., Kocer, M. D., Ozgencil, B., Bahcecioglu, B., Hacioglu, A. D., Bilici, O., Cin, S., Uzunoglu, E. C., Cumen, E. C., Aslan, L., Erozgur, B., Yildiz, S. S., Zengin, T., Kullac, S., Mizan, S. R., Baykan, B., Kopac, O., Karabacak, U., Aytekin, A., Deliktas, T. S., Buyukkarabacak, Y., Uzun, O., Karahan, B., Turkmen, M., Akdogan, A., Uctepe, F., Bandirmali, O., Erdogan, P., Demir, F., Bozkurt, G. K., Yilmaz, T., Sheikh, I. M. I., Orhan, K., Balci, B., Keyif, M. F., Bilgin, S., Cantimer, E., Yaman, S., Akkaya, E., Atesavci, S. N., Arslan, U., Asik, M., Koksal, S., Murtaza, M. I., Mustafa, S., Oun, H., Sam, Z. H., Brogan, A., Zaidi, R., Quinn, K., Taylor, F., Pang, G., Heath, H., Smart, N. J., Home, J., Mauro, D., Noone, T. M., Fenn, J., Sinha, A., Lowe, R., Hutchings, I., Longstaff, L., Smith, A. G., Edwards, J. A., Alcocer, B. P., Oakley, T., Thomas-Davies, M., Hourston, G. J. M., Kankam, H. K. N., Ramana, A., Baker, C., Endo, Y., Wong, C., Anderson, R. G. J., Badran, A., Ali, A., Myers, L., Tippins, F., Stanley, S., Sandison, L., Schofield, E., Delf, J., Rees, S., Anyan-Brown, J., Long, K., Archer, M., Anakwenze, V., Goel, S., Sharma Khatiwada, A., Khan, S., Leafe, O., Lee, J., Embury-Young, Y., Edwards, L., Hazenberg, P., Agrawal, M., Guerero, D., Britton, F., Rejayee, M., Mahesh, S., Khaing, P. H., Baldwin, A., Iyer, S., Gaskell, P., Adlan, A., Cuckow, L., Barmayehvar, B., Rob, T., Ciurleo, C., Mural-Krishnan, S., Jong, N., Carlson, S., Abdelgalil, R., Goble, M., Doshi, A., Ogunleye, O., Marsh, L., Bagley, J., Poacher, A., Cantelo, J., Wylie, J., Govil, S., Hill, F., Beaver, D., Urquhart, A., Rakhimov, I., Raina, V., Clifford, T., Iorga, R., Cartwright, E., Harris, A. J., Shurovi, B., Wadanamby, S., Brown, E., Bradley, C., Ahmad, A., Jeyabraba, S., Hardaman, B., Truss, A., Mohamed, U. S., Kerin, M. J., Reynolds, J., Ridgway, P., Pietrabissa, A., Foschi, D., Sgroi, G., Rosati, G., Benevento, A., Coco, Claudio, Persiani, Roberto, Vasquez, G., Messina, F., De Manzini, N., Innocenti, P., Rosati, R., Altomare, D. F., Sartori, A., Salamone, G., Galleano, R., Cianchi, F., Wijnhoven, B. P. L., van de Ven, A. W. H., de Vos Tot Nederveen Cappel, R. J., de Castro, S. M. M., Meijerink, W. J. H. J., Mulder, I. M., Acherman, Y. I. Z., van Leeuwen, B. L., Schasfoort, R. A., Kloppenberg, F. W. H., Wiezer, R., Consten, E. C. J., Van Grevenstein, W. M. U., Schiphorst, A., Wijffels, N., Uittenbogaart, M., Klinkert, M., Koppe, M., de Hingh, I., Konsten, J., Polat, F., Berends, F., Langenhoff, B., Zimmerman, D., van Engelenburg, T., Vries, J. J. M., Baeten, C. I. M., Bastiaansen, A. J. N. M., van Geloven, A., Khan, I., Girones, J., Barrera Gomez, M., Sanz Ortega, G., Duran Munoz-Cruzado, V. M., Ruiz Montesinos, I., Enriquez-Navascues, J. M., Portugal Porras, V., Baixauli, J., Garcia Florez, L. J., Alonso Goncalves, S., Parajo, A., Sanchez-Guillen, L., Lujan Mompean, J. A., Soria Aledo, V., Arenal, J. J., Blanco Antona, F., Badia, J. M., Roura, J., Garcia Garcia, J., Elia-Guedea, M., Millan, M., Vinas-Salas, J., Garcia-Olmo, D., Prieto-Nieto, M. I., Medina-Fernandez, F. J., Romero-Simo, M., Frasson, M., Espi Macias, A., Tirnaksiz, M. B., Leventoglu, S., Kara, E., Tasci, Y., Pehlivan, M., Guner, A., Ozben, V., Agalar, C., Albayrak, D., Ertekin, C., Oncel, M., Sakman, G., Guler, S. A., Firat, O., Akkucuk, S., Ozbalci, G. S., Sozuer, E. M., Sengul, N., Schizas, A., Horgan, P. G., Singh, B., Harikrishnan, A., Stechman, M., Hayat, J., Coyne, P., Wilson, T., Arun, C., Manvydas, V., Moroni, P., Lo Secco, G., Argenti, F., Romano, F., Calcagno, P., Steccanella, F., Cisternino, G., Bottini, C., Realis Luc, A., Apicella, M., Candilio, G., Gubbiotti, F., De Luca, E., Casagranda, B., Decorato, A., Aquilino, F., Badii, B., Rahmee, C. N. S., Kleine, E., Yauw, S., de Zeeuw, S., Aarts, E., Teixeira da Silva, M., Brueren, L., Bokkerink, G., Schok, T., Graafland, M., Gonzalez de Chaves, P. E., Jimenez-Gomez, L. M., Garcia Galocha, J. L., Palos Campos, M. C., Jimenez Escovar, F., Hernandez-Lizoain, J. L., Monzonis Hernandez, X., Dominguez Sanchez, J. M., Vives-Rodriguez, E., Abrisqueta Carrion, J., Beltran de Heredia, J., Padilla Valverde, D., Alcazar Montero, J. A., Cordoba-Diaz de Laspra, E., Franco Chacon, M., Muriel, P., Pastor-Riquelme, P., Peinado Iribar, B., Alonso Hernandez, N., Costa-Navarro, D., Martinez Chillaron, E., Secilmis, E., Bamac, E., Koc, F., Kayaci Durak, M., Bayram, S., Ekrem, M., Uzun, S., Gok, A. F. K., Gorguner, F., Yildiz, T., Dalci, K., Kilinc, C., Koc, M., Yuksek, M. A., Ersoy, T., Celik, E., Parmar, E., Abuhussein, N., Metcalf, P., Atif, M., Heywood, E., Mayes, J. W., Kelly, M., Mitchell, H., Antoniou, I., Dean, R., Davies, N., Trecarten, S., Henderson, I., Holmes, C., Shuttleworth, R. H., Jindal, A., Hughes, F., Gouda, P., Fleck, R., Hanrahan, M., Karunakaran, P., Chen, J. H., Sykes, M. C., Sethi, R. K., Suresh, S., Patel, P., Patel, M., Varma, R. K., Mushtaq, J., Bolton, W., Khan, T., Morley, R., Favero, N., Adams, R., Thirumal, V., Kennedy, E. D., Ong, K. K., Tan, Y. H., Gabriel, J., Bakhsh, A., Low, J. Y. L., Yener, A., Paraoan, V., Preece, R., Tilston, T. W., Cumber, E., Dean, S., Ross, T., Mccance, E., Amin, H., Satterthwaite, L., Clement, K. D., Gratton, R., Mills, E. D., Chiu, S. M., Hung, G., Rafiq, N. M., Hayes, J. D. B., Robertson, K. L., Dynes, K., Huang, H. C., Assadullah, S., Duncumb, J. W., Moon, R. D. C., Poo, S. X., Mehta, J. K., Joshi, K. R., Callan, R., Norris, J. M., Chilvers, N. J., Keevil, H., Jull, P., Mallick, S., Elf, D., Carr, L., Player, C., Barton, E. C., Martin, A. L., Ratu, S. G., Roberts, E. J., Phan, P. N., Dyal, A. R., Rogers, J. E., Henson, A. D., Reid, N. B., Burke, D., Culleton, G., Lynne, S., Mansoor, S., Brennan, C., Blessed, R., Holloway, C., Hill, A., Goldsmith, T., Mackin, S., Kim, S., Woin, E., Brent, G., Coffin, J., Ziff, O., Momoh, Z., Debenham, R., Ahmed, M., Yong, C. S., Wan, J. C., Copley, H. C., Raut, P., Chaudhry, F. I., Nixon, G., Dorman, C., Tan, R., Kanabar, S., Canning, N., Dolaghan, M., Bell, N., Mcmenamin, M., Chhabra, A., Duke, K., Turner, L., Patel, T., Chew, L. S., Mirza, M., Lunawat, S., Oremule, B., Ward, N., Khan, M., Tan, E. T., Maclennan, D., Mcgregor, R. J., Chisholm, E. G., Griffin, E. J., Bell, L., Hughes, B. A., Davies, J., Haq, H., Ahmed, H., Ungcharoen, N., Whacha, C., Thethi, R., Markham, R. M., Lee, A. H. Y., Batt, E., Bullock, N. P., Francescon, C. T., Davies, J. E., Shafiq, N. M., Zhao, J., Vivekanantham, S., Barai, I., Allen, J. L. Y., Marshall, D. C., Mcintyre, C. J., Wilson, H. C. P., Ashton, A. J., Lek, C., Behar, N., Davis-Hall, M., Seneviratne, N., Esteve, L., Sirakaya, M., Ali, S., Pope, S., Ahn, J. S., Craig-McQuaide, A., Gatfield, W. A., Leong, S., Demetri, A. M., Kerr, A. L., Rees, C., Loveday, J., Liu, S., Wijesekera, M., Maru, D., Attalla, M., Smith, N., Brown, D., Sritharan, P., Shah, A., Charavanamuttu, V., Heppenstall-Harris, G., Ng, K., Raghvani, T., Rajan, N., Hulley, K., Moody, N., Williams, M., Cotton, A., Sharifpour, M., Lwin, K. N., Bright, M., Chitnis, A. R., Abdelhadi, M., Semana, A. D., Morgan, F., Reid, R., Dickson, J., Anderson, L., Mcmullan, R., Ahern, N., Asmadi, A., Anderson, L. B., Lua Boon Xuan, J., Crozier, L., Mcaleer, S., Lees, D. M., Adebayo, A. A., Das, M., Amphlett, A. H., Al-Robeye, A., Valli, A., Khangura, J., Winarski, A., Woodward, H., Gouldthrope, C., Turner, M., Sasapu, K., Tonkins, M., Wild, J. R. L., Robinson, M., Hardie, J., Heminway, R., Narramore, R., Ramjeeawon, N., Hibberd, A., Winslow, F., Ho, W., Chong, B. F., Lim, K., Ho, S., Crewdson, J. A., Singagireson, S., Kalra, N., Koumpa, F., Jhala, H., Soon, W. C., Karia, M., Rasiah, M. G., Xylas, D., Gilbert, H., Sundar-Singh, M., Wills, J., Akhtar, S., Patel, S., Hu, L., Brathwaite-Shirley, C., Nayee, H., Amin, O., Rangan, T., Turner, E. J. H., Mccrann, C., Shepherd, R., Patel, N., Prest-Smith, J., Auyoung, E., Murtaza, A., Coates, A., Prys-Jones, O., King, M., Gaffney, S., Dewdney, C. J., Nehikhare, I., Lavery, J., Bassett, J., Davies, K., Ahmad, K., Collins, A., Acres, M., Egerton, C., Cheng, K., Chen, X., Chan, N., Sheldon, A., Empey, J., Ingram, E., Malik, A., Johnstone, M., Goodier, R., Shah, J. P., Giles, J. E., Sanders, J. A., Mclure, S. W., Pal, S., Rangedara, A., Baker, A. N., Asbjoernsen, C. A., Girling, C., Gray, L., Gauntlett, L., Joyner, C., Qureshi, S., Mogan, Y. P., Ng, J. C. K., Kumar, A. N., Park, J. H., Tan, D., Choo, K. P., Raman, K. P., Buakuma, P., Xiao, C., Govinden, S., Thompson, O. D., Charalambos, M. A., Karsan, R. B., Dogra, T., Bullman, L. M., Dawson, P. M., Frank, A. L., Abid, H., Tung, L., Qureshi, U., Tahmina, A., Matthews, B. W., Harris, R. T., O'Connor, A., Mazan, K., Iqbal, S., Stanger, S. A., Thompson, J. D., Sullivan, J. A. L., Uppal, E., Macaskill, A., Bamgbose, F. A., Neophytou, C., Carroll, A. F., Rookes, C. W., Datta, U., Dhutia, A. J., Rashid, S., Ahmed, N., Lo, T., Bhanderi, S., Blore, C. D., Ahmed, S., Shaheen, H., Abburu, S., Majid, S., Abbas, Z., Talukdar, S. S., Burney, L. J., Patel, J. B., Al-Obaedi, O., Roberts, A. W., Mahboob, S., Sheth, S., Karia, P., Prabhudesai, A., Kow, K., Koysombat, K., Wang, S., Morrison, P., Maheswaran, Y., Keane, P., Copley, P. C., Brewster, O., Xu, G. X., Harries, P., Wall, C., Al-Mousawi, A., Bonsu, S., Cunha, P., Ward, T., Paul, J., Nadanakumaran, K., Tayeh, S., Holyoak, H., Remedios, J., Theodoropoulou, K., Luhishi, A., Jacob, L., Long, F., Atayi, A., Sarwar, S., Parker, O., Harvey, J., Ross, H., Rampal, R., Thomas, G., Vanmali, P., Mcgowan, C., Stein, J., Robertson, V., Carthew, L., Teng, V., Fong, J., Street, A. N., Thakker, C. E., O'Reilly, D., Bravo, M., Pizzolato, A., Khokhar, H. A., Ryan, M., Cheskes, L., Carr, R., Salih, A. E., Bassiony, S., Yuen, R., Chrastek, D., Rosen