Search

Your search keyword '"Salmon, Adam B."' showing total 381 results
Start Over Author "Salmon, Adam B."
381 results on '"Salmon, Adam B."'

1. Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin

Author

Miller, Richard A, Harrison, David E, Cortopassi, Gino A, Dehghan, Ishmael, Fernandez, Elizabeth, Garratt, Michael, Geisler, John G, Ginsburg, Brett C, Han, Melissa L, Kaczorowski, Catherine C, Kumar, Navasuja, Leiser, Scott F, Lopez-Cruzan, Marisa, Milne, Ginger, Mitchell, James R, Nelson, James F, Reifsnyder, Peter C, Salmon, Adam B, Korstanje, Ron, Rosenthal, Nadia, and Strong, Randy

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Women's Health, Aging, Animals, Canagliflozin, Male, Female, Thiosulfates, Longevity, Mice, Sodium-Glucose Transporter 2 Inhibitors, Sex Factors, Alpha-ketoglutarate, SGLT2 inhibitor Canagliflozin, Lifespan, Genetics, Clinical sciences
Abstract

Genetically heterogeneous UM-HET3 mice born in 2020 were used to test possible lifespan effects of alpha-ketoglutarate (AKG), 2,4-dinitrophenol (DNP), hydralazine (HYD), nebivolol (NEBI), 16α-hydroxyestriol (OH_Est), and sodium thiosulfate (THIO), and to evaluate the effects of canagliflozin (Cana) when started at 16 months of age. OH_Est produced a 15% increase (p = 0.0001) in median lifespan in males but led to a significant (7%) decline in female lifespan. Cana, started at 16 months, also led to a significant increase (14%, p = 0.004) in males and a significant decline (6%, p = 0.03) in females. Cana given to mice at 6 months led, as in our previous study, to an increase in male lifespan without any change in female lifespan, suggesting that this agent may lead to female-specific late-life harm. We found that blood levels of Cana were approximately 20-fold higher in aged females than in young males, suggesting a possible mechanism for the sex-specific disparities in its effects. NEBI was also found to produce a female-specific decline (4%, p = 0.03) in lifespan. None of the other tested drugs provided a lifespan benefit in either sex. These data bring to 7 the list of ITP-tested drugs that induce at least a 10% lifespan increase in one or both sexes, add a fourth drug with demonstrated mid-life benefits on lifespan, and provide a testable hypothesis that might explain the sexual dimorphism in lifespan effects of the SGLT2 inhibitor Cana.

Published
2024

6. Determination of dexamethasone dose for cortisol suppression in adult common marmosets (Callithrix jacchus)

Author

Phillips, Kimberley A, Lopez, Matthew, Salmon, Adam B, Ross, Corinna N, Abbott, David H, and Capitanio, John P

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Animals, Callithrix, Hydrocortisone, Dexamethasone, common marmoset, dexamethasone suppression test, glucocorticoid, Zoology, Virology, Veterinary sciences
Abstract

We conducted a dose-response study of dexamethasone to investigate an optimal dexamethasone suppression test for common marmosets. Twelve marmosets received 0.1, 0.5, or 1.0 mg/kg dexamethasone. Doses of 0.5 and 1.0 mg/kg both suppressed endogenous cortisol for at least 18 h with greater individual variability in the lower 0.5 mg/kg dose.

Published
2022

8. Pan-primate studies of age and sex

Author

Horvath, Steve, Haghani, Amin, Zoller, Joseph A., Lu, Ake T., Ernst, Jason, Pellegrini, Matteo, Jasinska, Anna J., Mattison, Julie A., Salmon, Adam B., Raj, Ken, Horvath, Markus, Paul, Kimberly C., Ritz, Beate R., Robeck, Todd R., Spriggs, Maria, Ehmke, Erin E., Jenkins, Susan, Li, Cun, and Nathanielsz, Peter W.

