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3. Contributors

Author

Ahmadi, Ehsaneh Daghigh, primary, Akbari, Mohsen, additional, Anjana, J., additional, Assunção-Silva, R.C., additional, Badea, Smaranda, additional, Baino, Francesco, additional, Chen, Jyh-Ping, additional, Choonara, Yahya E., additional, Davari, Hamid Reza, additional, Deepthi, S., additional, Dolatshahi-Pirouz, Alireza, additional, du Toit, Lisa C., additional, Godau, Brent, additional, Gokulu, Ipek Simay, additional, Gomes, E.D., additional, Gracia-Sancho, Jordi, additional, Jayakumar, R., additional, Joghataie, Mohammad Taghi, additional, Kaplan, David L., additional, Kargozar, Saeid, additional, Karperien, Lucas, additional, Khurshid, Zohaib, additional, Kizilel, Seda, additional, Kumar, Pradeep, additional, Lo, Amy C.Y., additional, Mallapragada, Surya K., additional, Mammadova, Najiba, additional, Milan, Peiman Brouki, additional, Moghadam, Zoha Salehi, additional, Mony, Ullas, additional, Mottaghy, Khosrow, additional, Mozafari, Masoud, additional, Moztarzadeh, Sina, additional, Najeeb, Shariq, additional, Navaei, Ali, additional, Navaei, Tina, additional, Nikkhah, Mehdi, additional, Oran, Dilem Ceren, additional, Ortega-Ribera, Martí, additional, Patel, Bhavika B., additional, Pillay, Viness, additional, Pradeep, Priyamvada, additional, Rahmati, Maryam, additional, Raja, Tehmeena Israr, additional, Rajadas, Jayakumar, additional, Saeb, Mohammad Reza, additional, Sakaguchi, Donald S., additional, Salehi, Sahar, additional, Salgado, A.J., additional, Samadikuchaksaraei, Ali, additional, Sandquist, Elizabeth J., additional, Scheibel, Thomas, additional, Sefat, Farshid, additional, Shalumon, K.T., additional, Sharma, Anup D., additional, Silva, N.A., additional, Singer, Bernhard B., additional, Tariverdian, Tara, additional, Tsang, Ken K., additional, Urbanska, Aleksandra M., additional, Uz, Metin, additional, Villa, Rosa, additional, Wicklein, Vanessa J., additional, Wong, Francisca S.Y., additional, Wu, Wutian, additional, Yeste, Jose, additional, Yousaf, Safiyya, additional, Zafar, Muhammad Sohail, additional, Zarintaj, Payam, additional, and Zohaib, Sana, additional

Published
2019
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10. Effect of levodopa on reward and impulsivity in a rat model of Parkinson’s disease

Author

Carvalho, M.M. Campos, F.L. Marques, M. Soares-Cunha, C. Kokras, N. Dalla, C. Leite-Almeida, H. Sousa, N. Salgado, A.J.

Abstract

The use of dopamine replacement therapies (DRT) in the treatment of Parkinson’s disease (PD) can lead to the development of dopamine dysregulation syndrome (DDS) and impulse control disorders (ICD), behavioral disturbances characterized by compulsive DRT self-medication and development of impulsive behaviors. However, the mechanisms behind these disturbances are poorly understood. In animal models of PD, the assessment of the rewarding properties of levodopa (LD), one of the most common drugs used in PD, has produced conflicting results, and its ability to promote increased impulsivity is still understudied. Moreover, it is unclear whether acute and chronic LD therapy differently affects reward and impulsivity. In this study we aimed at assessing, in an animal model of PD with bilateral mesostriatal and mesocorticolimbic degeneration, the behavioral effects of LD therapy regarding reward and impulsivity. Animals with either sham or 6-hydroxydopamine (6-OHDA)-induced bilateral lesions in the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) were exposed to acute and chronic LD treatment. We used the conditioned place preference (CPP) paradigm to evaluate the rewarding effects of LD, whereas impulsive behavior was measured with the variable delay-to-signal (VDS) task. Correlation analyses between behavioral measurements of reward or impulsivity and lesion extent in SNc/VTA were performed to pinpoint possible anatomical links of LD-induced behavioral changes. We show that LD, particularly when administered chronically, caused the development of impulsive-like behaviors in 6-OHDA-lesioned animals in the VDS. However, neither acute or chronic LD administration had rewarding effects in 6-OHDA-lesioned animals in the CPP. Our results show that in a bilateral rat model of PD, LD leads to the development of impulsive behaviors, strengthening the association between DRT and DDS/ICD in PD. © 2017 Carvalho, Campos, Marques, Soares-Cunha, Kokras, Dalla, Leite- Almeida, Sousa and Salgado.

Published
2017

13. Corrigendum to ‘Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations’ [Biochimie 95–12 (2013) 2297–2303]

Author

Fraga, J.S., primary, Silva, N.A., additional, Lourenço, A.S., additional, Gonçalves, V., additional, Neves, N.M., additional, Reis, R.L., additional, Rodrigues, A.J., additional, Manadas, B., additional, Sousa, N., additional, and Salgado, A.J., additional

Published
2016
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23. In vivo response to starch‐based scaffolds designed for bone tissue engineering applications.

Author

Salgado, A.J., Coutinho, O.P., Reis, R.L., and Davies, J.E.

Abstract

Our purpose was to evaluate the in vivo endosseous response to three starch‐based scaffolds implanted in rats (n = 54). We implanted the three scaffold groups; a 50/50 (wt %) blend of corn starch and ethylene‐vinyl alcohol (SEVA‐C), the same composition coated with a biomimetic calcium phosphate (Ca‐P) layer (SEVA‐C/CaP), and a 50/50 (wt %) blend of corn starch and cellulose acetate (SCA), all produced by extrusion with blowing agents, into distal femurs proximal to the epiphyseal plate, for 1, 3, or 6 weeks. Our results showed that at 1 week considerable reparative bone formed around all scaffold groups, although the bone was separated from the scaffold by an intervening soft tissue interfacial zone that comprised two distinct compartments: the surface of the scaffold was occupied by multinucleate giant cells and the compartment between these cells and the surrounding bone was occupied by a streaming fibrous‐like tissue. The extracellular matrix of the latter was continuous with the extracellular bone matrix itself, labeled positively for osteocalcin and appeared mineralized by back‐scattered electron imaging. All three scaffolds showed a similar tissue response, with the soft tissue interface diminishing with time. No bone contact was observed with SEVA‐C at any time point, only transitory bone contact was observed with SEVA‐C/CaP at 3 weeks, but SCA exhibited direct bone contact at 6 weeks where 56.23 ± 6.46% of the scaffold surface was occupied by bone. We conclude that all materials exhibited a favorable bony response and that the rapidly forming initial "connective tissue" seen around all scaffolds was a very early form of bone formation. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006 [ABSTRACT FROM AUTHOR]

Published
2007
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