O'Sullivan, H., Amajuoyi, A., Wang, A., Sitta, O., Wye, J., Qamar, M. A., Major, C., Kaushal, A., Morgan, C., Petrarca, M., Allot, R., Verma, K., Dutt, S., Chilima, C. P., Peroos, S., Kosasih, S. R., Chin, H., Ashken, L., Pearse, R. J., O'Loughlin, R. A., Menon, A., Singh, K., Norton, J., Sagar, R., Jathanna, N., Rothwell, L., Watson, N., Harding, F., Dube, P., Khalid, H., Punjabi, N., Sagmeister, M., Gill, P., Shahid, S., Hudson-Phillips, S., George, D., Ashwood, J., Lewis, T., Dhar, M., Sangal, P., Rhema, I. A., Kotecha, D., Afzal, Z., Syeed, J. A., Prakash, E., Jalota, P., Herron, J., Kimani, L., Delport, A., Shukla, A., Agarwal, V., Parthiban, S., Thakur, H., Cymes, W., Rinkoff, S., Turnbull, J. A., Hayat, M., Darr, S., Khan, U., Lim, J., Higgins, A., Lakshmipathy, G., Forte, B., Canning, E., Jaitley, A., Lamont, J., Toner, E., Ghaffar, A., Mcdowell, M., Salmon, D., O'Carroll, O., Khan, A., Kelly, M. E., Clesham, K., Palmer, C., Lyons, R., Bell, A., Chin, R., Waldron, R. M., Trimble, A., Cox, S. E., Ashfaq, U., Campbell, J., Holliday, R. B. S., Mccabe, G., Morris, F., Priestland, R., Vernon, O. K., Ledsam, A., Vaughan, R., Lim, D., Bakewell, Z. R., Hughes, R. K., Koshy, R. M., Jackson, H. R., Narayan, P., Cardwell, A. E., Jubainville, C. L., Arif, T., Elliott, L. E., Gupta, V., Bhaskaran, G., Odeleye, A., Ahmed, F., Shah, R., Pickard, J., Suleman, Y. N., North, A. S., Mcclymont, L. F., Hussain, N., Ibrahim, I., Ng, G. S., Wong, V., Lim, A. E., Harris, L. N., Tharmachandirar, T., Mittapalli, D., Patel, V., Lakhani, M., Bazeer, H. Z., Narwani, V., Sandhu, K. K., Wingfield, L. R., Gentry, S., Adjei, H., Bhatti, M., Braganza, L., Barnes, J., Mistry, S., Chillarge, G., Stokes, S., Cleere, J., Bucko, A. M., Meek, J., Boxall, N., Heywood, E. G., Wiltshire, J. J., Toh, C., Ward, A. E., Shurovi, B. N., Horth, D., Patel, B. Y., Ali, B., Spencer, T., Axelson, T., Kretzmer, L., Chhina, C., Anandarajah, C., Fautz, T., Horst, C., Thevathasan, A. A., Ng, J. Q., Hirst, F., Brewer, C. F., Logan, A. E., Lockey, J. W., Forrest, P. R., Keelty, N., Wood, A. D., Springford, L. R., Avery, P., Schulz, T. M., Bemand, T. P., Howells, L., Collier, H., Khajuria, A., Tharakan, R. G., Parsons, S., Buchan, A. M., Mcgalliard, R. J., Mason, J. D., Cundy, O. J., Li, N., Redgrave, N. A., Watson, R. P., Pezas, T. P., Dennis, Y. F., Segall, E., Hameed, M., Lynch, A. S., Chamberlain, M., Peck, F. S., Neo, Y. N., Russell, G., Elseedawy, M., Foster, N. L., Soo, Y. H., Puan, L., Dennis, R., Goradia, H., Qureshi, A., Osman, S., Reeves, T., Dinsmore, L., Marsden, M., Lu, Q., Pitts-Tucker, T., Dunn, C. E., Walford, R. A., Heathcote, E., Martin, R., Pericleous, A., Brzyska, K., Reid, K. G., Williams, M. R., Wetherall, N., Mcaleer, E., Thomas, D., Kiff, R., Milne, S., Holmes, M. J. V., Bartlett, J., Lucas de Carvalho, J., Bloomfield, T., Tongo, F., Bremner, R. H., Yong, N., Atraszkiewicz, B. A., Mehdi, A., Tahir, M., Sherliker, G. X. J., Tear, A. K., Pandey, A., Broyd, A., Omer, H. M., Raphael, M., Chaudhry, W. W., Shahidi, S., Jawad, A. S., Gill, C. K., Hindle Fisher, I., Adeleja, I., Clark, I. J., Aidoo-Micah, G. E., Stather, P. W., Salam, G. J., Glover, T. E., Deas, G., Sim, N. K., Obute, R. D., Wynell-Mayow, W. M., Sait, M. S., Mitha, N., de Bernier, G. L., Siddiqui, M., Shaunak, R., Wali, A., Cuthbert, G., Bhudia, R., Webb, E., Shah, S., Ansari, N., Perera, M., Kelly, N., Mcallister, R., Stanley, G. H., Keane, C. P., Shatkar, V., Maxwell-Armstrong, C., Henderson, L. A., Maple, N., Manson, R., Adams, R. D., Semple, E., Mills, M., Daoub, A., Marsh, A., Ramnarine, A., Hartley, J., Malaj, M., Jewell, P. D., Whatling, E. A., Hitchen, N., Chen, M., Goh, B., Fern, J., Rogers, S., Derbyshire, L., Robertson, D. T., Deekonda, P., Abid, A., Harrison, P. L. M., Aildasani, L., Turley, H., Sherif, M. A., Pandey, G., Filby, J. J., Johnston, A., Burke, E., Mohamud, M., Gohil, K., Tsui, A. Y., Singh, R., Lim, S. J., O'Sullivan, K., Mckelvey, L. L., O'Neill, S., Roberts, H. F., Brown, F. S., Cao, Y., Buckle, R. T., Liew, Y., Sii, S., Ventre, C. M., Graham, C. J., Filipescu, T., Yousif, A., Dawar, R., Wright, A., Peters, M., Varley, R., Owczarek, S., Hartley, S., Khattak, M., Iqbal, A., Ali, M., Durrani, B., Narang, Y., Bethell, G. S., Horne, L., Pinto, R., Nicholls, K., Kisyov, I., Torrance, H. D., English, W., Lakhani, S. M., Ashraf, S. F., Venn, M., Elangovan, V., Kazmi, Z., Brecher, J., Sukumar, S., Mastan, A., Mortimer, A., Parker, J., Boyle, J., Elkawafi, M., Beckett, J., Mohite, A., Narain, A., Mazumdar, E., Sreh, A., Hague, A., Weinberg, D., Fletcher, L., Steel, M., Shufflebotham, H., Masood, M., Sinha, Y., Jenvey, C., Kitt, H., Slade, R., Craig, A. R., Deall, C., Reakes, T., Chervenkoff, J., Strange, E., O'Bryan, M., Murkin, C., Joshi, D., Bergara, T., Naqib, S., Wylam, D., Scotcher, S. E., Hewitt, C. M., Stoddart, M. T., Kerai, A., Trist, A. J., Cole, S. J., Knight, C. L., Stevens, S., Cooper, G. E., Ingham, R., Dobson, J., O'Kane, A., Moradzadeh, J., Duffy, A., Henderson, C., Ashraf, S., Mclaughin, C., Hoskins, T. C., Reehal, R. S., Bookless, L. R., Mclean, R. C., Stone, E. J., Wright, E. V., Abdikadir, H. R., Roberts, C., Spence, O., Srikantharajah, M., Ruiz, E. M., Matthews, J. H., Gardner, E., Hester, E., Naran, P., Simpson, R., Minhas, M., Cornish, E., Semnani, S. A., Rojoa, D., Radotra, A., Eraifej, J., Eparh, K., Smith, D. N. E., Mistry, B. D., Hickling, S. L., Din, W., Liu, C., Mithrakumar, P., Mirdavoudi, V., Rashid, M., Mcgenity, C., Hussain, O., Kadicheeni, M., Gardner, H., Anim-Addo, N., Pearce, J., Aslanyan, A., Ntala, C., Sorah, T., Parkin, J., Alizadeh, M., White, A., Edozie, F., Johnston, J., Kahar, A., Navayogaarajah, V., Carter, D., Khonsari, P., Burgess, A., Patel, B., Kong, C., Ponweera, A., Cody, A., Tan, Y., Ng, A. Y. L., Croall, A., Allan, C., Ng, S., Raghuvir, V., Telfer, R., Greenhalgh, A. D., Mckerr, C. N., Edison, M. A., Patel, B. A., Dear, K., Hardy, M. R., Williams, P., Hassan, S., Sajjad, U., O'Neill, E. M., Lopes, S., Healy, L., Jamal, N., Tan, S., Lazenby, D., Husnoo, S. B., Beecroft, S., Sarvanandan, T., Weston, C., Bassam, N., Rabinthiran, S., Hayat, U., Ng, L., Varma, D., Sukkari, M., Mian, A., Omar, A., Kim, J. W., Sellathurai, J., Mahmood, J., O'Connell, C., Bose, R., Heneghan, H., Lalor, P., Matheson, J., Doherty, C., Cullen, C., Cooper, D., Angelov, S., Drislane, C., Smith, A. C. D., Kreibich, A., Palkhi, E., Durr, A., Lotfallah, A., Gold, D., Mckean, E., Dhanji, A., Anilkumar, A., Thacoor, A., Siddiqui, Z. H., Lim, S., Piquet, A., Anderson, S. M., Mccormack, D. R., Gulati, J., Ibrahim, A., Murray, S. E., Walsh, S. L., Mcgrath, A., Ziprin, P., Chua, E. Y., Lou, C. N., Bloomer, J., Paine, H. R., Osei-Kuffour, D., White, C. J., Szczap, A., Gokani, S., Patel, K., Malys, M. K., Reed, A., Torlot, G. E., Cumber, E. M., Charania, A., Ahmad, S., Varma, N., Cheema, H., Austreng, L., Petra, H., Chaudhary, M., Zegeye, M. I., Cheung, F., Coffey, D., Heer, R. S., Singh, S., Seager, E., Cumming, S., Suresh, R. S., Verma, S., Ptacek, I. B., Gwozdz, A. M., Yang, T., Khetarpal, A. A., Shumon, S., Fung, T. M. P., Leung, W., Kwang, P., Chew, L., Loke, W., Curran, A., Chan, C., Mcgarrigle, C., Mohan, K., Cullen, S., Wong, E., Toale, C., Collins, D., Keane, N., Traynor, B. P., Shanahan, D., Yan, A., Jafree, D. J., Topham, C., Mitrasinovic, S., Omara, S., Bingham, G., Lykoudis, P. M., Miranda, B. H., Whitehurst, K., Kumaran, G., Devabalan, Y., Aziz, H., Shoa, M., Dindyal, S., Yates, J. A., Bernstein, I., Rattan, G., Coulson, R., Stezaker, S., Isaac, A., Salem, M., Mcbride, A., Mcfarlane, H., Yow, L., Macdonald, J., Bartlett, R. D., Turaga, S., White, U., Liew, W., Yim, N., Ang, A., Simpson, A., Mcauley, D., Craig, E., Murphy, L., Shepherd, P., Kee, J. Y., Abdulmajid, A., Chung, A., Warwick, H. L., Livesey, A., Holton, P., Theodoreson, M. D., Jenkin, S. L., Turner, J., Entwisle, J. H., Marchal, S. T., O'Connor, S., Blege, H. K., Aithie, J. M., Sabine, L. M., Stewart, G. E., Jackson, S., Kishore, A., Lankage, C. M., Acquaah, F., Joyce, H. L., Mckevitt, K. L., Coffey, C. J., Fawaz, A. S., Dolbec, K. S., O'Sullivan, D. A., Geraghty, J. M., Lim, E., Bolton, L., Fitzpatrick, D., Robinson, C., Ramtoola, T., Collinson, S., Grundy, L., Mcenhill, P. M., Harbhajan Singh, G. S., Loughran, D., Golding, D. M., Keeling, R. E., Williams, R. P., Whitham, R. D. J., Yoganathan, S., Nachiappan, R., Egan, R. J., Owasil, R., Kwan, M. L., He, A., Goh, R. W., Bhome, R., Wilson, H., Teoh, P. J., Raji, K., Jayakody, N., Matthams, J., Chong, J., Luk, C. Y., Greig, R. J., Trail, M., Charalambous, G., Rocke, A. S., Gardiner, N., Bulley, F., Warren, N., Brennan, E., Fergurson, P., Wilson, R., Whittingham, H., Brown, E. J., Khanijau, R., Gandhi, K., Morris, S., Boulton, A. J., Chandan, N., Barthorpe, A. E., Maamari, R., Sandhu, S., Mccann, M., Higgs, L., Balian, V., Reeder, C., Diaper, C., Sale, T., Ali, H., Archer, C. H., Clarke, A. K., Heskin, J., Hurst, P. C., Farmer, J. D., O'Flynn, L. D., Doan, L., Shuker, B. A., Stott, G. D., Vithanage, N. A., Hoban, K. A., Nesargikar, P. N., Kennedy, H. R., Grossart, C. M., Tan, E. S. M., Roy, C. S. D., Sim, P., Leslie, K. E., Sim, D., Abul, M. H., Cody, N., Tay, A. Y., Woon, E., Sng, S., Mah, J., Robson, J., Shakweh, E., Wing, V. C., Mills, H., Li, M. M., Barrow, T. R., Balaji, S., Jordan, H. E. M., Phillips, C., Naveed, H., Hirani, S., Tai, A., Ratnakumaran, R., Sahathevan, A., Shafi, A. M. A., Seedat, M., Weaver, R., Batho, A., Punj, R., Selvachandran, H., Bhatt, N., Botchey, S., Khonat, Z., Brennan, K., Morrison, C. J., Devlin, E., Linton, A., Galloway, E., Mcgarvie, S., Ramsay, N., Mcrobbie, H. D., Whewell, H., Dean, W., Nelaj, S., Eragat, M., Mishra, A., Kane, T., Zuhair, M., Wells, M., Wilkinson, D., Woodcock, N., Sun, E., Aziz, N., Abd Ghaffar, M. K., Bath, M. F., Nepogodiev, D., Coco C. (ORCID:0000-0002-4713-7093), and Persiani R. (ORCID:0000-0002-1537-5097)
- Abstract
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
- Published
- 2018
6. Retrorectal/presacral epidermoid cyst: Report of a case [Retrorektal/presakral epidermoid kist: Olgu sunumu]
- Author
-
Kesici U., Sakman G., Mataraci E., and Çukurova Üniversitesi
- Subjects
Cyst ,integumentary system ,Presacral ,Rectal ,Epidermoid ,Perianal - Abstract
Although epidermal cysts are frequently observed throughout the body, they are rarely found in the retrorectal/presacral regions. Retrorectal epidermal cysts are congenital lesions of ectodermal origin and generally occur in women during the reproductive period. In this case report, a 47 year old female patient with 25 years of complaint of a mass extending from the perianal region to the retrococcygeal region is discussed. A total mass excision with paracoccygeal incision was performed under spinal anesthesia. The histopathologic examination demonstrated an epidermal cyst. Correct diagnosis and appropriate treatment when first detected significantly decrease the recurrence and complication risks in all retrorectal tumors. Any mass should be completely removed in the treatment.
