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13 results on '"Salvadori, Costanza"'

8. Increased Plasma Levels of lncRNAs LINC01268, GAS5 and MALAT1 Correlate with Negative Prognostic Factors in Myelofibrosis

Author

Fantini, Sebastian, primary, Rontauroli, Sebastiano, additional, Sartini, Stefano, additional, Mirabile, Margherita, additional, Bianchi, Elisa, additional, Badii, Filippo, additional, Maccaferri, Monica, additional, Guglielmelli, Paola, additional, Ottone, Tiziana, additional, Palmieri, Raffaele, additional, Genovese, Elena, additional, Carretta, Chiara, additional, Parenti, Sandra, additional, Mallia, Selene, additional, Tavernari, Lara, additional, Salvadori, Costanza, additional, Gesullo, Francesca, additional, Maccari, Chiara, additional, Zizza, Michela, additional, Grande, Alexis, additional, Salmoiraghi, Silvia, additional, Mora, Barbara, additional, Potenza, Leonardo, additional, Rosti, Vittorio, additional, Passamonti, Francesco, additional, Rambaldi, Alessandro, additional, Voso, Maria Teresa, additional, Mecucci, Cristina, additional, Tagliafico, Enrico, additional, Luppi, Mario, additional, Vannucchi, Alessandro Maria, additional, and Manfredini, Rossella, additional

Published
2021
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9. Increased Plasma Levels of lncRNAs LINC01268, GAS5 and MALAT1 Correlate with Negative Prognostic Factors in Myelofibrosis

Author

Fantini, Sebastian, Rontauroli, Sebastiano, Sartini, Stefano, Mirabile, Margherita, Bianchi, Elisa, Badii, Filippo, Maccaferri, Monica, Guglielmelli, Paola, Ottone, Tiziana, Palmieri, Raffaele, Genovese, Elena, Carretta, Chiara, Parenti, Sandra, Mallia, Selene, Tavernari, Lara, Salvadori, Costanza, Gesullo, Francesca, Maccari, Chiara, Zizza, Michela, Grande, Alexis, Salmoiraghi, Silvia, Mora, Barbara, Potenza, Leonardo, Rosti, Vittorio, Passamonti, Francesco, Rambaldi, Alessandro, Voso, Maria Teresa, Mecucci, Cristina, Tagliafico, Enrico, Luppi, Mario, Vannucchi, Alessandro Maria, and Manfredini

Subjects
MPN, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Myelofibrosis, Biomarkers, LncRNAs, Prognosis, Settore MED/15, biomarkers, lncRNAs, myelofibrosis, prognosis, RC254-282
Abstract

Long non-coding RNAs (lncRNAs) have been recently described as key mediators in the development of hematological malignancies. In the last years, circulating lncRNAs have been proposed as a new class of non-invasive biomarkers for cancer diagnosis and prognosis and to predict treatment response. The present study is aimed to investigate the potential of circulating lncRNAs as non-invasive prognostic biomarkers in myelofibrosis (MF), the most severe among Philadelphia-negative myeloproliferative neoplasms. We detected increased levels of seven circulating lncRNAs in plasma samples of MF patients (n = 143), compared to healthy controls (n = 65). Among these, high levels of LINC01268, MALAT1 or GAS5 correlate with detrimental clinical variables, such as high count of leukocytes and CD34+ cells, severe grade of bone marrow fibrosis and presence of splenomegaly. Strikingly, high plasma levels of LINC01268 (p = 0.0018), GAS5 (p = 0.0008) or MALAT1 (p = 0.0348) are also associated with a poor overall-survival while high levels of LINC01268 correlate with a shorter leukemia-free-survival. Finally, multivariate analysis demonstrated that the plasma level of LINC01268 is an independent prognostic variable, suggesting that, if confirmed in future in an independent patients’ cohort, it could be used for further studies to design an updated classification model for MF patients.

Published
2021

12. Transcriptional Alterations of ET-1 Axis and DNA Damage in Lung Tissue of a Rat Obesity Model

Author

Del Ry, Silvia, primary, Cabiati, Manuela, additional, Salvadori, Costanza, additional, Guiducci, Letizia, additional, Caselli, Chiara, additional, Prescimone, Tommaso, additional, Facioni, Maria Sole, additional, Azzarà, Alessia, additional, Chiaramonte, Anna, additional, Mazzoni, Stefano, additional, Bruschi, Fabrizio, additional, Giannessi, Daniela, additional, and Scarpato, Roberto, additional

Published
2015
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