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2. Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity

Author

Shenoy, Anukul T., Lyon De Ana, Carolina, Arafa, Emad I., Salwig, Isabelle, Barker, Kimberly A., Korkmaz, Filiz T., Ramanujan, Aditya, Etesami, Neelou S., Soucy, Alicia M., Martin, Ian M. C., Tilton, Brian R., Hinds, Anne, Goltry, Wesley N., Kathuria, Hasmeena, Braun, Thomas, Jones, Matthew R., Quinton, Lee J., Belkina, Anna C., and Mizgerd, Joseph P.

Published
2021
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3. Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway

Author

Ianni, Alessandro, primary, Hofmann, Michael, additional, Kumari, Poonam, additional, Tarighi, Shahriar, additional, Al-Tamari, Hamza M, additional, Görgens, André, additional, Giebel, Bernd, additional, Nolte, Hendrik, additional, Krüger, Marcus, additional, Salwig, Isabelle, additional, Pullamsetti, Soni Savai, additional, Günther, Andreas, additional, Schneider, André, additional, and Braun, Thomas, additional

Published
2021
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4. Multilineage murine stem cells generate complex organoids to model distal lung development and disease

Author

Vazquez-Armendariz, Ana Ivonne, Heiner, Monika, El Agha, Elie, Salwig, Isabelle, Hoek, Andreas, Hessler, Marie Christin, Shalashova, Irina, Shrestha, Amit, Carraro, Gianni, Mengel, Jan Philip, Günther, Andreas, Morty, Rory Edward, Vadász, István, Schwemmle, Martin, Kummer, Wolfgang, Hain, Torsten, Goesmann, Alexander, Bellusci, Saverio, Seeger, Werner, Braun, Thomas, Herold, Susanne, and Justus Liebig University Giessen

Subjects
ddc:610
Published
2020
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5. Multilineage murine stem cells generate complex organoids to model distal lung development and disease

Author

Vazquez‐Armendariz, Ana Ivonne, primary, Heiner, Monika, additional, El Agha, Elie, additional, Salwig, Isabelle, additional, Hoek, Andreas, additional, Hessler, Marie Christin, additional, Shalashova, Irina, additional, Shrestha, Amit, additional, Carraro, Gianni, additional, Mengel, Jan Philip, additional, Günther, Andreas, additional, Morty, Rory Edward, additional, Vadász, István, additional, Schwemmle, Martin, additional, Kummer, Wolfgang, additional, Hain, Torsten, additional, Goesmann, Alexander, additional, Bellusci, Saverio, additional, Seeger, Werner, additional, Braun, Thomas, additional, and Herold, Susanne, additional

Published
2020
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7. Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity.

Author

Shenoy, Anukul T., Lyon De Ana, Carolina, Arafa, Emad I., Salwig, Isabelle, Barker, Kimberly A., Korkmaz, Filiz T., Ramanujan, Aditya, Etesami, Neelou S., Soucy, Alicia M., Martin, Ian M. C., Tilton, Brian R., Hinds, Anne, Goltry, Wesley N., Kathuria, Hasmeena, Braun, Thomas, Jones, Matthew R., Quinton, Lee J., Belkina, Anna C., and Mizgerd, Joseph P.

Subjects
ANTIGEN presentation, EPITHELIAL cells, CELL physiology, LUNGS, ANTIGEN presenting cells, PROTEIN C, T cells
Abstract

Barrier tissues are populated by functionally plastic CD4+ resident memory T (TRM) cells. Whether the barrier epithelium regulates CD4+ TRM cell locations, plasticity and activities remains unclear. Here we report that lung epithelial cells, including distinct surfactant protein C (SPC)lowMHChigh epithelial cells, function as anatomically-segregated and temporally-dynamic antigen presenting cells. In vivo ablation of lung epithelial MHC-II results in altered localization of CD4+ TRM cells. Recurrent encounters with cognate antigen in the absence of epithelial MHC-II leads CD4+ TRM cells to co-express several classically antagonistic lineage-defining transcription factors, changes their cytokine profiles, and results in dysregulated barrier immunity. In addition, lung epithelial MHC-II is needed for surface expression of PD-L1, which engages its ligand PD-1 to constrain lung CD4+ TRM cell phenotypes. Thus, we establish epithelial antigen presentation as a critical regulator of CD4+ TRM cell function and identify epithelial-CD4+ TRM cell immune interactions as core elements of barrier immunity. The maintenance of T resident memory (TRM) cells within pulmonary tissues is incompletely understood. Here the authors show that antigen presentation by lung epithelial cells maintains function and phenotype of pulmonary TRM cells within specific locational niches. [ABSTRACT FROM AUTHOR]

Published
2021
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8. Estimation of absolute number of alveolar epithelial type 2 cells in mouse lungs: a comparison between stereology and flow cytometry

Author

DZHURAEV, GEORGY, primary, RODRÍGUEZ‐CASTILLO, JOSÉ ALBERTO, additional, RUIZ‐CAMP, JORDI, additional, SALWIG, ISABELLE, additional, SZIBOR, MARTIN, additional, VADÁSZ, ISTVÁN, additional, HEROLD, SUSANNE, additional, BRAUN, THOMAS, additional, AHLBRECHT, KATRIN, additional, ATZBERGER, ANN, additional, MÜHLFELD, CHRISTIAN, additional, SEEGER, WERNER, additional, and MORTY, RORY E., additional

Published
2019
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10. A novel mouse Cre-driver line targeting Perilipin 2-expressing cells in the neonatal lung