- Published
- 2013
7. Retrorectal/presacral epidermoid cyst: Report of a case
- Author
-
Kesici U., Sakman G., Mataraci E., and Giresun Üniversitesi
- Subjects
Cyst ,integumentary system ,Presacral ,Rectal ,Epidermoid ,Perianal - Abstract
Although epidermal cysts are frequently observed throughout the body, they are rarely found in the retrorectal/presacral regions. Retrorectal epidermal cysts are congenital lesions of ectodermal origin and generally occur in women during the reproductive period. In this case report, a 47 year old female patient with 25 years of complaint of a mass extending from the perianal region to the retrococcygeal region is discussed. A total mass excision with paracoccygeal incision was performed under spinal anesthesia. The histopathologic examination demonstrated an epidermal cyst. Correct diagnosis and appropriate treatment when first detected significantly decrease the recurrence and complication risks in all retrorectal tumors. Any mass should be completely removed in the treatment.
- Published
- 2013
8. Reconstruction of cervical esophagus defects by free jejunal flap after proximal esophageal carcinoma resections
- Author
-
Parsak C.K., Tuncer U., Kesiktas E., Akcam T., Sakman G., Ozdemir S., Tarkan O., and Çukurova Üniversitesi
- Subjects
Free jejunal flap ,Esophageal cancer ,Microvascular ,Reconstruction - Abstract
Background. Surgical treatment of proximal esophageal defects remains one of the greatest challenges to surgeons. Objectives. The aim of this study was to evaluate the free jejunal flap surgical technique and the surgical outcomes in patients who underwent it for proximal esophageal carcinoma resections. Material and Methods. The medical records of nine patients who underwent free jejunal flap reconstruction of the cervical esophagus for proximal esophageal cancer between January 2007 and December 2009 at the Cukurova University Faculty of Medicine, Adana, Turkey, were evaluated retrospectively. The patients' age, gender, symptoms, laboratory findings, diagnostic procedures, stage of disease, pathology, flap viability, length of hospitalization, post-operative ability to swallow, post-operative morbidity, mortality and recurrence were evaluated. The patients were followed up for 11 to 36 months. Results. Although the free jejunal flap technique is a time-consuming and multi-step procedure, all of the free jejunal flaps survived. All of the patients exhibited good post-operative swallowing ability. One patient developed a salivary fistula. There was only one death, resulting from sepsis caused by late diagnosis of displacement of the jejunostomy tube. Conclusions. All the patients regained their capacity to swallow, which improved their quality of life. The free jejunal flap procedure offers rapid rehabilitation and improved quality of life. The study involved only a limited number of patients, but confirmed that with the cooperation of the surgical teams, free jejunal flaps can be used successfully on suitable patients requiring laryngopharyngectomy with cervical esophagectomy. © Copyright by Wroclaw Medical University.
- Published
- 2011
9. A rare complication of abdominal aortic reconstructive surgery: Sigmoidal necrotic mucosal prolapse. First presentation in the literature
- Author
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Parsak C.K., Poyrazoglu H., Yalav O., Sakman G., Doran F., and Çukurova Üniversitesi
- Subjects
Intestinal ischemia ,Postoperative complications ,Necrotic mucosal prolapse ,Aortic graft surgery - Abstract
The complications of aortic graft surgery include graft occlusion, hemorrhage, infection, pseudo aneurysm formation, aortaenteric fistula, and intestinal ischemia. We reported a rare complication of aorta bifemoral graft that caused sigmoidal mucosal ischemia. A 56-year-old man had been performed aorta bifemoral graft surgery for bilateral total iliac artery occlusion. The patient suffered from nonspecific abdominal complaints, constipation and necrotic mucosal prolapse. In physical examination, abdomen was normal but there was an approximately 20-25 cm length of necrotic mucosal tissue protruded from anal region. Colonoscopy revealed extremely narrowing of the middle of sigmoid colon and proximal rectum, their fragile and hyperemic mucosa and ulcers. Total parenteral nutrition was given within the first week after the hospitalization. The necrotic tissue was excised under local anesthesis. The patient was administered medical treatment for 20 days. No pathological finding was established in the physical examination of abdomen during the hospitalization period. Clinical, radiological, and endoscopic examinations were normal after 12 months. In conclusion; in the postoperative course of aortic graft surgery, the patients should be monitored carefully due to the probability of intestinal ischemia. Therefore, sigmoidal mucosal ischemia should be considered when necrotic mucosal prolapse and spillages were seen from anal canal after aorta-bifemoral grafting.
- Published
- 2010
10. Evaluating the trace elements in preoperative and postoperative duration of hydatid surgery
- Author
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Sakman, G., Parsak, C. K., Koltas, I. S., Gulsah Seydaoglu, Sonmez, H., Hanta, I., and Çukurova Üniversitesi
- Abstract
PubMedID: 18176676 Objective: To evaluate the preoperative and postoperative values of serum levels of zinc, magnesium, and copper in patients with cystic echinococcosis (CE). Methods: This study was conducted on patients with CE between 2000-2005 at the Faculty of Medicine, University of Cukurova, Adana, Turkey. Serum levels of zinc, copper, and magnesium of 85 patients with CE were measured both before and one year after the operation. Patients with liver CE (85 patients, 48 males) and healthy adults (40 adults, 17 males) as the control group were enrolled in the study. Results: When compared with the control group, the mean serum levels of zinc and magnesium were lower and the mean serum level of copper was higher in the preoperative period. It was found that as duration of symptoms increased, serum zinc and magnesium levels decreased and copper levels increased. The serum levels of these elements in postoperative and control patients after one year compared equally with the levels in the initial control. Conclusion: The probability of increased consumption of zinc and magnesium and secretion of copper by the parasite may lead to evaluating the follow up of hydatid surgery in addition to radiological and serological methods.
- Published
- 2008
11. Hydatid disease involvement of primary subcutaneous tissue in the posterior proximal thigh - An unusual localization [1]
- Author
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Parsak C.K., Eray I.C., Sakman G., Eray S.I., Gumurdurlu D., Akcam T., and Çukurova Üniversitesi
- Abstract
PubMedID: 18377614 [No abstract available]
- Published
- 2008
12. Pelvi-perineal myolipoma
- Author
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Sakman G., Parsak C.K., Akcam T., Alabaz O., and Çukurova Üniversitesi
- Abstract
[No abstract available]
- Published
- 2007
13. Surprise cytologic diagnosis of an abdominal subcutaneous nodule: Malignant mesothelioma
- Author
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Uguz, A., Ersoz, C., Cevlik, F., Sakman, G., Zeren, H., Zorludemir, S., and Çukurova Üniversitesi
- Abstract
WOS: 000245174600254 …
- Published
- 2007
14. Memenin fillodes tümöründe cerrahi tedavi
- Author
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Sakman G. and Çukurova Üniversitesi
- Abstract
[No abstract available]
- Published
- 2006
15. Occult cystobiliary communication presenting as postoperative biliary leakage after hydatid liver surgery: Are there significant preoperative clinical predictors?
- Author
-
Demircan, O., Baymus, M., Gulsah Seydaoglu, Akinoglu, A., Sakman, G., and Çukurova Üniversitesi
- Subjects
Adult ,Male ,Echinococcosis, Hepatic ,Biliary Fistula ,Prognosis ,Postoperative Complications ,Risk Factors ,parasitic diseases ,Bile ,Humans ,Original Article ,Female ,Follow-Up Studies ,Retrospective Studies - Abstract
PubMedID: 16749978 Background: Occult cystobiliary communication (CBC) presents with biliary leakage, if the cystobiliary opening cannot be detected and repaired at operation. We investigated the clinical signs associated with the risk of occult CBC in the preoperative period by studying patients who developed biliary leakage after hydatid liver surgery. Methods: We analyzed the records of 191 patients treated for hydatid liver cyst. Postoperative biliary leakage developed in 41 patients (21.5%). Independent predictive factors were established by logistic regression analysis using clinical parameters, whose cutoff values were determined by receiver operating characteristic (ROC) curves. Results: Postoperative biliary leakage presented as external biliary fistula in 31 (75.6%) of 41 patients, as biliary peritonitis in 6 (14.6%) and as cyst cavity biliary abscess in 4 (9.8%). Independent clinical predictors of occult CBC, represented by biliary leakage, were alkaline phosphatase > 250 U/L, total bilirubin > 17.1 µmol/L, direct bilirubin > 6.8 µmol/L, ?-glutamyl transferase > 34.5 U/L, eosinophils > 0.09 and cyst diameter > 8.5 cm. Multilocular or degenerate cysts increased the risk of biliary leakage (p = 0.012). Postoperative complication rates were 53.7% in the patients with biliary leakage, and 10.0% (p < 0.001) in those without. The mean postoperative hospital stay was longer in patients with biliary leakage (14.3 [and standard deviation (SD) 1.9] d) than in those without (7.3 [SD 2.3] d) (p < 0.001). Nineteen (61.3%) of 31 biliary fistulae closed spontaneously within 10 days. The remaining 12 (38.7%) fistulae closed within 7 days after endoscopic sphincterotomy. Conclusion: Factors that predict occult CBC due to hydatid liver cyst were identified. These factors should allow the likelihood of CBC to be determined and, thus, indicate the need for additional procedures during operation to prevent the complications of biliary leakage. © 2006 CMA Media Inc.
