Search

Your search keyword '"Salzano, Marco"' showing total 11 results
Start Over Author "Salzano, Marco"
11 results on '"Salzano, Marco"'

3. The use of a panel of monoclonal antibodies can lower false-negative diagnoses of peritoneal washing in ovarian tumors

Author

Mottolese, Marcella, Salzano, Marco, Vincenzoni, Cristina, Benevolo, Maria, Bigotti, Aldo, Iacovelli, Annunziaia, Lombardi, Antonio, Atlante, Giuseppe, and Natali, Pier Giorgio

Subjects
Ovarian cancer -- Metastasis, Monoclonal antibodies, Ovarian cancer -- Diagnosis, Metastasis -- Diagnosis, Health
Abstract

The examination of peritoneal washings is an important part of both the initial staging and follow-up of ovarian cancer. If cancerous cells have begun to spread from the ovary, they may be detected by rinsing the abdominal cavity and examining the fluid. In cases where there is no cancer spread large enough to be visible to the surgeon, these washings may provide the only indication that the cancer is advancing. Likewise, in the follow-up of patients who have already been treated for ovarian cancer, the presence of cancer cells in fluid rinsed from the abdominal cavity may provide the first indication of recurrence. The examination of the rinsing fluids is not straightforward, however. Normal cells will be recovered with this method, and even with careful examination cancerous cells may not be detected among the normal cells. A study was conducted to determine if monoclonal antibodies may be used to improve the examination of such washings. Monoclonal antibodies are highly specific and may be used to immunocytochemically stain cancer cells; the cells stained in this manner would then stand out noticeably against the background of normal cells, which stain little or not at all. Four different monoclonal antibodies were tested in the evaluation of 117 patients who were undergoing surgery for ovarian abnormalities and 121 patients who were undergoing a 'second-look' operation to observe for signs of recurrent cancer. The fluid used to rinse the abdomen was examined in the conventional way, and the cells were also stained with the monoclonal antibodies. For the patients undergoing their first surgical procedure, the traditional technique identified cancerous cells in 11 of 27 cases involving early cancer and 21 of 30 cases of advanced cancer. The antibodies, on the other hand, detected cancerous cells in the rinsing fluid in 15 of 27 early cancer cases and in 25 of 30 cases of advanced cancer. Similarly, for the patients being followed-up, traditional examination revealed cancerous cells in 39 of 121 cases while the antibodies revealed cancerous cells in 61 of 121 cases. These results indicate that the use of monoclonal antibodies to stain cells in fluid rinsed from the abdomen can increase the chances for the detection of ovarian cancer cells. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

5. Scrambler Therapy® MC-5A for Complex Regional Pain Syndrome: Case Reports.

Author

Raucci, Umberto, Tomasello, Caterina, Marri, Marcello, Salzano, Marco, Gasparini, Augusto, and Conicella, Elena

Abstract

Background Complex regional pain syndrome ( CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical therapy, regional anesthesia, and neuromodulation. Aim We evaluated Scrambler Therapy® ( ST) in terms of efficacy, safety, and durability of treatment effect in patients suffering from CRPS. Materials and Methods We report the response to ST in four patients with CRPS referred to the Pain Center of Bambino Gesù Children's Hospital. The patients previously did not respond to conventional and nonconventional medical treatments. Results The treatment with ST was found effective in all four of our patients; they obtained pain relief for long periods and an improvement in their quality of life. We observed a progressive improvement with complete disappearance of neuropathic pain. Patients also reported a muscle strength increase that allowed them to resume normal daily activities. Discussion and Conclusion We conclude that ST may offer a therapeutic opportunity for patients with neuropathic pain resulting from CRPS, without side effects and with minimal discomfort during treatment. The observed pain relief indicates that ST could be an effective option for such patients. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

11. Scrambler Therapy(®) MC-5A for Complex Regional Pain Syndrome: Case Reports.

Author

Raucci U, Tomasello C, Marri M, Salzano M, Gasparini A, and Conicella E

Subjects
Female, Humans, Male, Pain Measurement methods, Quality of Life, Complex Regional Pain Syndromes therapy, Electric Stimulation Therapy methods, Pain Management methods
Abstract

Background: Complex regional pain syndrome (CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical therapy, regional anesthesia, and neuromodulation., Aim: We evaluated Scrambler Therapy(®) (ST) in terms of efficacy, safety, and durability of treatment effect in patients suffering from CRPS., Materials and Methods: We report the response to ST in four patients with CRPS referred to the Pain Center of Bambino Gesù Children's Hospital. The patients previously did not respond to conventional and nonconventional medical treatments., Results: The treatment with ST was found effective in all four of our patients; they obtained pain relief for long periods and an improvement in their quality of life. We observed a progressive improvement with complete disappearance of neuropathic pain. Patients also reported a muscle strength increase that allowed them to resume normal daily activities., Discussion and Conclusion: We conclude that ST may offer a therapeutic opportunity for patients with neuropathic pain resulting from CRPS, without side effects and with minimal discomfort during treatment. The observed pain relief indicates that ST could be an effective option for such patients., (© 2016 World Institute of Pain.)

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results