Published
2023
Full Text
View/download PDF

9. Correction to: Lifespan effects in male UM‑HET3 mice treated with sodium thiosulfate, 16‑hydroxyestriol, and late‑start canagliflozin

Author

Miller, Richard A., Harrison, David E., Cortopassi, Gino A., Dehghan, Ishmael, Fernandez, Elizabeth, Garratt, Michael, Geisler, John G., Ginsburg, Brett C., Han, Melissa L., Jiang, Nisi, Kaczorowski, Catherine C., Kumar, Navasuja, Leiser, Scott F., Lopez‑Cruzan, Marisa, Milne, Ginger, Mitchell, James R., Nelson, James F., Reifsnyder, Peter C., Salmon, Adam B., Xu, Ziying, Korstanje, Ron, Rosenthal, Nadia, and Strong, Randy

Published
2024
Full Text
View/download PDF

13. DNA methylation age analysis of rapamycin in common marmosets

Author

Horvath, Steve, Zoller, Joseph A, Haghani, Amin, Lu, Ake T, Raj, Ken, Jasinska, Anna J, Mattison, Julie A, and Salmon, Adam B

Subjects
Biological Sciences, Genetics, Aging, Animals, Callithrix, Chlorocebus aethiops, DNA Methylation, Epigenesis, Genetic, Macaca mulatta, Mice, Sirolimus, Marmoset, Development, Epigenetic clock, DNA methylation, Clinical sciences
Abstract

Human DNA methylation data have previously been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Subsequent studies demonstrate that similar epigenetic clocks can also be developed for mice and many other mammals. Here, we describe epigenetic clocks for common marmosets (Callithrix jacchus) based on novel DNA methylation data generated from highly conserved mammalian CpGs that were profiled using a custom Infinium array (HorvathMammalMethylChip40). From these, we developed and present here two epigenetic clocks for marmosets that are applicable to whole blood samples. We find that the human-marmoset clock for relative age exhibits moderately high age correlations in two other non-human primate species: vervet monkeys and rhesus macaques. In a separate cohort of marmosets, we tested whether intervention with rapamycin, a drug shown to extend lifespan in mice, would alter the epigenetic age of marmosets, as measured by the marmoset epigenetic clocks. These clocks did not detect significant effects of rapamycin on the epigenetic age of marmoset blood. The common marmoset stands out from other mammals in that it is not possible to build accurate estimators of sex based on DNA methylation data: the accuracy of a random forest predictor of sex (66%) was substantially lower than that observed for other mammals (which is close to 100%). Overall, the epigenetic clocks developed here for the common marmoset are expected to be useful for age estimation of wild-born animals and for anti-aging studies in this species.

