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16 results on '"Salas-Labadía, Consuelo"'

2. Variants in ARID5B gene are associated with the development of acute lymphoblastic leukemia in Mexican children

Author

Reyes-León, Adriana, Ramírez-Martínez, Maribel, Fernández-García, Diana, Amaro-Muñoz, David, Velázquez-Aragón, José Antonio, Salas-Labadía, Consuelo, Zapata-Tarrés, Marta, Velasco-Hidalgo, Liliana, López-Santiago, Norma, López-Ruiz, Mayra Ivette, Malavar-Guadarrama, Monica Anabell, Cárdenas-Cardós, Rocío, Paredes-Aguilera, Rogelio, Rivera-Luna, Roberto, Dean, Michael, and Pérez-Vera, Patricia

Published
2019
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4. Pure Interstitial Trisomy 11q Arising from a Nonrecurrent 11q13.1q22.3 Mosaic Intrachromosomal Duplication in a Patient with Craniofacial Dysmorphism and Genital Anomalies

Author

Martínez Anaya, Daniel, primary, Juárez-Velázquez, María del Rocío, additional, Reyes Ruvalcaba, Sinuhé, additional, Navarrete-Meneses, María del Pilar, additional, Salas Labadía, Consuelo, additional, Lieberman Hernández, Esther, additional, and Pérez-Vera, Patricia, additional

Published
2023
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5. CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

Author

Moreno Lorenzana, Dafné, Juárez Velázquez, María del Rocío, Reyes León, Adriana, Martínez Anaya, Daniel, Hernández Monterde, Adrián, Salas Labadía, Consuelo, Navarrete Meneses, María del Pilar, Zapata Tarrés, Marta, Juárez Villegas, Luis, Jarquín Ramírez, Berenice, Cárdenas Cardós, Rocío, Herrera Almanza, Martha, Paredes Aguilera, Rogelio, and Pérez Vera, Patricia

Subjects
CRLF2, Fusion Proteins, bcr-abl, acute lymphoblastic leukemia, Ikaros Transcription Factor, primary rearrangements, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, hemic and lymphatic diseases, Pathology, Humans, Protein Isoforms, RB1-214, Receptors, Cytokine, Child, Mexico, Mexican children, Gene Rearrangement, TCF3‐PBX1 concurrent with P2RY8‐CRLF2, Original Articles, Precursor Cell Lymphoblastic Leukemia-Lymphoma, IKZF1, Child, Preschool, Original Article, Gene Fusion, Biomarkers, activated signaling pathways, Signal Transduction
Abstract

The gene fusions BCR‐ABL1, TCF3‐PBX1, and ETV6‐RUNX1 are recurrent in B‐cell acute lymphoblastic leukemia (B‐ALL) and are found with low frequency in coexistence with CRLF2 (cytokine receptor‐like factor 2) rearrangements and overexpression. There is limited information regarding the CRLF2 abnormalities and dominant‐negative IKZF1 isoforms associated with surrogate markers of Jak2, ABL, and Ras signaling pathways. To assess this, we evaluated 24 Mexican children with B‐ALL positive for recurrent gene fusions at diagnosis. We found CRLF2 rearrangements and/or overexpression, dominant‐negative IKZF1 isoforms, and surrogate phosphorylated markers of signaling pathways coexisting with recurrent gene fusions. All the BCR‐ABL1 patients expressed CRLF2 and were positive for pCrkl (ABL); most of them were also positive for pStat5 (Jak2/Stat5) and negative for pErk (Ras). TCF3‐PBX1 patients with CRLF2 abnormalities were positive for pStat5, most of them were also positive for pCrkl, and two patients were also positive for pErk. One patient with ETV6‐RUNX1 and intracellular CRLF2 protein expressed pCrkl. In some cases, the activated signaling pathways were reverted in vitro by specific inhibitors. We further analyzed a TCF3‐PBX1 patient at relapse, identifying a clone with the recurrent gene fusion, P2RY8‐CRLF2, rearrangement, and phosphorylation of the three surrogate markers that we studied. These results agree with the previous reports regarding resistance to treatment observed in patients with recurrent gene fusions and coexisting CRLF2 gene abnormalities. A marker phosphorylation signature was identified in BCR‐ABL1 and TCF3‐PBX1 patients. To obtain useful information for the assessment of treatment in B‐ALL patients with recurrent gene fusions, we suggest that they should be evaluated at diagnosis for CRLF2 gene abnormalities and dominant‐negative IKZF1 isoforms, in addition to the analyses of activation and inhibition of signaling pathways.

Published
2021

7. CRLF2andIKZF1abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

Author

Moreno Lorenzana, Dafné, primary, Juárez Velázquez, María del Rocío, additional, Reyes León, Adriana, additional, Martínez Anaya, Daniel, additional, Hernández Monterde, Adrián, additional, Salas Labadía, Consuelo, additional, Navarrete Meneses, María del Pilar, additional, Zapata Tarrés, Marta, additional, Juárez Villegas, Luis, additional, Jarquín Ramírez, Berenice, additional, Cárdenas Cardós, Rocío, additional, Herrera Almanza, Martha, additional, Paredes Aguilera, Rogelio, additional, and Pérez Vera, Patricia, additional

Published
2021
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8. Variants in ARID5B Gene Are Associated with the Development of Acute Lymphoblastic Leukemia in Mexican Children

Author

Reyes-León, Adriana, primary, Fernández-García, Diana, additional, Ramírez-Martínez, Maribel, additional, Amaro-Muñoz, David, additional, Velázquez-Aragón, José Antonio, additional, Salas-Labadía, Consuelo, additional, Zapata-Tarres, Marta, additional, Velasco-Hidalgo, Liliana, additional, Lopez-Santiago, Norma, additional, López-Ruíz, Mayra Ivette, additional, Malavar-Guadarrama, Mónica Anabell, additional, Cardenas-Cardos, Rocio, additional, Paredes-Aguilera, Rogelio Alejandro, additional, Dean, Michael, additional, Rivera-Luna, Roberto, additional, and Perez-Vera, Patricia, additional