- Published
- 2006
16. Surgical treatment of patients with phylloides tumor of the breast [Memenin fillodes tümöründe cerrahi tedavi]
- Author
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Sakman G., Parsak C.K., Aslan A., Akinoglu A., and Çukurova Üniversitesi
- Subjects
Fibroepithelial tumors ,Breast ,Phyllodes tumor - Abstract
Purpose: We aim to evaluate the diagnostic diffuculties and the surgical options and results for the phyllodes tumors, which are infrequent pathologies of breast tumors. Background: The most recognised clinical problems seen in phyllodes tumors are preoperatively differential diagnosis and postoperatively frequent local recurrences. The recommended management option is resection of tumor within at least 2 cm of surgical margin. Recurrence rate is reported as 15-25% in various studies. Materials and Methods: We evaluate the surgical procedures and results of 10 patients with phyllodes tumor retrospectively who admitted to General Surgery Department, School of Medicine, Cukurova University between 1997-2003. Physical examination, breast ultrasonography and mammography were used for preoperative diagnosis. Fine needle aspiration biopsy (FNA), incisional biopsy (IB), and frozen section were used for histopathological diagnosis. Four different surgical procedures were preferred for surgical treatment: 1) Wide mass excision with 2 cm of surgical margin, 2) Simple mastectomy, 3) Simple mastectomy with palpitated lymph node biopsy and 4) Modified radical mastectomy (MRM). Phyllodes tumors should be taken in account in patients with breast mass and with possible diagnosis of fibroadenoma. Differential diagnosis of phyllodes tumor is really upmost importance as the surgical management performed in one seans. Preoperative FNA and core biopsy performed routinely may have an important role as the clinical experience increase. Local recurrence is an important clinical problem in phyllodes tumors. Conclusion: Clinical and radiological evaluations are usually insufficient in the differential diagnosis of fibroadenoma and phyllodes tumours. Evaluation of lesions with frozen section in patients with phyllodes tumours may reduce the possibility of recurrent surgical procedures. Clinically palpitated axillar lymph nodes in patients with phyllodes tumors may not be important pathologically. Local recurrence of borderline phyllodes tumors underwent simple mastectomy for maintaining the proposed surgical margin may point out that prognostic criteria might be multi factorial.
- Published
- 2005
17. Fine needle aspiration cytology of amyloid goitre associated with familial mediterranean fever
- Author
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Ersöz C., Uguz A., Erkoçak E., Sakman G., Demircan O., and Çukurova Üniversitesi
- Subjects
Amyloid ,FMF ,Goitre ,Fine needle aspiration - Abstract
Background: Amyloidosis occasionally complicates the course of Familial Mediterranean Fever (FMF). Amyloid deposition may occur in various organs, but goitre secondary to amyloid deposition is rarely seen in FMF. Method: We report the case of a 29-year-old male with amyloid goitre (AG) secondary to FMF. Fine needle aspiration cytology (FNAC) enabled correct diagnosis of AG prior to surgery. Results: Cytologic slides revealed abundant amorphus material with the staining characteristics of amyloid. Histopathological findings in the thyroidectomy specimen confirmed the FNAC. A parathyroid gland was also infiltrated with amyloid. Conclusions: The diagnosis of AG should always be suspected in patients with FMF when they present with an enlarged thyroid and FNAC should be the first pre-operative diagnostic tool. Besides, other conditions in which amyloid deposition occur-especially medullary carcinoma of the thyroid-should always be kept in mind in the differantial diagnosis.
- Published
- 2004
18. Surgery in Fasciola hepatica Pancreatitis: Report of a Case and Review of Literature
- Author
-
Parsak, C, primary, Koltas, I, additional, Sakman, G, additional, Erkocak, E, additional, and Inal, M, additional
- Published
- 2007
- Full Text
- View/download PDF
19. Alveolar Hydatid Disease: Imaging Findings and Surgical Approach
- Author
-
Parsak, C. K., primary, Demiryurek, H. H., additional, Inal, M., additional, Sakman, G., additional, Koltas, I. S., additional, Erkocak, E. U., additional, Korkmaz*, M., additional, and Acarturk, T. O., additional
- Published
- 2007
- Full Text
- View/download PDF
20. A Rare Complication in Breast Cancer Surgery: Chylous Fistula and its Treatment
- Author
-
Sakman, G., primary, Parsak, C. K., additional, and Demircan, O., additional
- Published
- 2007
- Full Text
- View/download PDF
21. The Effectiveness of Nitric Oxide Derivates in Hydatid Disease.
- Author
-
Parsak, C.K., Hanta, I., Koltas, I.S., Sakman, G., Akcam, T., Kuleci, S., and Alabaz, O.
- Abstract
The purpose of this study was to assess the possible alterations of the levels of plasma NO derivates which are thought to reflect the immune status of the body against cystic echinococcus (CE). Materials and Methods: Plasma NO
2 and NO3 levels of 95 patients with CE were analyzed before treatment and then after a 1 year. All patients were classified according to the WHOIWGE classification of cystic hydatid disease. The levels of NO2 and NO3 were detected from sera by using a photometric endpoint determination on the basis of absorbance in the visible range at 550 nm. Results: Pretreatment levels of plasma NO2 and NO3 of the CE group were significantly higher than those in the control group (p < 0.001). However, the posttreatment NO2 and NO3 levels of the CE group were significantly lower than the pretreatment levels (p < 0.001). Hence, a positive correlation was found between fertile capacity of CE and the levels of NO2 and NO3 (p < 0.05). Conclusion: The analysis of the levels of plasma NO derivates should be considered for the at preoperative detection of hydatid disease and postoperative follow-up in addition to radiological and serological methods. [ABSTRACT FROM AUTHOR]- Published
- 2007
- Full Text
- View/download PDF
22. Comparing the Drain Materials: What Happens due to Them?
- Author
-
Parsak, C., Sire, A., Sakman, G., Akcam, T., Satar, S., Seydaoglu, G., and Sonmez, H.
- Abstract
Our aim was to compare drain materials with respect to their peritoneal reactions, abdominal infections, wound infections and omental covering. Materials and Methods: Pieces of silicon, plastic, caoutchouc and latex drains were placed in the abdominal cavity of rats. Laparotomies at intervals of 0, 2, and 5 days were performed in each group of animals. Drain infection, wound infection, reactional periteoneal fluid occurrence and omental covering of drain were noted. Results: Similar bacteria species were established in drain and wound cultures. While drain infections were observed mostly in the caoutchouc group on the 2nd day, drain infection was established in each group on the 5th day. Reactional fluid occurrence was observed most frequently in the latex group. The caoutchouc group exhibited the highest degree of omental covering. Conclusion: The placement of unnecessary drains should be avoided. Drains must be removed as early as possible. In surgery, silicon drains should be preferred because of their low complication, obstruction and foreign body reaction rates. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
23. Occult cystobiliary communication presenting as postoperative biliary leakage after hydatid liver surgery: are there significant preoperative clinical predictors?
- Author
-
Demircan O, Baymus M, Seydaoglu G, Akinoglu A, and Sakman G
- Abstract
BACKGROUND: Occult cystobiliary communication (CBC) presents with biliary leakage, if the cystobiliary opening cannot be detected and repaired at operation. We investigated the clinical signs associated with the risk of occult CBC in the preoperative period by studying patients who developed biliary leakage after hydatid liver surgery. METHODS: We analyzed the records of 191 patients treated for hydatid liver cyst. Postoperative biliary leakage developed in 41 patients (21.5%). Independent predictive factors were established by logistic regression analysis using clinical parameters, whose cutoff values were determined by receiver operating characteristic (ROC) curves. RESULTS: Postoperative biliary leakage presented as external biliary fistula in 31 (75.6%) of 41 patients, as biliary peritonitis in 6 (14.6%) and as cyst cavity biliary abscess in 4 (9.8%). Independent clinical predictors of occult CBC, represented by biliary leakage, were alkaline phosphatase > 250 U/L, total bilirubin > 17.1 micromol/L, direct bilirubin > 6.8 micromol/L, gamma-glutamyl transferase > 34.5 U/L, eosinophils > 0.09 and cyst diameter > 8.5 cm. Multilocular or degenerate cysts increased the risk of biliary leakage (p = 0.012). Postoperative complication rates were 53.7% in the patients with biliary leakage, and 10.0% (p < 0.001) in those without. The mean postoperative hospital stay was longer in patients with biliary leakage (14.3 [and standard deviation {SD} 1.9] d) than in those without (7.3 [SD 2.3] d) (p < 0.001). Nineteen (61.3%) of 31 biliary fistulae closed spontaneously within 10 days. The remaining 12 (38.7%) fistulae closed within 7 days after endoscopic sphincterotomy. CONCLUSION: Factors that predict occult CBC due to hydatid liver cyst were identified. These factors should allow the likelihood of CBC to be determined and, thus, indicate the need for additional procedures during operation to prevent the complications of biliary leakage. [ABSTRACT FROM AUTHOR]
- Published
- 2006
24. GASTROÖZEFAGEAL REFLÜ HASTALIĞINDA LAPAROSKOPİK NİSSEN FUNDOPLİKASYONUNUN ETKİNLİĞİ.
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PARSAK, C. K., SAKMAN, G., AKÇAM, T., SATAR, S., EZİCİ, H., and SÖNMEZ, H.
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- 2007
25. AKUT APANDİSİT TANI VE TEDAVİSİNDE LAPAROSKOPİNİN YERİ.
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PARSAK, C. K., SAKMAN, G., ERAY, C. İ., ELKAN, H., SEBE, A., and SATAR, S.
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- 2007
26. Intestinal Behcet’s Disease with Perianal Abscess and Necrosis: A Case Report.
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Parsak, C.K., Sakman, G., Ozer, H.T., and Alabaz, O.
- Abstract
Behçet’s disease (BD) is an inflammatory multisystem disorder, characterized by recurrent oral and genital ulcers, erythema nodosum-like lesions, papulopustular lesions, uveitis, large vessel thrombosis as well as neurologic and gastrointestinal manifestations. Case Report: A 55-year-old man with BD was admitted to the emergency room with perianal abscess and necrosis. One day after abscess drainage and débridement the patient developed peritonitis, and sepsis ensued. Histopathologic examination of the skin overlaying the débridement area revealed vasculitis and fibrinoid necrosis. Emergency laporatomy revealed multiple ‘punchedout’ perforations with 0.5-1 cm in diameter over the whole small intestine concentrating in the terminal ileum. Débridement - primary repair and partial ileal resection - of ileostomy was done. The patient died due to sepsis and multiple organ failure on the first postoperative day. Histopathologic examination revealed nonspecific inflammatory cell infiltrates surrounding capillaries and venules, especially in the submucosa and serosa (vasculitis) with no evidence of granulomatous inflammation. Conclusion: Anal abscess or necrosis in a patients with BD may be a clue to the presence of intestinal BD with imminent perforation, representing the widespread vasculitis of the gut in BD. [ABSTRACT FROM AUTHOR]
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- 2007
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27. Serum malondialdehyde level in patients with cystic echinococcosis
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Koltas, I. S., Yucebilgic, G., Ramazan Bilgin, Parsak, C. K., Sakman, G., and Çukurova Üniversitesi
- Abstract
PubMedID: 17106545 Objective: To investigate the changes of serum malondialdehyde (MDA) level for the oxidative stress hypothesis in patients with cystic echinococcosis (CE). Methods: The study was conducted on patients with CE before the surgical treatment. Anti-Echinococcus granulosus antibodies were determined by serological method. We assayed MDA activities measured of 57 subjects and matched in 45 healthy control. This study took place in the Faculty of Medicine, University of Cukurova, Balcali Hospital in Adana, Turkey, between March 2004 and October 2005. Results: The mean ± SD of MDA levels of patients with CE was 6.70 ± 1.66 and healthy controls was 2.53 ± 0.43. The difference between MDA levels of patients and controls was statistically significant (p
28. Cystic echinococcosis in Turkey from 2001-2005,Türkiye'de 2001-2005 Yillari Arasinda Kistik Ekinokokkozis
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Yazar, S., Ozkan, A. T., Hökelek, M., Polat, E., Yilmaz, H., Ozbilge, H., Ustün, S., Koltaş, I. S., Ertek, M., NERMİN SAKRU, Alver, O., Cetinkaya, Z., Koç, Z., Demirci, M., Aktaş, H., Parsak, C. K., Ozerdem, D., Sakman, G., Cengiz, Z. T., Ozer, A., Keklik, K., Yemenici, N., Turan, M., Daştan, A., Kaya, E., Tamer, G. S., Girginkardeşler, N., Türk, M., Sinirtaş, M., Evci, C., Kiliçturgay, S., Mutlu, F., and Artiş, T.