Published
2021

26. DNA methylation networks underlying mammalian traits

Author

Haghani, Amin, primary, Li, Caesar Z., additional, Robeck, Todd R., additional, Zhang, Joshua, additional, Lu, Ake T., additional, Ablaeva, Julia, additional, Acosta-Rodríguez, Victoria A., additional, Adams, Danielle M., additional, Alagaili, Abdulaziz N., additional, Almunia, Javier, additional, Aloysius, Ajoy, additional, Amor, Nabil M.S., additional, Ardehali, Reza, additional, Arneson, Adriana, additional, Baker, C. Scott, additional, Banks, Gareth, additional, Belov, Katherine, additional, Bennett, Nigel C., additional, Black, Peter, additional, Blumstein, Daniel T., additional, Bors, Eleanor K., additional, Breeze, Charles E., additional, Brooke, Robert T., additional, Brown, Janine L., additional, Carter, Gerald, additional, Caulton, Alex, additional, Cavin, Julie M., additional, Chakrabarti, Lisa, additional, Chatzistamou, Ioulia, additional, Chavez, Andreas S., additional, Chen, Hao, additional, Cheng, Kaiyang, additional, Chiavellini, Priscila, additional, Choi, Oi-Wa, additional, Clarke, Shannon, additional, Cook, Joseph A., additional, Cooper, Lisa N., additional, Cossette, Marie-Laurence, additional, Day, Joanna, additional, DeYoung, Joseph, additional, Dirocco, Stacy, additional, Dold, Christopher, additional, Dunnum, Jonathan L., additional, Ehmke, Erin E., additional, Emmons, Candice K., additional, Emmrich, Stephan, additional, Erbay, Ebru, additional, Erlacher-Reid, Claire, additional, Faulkes, Chris G., additional, Fei, Zhe, additional, Ferguson, Steven H., additional, Finno, Carrie J., additional, Flower, Jennifer E., additional, Gaillard, Jean-Michel, additional, Garde, Eva, additional, Gerber, Livia, additional, Gladyshev, Vadim N., additional, Goya, Rodolfo G., additional, Grant, Matthew J, additional, Green, Carla B., additional, Hanson, M. Bradley, additional, Hart, Daniel W., additional, Haulena, Martin, additional, Herrick, Kelsey, additional, Hogan, Andrew N., additional, Hogg, Carolyn J., additional, Hore, Timothy A., additional, Huang, Taosheng, additional, Izpisua Belmonte, Juan Carlos, additional, Jasinska, Anna J., additional, Jones, Gareth, additional, Jourdain, Eve, additional, Kashpur, Olga, additional, Katcher, Harold, additional, Katsumata, Etsuko, additional, Kaza, Vimala, additional, Kiaris, Hippokratis, additional, Kobor, Michael S., additional, Kordowitzki, Pawel, additional, Koski, William R., additional, Krützen, Michael, additional, Kwon, Soo Bin, additional, Larison, Brenda, additional, Lee, Sang-Goo, additional, Lehmann, Marianne, additional, Lemaître, Jean-François, additional, Levine, Andrew J., additional, Li, Xinmin, additional, Li, Cun, additional, Lim, Andrea R., additional, Lin, David T. S., additional, Lindemann, Dana M., additional, Liphardt, Schuyler W., additional, Little, Thomas J., additional, Macoretta, Nicholas, additional, Maddox, Dewey, additional, Matkin, Craig O., additional, Mattison, Julie A., additional, McClure, Matthew, additional, Mergl, June, additional, Meudt, Jennifer J., additional, Montano, Gisele A., additional, Mozhui, Khyobeni, additional, Munshi-South, Jason, additional, Murphy, William J., additional, Naderi, Asieh, additional, Nagy, Martina, additional, Narayan, Pritika, additional, Nathanielsz, Peter W., additional, Nguyen, Ngoc B., additional, Niehrs, Christof, additional, Nyamsuren, Batsaikhan, additional, O’Brien, Justine K., additional, Ginn, Perrie O’Tierney, additional, Odom, Duncan T, additional, Ophir, Alexander G., additional, Osborn, Steve, additional, Ostrander, Elaine A., additional, Parsons, Kim M., additional, Paul, Kimberly C., additional, Pedersen, Amy B., additional, Pellegrini, Matteo, additional, Peters, Katharina J., additional, Petersen, Jessica L., additional, Pietersen, Darren W., additional, Pinho, Gabriela M., additional, Plassais, Jocelyn, additional, Poganik, Jesse R., additional, Prado, Natalia A., additional, Reddy, Pradeep, additional, Rey, Benjamin, additional, Ritz, Beate R., additional, Robbins, Jooke, additional, Rodriguez, Magdalena, additional, Russell, Jennifer, additional, Rydkina, Elena, additional, Sailer, Lindsay L., additional, Salmon, Adam B., additional, Sanghavi, Akshay, additional, Schachtschneider, Kyle M., additional, Schmitt, Dennis, additional, Schmitt, Todd, additional, Schomacher, Lars, additional, Schook, Lawrence B., additional, Sears, Karen E., additional, Seifert, Ashley W., additional, Shafer, Aaron B.A., additional, Shindyapina, Anastasia V., additional, Simmons, Melanie, additional, Singh, Kavita, additional, Sinha, Ishani, additional, Slone, Jesse, additional, Snell, Russel G., additional, Soltanmohammadi, Elham, additional, Spangler, Matthew L., additional, Spriggs, Maria, additional, Staggs, Lydia, additional, Stedman, Nancy, additional, Steinman, Karen J., additional, Stewart, Donald T, additional, Sugrue, Victoria J., additional, Szladovits, Balazs, additional, Takahashi, Joseph S., additional, Takasugi, Masaki, additional, Teeling, Emma C., additional, Thompson, Michael J., additional, Van Bonn, Bill, additional, Vernes, Sonja C., additional, Villar, Diego, additional, Vinters, Harry V., additional, Vu, Ha, additional, Wallingford, Mary C., additional, Wang, Nan, additional, Wilkinson, Gerald S., additional, Williams, Robert W., additional, Yan, Qi, additional, Yao, Mingjia, additional, Young, Brent G., additional, Zhang, Bohan, additional, Zhang, Zhihui, additional, Zhao, Yang, additional, Zhao, Peng, additional, Zhou, Wanding, additional, Zoller, Joseph A., additional, Ernst, Jason, additional, Seluanov, Andrei, additional, Gorbunova, Vera, additional, Yang, X. William, additional, Raj, Ken, additional, and Horvath, Steve, additional

