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The first consistent series of mononuclear 17-electron complexes of three Group 7 elements has been isolated in crystalline form and studied by X-ray diffraction and spectroscopic methods. The paramagnetic compounds have a composition of [M 0 (CO)(CNp-F-Ar DArF2 ) 4 ] (M=Mn, Tc, Re; Ar DArF2 =2,6-(3,5-(CF 3 ) 2 C 6 H 3 ) 2 C 6 H 2 F) and are stabilized by four sterically encumbering isocyanides, which prevent the metalloradicals from dimerization. They have a square pyramidal structure with the carbonyl ligands as apexes. The frozen-solution EPR spectra of the rhenium and technetium compounds are clearly anisotropic with large 99 Tc and 185,187 Re hyperfine interactions for one component. High-field EPR (Q band and W band) has been applied for the elucidation of the EPR parameters of the manganese(0) complex., (© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

The first crystalline technetium complex in a negative oxidation state, [Tc -I (CO)(CN p -F-Ar DArF2 ) 4 ] - , was isolated and structurally characterized as its [Na(Crypt-2.2.2)] + salt. It mirrors the properties of the textbook organometallic compound Na[Tc(CO) 5 ], which has eluded isolation and structural characterization until today. [Na(Crypt-2.2.2)][Tc -I (CO)(CN p -F-Ar DArF2 ) 4 ] reacts expectedly as a nucleophile, which is demonstrated by reactions with HCl and ClSnMe 3 . They give the unprecedented monohydrido and trimethylstannyl complexes of technetium.

Objective: Equinus foot deformity (EFD) is the most common deformity following a stroke. Several approaches have been suggested for its correction, including pharmacological, surgical, and physical therapy (PT) interventions. This scoping review aims to map and synthesize the available evidence focusing on physical therapy treatments for EFD caused by triceps surae (TS) spasticity., Methods: Scoping review methodological frameworks have been used. Pubmed, Cinahl, and Cochrane databases were searched for primary literature. Studies focusing on the treatment of EFD in adult stroke patients were included only when the intervention involved PT treatments and presented at least one outcome measure for the functional and/or structural condition of the TS. Data were systematically collected and reported in tables inclusive of type of intervention, sample characteristics, dosage, comparators, outcomes, follow-up timeline, and treatment efficacy. A narrative synthesis was also added., Results: Of the 642 experimental or observational screened studies, 53 were included, focusing on stretching exercises, shock waves, electrical stimulation, dry needling, TENS, vibration therapy, ultrasounds, cryotherapy, and active physiotherapy. Patients with EFD benefited from specific physical therapy treatments. These usually resulted in Modified Ashworth Scale reduction, typically by 1 point, and an increase in ROM. Interventions consisting of shock waves, dry needling, and electrostimulation showed the best results in reducing EFD. Heterogeneous dosage and delivery mode generally limited conclusions., Conclusions: This scoping review summarized available primary literature based on PT treatments for the correction of EFD. By highlighting the remaining gaps in knowledge, it provides a reference for future studies on this pathology. Further investigations are necessary to pinpoint the best dosage and delivery methods. Future studies should investigate whether early rehabilitation programs started during the acute phase might help prevent or limit the development of secondary deformities., Competing Interests: Authors MBò and AM were also employed by Merlo Bioengineering. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Campanini, Bò, Salsi, Bassi, Damiano, Scaltriti, Lusuardi and Merlo.)

The mixed isocyanide/carbonyl complexes cis- and trans-[Re(CO)3Br(CNArDipp2)2] (ArDipp2 = 2,6-(2,6-(i-Pr)2C6H3)2C6H3) can be synthesized from reactions of [Re(CO)5Br] and CNArDipp2 depending on the conditions applied. Reduction of the neutral Re(i) species gives the monoanionic complex [Re(CO)3(CNArDipp2)2]- or the neutral [Re(CO)3(CNArDipp2)2], which contain rhenium in the formal oxidation states "-1" and "0", respectively.

A series of 16 "3 + 2" mixed-ligand complexes of the general composition [ReO(L1)(L2)] (H 2 L1a-H 2 L1d = tridentate thiosemicarbazones having a phenyl group with 4-H, 4-F, 3,5-di-F, and 4-CF 3 substituents; HL2a-HL2d = bidentate N , N -diethyl- N '-benzoylthioureas with 4-H, 4-F, 3,5-di-F, and 4-CF 3 substituents at the benzoyl groups) have been synthesized and characterized by spectroscopic methods and X-ray diffraction. Irrespective of the individual fluorine substitution, the complexes are stable and possess the same general structure. Some systematic electronic effects of the fluorine-substitution patterns of the ligands have been found on the 13 C NMR chemical shifts of the N-C═N carbon atoms of the {L1} 2- and the C═O carbon atoms of the {L2} - ligands. Antiparasitic properties of the rhenium complexes have been tested against epimastigotes and trypomastigotes forms of two Trypanosoma cruzi strains and the amastigotes form of one of them. The results of this study indicate that the activity of the rhenium complexes can clearly be modulated by fluorine substitution of their ligands. Some of the fluorinated compounds show a high activity against epimastigotes and trypomastigotes forms of the parasites. Reactions between (NBu 4 )[TcOCl 4 ] and two representatives of the fluorinated ligands (H 2 L1b, 4-F-substituted, and H 2 L1c, 4-CF 3 -substituted) form stable complexes of the composition [TcOCl(L1b)] and [TcOCl(L1c)]. Subsequent reactions of these products with HL2b (4-F-substituted) give the corresponding [TcO(L1)(L2)] mixed-ligand complexes. Also, the technetium compounds are stable as solids and in solutions and have structures corresponding to those of their rhenium analogues.