29. Candida peritonitis unrelated with continuous ambulatory peritonea dialysis (CAPD) in adult patients in a Turkey hospital
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Kurtaran, B., Kibar, F., Ulu, A., AYSE SEZA INAL, Komur, S., Sakman, G., Aksu, H. S. Z., and Tasova, Y.
30. Ruptured hydatid cyst following minimal trauma and few signs on presentation
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Gulalp, B., Koseoglu, Z., Toprak, N., Satar, S., Sebe, A., Gokel, Y., Sakman, G., and Ozgur Karcioglu
31. Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options
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Orhan Agcaoglu, Sam Van Slycke, Sibel Özkan Gürdal, Ali Ugur Emre, Atakan Sezer, Marcin Barczyński, Fusun Saygili, Marco Raffaelli, Giannis Koutelidakis, Banu Ozturk Ceyhan, Murat Faik Erdogan, Orhan Demircan, Mehmet Celik, Yusuf Bukey, Yong Sang Lee, Fatih Tunca, Seok Mo Kim, Oğuzhan Deyneli, Ibrahim Sahin, Ali İlker Filiz, Abut Kebudi, Mehmet Haciyanli, Yeşim Erbil, Martin Almquist, Menno R. Vriens, Tevfik Sabuncu, Meral Mert, Mehmet Uludag, Taner Bayraktaroglu, Serdar Özbaş, Dilek Yazici, Yusuf Alper Sonmez, Zeynep Cantürk, Kyriakos Vamvakidis, Guldeniz Karadeniz Cakmak, Gianlorenzo Dionigi, Baris Akinci, Thomas Clerici, Eren Berber, Tarik Terzioglu, Gunay Gurleyik, Hulya Iliksu Gozu, Gurhan Sakman, Ozlem Celik, P. Riss, Ilya Sleptsov, Rumen Pandev, Özer Makay, David Scott Coombes, Jesus Villar-Del-Moral, Nuh Zafer Cantürk, Radu Mihai, Sergii Cherenko, Yasemin Giles Şenyürek, Mustafa Umit Ugurlu, Fahri Bayram, Guzide Gonca Oruk, Faruk Alagol, Sibel Guldiken, Serdar Tezelman, Quan-Yang Duh, Fausto Palazzo, Serkan Teksoz, Bekir Kuru, Agcaoglu, Orhan, Sezer, Atakan, Makay, Ozer, Erdogan, Murat Faik, Bayram, Fahri, Guldiken, Sibel, Raffaelli, Marco, Sonmez, Yusuf Alper, Lee, Yong-Sang, Vamvakidis, Kyriakos, Mihai, Radu, Duh, Quan-Yang, Akinci, Baris, Alagol, Faruk, Almquist, Martin, Barczynski, Marcin, Bayraktaroglu, Taner, Berber, Eren, Bukey, Yusuf, Cakmak, Guldeniz Karadeniz, Canturk, Nuh Zafer, Canturk, Zeynep, Celik, Mehmet, Celik, Ozlem, Ceyhan, Banu Ozturk, Cherenko, Sergii, Clerici, Thomas, Coombes, David Scott, Demircan, Orhan, Deyneli, Oguzhan, Dionigi, Gianlorenzo, Emre, Ali Ugur, Erbil, Yesim, Filiz, Ali Ilker, Gozu, Hulya Iliksu, Gurdal, Sibel Ozkan, Gurleyik, Gunay, Haciyanli, Mehmet, Kebudi, Abut, Kim, Seokmo, Koutelidakis, Giannis, Kuru, Bekir, Mert, Meral, Oruk, Guzide Gonca, Ozbas, Serdar, Palazzo, Fausto, Pandev, Rumen, Riss, Phillip, Sabuncu, Tevfik, Sahin, Ibrahim, Sakman, Gurhan, Saygili, Fusun, Senyurek, Yasemin Giles, Sleptsov, Ilya, Van Slycke, Sam, Teksoz, Serkan, Terzioglu, Tarik, Tezelman, Serdar, Tunca, Fatih, Ugurlu, Mustafa Umit, Uludag, Mehmet, Villar-del-Moral, Jesus, Vriens, Menno, Yazici, Dilek, Ağcaoğlu, Orhan (ORCID 0000-0003-1617-3953 & YÖK ID175476), Alagöl, Faruk, Deyneli, Oğuzhan (ORCID 0000-0001-6582-7031 & YÖK ID 171914), Yazıcı, Dilek, Sezer, A., Makay, O., Erdoğan, M. F., Bayram, F., Güldiken, S., Raffaelli, M., Sönmez, Y. A., Lee, Y.-S., Vamvakidis, K., Mihai, R., Duh, Q.-Y., Akıncı, B., Almquist, M., Barczynski, M., Bayraktaroğlu, T., Berber, E., Bukey, Y., Çakmak, G. K., Cantürk, N. Z., Cantürk, Z., Çelik, M., Çelik O., Ceyhan, B. O., Cherenko, S., Clerici, T., Coombes, D. S., Demircan, O., Dionigi, G., Emre, A. U., Erbil, Y., Filiz, A. I., Gozu, H. I., Gürdal, S. O., Gürleyik, G., Hacıyanlı, M., Kebudi, A., Kim, S., Koutelidakis, G., Kuru, B., Mert, M., Oruk, G. G., Özbaş, S., Palazzo, F., Pandev, R., Riss, P., Sabuncu, T., Şahin, I., Sakman, G., Saygılı, F., Şenyürek, Y. G., Sleptsov, I., Van Slycke, S., Teksöz, S., Terzioğlu, T., Tunca, F., Uğurlu, M. U., Uludağ, M., Villar-del-Moral, J., Vriens, M., School of Medicine, and Acibadem University Dspace
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Qualtrics ,medicine.medical_specialty ,Cinacalcet ,Consensus ,Settore MED/18 - CHIRURGIA GENERALE ,education ,Delphi method ,Disease ,030230 surgery ,03 medical and health sciences ,0302 clinical medicine ,Pandemic ,Health care ,medicine ,Humans ,Intensive care medicine ,Survey ,Endocrine disease ,Expert Testimony ,Pandemics ,business.industry ,SARS-CoV-2 ,COVID-19 ,Guideline ,medicine.disease ,Surgery ,Expert opinion ,030220 oncology & carcinogenesis ,Original Article ,business ,Primary hyperparathyroidism ,medicine.drug - Abstract
Purpose: the COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic. Methods: we used Delphi method with a nine-scale Likert scale on two rounds of voting involving 64 experienced eminent surgeons and endocrinologists who had the necessary experience to provide insight on endocrine disorder management. All voting was done by email using a standard questionnaire. Results: overall, 37 recommendations were voted on. In two rounds, all recommendations reached an agreement and were either endorsed or rejected. Endorsed statements include dietary change in primary hyperparathyroidism, Cinacalcet treatment in secondary hyperparathyroidism, alpha-blocker administration for pheochromocytoma, methimazole ± β-blocker combination for Graves’ disease, and follow-up for fine-needle aspiration results of thyroid nodules indicated as Bethesda 3–4 cytological results and papillary microcarcinoma. Conclusion: this survey summarizes expert opinion for the management of endocrine surgical conditions during unprecedented times when access to surgical treatment is severely disrupted. The statements are not applicable in circumstances in which surgical treatment is possible., NA
- Published
- 2021
32. ASO Visual Abstract: Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in the NEOSENTITURK-trials MF18-02/18-03.
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Cabioglu N, Karanlik H, Igci A, Muslumanoglu M, Gulcelik MA, Uras C, Kocer HB, Trabulus DC, Ozkurt E, Cakmak GK, Tukenmez M, Bademler S, Yildirim N, Akgul GG, Sen E, Senol K, Emiroglu S, Citgez B, Ersoy YE, Dag A, Zengel B, Basaran G, Kara H, Dilege E, Ugurlu MU, Celik A, Ilgun S, Bolukbasi Y, Karaman N, Sakman G, Ozbas S, Kilic HG, Polat AK, Ozemir IA, Kilic B, Altınok A, Varol E, Dogan L, Akcan A, Ozcinar B, Zer L, Soyder A, Velidedeoglu M, Erozgen F, Goktepe B, Dogan M, Kebudi A, Yigit B, Celik B, Yormaz S, Arici C, Agcaoglu O, Sevinc AI, Atahan MK, Valiyeva V, Baran E, Aljorani I, Utkan Z, Yeniay L, Kivilcim T, Soran A, Aydiner A, Ibis K, and Ozmen V
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- 2025
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33. Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the NEOSENTITURK-Trials MF18-02/18-03.
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Cabioglu N, Karanlik H, Igci A, Muslumanoglu M, Gulcelik MA, Uras C, Kocer HB, Trabulus DC, Ozkurt E, Cakmak GK, Tukenmez M, Bademler S, Yildirim N, Akgul GG, Sen E, Senol K, Emiroglu S, Citgez B, Ersoy YE, Dag A, Zengel B, Basaran G, Kara H, Dilege E, Ugurlu MU, Celik A, Ilgun S, Bolukbasi Y, Karaman N, Sakman G, Ozbas S, Kilic HG, Polat AK, Ozemir IA, Kilic B, Altınok A, Varol E, Dogan L, Akcan A, Ozcinar B, Zer L, Soyder A, Velidedeoglu M, Erozgen F, Goktepe B, Dogan M, Kebudi A, Yigit B, Celik B, Yormaz S, Arici C, Agcaoglu O, Sevinc AI, Atahan MK, Valiyeva V, Baran E, Aljorani I, Utkan Z, Yeniay L, Kivilcim T, Soran A, Aydiner A, Ibis K, and Ozmen V
- Subjects
- Adult, Aged, Female, Humans, Middle Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Axilla pathology, Follow-Up Studies, Lymphatic Metastasis, Neoplasm Staging, Prognosis, Prospective Studies, Receptor, ErbB-2 metabolism, Retrospective Studies, Sentinel Lymph Node pathology, Sentinel Lymph Node surgery, Survival Rate, Breast Neoplasms pathology, Breast Neoplasms drug therapy, Breast Neoplasms surgery, Neoadjuvant Therapy, Neoplasm Recurrence, Local pathology, Sentinel Lymph Node Biopsy
- Abstract
Background: This study aims to identify factors predicting recurrence and unfavorable prognosis in cN+ patients who have undergone sentinel lymph node biopsy (SLNB) following neoadjuvant chemotherapy (NAC)., Methods: The retrospective multi-centre "MF18-02" and the prospective multi-centre cohort registry trial "MF18-03" (NCT04250129) included patients with cT1-4N1-3M0 with SLNB+/- axillary lymph node dissection (ALND) post-NAC., Results: A total of 2407 cN+ patients, who later achieved cN0 status after NAC and subsequently underwent SLNB, were studied. The majority had cT1-2 (79.1%) and N1 (80.7%). After a median follow-up time of 41 months, the rates of locoregional recurrence and axillary recurrence (AR) were 1.83% and 0.37%, respectively. No significant difference in locoregional recurrence or AR rates was observed between the SLNB/targeted axillary dissection-only (n = 1470) and ALND (n = 937) groups. Factors significantly linked with AR included age younger than 45 years, nonpathological complete response (non-pCR) in the breast, and nonluminal pathology. Locoregional recurrences were associated with nonluminal or HER2(+) pathology, non-pCR in the breast, and ALND. Poor prognostic factors for disease-free survival (DFS) included having cT3-T4, no breast pCR (non-pCR), ypN(+), and nonluminal pathology. No significant difference was found in DFS or disease-specific survival (DSS) rates among ypN0, ypN-isolated tumour cells, ypNmic, and ypN1. However, significant decreases in DFS and DSS rates were observed when comparing ypN2 or ypN3 disease with ypN0., Conclusions: The present large registry data indicate that younger patients (<45), those with nonluminal pathology, and those who only partially respond in the breast are more susceptible to axillary and locoregional recurrences., Competing Interests: Disclosures: The authors declare that they have no conflict of interest., (© 2024. Society of Surgical Oncology.)
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- 2025
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34. De-Escalation of Nodal Surgery in Clinically Node-Positive Breast Cancer.
