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214 results on '"Salmaso R"'

2. The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI)

Author

Elefanti, L., Zamuner, C., Del Fiore, P., Stagni, C., Pellegrini, S., Dall'Olmo, L., Fabozzi, A., Senetta, R., Ribero, S., Salmaso, R., Mocellin, S., Bassetto, F., Cavallin, F., Tosi, A. L., Galuppini, F., Dei Tos, A. P., Menin, C., and Cappellesso, R.

Subjects
Male, Skin Neoplasms, DNA Copy Number Variations, NRAS, Polymorphism, Single Nucleotide, Article, Acral melanoma, ARID1A, BRAF, Copy number variations, KIT, PREX2, TERT promoter, TP53, lcsh:Chemistry, Aged, Aged, 80 and over, Female, Humans, Italy, Melanoma, Middle Aged, Mutation, Neoplasm Grading, Neoplasm Staging, Prognosis, Biomarkers, Tumor, Disease Susceptibility, 80 and over, Polymorphism, lcsh:QH301-705.5, Tumor, Single Nucleotide, acral melanoma, copy number variations, lcsh:Biology (General), lcsh:QD1-999, Biomarkers
Abstract

Acral melanoma (AM) is a rare and aggressive subtype of melanoma affecting the palms, soles, and nail apparatus with similar incidence among different ethnicities. AM is unrelated to ultraviolet radiation and has a low mutation burden but frequent chromosomal rearrangements and gene amplifications. Next generation sequencing of 33 genes and somatic copy number variation (CNV) analysis with genome-wide single nucleotide polymorphism arrays were performed in order to molecularly characterize 48 primary AMs of Italian patients in association with clinicopathological and prognostic features. BRAF was the most commonly mutated gene, followed by NRAS and TP53, whereas TERT promoter, KIT, and ARID1A were less frequently mutated. Gains and losses were recurrently found in the 1q, 6p, 7, 8q, 20 and 22 chromosomes involving PREX2, RAC1, KMT2C, BRAF, CCND1, TERT, and AKT3 genes, and in the 6q, 9, 10, 11q and 16q chromosomes including CDKN2A, PTEN, and ADAMTS18 genes, respectively. This study confirmed the variety of gene mutations and the high load of CNV in primary AM. Some genomic alterations were associated with histologic prognostic features. BRAF mutations, found with a higher rate than previously reported, correlated with a low Breslow thickness, low mitotic count, low CNV of the AMs, and with early-stage of disease.

Published
2021

12. Myoepithelial carcinoma of mixed cell type: a rare entity

Author

Erica Dalla Venezia, Brambullo T, Kohlscheen E, Salmaso R, Cappellesso R, De Antoni E, Dalla Venezia E, Vindigni V, and Bassetto F

Subjects
Pathology, medicine.medical_specialty, Mesenchymal stem cell, Myoepithelial cell, Myoepithelial Carcinoma, Rare entity, Mixed cell, Biology, medicine.disease, stomatognathic diseases, medicine, Carcinoma, Pediatric dermatology, Large group
Abstract

Myoepitheliomas represent a large group of uncommon mesenchymal neoplasms characterized by myoepithelial differentiation.

Published
2018

20. Parotid, breast, and fascial involvement in a patient who fulfilled the ACR criteria for Churg-Strauss syndrome

Author

Leonardo Punzi, A. Ruffatti, Andrea Doria, Modesti, Francesca Ometto, Salmaso R, and Visentin Ms

Subjects
Pathology, medicine.medical_specialty, business.industry, Immunology, Churg-strauss syndrome, General Medicine, medicine.disease, Acr criteria, Dermatology, respiratory tract diseases, Rheumatology, immune system diseases, hemic and lymphatic diseases, Necrotizing Vasculitis, otorhinolaryngologic diseases, medicine, Immunology and Allergy, Nasal polyps, cardiovascular diseases, business, Asthma
Abstract

Churg–Strauss syndrome (CSS) is a rare, systemic, necrotizing vasculitis of small vessels that occurs in subjects with a background of asthma, allergic rhinitis, and/or nasal polyps (1). Lungs, ski...

Published
2012

21. Occurrence of squamous cell carcinoma in an area of lichen simplex chronicus: case report and pathogenetic hypothesis

Author

Tiengo, Cesare, Deluca, J, Belloni Fortina, A, Salmaso, R, Galifi, F, Alaibac, MAURO SALVATORE ALESSANDRO, and BELLONI FORTINA, Anna

Subjects
Male, medicine.medical_specialty, Pathology, Leg, Skin Neoplasms, business.industry, Follow up studies, Dermatology, Middle Aged, medicine.disease, Malignant transformation, Diagnosis, Differential, medicine.anatomical_structure, medicine, Carcinoma, Squamous Cell, Humans, Surgery, Basal cell, Differential diagnosis, Neurodermatitis, Keratinocyte, business, Follow-Up Studies
Abstract

Background: Lichen simplex chronicus is a common skin disorder characterized by circumscribed, lichenified, pruritic plaque secondary to local repetitive trauma, notably rubbing and scratching. Objective: We describe a case of a squamous cell carcinoma arising in a patient with a long-lasting history of lichen simplex chronicus and discuss the potential role of the microenvironment in predisposing the malignant transformation. Conclusion: Here we propose a hypothesis in which rubbing and scratching contribute to an excess of inflammatory mediators, which in turn may lead to alterations in the processes of keratinocyte proliferation and differentiation. Renseignements de base: Le lichen simplex chronique est une affection cutanée courante caractérisée par une plaque pruritique lichénifiée circonscrite consécutive à des traumatismes locaux répétés, notamment le frottement et le grattage. Objectif: Nous décrivons un cas de carcinome squameux chez un patient présentant depuis longtemps des antécédents de lichen simplex chronique, et nous discutons du rôle potentiel du micro-environnement dans la prédisposition de la transformation maligne. Conclusion: Nous proposons ici une hypothèse selon laquelle le frottement et le grattage contribuent à un excès de médiateurs inflammatoires, lesquels peuvent à leur tour venir modifier les processus de prolifération et de différenciation des kératinocytes.

Published
2012

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