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198 results on '"Salvolini, E."'

19. Differential expression of nicotinamide N‐methyltransferase in cutaneous keratoacanthoma and squamous cell carcinoma: an immunohistochemical study.

Author

Sartini, D., Pompei, V., Lucarini, G., Rubini, C., Molinelli, E., Brisigotti, V., Salvolini, E., Campanati, A., Offidani, A., and Emanuelli, M.

Subjects
SQUAMOUS cell carcinoma, BENIGN tumors, NIKON digital cameras, BASAL cell carcinoma, NONINVASIVE diagnostic tests
Abstract

Nowadays, we are witnessing a worldwide increasing incidence of non-melanoma skin cancers (NMSCs), whose major types are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). GLO:3NZ/01mar20:jdv16048-fig-0002.jpg PHOTO (COLOR): NNMT immunohistochemical expression in KA, SCC of the trunk and extremities, and head and neck SCC. Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma. [Extracted from the article]

Published
2020
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22. Expression of CD38 in human neuroblastoma SH-SY5Y cells

Author

Orciani, M, Trubiani, O, Cavaletti, G, Guarnieri, S, Salvolini, E, Tredici, G, Di Primio, R, Di Primio, R., CAVALETTI, GUIDO ANGELO, TREDICI, GIOVANNI, Orciani, M, Trubiani, O, Cavaletti, G, Guarnieri, S, Salvolini, E, Tredici, G, Di Primio, R, Di Primio, R., CAVALETTI, GUIDO ANGELO, and TREDICI, GIOVANNI

Abstract

Human CD38 antigen is a 42-45 kDa type II transmembrane glycoprotein with a short N-terminal cytoplasmic domain and a long C-terminal extracellular region. It is widely expressed in different cell types including thymocytes, activated T cells, and terminally differentiated B cells (plasma cells) and it is involved in cellular proliferation and adhesion. CD38 acts as an ectocyclase that converts NAD+ to the Ca2+ -releasing second messenger cyclic ADP-ribose (cADPR). It has been also demonstrated that increased extracellular levels of NAD+ and cADPR are involved in inflammatory diseases and in cellular damage, such as ischemia. In the present study, we have characterized the expression of CD38 in human neuroblastoma SH-SY5Y cell line. All-trans-retinoic acid (ATRA) treatment was used to induce cell differentiation. Our results indicate that: a) even if SH-SY5Y cells have a negative phenotype express CD38 at nuclear level, ATRA treatment does not influence this pattern; b) CD38 localizing to the nucleus may co-localize with p80-coilin positive nuclear-coiled bodies; c) purified nuclei, by Western blot determinations using anti-CD38 antibodies, display a band with a molecular mass of approximately 42 kDa; d) SH-SY5Y cells show nuclear ADP-ribosyl cyclase due to CD38 activity; e) the basal level of CD38 mRNA shows a time-dependent increase after treatment with ATRA. These results suggest that the presence of constitutive fully functional CD38 in the SH-SY5Y nucleus has some important implications for intracellular generation of cADP-ribose and subsequent nucleoplasmic calcium release.

Published
2008

44. Anorexia nervosa: a role for L-arginine supplementation in cardiovascular risk factors?

Author

Vignini A, D'Angelo M, Nanetti L, Camilloni MA, Cester AM, Faloia E, Salvolini E, and Mazzanti L

Abstract

Objective: The aim of the present study was to evaluate the effects of a short-term oral L-arginine treatment on platelet NO production, intracellular calcium concentration, iNOS and eNOS expression, in AN patients. Method: Forty outpatients belonging to restricting subtype and 40 normal participants age and sex matched were enrolled in the study. Results: NO production was significantly elevated in the platelets from AN patients compared with controls while [Ca(2+)](i) was significantly decreased in patients with respect to controls. Western blot analysis demonstrated that iNOS isoform was more pronounced in the cell lysates from AN patients than controls. After supplementation with L-arginine, both NO production and [Ca(2+)](i) seem to return to control levels, suggesting a probable recovery of their metabolisms. The same was found after western blot analysis of NOS expression. Discussion: The results here proposed can be considered highly indicative of a positive effect of L-arginine supplementation on platelet NO production in AN patients. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010 [ABSTRACT FROM AUTHOR]

Published
2010
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45. Relationships between Na+,K+-ATPase, sialic acid content and fluidity in rainbow trout density-separated erythrocytes

Author

Salvolini, E., Nanetti, L., Moretti, N., Vignini, A., Martarelli, D., Frontini, A., Santroni, A. M., Falcioni, G., and Mazzanti, L.