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Cabioglu N, Koçer HB, Karanlik H, Gülçelik MA, Igci A, Müslümanoglu M, Uras C, Mantoglu B, Trabulus DC, Akgül G, Tükenmez M, Senol K, Özkurt E, Sen E, Karadeniz Çakmak G, Bademler S, Emiroglu S, Yildirim N, Kara H, Dag A, Dilege E, Altinok A, Basaran G, Varol E, Ugurlu Ü, Bölükbasi Y, Ersoy YE, Zengel B, Karaman N, Özbas S, Zer L, Gül Kiliç H, Agcaoglu O, Sakman G, Utkan Z, Soyder A, Akcan A, Ergün S, Yilmaz R, Aydiner A, Soran A, Ibis K, and Özmen V
- Abstract
Importance: Increasing evidence supports the oncologic safety of de-escalating axillary surgery for patients with breast cancer after neoadjuvant chemotherapy (NAC)., Objective: To evaluate the oncologic outcomes of de-escalating axillary surgery among patients with clinically node (cN)-positive breast cancer and patients whose disease became cN negative after NAC (ycN negative)., Design, Setting, and Participants: In the NEOSENTITURK MF-1803 prospective cohort registry trial, patients from 37 centers with cT1-4N1-3M0 disease treated with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) alone or with ypN-negative or ypN-positive disease after NAC were recruited between February 15, 2019, and January 1, 2023, and evaluated., Exposure: Treatment with SLNB or TAD after NAC., Main Outcomes and Measures: The primary aim of the study was axillary, locoregional, or distant recurrence rates; disease-free survival; and disease-specific survival. Number of axillary lymph nodes removed was also evaluated., Results: A total of 976 patients (median age, 46 years [range, 21-80 years]) with cT1-4N1-3M0 disease underwent SLNB (n = 620) or TAD alone (n = 356). Most of the cohort had a mapping procedure with blue dye alone (645 [66.1%]) with (n = 177) or without (n = 468) TAD. Overall, no difference was found between patients treated with TAD and patients treated with SLNB in the median number of total lymph nodes removed (TAD, 4 [3-6] vs SLNB, 4 [3-6]; P = .09). Among patients with ypN-positive disease, those who underwent TAD were more likely to have a lower median lymph node ratio (TAD, 0.28 [IQR, 0.20-0.40] vs SLNB, 0.33 [IQR, 0.20-0.50]; P = .03). At a median follow-up of 39 months (IQR, 29-48 months), no significant difference was found in the rates of ipsilateral axillary recurrence (0.3% [1 of 356] vs 0.3% [2 of 620]; P ≥ .99) or locoregional recurrence (0.6% [2 of 356] vs 1.1% [7 of 620]; P = .50) between the TAD and SLNB groups, with an overall locoregional recurrence rate of 0.9% (9 of 976). The initial clinical tumor stage, pathologic complete response, and use of blue dye alone as a mapping procedure were not associated with the outcome. Even though patients with TAD demonstrated an increased disease-free survival rate compared with the SLNB group, this difference did not reach statistical significance (94.9% vs 92.6%; P = .07). Factors associated with decreased 5-year disease-specific survival were cN2-3 axillary stage (cN1, 98.7% vs cN2-3, 96.8%; P = .03) and nonluminal type tumor pathologic characteristics (luminal, 98.9% vs nonluminal, 96.9%; P = .007)., Conclusions and Relevance: The short-term results suggest very low rates of axillary and locoregional recurrence in a select group of patients with cN-negative disease after NAC treated with TAD alone or SLNB alone followed by regional nodal irradiation regardless of the SLNB technique or nodal pathology. Whether TAD might provide a clear survival advantage compared with SLNB remains to be proven in studies with longer follow-up.
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- 2025
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35. Combined analysis of the MF18-02/MF18-03 NEOSENTITURK studies: ypN-positive disease does not necessitate axillary lymph node dissection in patients with breast cancer with a good response to neoadjuvant chemotherapy as long as radiotherapy is provided.
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Muslumanoglu M, Cabioglu N, Igci A, Karanlık H, Kocer HB, Senol K, Mantoglu B, Tukenmez M, Çakmak GK, Ozkurt E, Gulcelik MA, Emiroglu S, Mollavelioglu B, Yildirim N, Bademler S, Zengel B, Trabulus DC, Ugurlu MU, Uras C, Ilgun S, Akgul GG, Akcan A, Yormaz S, Ersoy YE, Ozbas S, Dilege E, Citgez B, Bolukbasi Y, Altınok A, Dag A, Basaran G, Utkan NZ, Ozcinar B, Arici C, AlJorani I, Kara H, Yigit B, Sen E, Erozgen F, Soyder A, Celik B, Kilic HG, Zer L, Sakman G, Yeniay L, Atahan K, Varol E, Veliyeva V, Goktepe B, Velidedeoglu M, Karaman N, Soran A, Aydiner A, Yılmaz R, Ibis K, and Ozmen V
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- Humans, Female, Middle Aged, Aged, Adult, Retrospective Studies, Sentinel Lymph Node Biopsy, Prospective Studies, Lymphatic Metastasis, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Breast Neoplasms pathology, Breast Neoplasms therapy, Neoadjuvant Therapy methods, Lymph Node Excision, Axilla
- Abstract
Background: The omission of axillary lymph node dissection (ALND) remains controversial for patients with residual axillary disease after neoadjuvant chemotherapy (NAC), regardless of the residual burden. This study evaluated the oncologic safety and factors associated with outcomes in patients with residual axillary disease. These patients were treated solely with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD), without ALND, after NAC., Methods: A joint analysis of two different multicenter cohorts-the retrospective cohort registry MF18-02 and the prospective observational cohort registry MF18-03 (NCT04250129)-was conducted between January 2004 and August 2022. All patients received regional nodal irradiation., Results: Five hundred and one patients with cT1-4, N1-3M0 disease who achieved a complete clinical response to NAC underwent either SLNB alone (n = 353) or TAD alone (n = 148). At a median follow-up of 42 months, axillary and locoregional recurrence rates were 0.4% (n = 2) and 0.8% (n = 4). No significant difference was found in disease-free survival (DFS) and disease-specific survival (DSS) rates between patients undergoing TAD alone versus SLNB alone, those with breast positive versus negative pathologic complete response, SLN methodology, total metastatic LN of one versus ≥2, or metastasis types as isolated tumor cells with micrometastases versus macrometastases. In the multivariate analysis, patients with nonluminal pathology were more likely to have a worse DFS and DSS, respectively, without an increased axillary recurrence., Conclusions: The omission of ALND can be safely considered for patients who achieve a complete clinical response after NAC, even if residual disease is detected by pathologic examination. Provided that adjuvant radiotherapy is administered, neither the SLNB method nor the number of excised LNs significantly affects oncologic outcomes., (© 2024 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.)
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- 2025
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36. Papillary microcarcinoma of the thyroid gland: Evaluation of TERT and BRAFV-600E expression and their relationship with clinicopathological findings.
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Yeşiloğlu AA, Uğuz AH, Erdoğan KE, and Sakman G
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- Humans, Female, Male, Middle Aged, Adult, Aged, Lymphatic Metastasis pathology, Lymphatic Metastasis genetics, Immunohistochemistry methods, Biomarkers, Tumor metabolism, Biomarkers, Tumor genetics, Thyroid Gland pathology, Thyroid Gland metabolism, Aged, 80 and over, Thyroid Cancer, Papillary genetics, Thyroid Cancer, Papillary pathology, Thyroid Cancer, Papillary metabolism, Telomerase genetics, Telomerase metabolism, Proto-Oncogene Proteins B-raf genetics, Proto-Oncogene Proteins B-raf metabolism, Thyroid Neoplasms genetics, Thyroid Neoplasms pathology, Thyroid Neoplasms metabolism, Mutation, Carcinoma, Papillary pathology, Carcinoma, Papillary genetics, Carcinoma, Papillary metabolism
- Abstract
Papillary microcarcinomas (PMCs) are papillary carcinomas ≤1 cm in size, with an increasing incidence. Although generally indolent, some cases exhibit aggressive behavior. Recently, active surveillance has been recommended to avoid surgical treatment. Identifying molecular changes that predict aggressiveness in PMCs has gained importance, but studies are limited. We aimed to demonstrate TERT expression and BRAF V600E positivity immunohistochemically in PMCs and correlate them with histomorphological features, subtypes, and clinicopathological findings. We included 95 PMC cases diagnosed between 2010 and 2019 at the Department of Pathology, Faculty of Medicine, XXX University. We investigated TERT expression using RT-PCR. We evaluated BRAF V600E mutation immunohistochemically. We evaluated the relationship between genetic, histomorphological, and clinicopathological findings. In patients with multifocality and those with a tumor size ≥0.5 cm, the frequency of lymph node metastasis was significantly higher. A positive correlation was shown between BRAF V600E positivity and lymph node metastasis, lymphovascular invasion, advanced disease stage, and classical subtype by univariate analyses. We detected TERT expression in 18 of 95 patients (7.8 %). No relationship could be detected between TERT expression alone or combined with BRAF positivity and clinicopathological features. Although TERT mutations are associated with aggressiveness in thyroid cancers, this association was absent in PMCs. The presence of TERT expression was demonstrated in some cases. However, TERT expression could not be associated with clinicopathological findings, which is consistent with the literature suggesting that TERT plays a role in advanced stages of carcinogenesis., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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37. Correlation of TIRADS scoring in thyroid nodules with preoperative fine needle aspiration biopsy and postoperative specimen pathology.
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Atar C, Dalcı K, Aktar Y, Totik N, Topal U, Eray İC, Akçam AT, and Sakman G
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- Humans, Female, Adult, Middle Aged, Male, Retrospective Studies, Biopsy, Fine-Needle methods, Data Systems, Ultrasonography methods, Thyroid Nodule diagnostic imaging, Thyroid Nodule surgery, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms surgery
- Abstract
Introduction: The aim of our study is to determine the value of Thyroid Imaging Reporting and Data Systems (TIRADS) scoring in predicting malignancy in thyroid nodules by examining its relationship with fine needle aspiration biopsy and postoperative histopathological results., Materials and Methods: In this study, patients who underwent surgery after ultrasonographic examination and fine needle aspiration biopsy for thyroid nodules at the General Surgery Clinic of Çukurova University Faculty of Medicine between January 2014 and November 2021 were retrospectively analyzed. The thyroid ultrasonography and fine needle aspiration biopsy of the included patients were performed by a clinician with 15 years of experience. The ultrasonographic features of the nodules were re-evaluated by the same clinician, and the American College of Radiology (ACR) TIRADS score was determined. Fine needle aspiration biopsy results were grouped according to Bethesda criteria. Postoperative histopathological examination results were divided into two groups: benign and malignant. The ACR TIRADS score was compared with fine needle aspiration biopsy and histopathological results. The performance of the ACR TIRADS score in predicting malignancy was determined., Results: 79.8% of the 397 patients were female, and the mean age was 50.9 ± 12.8 years. The mean diameter of the nodules was 27.4 ± 15.8 mm. There was a significant, positive, but weak correlation between ACR TIRADS and Bethesda (p < 0.001) (r = 0.33). When the ACR TIRADS score was compared with histopathological results, it was found that the rate of malignancy increased as the TIRADS score increased (p < 0.001). The rates of malignancy diagnosis were 0% for TR1, 13.2% for TR2, 21.7% for TR3, 50.3% for TR4, and 72.4% for TR5. The area under the receiver operating characteristic curve for TIRADS in predicting malignancy was 0.747 (95% CI: 0.699-0.796, p < 0.001). TIRADS can distinguish malignancy with 75% accuracy. The optimal cutoff point was determined as TR4 with 80.3% sensitivity and 60.8% specificity., Conclusion: The ACR TIRADS scoring system is an effective risk classification system for thyroid nodules, providing 75% accuracy in predicting malignancy, with 80.3% sensitivity and 60.8% specificity values., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
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38. Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis.
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Akkoc Y, Dalci K, Karakas HE, Erbil-Bilir S, Yalav O, Sakman G, Celik F, Arikan S, Zeybek U, Ergin M, Akkiz H, Dilege E, Dengjel J, Dogan-Ekici AI, and Gozuacik D
- Subjects
- Animals, Mice, Cell Line, Tumor, Cell Movement, Fibroblasts metabolism, Interleukin-6 metabolism, Transforming Growth Factor beta metabolism, Humans, Female, Autophagy, Breast Neoplasms metabolism, Cytokines metabolism
- Abstract
Macroautophagy/autophagy is an evolutionarily conserved cellular stress response mechanism. Autophagy induction in the tumor microenvironment (stroma) has been shown to support tumor metabolism. However, cancer cell-derived secreted factors that initiate communication with surrounding cells and stimulate autophagy in the tumor microenvironment are not fully documented. We identified CTF1/CT-1 (cardiotrophin 1) as an activator of autophagy in fibroblasts and breast cancer-derived carcinoma-associated fibroblasts (CAFs). We showed that CTF1 stimulated phosphorylation and nuclear translocation of STAT3, initiating transcriptional activation of key autophagy proteins. Additionally, following CTF1 treatment, AMPK and ULK1 activation was observed. We provided evidence that autophagy was important for CTF1-dependent ACTA2/α-SMA accumulation, stress fiber formation and fibroblast activation. Moreover, promotion of breast cancer cell migration and invasion by activated fibroblasts depended on CTF1 and autophagy. Analysis of the expression levels of CTF1 in patient-derived breast cancer samples led us to establish a correlation between CTF1 expression and autophagy in the tumor stroma. In line with our in vitro data on cancer migration and invasion, higher levels of CTF1 expression in breast tumors was significantly associated with lymph node metastasis in patients. Therefore, CTF1 is an important mediator of tumor-stroma interactions, fibroblast activation and cancer metastasis, and autophagy plays a key role in all these cancer-related events. Abbreviations: ACTA2/α-SMA: actin, alpha 2, smooth muscle CAFs: cancer- or carcinoma-associated fibroblasts CNT Ab.: control antibody CNTF: ciliary neurotrophic factor CTF1: cardiotrophin 1 CTF1 Neut. Ab.: CTF1-specific neutralizing antibody GFP-LC3 MEF: GFP-fused to MAP1LC3 protein transgenic MEF LIF: leukemia inhibitory factor IL6: interleukin 6 MEFs: mouse embryonic fibroblasts MEF-WT: wild-type MEFs OSM: oncostatin M TGFB/TGFβ: transforming growth factor beta.