Published
2018
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9. Expression of Ik6 and Ik8 Isoforms and Their Association with Relapse and Death in Mexican Children with Acute Lymphoblastic Leukemia

Author

Reyes-León, Adriana, primary, Juárez-Velázquez, Rocío, additional, Medrano-Hernández, Alma, additional, Cuenca-Roldán, Teresa, additional, Salas-Labadía, Consuelo, additional, del Pilar Navarrete-Meneses, María, additional, Rivera-Luna, Roberto, additional, López-Hernández, Gerardo, additional, Paredes-Aguilera, Rogelio, additional, and Pérez-Vera, Patricia, additional

Published
2015
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12. Cytogenomic and phenotypic analysis in low-level monosomy 7 mosaicism with non-supernumerary ring chromosome 7

Author

Salas-Labadía, Consuelo, primary, Cervantes-Barragán, David E., additional, Cruz-Alcívar, Roberto, additional, Daber, Robert D., additional, Conlin, Laura K., additional, Leonard, Laura D., additional, Spinner, Nancy B., additional, Durán-McKinster, Carola, additional, Dávila-Ortíz de Montellano, David J., additional, Del Castillo-Ruiz, Victoria, additional, and Pérez-Vera, Patricia, additional

Published
2014
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13. Significance ofCASP8AP2andH2AFZexpression in survival and risk of relapse in children with acute lymphoblastic leukemia

Author

Juárez-Velázquez, Rocío, primary, Reyes-León, Adriana, additional, Salas-Labadía, Consuelo, additional, Rivera-Luna, Roberto, additional, Velasco-Hidalgo, Liliana, additional, López-Hernández, Gerardo, additional, López-Santiago, Norma, additional, Paredes-Aguilera, Rogelio, additional, Domínguez-López, Aarón, additional, Bernáldez, Roberto, additional, and Pérez-Vera, Patricia, additional

Published
2014
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14. Significance of CASP8AP2 and H2AFZ expression in survival and risk of relapse in children with acute lymphoblastic leukemia.

Author

Juárez-Velázquez, Rocío, Reyes-León, Adriana, Salas-Labadía, Consuelo, Rivera-Luna, Roberto, Velasco-Hidalgo, Liliana, López-Hernández, Gerardo, López-Santiago, Norma, Paredes-Aguilera, Rogelio, Domínguez-López, Aarón, Bernáldez, Roberto, and Pérez-Vera, Patricia

Subjects
CANCER relapse, PROTEIN expression, LYMPHOBLASTIC leukemia in children, HEALTH outcome assessment, TUMORS in children, CANCER risk factors
Abstract

Novel biomarkers for risk refinement and stratification in childhood acute lymphoblastic leukemia (ALL) are needed to optimize treatment results. We studied the expression of CASP8AP2 and H2AFZ associated with relapse and survival in bone marrow samples from newly diagnosed children with ALL. We found: (a) an increased risk for early relapse in those patients with low expression of CASP8AP2 (odds ratio [OR] 3.93, 95% confidence interval [CI] 1.40-11.02, p < 0.05) confirming its usefulness as a predictive risk marker, although H2AFZ did not present the same effect; (b) patients with low expressions of CASP8AP2 and H2AFZ had inferior survival rates ( p < 0.001); (c) the predictive values regarding low expressions of H2AFZ and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse. [ABSTRACT FROM AUTHOR]

Published
2014
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15. Diagnóstico prenatal por amniocentesis. Experiencia clínica y citogenética en 1,500 casos.

Author

Grether-González, Patricia, Cámara-Polanco, Virginia, Ulloa-Avilés, Verónica, Salas-Labadía, Consuelo, Almanza-Márquez, Roberto, Kogan-Frenk, Samuel, and Kuttothara, Annie

Subjects
AMNIOCENTESIS, PRENATAL diagnosis, DIAGNOSIS of fetal diseases, ABORTION, EPIGENETICS, WOMEN'S health, CYTOGENETICS
Abstract

Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010

16. Variants in ARID5BGene Are Associated with the Development of Acute Lymphoblastic Leukemia in Mexican Children

Author

Reyes-León, Adriana, Fernández-García, Diana, Ramírez-Martínez, Maribel, Amaro-Muñoz, David, Velázquez-Aragón, José Antonio, Salas-Labadía, Consuelo, Zapata-Tarres, Marta, Velasco-Hidalgo, Liliana, Lopez-Santiago, Norma, López-Ruíz, Mayra Ivette, Malavar-Guadarrama, Mónica Anabell, Cardenas-Cardos, Rocio, Paredes-Aguilera, Rogelio Alejandro, Dean, Michael, Rivera-Luna, Roberto, and Perez-Vera, Patricia

Abstract

Introduction: Acute lymphoblastic leukemia (ALL) is the most common subtype of leukemia diagnosed in children under 18 years. According to the statistics of the Popular Medical Insurance Program in Mexico, the ALL incidence is 79.8 cases per million per year, and it is significantly increasing. Recently, several SNPs of ARID5Bgene have been associated with ALL susceptibility and are more strongly related with ALL risk in Hispanics. However, these observations are not necessarily representative of the situation in Mexico, since the proportion of Mexican patients included in these studies is unknown. It is essential for us to know if the genetic variants of ARID5Bconfer susceptibility to the development of the disease in our population and if these variants contribute to the higher incidence of childhood ALL in Mexico.

Published
2018
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