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Multidrug resistant bacteria are well-recognized as one of the greatest threats to human health worldwide. Antibacterial activity of nanoparticles has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. The antimicrobial effects of Ag, ZnO mixed solutions were examined in this work. Silver nitrate and zinc acetate were precursors for preparing two solutions (referred to as Sol1 and Sol2). These solutions contained well-known active antibacterial ions: Zn+2 and Ag+. The mixed solutions were made using Sol1 and Sol2 at three volume ratios (0.2, 0.4 and 0.8 %). The antibacterial activities of the mixed solutions were studied against Klebsiella pneumoniae; Acinetobacter baumannii; Escherichia coli; Pseudomonas aeruginosa and Staphylococcus aureus using the agar well diffusion method. All mixtures had an inhibitory effect against all pathogenic bacteria but with different inhibition zones. These zones were compared with those formed by Sol2 only to investigate the effect of Ag particles. The coexistence of nano and micro Ag particles was one of the important factors used to explain the results of inhibition zones. Utilizing the spin coating method, mixed solutions were deposited on glass substrates to produce three silver doped zinc oxide (Ag: ZnO) films. An experimental study of antiadhesive effects of Ag:ZnO films against pathogenic bacteria Pseudomonas aeruginosa has been performed. These effects increased by increasing the silver amount as a dopant material inside ZnO matrix. [ABSTRACT FROM AUTHOR]