Published
2023
Full Text
View/download PDF

28. Age‐related changes in hematological biomarkers in common marmosets.

Author

Hickmott, Alexana J., Cervantes, Lidia, Arroyo, Juan Pablo, Brasky, Kathy, Bene, Michael, Salmon, Adam B., Phillips, Kimberley A., and Ross, Corinna N.

Subjects
CALLITHRIX jacchus, BLOOD cell count, OLDER people, ERYTHROCYTES, MEAN platelet volume, CLINICAL chemistry
Abstract

Researchers and veterinarians often use hematology and clinical chemistry to evaluate animal health. These biomarkers are relatively easy to obtain, and understanding how they change across healthy aging is critical to clinical care and diagnostics for these animals. We aimed to evaluate how clinical biomarkers from a chemistry profile and complete blood count (CBC) change with age in common marmosets (Callithrix jacchus). We assessed blood samples collected during routine physical exams at the Southwest National Primate Research Center and the University of Texas Health San Antonio marmoset colonies from November 2020–November 2021. We found that chemistry and CBC profiles varied based on facility, sex, and age. Significant changes in albumin, phosphorus/creatinine ratio, albumin/globulin ratio, amylase, creatinine, lymphocyte percent, hematocrit, granulocytes percent, lymphocytes, hemoglobin, red cell distribution width, and platelet distribution width were all reported with advancing age. Aged individuals also demonstrated evidence for changes in liver, kidney, and immune system function compared with younger individuals. Our results suggest there may be regular changes associated with healthy aging in marmosets that are outside of the range typically considered as normal values for healthy young individuals, indicating the potential need for redefined healthy ranges for clinical biomarkers in aged animals. Identifying animals that exhibit values outside of this defined healthy aging reference will allow more accurate diagnostics and treatments for aging colonies. Research Highlights: The parameters that were reduced in peri‐geriatric or geriatric marmosets compared with younger marmosets were albumin, phosphorus/creatinine ratio, albumin/globulin ratio, calcium, glucose, lymphocytes, red blood cells, red cell distribution width, mean platelet volume, red cell distribution standard deviation, plateletcrit, platelet distribution width, and platelet distribution standard deviation.The parameters that were increased in peri‐geriatric and geriatric compared with young marmosets were amylase, creatinine,anion gap, granulocytes percent, and platelets.Our results suggest normal changes associated with healthy aging marmosets indicating the potential need for refinement of normal ranges for clinical biomarkers in aged marmosets. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice