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- 2023
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39. Modified techniques versus Hadfield's procedure in patients with periductal mastitis.
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Dalci K, Gumus S, Saritas AG, Gul MO, Rencuzogullari A, Akcam AT, Ulku A, Ergin M, and Sakman G
- Subjects
- Adult, Female, Humans, Nipples surgery, Retrospective Studies, Mammaplasty, Mastitis surgery, Surgical Wound
- Abstract
Background: Periductal mastitis (PM) is a rare disease characterized by chronic inflammation of the terminal mammary ducts. Complete removal of terminal lactiferous ducts with Hadfield procedure is a previously defined technique in treatment but carries various complications risks. This study aims to evaluate the effectiveness of modified techniques in the treatment of PM., Methods: Twenty women who underwent surgery due to PM between January 2012 and December 2019 were retrospectively analyzed. Types of PM were determined. All patients were operated on with three different incisions [Hadfield's operation with periareolar incision (n:11), periareolar combined radial incision (n:7), and round block incision (n:2)]., Results: The mean age was 37.5 ± 6.5 years (range: 24-49). Sixty percent of patients had type 3 PM. In Hadfield's procedure, NAC retraction (n:2), seroma (n:1), and hematoma (n:1) were seen. In the periareolar incision combined radial incision group only one patient had complications (seroma) and none in the round block method. Follow-up was 12 ± 1.5 months and disease relapse occurred in two patients in the Hadfield group. Patients who underwent round block were more satisfied with the appearance of the nipple., Conclusions: In the treatment of PM, the main principle of surgical treatment is the excision of the affected canal with a clear margin. Apart from the classical Hadfield procedure, the round block method and periareolar combined radial incision techniques can be performed in the treatment of PM., (© 2022. The Author(s).)
- Published
- 2022
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40. Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options.
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Agcaoglu O, Sezer A, Makay O, Erdogan MF, Bayram F, Guldiken S, Raffaelli M, Sonmez YA, Lee YS, Vamvakidis K, Mihai R, Duh QY, Akinci B, Alagol F, Almquist M, Barczynski M, Bayraktaroglu T, Berber E, Bukey Y, Cakmak GK, Canturk NZ, Canturk Z, Celik M, Celik O, Ceyhan BO, Cherenko S, Clerici T, Coombes DS, Demircan O, Deyneli O, Dionigi G, Emre AU, Erbil Y, Filiz AI, Gozu HI, Gurdal SO, Gurleyik G, Haciyanli M, Kebudi A, Kim S, Koutelidakis G, Kuru B, Mert M, Oruk GG, Ozbas S, Palazzo F, Pandev R, Riss P, Sabuncu T, Sahin I, Sakman G, Saygili F, Senyurek YG, Sleptsov I, Van Slycke S, Teksoz S, Terzioglu T, Tezelman S, Tunca F, Ugurlu MU, Uludag M, Villar-Del-Moral J, Vriens M, and Yazici D
- Subjects
- Consensus, Humans, SARS-CoV-2, COVID-19, Pandemics
- Abstract
Purpose: The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic., Methods: We used Delphi method with a nine-scale Likert scale on two rounds of voting involving 64 experienced eminent surgeons and endocrinologists who had the necessary experience to provide insight on endocrine disorder management. All voting was done by email using a standard questionnaire., Results: Overall, 37 recommendations were voted on. In two rounds, all recommendations reached an agreement and were either endorsed or rejected. Endorsed statements include dietary change in primary hyperparathyroidism, Cinacalcet treatment in secondary hyperparathyroidism, alpha-blocker administration for pheochromocytoma, methimazole ± β-blocker combination for Graves' disease, and follow-up for fine-needle aspiration results of thyroid nodules indicated as Bethesda 3-4 cytological results and papillary microcarcinoma., Conclusion: This survey summarizes expert opinion for the management of endocrine surgical conditions during unprecedented times when access to surgical treatment is severely disrupted. The statements are not applicable in circumstances in which surgical treatment is possible., (© 2021. Italian Society of Surgery (SIC).)
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- 2022
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41. Should tall cell thyroid cancers be evaluated differently from well-differentiated thyroid cancers?
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Dalci K, Topal U, Unal AG, Sarıtas AG, Guney IB, Uguz AH, and Sakman G
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neck Dissection, Prognosis, Retrospective Studies, Young Adult, Thyroid Cancer, Papillary diagnosis, Thyroid Cancer, Papillary pathology, Thyroid Cancer, Papillary surgery, Thyroid Neoplasms diagnosis, Thyroid Neoplasms pathology, Thyroid Neoplasms surgery, Thyroidectomy methods
- Abstract
Objective: In this study, we aimed to investigate the clinical features of Papillary thyroid carcinoma(PTC) Tall cell variant(TCV), long-term outcomes and surgical experience in papillary thyroid carcinoma., Material-Method: 33 patients who were operated in our clinic between August 2012 and March 2018 and diagnosed as TCV in their pathology evaluation were included in the study. The demographic and clinical features of the patients, pathological features of the tumor and long-term results were examined., Results: A total of 33 patients were included in our study. The mean age was 55.2(18-85) years. The female sex was more dominant (75.8%). The most common presenting complaint was swelling in the neck (75.7%).Total thyroidectomy was performed in 84.8% and completion thyroidectomy after lobectomy was performed in 15.2%. Neck dissection was performed in 33% of the patients. The mean tumor diameter was 3.6 (1-10) cm. The tumor was multifocal in 36.3% of the patients. The capsule invasion rate of the tumors was present in 69.7% of the patients, extrathyroidal rate was 39.4%, Metastatic lymph nodes were detected in 30.3% of the cases. The mean follow-up duration was 39.3+22.4(5.25-78.63) months. 39.4% of patients had distant metastasis during follow-up. Disease free survival rate was 57.6%, total survival was 42.4 + 3.8 (34.7-50.0) months., Conclusion: TCV is closely associated with larger tumor diameter, multifocal location, extrathyroidal spread and lymph node involvement, We believe that more aggressive surgery should be performed in the treatment of TCV cases and it is important to follow up the patients more closely., Key Word: Esophagus cancer, Neutrophil/lymphocyte ratio, Preoperative lymphocyte /neutrophil ratio, Prognosis.
- Published
- 2021
42. Surgical Trends in Breast Cancer in Turkey: An Increase in Breast-Conserving Surgery.
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Çakmak GK, Emiroğlu S, Sezer A, Canturk NZ, Yeniay L, Kuru B, Karanlık H, Soyder A, Gökgöz Ş, Sakman G, Ucuncu M, Akcay MN, Girgin S, Gurdal SO, Emiroglu M, Ozbas S, Öz AB, Arici C, Toktas O, Demircan O, Çalık A, Polat AK, Maralcan G, Demirer S, and Ozmen V
- Subjects
- Black Sea, Female, Humans, Neoplasm Recurrence, Local, Turkey epidemiology, Breast Neoplasms epidemiology, Breast Neoplasms surgery, Mastectomy, Segmental
- Abstract
Purpose: Breast cancer is the most frequent cancer in women, and there is a great variability in surgical practice for treating that cancer in different countries. The aims of this study were to analyze the effect of guidelines from the Turkish Federation of Breast Diseases Societies on academic institutions that have breast centers and to evaluate surgical practice in Turkey in 2018., Patients and Methods: Between January and March 2019, a survey was sent to breast surgeons who were working in breast centers in academic institutions. The sampling frame included 24 academic institutions with breast centers in 18 cities in Turkey to evaluate interdisciplinary differences among breast centers and seven regions in Turkey regarding patients' choices, surgical approaches, and academic institutions., Results: All surgeons responded to the survey, and all 4,381 patients were included. Most of the surgeons (73.9%) were working in a breast center. Multidisciplinary tumor boards were performed in 87% of the breast centers. The average time between clinical evaluation and initiation of treatment was 29 days; the longest time was in Southeast Anatolia (66 days). Only 6% of patients had ductal carcinoma in situ. Sentinel lymph node biopsy was available in every region across the country and was performed in 64.5% of the patients. In 2018, the overall breast-conserving surgery rate was 57.3% in Turkey, and it varied from 72.2% in the Black Sea region to 33.5% in Central Anatolia ( P < .001). Oncoplastic breast surgery options were available at all breast centers. However, 25% of the breast centers from the Black Sea region and half the breast centers from Eastern Anatolia and the Mediterranean region did not perform this type of surgery., Conclusion: Increasing rates of nonpalpable breast cancer and decreasing rates of locoregional recurrences favored breast-conserving surgery, especially in developed countries. Guidelines from the Turkish Federation of Breast Diseases Societies resulted in more comprehensive breast centers and improved breast health in Turkey.
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- 2020
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43. Is radioguided occult lesion localization (ROLL) an effective and reliable method in thyroid cancer and parathyroid redo surgery?
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Dalcı K, Topal U, Unal AG, Eray İC, Yalav O, Guuney IB, and Sakman G
- Abstract
Objective: The aim of this study is to share the efficacy of the radionuclide occult lesion localization (ROLL) technique in secondary neck exploration in patients who had undergone neck exploration due to thyroid or parathyroid pathology and to share our clinical experience., Material and Method: Data of 25 patients who underwent secondary neck exploration for recurrent thyroid cancer and parathyroid adenoma between January 2016 and December 2018 at the General Surgery Clinic of Balcalı Hospital, Çukurova University Faculty of Medicine were collected retrospectively. On the operation day, 0.5 mCi Tc-99m macroaggregate albumin was injected into the lesion under ultrasound guidance (USG). Nerve monitoring was used in all patients., Results: Twenty-five patients (21 females, 4 males) were included in the study. The mean age of the patients was 54.5 (24-79) years. Five patients were operated for parathyroid adenoma, 6 patients for papillary cancer after subtotal thyroidectomy, 13 patients for papillary cancer recurrence, 2 patients for medullary cancer recurrence, 2 patients for papillary cancer cervical lymph node metastasis and 1 patient for anaplastic cancer recurrence.Mean operative time was 100.6 min (60-160 min). Two patients had transient hypocalcemia and no other complications were seen. Parathyroid hormone (PTH) levels in patients with hyperparathyroidism, Thyroglobulin (Tg) levels in patients with recurrent papillary cancer, were significantly lower than preoperative levels (p<0.05)., Conclusion: We believe that ROLL technique reduces the complication rate by decreasing dissection time and width. We recommend using it for thyroid cancer and parathyroid redo surgery., Key Words: Parathyroid redo surgery, Radioguided surgery, Thyroid cancer.
- Published
- 2020
44. Comparison of Diverting Colostomy and Bowel Management Catheter Applications in Fournier Gangrene Cases Requiring Fecal Diversion.
- Author
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Eray IC, Alabaz O, Akcam AT, Ulku A, Parsak CK, Sakman G, and Seydaoglu G
- Abstract
In some patients of Fournier gangrene originated from perianal region, it is important to prevent fecal contamination in order to provide healing without wound infection. For this purposes, diverting colostomy or bowel management catheter methods were performed. In this study, it is aimed to carry out a comparison of prognosis and cost efficiency between diverting colostomy and bowel management catheter methods applied for preventing fecal contamination in Fournier's gangrene patients. Fourty-eight patients with diagnosis of Fournier's gangrene, serious perianal infections, and preserved sphincters and without rectum injury after debridement were included in the study. The cases were divided into two groups as patients who were subjected to colostomy for fecal diversion and who were subjected to bowel management catheter without colostomy. Then, the groups were compared in terms of age, predisposing factors, duration of hospital stay, mortality, additional surgery requirements, and cost. Fourty-eight patients were included the study. Sixteen patients were treated without colostomy. Decreased duration of total hospital stay, additional surgery requirements, and hospital expense in bowel management catheter group has determined. It is thought that preferring bowel management catheter method instead of colostomy in patients without rectum injury, who require diverting colostomy and have undamaged anal sphincters, can relieve patients, patients' relatives, healthcare organizations, and the national economy of a serious burden. In addition, although patients' satisfaction and workforce loss factors are not taken into consideration in this study, the bowel management catheter method is thought to have positive effects also on these parameters.