Subjects
*SIALIC acids, *FLUIDITY of biological membranes, *RAINBOW trout, *ERYTHROCYTES
Abstract

A correlation was found between membrane fluidity, sialic acid (SA) content and Na+,K+-ATPase activity in the rainbow trout Oncorhynchus mykiss erythrocyte membrane and this suggests that alterations in erythrocyte Na+,K+-ATPase activity might be caused by modified membrane fluidity through modified SA content. Copyright 2002 The Fisheries Society of the British Isles. Published by Elsevier Science Ltd. All rights reserved. [Copyright &y& Elsevier]

Published
2002
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47. 3D CT in the Demonstration of Ossified Stylohyoid Complex: A Pictorial Essay

Author

Salvolini, E., Serio, A., Fratto, G., and Salvolini, U.

Abstract

Ossification of the stylohyoid complex may be discovered during radiological examination of the cervical spine or at dental panoramic examination. Sometimes it is correlated with atypical facial pain. We report a case in which computed tomography demonstrated the ossified styloid chain with articulations using 3D bony surface reconstruction.

Published
1997
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49. In vitro evaluation of mesenchymal stem cell isolation possibility from different intra-oral tissues

Author

Orciani M, Di Primio R, Ferretti C, Orsini G, Salvolini E, Lazzarini R, and Monica Mattioli-Belmonte

Subjects
Periodontal Ligament, Periosteum, Humans, Cell Differentiation, Mesenchymal Stem Cells, Cell Separation, Cells, Cultured, Dental Pulp, Immunophenotyping
Abstract

Mesenchymal stem cells (MSCs) are of great interest for the regeneration of tissues and organs. Bone marrow is the first sources of MSCs, but in the recent years there has been interest in other tissues for the isolation of these pluripotent cells. In this study, we investigated the features of MSCs isolated from different oral regions in order to evaluate their potential application in the regeneration of damaged maxillofacial tissues. Sampling from human periodontal ligament, dental pulp, maxillary periosteum as well as bone marrow were collected in order to obtain different stem cell populations. Cells were morphologically and immunophenotipically characterized. Their proliferation potential and their ability to differentiate in osteoblasts were also assessed. All tested cell population showed a similar fibroblast-like morphology and superimposable immunophenotype. Slight differences were observed in proliferation and differentiation potential. Cells isolated from human periodontal ligament, dental pulp, maxillary periosteum had the characteristics of stem cells. Considering their peculiar feature they may alternatively represent interesting cell sources in stem cell-based bone/periodontal tissue regeneration approaches.

50. Analysis of nicotinamide N-methyltransferase in oral malignant melanoma and potential prognostic significance

Author

Eleonora Salvolini, Davide Sartini, Giulia Ganzetti, Giuseppe Colella, Corrado Rubini, Annamaria Offidani, Marco Mascitti, Andrea Santarelli, Monica Emanuelli, Mascitti, M., Santarelli, A., Sartini, D., Rubini, C., Colella, G., Salvolini, E., Ganzetti, G., Offidani, A., and Emanuelli, M.

Subjects
Male, 0301 basic medicine, Cancer Research, Nicotinamide N-methyltransferase, Dermatology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, nicotinamide N-methyltransferase, medicine, Humans, Melanoma, Survival rate, Aged, Aged, 80 and over, oral malignant melanoma, Univariate analysis, Nicotinamide, business.industry, Middle Aged, Prognosis, medicine.disease, Survival Rate, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, immunohistochemistry, Cutaneous melanoma, Cancer research, Immunohistochemistry, Female, Mouth Neoplasms, business
Abstract

Oral malignant melanoma (OMM) is an aggressive tumour, and shows deep tissue invasion at initial presentation. The prognosis is worse than that for cutaneous melanoma (CM), and the overall 5-year survival rate is 10-25%. A study of the molecular mechanisms involved in the development of OMM is necessary to identify new prognostic markers. In this study, we evaluated the possible role of nicotinamide N-methyltransferase (NNMT) in OMM. We carried out immunohistochemical analyses to evaluate the expression of NNMT in 15 OMM and 15 CM, measuring the percentage of positive cells and the value of NNMT expression intensity. Furthermore, we explored the relationship between NNMT levels and the prognostic parameters of patients with OMM. NNMT was significantly more expressed in CM compared with OMM, whereas higher staining intensity for NNMT was observed in OMM cases (P

Published
2019
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