Author

Strong, Randy, primary, Miller, Richard A., additional, Cheng, Catherine J., additional, Nelson, James F., additional, Gelfond, Jonathan, additional, Allani, Shailaja Kesaraju, additional, Diaz, Vivian, additional, Dorigatti, Angela Olsen, additional, Dorigatti, Jonathan, additional, Fernandez, Elizabeth, additional, Galecki, Andrzej, additional, Ginsburg, Brett, additional, Hamilton, Karyn L., additional, Javors, Martin A., additional, Kornfeld, Kerry, additional, Kaeberlein, Matt, additional, Kumar, Suja, additional, Lombard, David B., additional, Lopez‐Cruzan, Marisa, additional, Miller, Benjamin F., additional, Rabinovitch, Peter, additional, Reifsnyder, Peter, additional, Rosenthal, Nadia A., additional, Bogue, Molly A., additional, Salmon, Adam B., additional, Suh, Yousin, additional, Verdin, Eric, additional, Weissbach, Herbert, additional, Newman, John, additional, Maccchiarini, Francesca, additional, and Harrison, David E., additional

Published
2022
Full Text
View/download PDF

40. Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice

Author

Snyder, Jessica M., primary, Casey, Kerriann M., additional, Galecki, Andrzej, additional, Harrison, David E., additional, Jayarathne, Hashan, additional, Kumar, Navasuja, additional, Macchiarini, Francesca, additional, Rosenthal, Nadia, additional, Sadagurski, Marianna, additional, Salmon, Adam B., additional, Strong, Randy, additional, Miller, Richard A., additional, and Ladiges, Warren, additional

Published
2022
Full Text
View/download PDF

46. The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology

Author

Buffenstein, Rochelle, Amoroso, Vincent, Andziak, Blazej, Avdieiev, Stanislav, Azpurua, Jorge, Barker, Alison J., Bennett, Nigel C., Brieno-Enriquez, Miguel A., Bronner, Gary N., Coen, Clive, Delaney, Martha A., Dengler-Crish, Christine M., Edrey, Yael H., Faulkes, Chris G., Frankel, Daniel, Friedlander, Gerard, Gibney, Patrick A., Gorbunova, Vera, Hine, Christopher, Holmes, Melissa M., Jarvis, Jennifer U. M., Kawamura, Yoshimi, Kutsukake, Nobuyuki, Kenyon, Cynthia, Khaled, Walid T., Kikusui, Takefumi, Kissil, Joseph, Lagestee, Samantha, Larson, John, Lauer, Amanda, Lavrenchenko, Leonid A., Lee, Angela, Levitt, Jonathan B., Lewin, Gary R., Hardell, Kaitlyn N. Lewis, Lin, Tzu Hua D., Mason, Matthew J., McCloskey, Dan, McMahon, Mary, Miura, Kyoko, Mogi, Kazutaka, Narayan, Vikram, O'Connor, Timothy P., Okanoya, Kazuo, O'Riain, M. Justin, Park, Thomas J., Place, Ned J., Podshivalova, Katie, Pamenter, Matthew E., Pyott, Sonja J., Reznick, Jane, Ruby, J. Graham, Salmon, Adam B., Santos-Sacchi, Joseph, Sarko, Diana K., Seluanov, Andrei, Shepard, Alyssa, Smith, Megan, Storey, Kenneth B., Tian, Xiao, Vice, Emily N., Viltard, Melanie, Watarai, Akiyuki, Wywial, Ewa, Yamakawa, Masanori, Zemlemerova, Elena D., Zions, Michael, Smith, Ewan St John, Buffenstein, Rochelle, Amoroso, Vincent, Andziak, Blazej, Avdieiev, Stanislav, Azpurua, Jorge, Barker, Alison J., Bennett, Nigel C., Brieno-Enriquez, Miguel A., Bronner, Gary N., Coen, Clive, Delaney, Martha A., Dengler-Crish, Christine M., Edrey, Yael H., Faulkes, Chris G., Frankel, Daniel, Friedlander, Gerard, Gibney, Patrick A., Gorbunova, Vera, Hine, Christopher, Holmes, Melissa M., Jarvis, Jennifer U. M., Kawamura, Yoshimi, Kutsukake, Nobuyuki, Kenyon, Cynthia, Khaled, Walid T., Kikusui, Takefumi, Kissil, Joseph, Lagestee, Samantha, Larson, John, Lauer, Amanda, Lavrenchenko, Leonid A., Lee, Angela, Levitt, Jonathan B., Lewin, Gary R., Hardell, Kaitlyn N. Lewis, Lin, Tzu Hua D., Mason, Matthew J., McCloskey, Dan, McMahon, Mary, Miura, Kyoko, Mogi, Kazutaka, Narayan, Vikram, O'Connor, Timothy P., Okanoya, Kazuo, O'Riain, M. Justin, Park, Thomas J., Place, Ned J., Podshivalova, Katie, Pamenter, Matthew E., Pyott, Sonja J., Reznick, Jane, Ruby, J. Graham, Salmon, Adam B., Santos-Sacchi, Joseph, Sarko, Diana K., Seluanov, Andrei, Shepard, Alyssa, Smith, Megan, Storey, Kenneth B., Tian, Xiao, Vice, Emily N., Viltard, Melanie, Watarai, Akiyuki, Wywial, Ewa, Yamakawa, Masanori, Zemlemerova, Elena D., Zions, Michael, and Smith, Ewan St John