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- 2015
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45. Comparison of early surgical alternatives in the management of open abdomen: a randomized controlled study.
- Author
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Rencüzoğulları A, Dalcı K, Eray İC, Yalav O, Okoh AK, Akcam T, Ülkü A, Sakman G, and Parsak CP
- Subjects
- Decompression, Surgical methods, Female, Humans, Male, Middle Aged, Negative-Pressure Wound Therapy methods, Postoperative Complications, Treatment Outcome, Abdominal Cavity surgery, Abdominal Injuries surgery, Compartment Syndromes surgery
- Abstract
Background: Abdominal compartment syndrome (ACS) is a clinical syndrome characterized by progressive intraabdominal organ dysfunction resulting from an acute increase in intra-abdominal pressure (IAP). In the absence of prompt treatment, ACS can lead to lethal organ failure. Treatment of ACS is achieved by immediate decompression of the abdominal cavity. As to how and when decompression laparotomy should be performed depends on the clinical condition of the patients. There is limited data regarding outcomes of abdominal closure techiques. The present study aimed to investigate two different temporary closure methods, the vacuum assisted closure (VAC) and Bogota bag techniques, in 40 patients who underwent decompressive laparotomy as part of the management of ACS., Methods: The study included 40 patients who developed ACS during follow-up or following trauma and abdominal surgery. As part of the treatment for ACS, these patients underwent decompressive laparotomy at the Cukurova University Medical Faculty, General Surgery Department and followed up in the Intensive Care Unit of the same hospital. VAC and Bogota bag procedures were performed as temporary closure methods for the treatment of ACS. Patients were randomly assigned to each of the two groups according to the temporary closure method performed. Clinical, laboratory, mortality and morbidity results of the patients in both groups were compared., Results: Demographic features of the patients (age, sex, body mass index, co-morbidities) were similar between the two groups. The most common reason of ACS was gastrointestinal perforation in 12 (30%) patients. Decrease in incision width was significantly faster in the VAC group than in the Bogota group. Primary closure of fascia was considered appropriate in 16.9 days in the VAC group and 20.5 days in the Bogota bag group. The decrease in abdominal pressure was similar between the two groups on days 1, 4 and 7 but appeared to be significantly lower on day 14 in the VAC group. 12 patients (30%) died during the study. Among the deceased patients, 5 (12%) were in the VAC group, whereas, 7 (17.5%) belonged to the Bogota bag group., Conclusion: Based on these results, it is suggested that VAC has advantages when compared to the Bogota bag as a temporary closure method in the management of abdominal compartment syndrome.
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- 2015
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46. Clinical characterization of unusual cystic echinococcosis in southern part of Turkey.
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Akcam AT, Ulku A, Koltas IS, Izol V, Bicer OS, Kilicbagir E, Sakman G, Poyrazoglu H, Erman T, Aridogan IA, Parsak CK, Inal M, and Iskit S
- Subjects
- Adolescent, Adult, Aged, Central Nervous System Infections complications, Central Nervous System Infections surgery, Child, Echinococcosis complications, Echinococcosis surgery, Echinococcosis, Hepatic complications, Echinococcosis, Hepatic diagnosis, Echinococcosis, Hepatic surgery, Echinococcosis, Pulmonary complications, Echinococcosis, Pulmonary diagnosis, Echinococcosis, Pulmonary surgery, Female, Humans, Kidney Diseases complications, Kidney Diseases surgery, Male, Middle Aged, Peritoneal Diseases complications, Peritoneal Diseases surgery, Retroperitoneal Space surgery, Retrospective Studies, Splenic Diseases complications, Splenic Diseases surgery, Turkey, Young Adult, Central Nervous System Infections diagnosis, Echinococcosis diagnosis, Kidney Diseases diagnosis, Peritoneal Diseases diagnosis, Splenic Diseases diagnosis
- Abstract
Background and Objectives: The incidence of primary extrahepatic cystic echinococcosis (CE) is rare. Generally, radiological and serological findings can help establish the diagnosis of hepatic and pulmonary CE, but a CE in an unusual location with atypical radiological findings may complicate the differential diagnosis. The objective of this study is to present the characteristics of cases with extrahepatic CE in respect of sites of involvement, clinical presentations, radiological findings, serological diagnostic evaluations, and outcomes of infected patients., Design and Settings: A retrospective analysis of surgically treated CE was conducted between January 1993 and January 2014 in the General Surgery, Pediatric Surgery, Urology, Cardiovascular Surgery, Neurosurgery, and Orthopedics departments of University of Cukurova, Faculty of Medicine, Balcal Hospital., Patients and Methods: Among the 661 patients managed for CE, 134 had unusual sites of involvement. Radiological and serological examinations were used to differentiate CE from alveolar echinococcosis., Results: Of 134 cases with unusual sites of involvement, 32 cases had liver CE (23.9%), 7 cases had lung CE (5.2%), and 2 cases had concomitant liver and lung CE (1.5%). In 93 (69.4%) cases, unusual organ involvement was isolated without any liver or lung involvement. The mean age was 45 years. Abdominal pain was the main symptom and was found in 104 patients. Thirty-one (23.1%) of 134 extrahepatic CE cases were evaluated as negative with indirect hemagglutination (IHA). However, positive results were obtained in 54 cases evaluated with Echinococcus granulosus IgG Western blot (WB), including 10 IHA-negative cases., Conclusion: CE with unusual localizations may cause serious problems of diagnostic confusion. The combination of clinical history, radiological findings, and serological test results (especially the WB) are valuable in diagnosing extrahepatic CE.
- Published
- 2014
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47. Expression of p53, Ki67, epidermal growth factor receptor, transforming growth-factorα, and p21 in primary and secondary hyperparathyroidism.
- Author
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Paydas S, Acikalim A, Kaya B, Bicer BH, Ulker M, Demircan O, Uguz A, Balal M, Sakman G, Sertdemir Y, Karaer R, and Altun E
- Abstract
Background: Secondary hyperparathyroidism (SH) is major problem in chronic renal failure. There are studies to examine proliferation and apoptosis associated biomarkers expressions in parathyroid lesions to reveal specific features. In this study, we evaluated the expression of some growth factors and their receptors in parathyroid gland of patients with SH or primary hyperparathyroidism (PH)., Materials and Methods: A total of 49 patients had been operated for PH and 26 for SH. Parathyroid tissue samples were evaluated histopathologically and immunohistochemically using antibodies to human p53, Kİ-67, anti-human p21, antitransforming growth factor (TGF) α, CPP32 (caspase 3), and epidermal growth factor receptor (EGFR)., Results: Adenoma was higher in PH compared with SH as 48/49 and 3/26, respectively (P = 0.000). Parathyroid hyperplasia was found in 23/26 patients with SH and 1/49 patient with PH. In parathyroid tissue there were no difference between PH and SH for p53, Ki-67, caspase, EGFR expressions; while there were significantly difference for TGFα (P = 0.047) and borderline significant difference for p21 (P = 0.06) expressions., Conclusion: Adenoma was priority present in PH patients, hyperplasia was present in SH. There were no differences between primary and SH or adenoma and hyperplasia for expressions of cycline-dependent kinase inhibitor p21, p53, EGFR, Ki67, caspase; while TGFα expression was found to be different.
- Published
- 2014
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48. Outcomes of Total Parathyroidectomy with Autotransplantation versus Subtotal Parathyroidectomy with Routine Addition of Thymectomy to both Groups: Single Center Experience of Secondary Hyperparathyroidism.
- Author
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Sakman G, Parsak CK, Balal M, Seydaoglu G, Eray IC, Sarıtaş G, and Demircan O
- Abstract
Background: Secondary hyperparathyroidism is a common acquired disorder seen in chronic renal failure. It may result in potentially serious complications including metabolic bone diseases, severe atherosclerosis and undesirable cardiovascular events. Parathyroidectomy is required in about 20% of patients after 3-10 years of dialysis and in up to 40% after 20 years., Aims: The aim of the current study was to evaluate the short-term and long-term outcomes of patients with secondary hyperparathyroidism who had undergone total parathyroidectomy with autotransplantation and thymectomy or subtotal parathyroidectomy with thymectomy by the same surgical team during the study period., Study Design: Retrospective comparative study., Methods: Clinical data of 50 patients who underwent parathyroid surgery for secondary hyperparathyroidism between 2003 and 2011 were reviewed retrospectively. Patients were divided into two subgroups of total parathyroidectomy with autotransplantation or subtotal parathyroidectomy. Thymectomy was routinely performed for both groups. Short term outcome parameters included intact parathyroid hormone, ionized calcium and alkaline phosphatase levels. Bone pain, bone fractures, persistent or recurrent disease were included in long term outcome parameters., Results: The mean duration of dialysis was eight years. The mean ionized calcium levels dropped significantly in the total parathyroidectomy with autotransplantation group (p=0.016). No serious postoperative complications were observed. Postoperative intravenous calcium supplementation was required in four patients in the total parathyroidectomy with autotransplantation group (total PTX+AT) and in three patients in the subtotal parathyroidectomy group (subtotal PTX). Postoperatively, all patients received oral calcium carbonate and calcitriol. The length of average hospital stay was 5 (3-10) days. Including nine patients who underwent successful renal transplantation pre-operative bone symptoms, hypercalcemia, hyperphosphatemia, and an increased alkaline phosphatase levels were improved or resolved in all patients. After a mean follow-up of 65 months, three patients (6%) had persistent and one (2%) had recurrent disease., Conclusion: Total parathroidectomy with autotransplantation is a beneficial and safe surgical procedure for patients on chronic dialysis with otherwise uncontrollable secondary hyperparathroidism and even in patients who have undergone renal transplantation after parathyroidectomy. Careful cervical exploration and routine thymectomy should be considered as a routine part of the surgical approach regardless of the preferred technique.
- Published
- 2014
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49. Retrorectal/Presacral epidermoid cyst: report of a case.
- Author
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Kesici U, Sakman G, and Mataraci E
- Abstract
Although epidermal cysts are frequently observed throughout the body, they are rarely found in the retrorectal/presacral regions. Retrorectal epidermal cysts are congenital lesions of ectodermal origin and generally occur in women during the reproductive period. In this case report, a 47 year old female patient with 25 years of complaint of a mass extending from the perianal region to the retro-coccygeal region is discussed. A total mass excision with paracoccygeal incision was performed under spinal anesthesia. The histopathologic examination demonstrated an epidermal cyst. Correct diagnosis and appropriate treatment when first detected significantly decrease the recurrence and complication risks in all retrorectal tumors. Any mass should be completely removed in the treatment.
- Published
- 2013
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50. Analysis of PTEN, VEGF, HER2 and P53 status in determining colorectal cancer benefit from bevacizumab therapy.
- Author
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Kara O, Duman BB, Kara B, Erdogan S, Parsak CK, and Sakman G
- Subjects
- Adult, Aged, Bevacizumab, Colorectal Neoplasms metabolism, Colorectal Neoplasms pathology, Female, Humans, Immunohistochemistry methods, Male, Middle Aged, Prognosis, Retrospective Studies, Young Adult, Angiogenesis Inhibitors pharmacology, Antibodies, Monoclonal, Humanized therapeutic use, Colorectal Neoplasms drug therapy, PTEN Phosphohydrolase metabolism, Receptor, ErbB-2 metabolism, Tumor Suppressor Protein p53 metabolism, Vascular Endothelial Growth Factor A metabolism
- Abstract
Background: No factor has thus far been identified to predict the efficacy of bevacizumab therapy for colorectal cancer. We here therefore studied PTEN, VEGF, HER2 and p53 by immunohistochemistry as possible prognostic and predictive factors., Materials and Methods: A total of 34 retrospectively collected tumor samples were evaluated, all from patients receiving bevacizumab-based regimens. VEGF-A, PTEN, HER2, p53 were assessed and data was compared with clinicopathologic characteristics of patients and the bevacizumab response rate., Results: In this study, the median age of the 34 metastatic colorectal cancer patients was 55.5 (24-75), twelve (35.3%) being women and 22 (64.7%) men. PTEN, VEGF, HER2, p53 expressions were compared with bevacizumab response and other chacteristics of disease. Statistical significant differences were not found between bevacizumab response rates and different expression levels of VEGF, PTEN, HER2 and p53 (respectively p=0.256, p=0.832, p=0.189, p=0.131). However, a survival difference was noted in the VEGF expression negative group (median OS:55 months; 95%CI, 22-88 months) (p=0.01). There was no statistically significant OS difference in other groups (PTEN p=0.6, HER2 p=0.189, p53 p=0.13)., Conclusions: We did not find any predictive factor for BV therapy in our study. VEGF negative expression could be an important prognostic factor in metastatic colorectal carcinoma.
- Published
- 2012
- Full Text
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