Author

Ntokou, Aglaia, primary, Szibor, Marten, additional, Rodríguez-Castillo, José Alberto, additional, Quantius, Jennifer, additional, Herold, Susanne, additional, El Agha, Elie, additional, Bellusci, Saverio, additional, Salwig, Isabelle, additional, Braun, Thomas, additional, Voswinckel, Robert, additional, Seeger, Werner, additional, Morty, Rory E., additional, and Ahlbrecht, Katrin, additional

Published
2017
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11. Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

Author

Szibor, Marten, primary, Dhandapani, Praveen K., additional, Dufour, Eric, additional, Holmström, Kira M., additional, Zhuang, Yuan, additional, Salwig, Isabelle, additional, Wittig, Ilka, additional, Heidler, Juliana, additional, Gizatullina, Zemfira, additional, Gainutdinov, Timur, additional, Consortium, German Mouse Clinic, additional, Fuchs, Helmut, additional, Gailus-Durner, Valérie, additional, de Angelis, Martin Hrabě, additional, Nandania, Jatin, additional, Velagapudi, Vidya, additional, Wietelmann, Astrid, additional, Rustin, Pierre, additional, Gellerich, Frank N., additional, Jacobs, Howard T., additional, and Braun, Thomas, additional

Published
2016
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12. Bronchoalveolar Sublineage Specification of Pluripotent Stem Cells: Effect of Dexamethasone Plus cAMP-Elevating Agents and Keratinocyte Growth Factor

Author

Katsirntaki, Katherina, primary, Mauritz, Christina, additional, Olmer, Ruth, additional, Schmeckebier, Sabrina, additional, Sgodda, Malte, additional, Puppe, Verena, additional, Eggenschwiler, Reto, additional, Duerr, Julia, additional, Schubert, Susanne C., additional, Schmiedl, Andreas, additional, Ochs, Matthias, additional, Cantz, Tobias, additional, Salwig, Isabelle, additional, Szibor, Marten, additional, Braun, Thomas, additional, Rathert, Christian, additional, Martens, Andreas, additional, Mall, Marcus A., additional, and Martin, Ulrich, additional

Published
2015
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13. Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

Author

Szibor, Marten, Dhandapani, Praveen K., Dufour, Eric, Holmström, Kira M., Zhuang, Yuan, Salwig, Isabelle, Wittig, Ilka, Heidler, Juliana, Gizatullina, Zemfira, Gainutdinov, Timur, Fuchs, Helmut, Gailus-Durner, Valérie, de Angelis, Martin Hrabě, Nandania, Jatin, Velagapudi, Vidya, Wietelmann, Astrid, Rustin, Pierre, Gellerich, Frank N., Jacobs, Howard T., and Braun, Thomas

Abstract

Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow under conditions when the classical respiratory chain is impaired, limiting excess production of oxygen radicals and supporting redox and metabolic homeostasis. AOX from Ciona intestinalis has been used to study and mitigate mitochondrial impairments in mammalian cell lines, Drosophila disease models and, most recently, in the mouse, where multiple lentivector-AOX transgenes conferred substantial expression in specific tissues. Here, we describe a genetically tractable mouse model in which Ciona AOX has been targeted to the Rosa26 locus for ubiquitous expression. The AOXRosa26 mouse exhibited only subtle phenotypic effects on respiratory complex formation, oxygen consumption or the global metabolome, and showed an essentially normal physiology. AOX conferred robust resistance to inhibitors of the respiratory chain in organello; moreover, animals exposed to a systemically applied LD50 dose of cyanide did not succumb. The AOXRosa26 mouse is a useful tool to investigate respiratory control mechanisms and to decipher mitochondrial disease aetiology in vivo.

Published
2017
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14. Induction of Smooth Muscle Cell Migration During Arteriogenesis Is Mediated by Rap2

Author

Pöling, Jochen, primary, Szibor, Marten, additional, Schimanski, Silvia, additional, Ingelmann, Marie-Elisabeth, additional, Rees, Wolfgang, additional, Gajawada, Praveen, additional, Kochfar, Zaber, additional, Lörchner, Holger, additional, Salwig, Isabelle, additional, Shin, Jae-Young, additional, Wiebe, Karsten, additional, Kubin, Thomas, additional, Warnecke, Henning, additional, and Braun, Thomas, additional

Published
2011
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15. Nitric Oxide-associated Protein 1 (NOA1) Is Necessary for Oxygen-dependent Regulation of Mitochondrial Respiratory Complexes

Author

Heidler, Juliana, primary, Al-Furoukh, Natalie, additional, Kukat, Christian, additional, Salwig, Isabelle, additional, Ingelmann, Marie-Elisabeth, additional, Seibel, Peter, additional, Krüger, Marcus, additional, Holtz, Jürgen, additional, Wittig, Ilka, additional, Braun, Thomas, additional, and Szibor, Marten, additional

Published
2011
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16. Solvent-Induced Chirality in the Hydroboration of Ketones

Author

Baldauf, Christoph, primary, Dickerhof, Nina, additional, Hüttenhain, Stefan H., additional, Kern, Stefanie, additional, Krummrich, Nancy, additional, Kruse, Friedrich, additional, May, Janine, additional, Meister, Melanie, additional, Müller, Kristina, additional, Rauer, Sabine, additional, Salwig, Isabelle, additional, Scharfenecker, Nico, additional, and Spitznagel, Birgit, additional

Published
2008
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