Abstract

The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical interest not only because of its extraordinary longevity, but also because of unusual protective features (e.g. its tolerance of variable oxygen availability), which may be pertinent to several human disease states, including ischemia/reperfusion injury and neurodegeneration. A recent article entitled 'Surprisingly long survival of premature conclusions about naked mole-rat biology' described 28 'myths' which, those authors claimed, are a 'perpetuation of beautiful, but falsified, hypotheses' and impede our understanding of this enigmatic mammal. Here, we re-examine each of these 'myths' based on evidence published in the scientific literature. Following Braude et al., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of which persist solely in the popular press; (ii) 'myths' that are based on incomplete understanding, where more evidence is clearly needed; (iii) 'myths' where the accumulation of evidence over the years has led to a revision in interpretation, but where there is no significant disagreement among scientists currently working in the field; (iv) 'myths' where there is a genuine difference in opinion among active researchers, based on alternative interpretations of the available evidence. The term 'myth' is particularly inappropriate when applied to competing, evidence-based hypotheses, which form part of the normal evolution of scientific knowledge. Here, we provide a comprehensive critical review of naked mole-rat biology and attempt to clarify some of these misconceptions.

Published
2022

48. Resilience to aging is a heterogeneous characteristic defined by physical stressors

Author

Lei, Haoyi, Huffman, Derek M., Salmon, Adam B., LeBrasseur, Nathan K., Carter, Christy, Richardson, Arlan, Austad, Steve, and Ladiges, Warren

Subjects
Article
Abstract

Physical resilience, the capacity to respond to and recover from a stressful event, declines with advancing age. Individuals respond differently to physical stressors across their lifespans. While the biological underpinnings of resilience remain unclear, a plausible determinant is the capacity of an individual's cellular and molecular levels to return to homeostasis after a physical challenge. Impaired resilience may not only be a consequence of aging but could also be a contributing factor to the aging process. Therefore, resilience at relatively younger ages could be predictive of future health and lifespan. By utilizing standardized physical challenges and measuring stress response patterns, the relative resilience of individuals can be quantified and classified. Current preclinical research suggests that several physical stressors could be used to measure resilience in clinical aging studies. A mechanistic understanding of why some individuals are more resilient to physical stressors than others could help identify protective factors and therapeutic ways to promote healthy aging.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results