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4. Vaccines and Myocardial Injury in Patients Hospitalized for COVID-19 Infection: the CardioCOVID-Gemelli Study

Author

Montone, Rocco Antonio, primary, Rinaldi, Riccardo, additional, Masciocchi, Carlotta, additional, Lilli, Livia, additional, Damiani, Andrea, additional, La Vecchia, Giulia, additional, Iannaccone, Giulia, additional, Basile, Mattia, additional, Salzillo, Carmine, additional, Caff, Andrea, additional, Bonanni, Alice, additional, De Pascale, Gennaro, additional, Grieco, Domenico Luca, additional, Tanzarella, Eloisa Sofia, additional, Buonsenso, Danilo, additional, Murri, Rita, additional, Fantoni, Massimo, additional, Liuzzo, Giovanna, additional, Sanna, Tommaso, additional, Richeldi, Luca, additional, Sanguinetti, Maurizio, additional, Massetti, Massimo, additional, Trani, Carlo, additional, Tshomba, Yamume, additional, Gasbarrini, Antonio, additional, Valentini, Vincenzo, additional, Antonelli, Massimo, additional, and Crea, Filippo, additional

Published
2024
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5. Vaccines and Myocardial Injury in Patients Hospitalized for COVID-19 Infection: the CardioCOVID-Gemelli Study

Author

Montone, Rocco Antonio, Rinaldi, Riccardo, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Basile, Mattia, Salzillo, Carmine, Caff, Andrea, Bonanni, Alice, De Pascale, Gennaro, Grieco, Domenico Luca, Tanzarella, Eloisa Sofia, Buonsenso, Danilo, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Richeldi, Luca, Sanguinetti, Maurizio, Massetti, Massimo, Trani, Carlo, Tshomba, Yamume, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Massetti, Massimo (ORCID:0000-0002-7100-8478), Trani, Carlo (ORCID:0000-0001-9777-013X), Tshomba, Yamume (ORCID:0000-0001-7304-7553), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco Antonio, Rinaldi, Riccardo, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Basile, Mattia, Salzillo, Carmine, Caff, Andrea, Bonanni, Alice, De Pascale, Gennaro, Grieco, Domenico Luca, Tanzarella, Eloisa Sofia, Buonsenso, Danilo, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Richeldi, Luca, Sanguinetti, Maurizio, Massetti, Massimo, Trani, Carlo, Tshomba, Yamume, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Massetti, Massimo (ORCID:0000-0002-7100-8478), Trani, Carlo (ORCID:0000-0001-9777-013X), Tshomba, Yamume (ORCID:0000-0001-7304-7553), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

Background: Myocardial injury is prevalent among patients hospitalized for COVID-19. However, the role of COVID-19 vaccines in modifying the risk of myocardial injury is unknown. Objectives: To assess the role of vaccines in modifying the risk of myocardial injury in COVID-19. Methods: We enrolled COVID-19 patients admitted from March 2021 to February 2022 with known vaccination status and ≥1 assessment of hs-cTnI within 30 days from the admission. The primary endpoint was the occurrence of myocardial injury (hs-cTnI levels >99th percentile upper reference limit). Results: 1019 patients were included (mean age 67.7±14.8 years, 60.8% male, 34.5% vaccinated against COVID-19). Myocardial injury occurred in 145 (14.2%) patients. At multivariate logistic regression analysis, advanced age, chronic kidney disease and hypertension, but not vaccination status, were independent predictors of myocardial injury. In the analysis according to age tertiles distribution, myocardial injury occurred more frequently in the III tertile (≥76 years) compared to other tertiles (I tertile:≤60 years;II tertile:61-75 years) (p<0.001). Moreover, in the III tertile, vaccination was protective against myocardial injury (OR 0.57, CI 95% 0.34-0.94; p=0.03), while a previous history of coronary artery disease was an independent positive predictor. In contrast, in the I tertile, chronic kidney disease (OR 6.94, 95% CI 1.31-36.79, p=0.02) and vaccination (OR 4.44, 95% CI 1.28-15.34, p=0.02) were independent positive predictors of myocardial injury. Conclusions: In patients ≥76 years, COVID-19 vaccines were protective for the occurrence of myocardial injury, while in patients ≤60 years, myocardial injury was associated with previous COVID-19 vaccination. Further studies are warranted to clarify the underlying mechanisms.

Published
2024

6. Short-term air pollution exposure and mechanisms of plaque instability in acute coronary syndromes: An optical coherence tomography study

Author

Rinaldi, Riccardo, primary, Russo, Michele, additional, Bonanni, Alice, additional, Camilli, Massimiliano, additional, Caffè, Andrea, additional, Basile, Mattia, additional, Salzillo, Carmine, additional, Animati, Francesco Maria, additional, Trani, Carlo, additional, Niccoli, Giampaolo, additional, Crea, Filippo, additional, and Montone, Rocco A., additional

Published
2023
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7. Air pollution and plaque healing in acute coronary syndromes

Author

Russo, Michele, Rinaldi, Riccardo, Camilli, Massimiliano, Bonanni, Alice, Caffè, Andrea, Basile, Mattia, Salzillo, Carmine, Colucci, Michele, Torre, Ilaria, Sanna, Tommaso, Liuzzo, Giovanna, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), Montone, Rocco A, Russo, Michele, Rinaldi, Riccardo, Camilli, Massimiliano, Bonanni, Alice, Caffè, Andrea, Basile, Mattia, Salzillo, Carmine, Colucci, Michele, Torre, Ilaria, Sanna, Tommaso, Liuzzo, Giovanna, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, Crea, Filippo, Montone, Rocco Antonio, Sanna, Tommaso (ORCID:0000-0002-5760-6885), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Burzotta, Francesco (ORCID:0000-0002-6569-9401), Trani, Carlo (ORCID:0000-0001-9777-013X), Niccoli, Giampaolo (ORCID:0000-0002-3187-6262), Crea, Filippo (ORCID:0000-0001-9404-8846), and Montone, Rocco A

Abstract

N/A

Published
2023

9. Myocardial Injury Portends a Higher Risk of Mortality and Long-Term Cardiovascular Sequelae after Hospital Discharge in COVID-19 Survivors

Author

Rinaldi, Riccardo, Basile, Mattia, Salzillo, Carmine, Grieco, Domenico Luca, Caffè, Andrea, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Bonanni, Alice, De Pascale, Gennaro, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Massetti, Massimo, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, Montone, Rocco Antonio, On Behalf Of The Gemelli Against Covid Group, Null, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Massetti, Massimo (ORCID:0000-0002-7100-8478), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Crea, Filippo (ORCID:0000-0001-9404-8846), Rinaldi, Riccardo, Basile, Mattia, Salzillo, Carmine, Grieco, Domenico Luca, Caffè, Andrea, Masciocchi, Carlotta, Lilli, Livia, Damiani, Andrea, La Vecchia, Giulia, Iannaccone, Giulia, Bonanni, Alice, De Pascale, Gennaro, Murri, Rita, Fantoni, Massimo, Liuzzo, Giovanna, Sanna, Tommaso, Massetti, Massimo, Gasbarrini, Antonio, Valentini, Vincenzo, Antonelli, Massimo, Crea, Filippo, Montone, Rocco Antonio, On Behalf Of The Gemelli Against Covid Group, Null, De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Sanna, Tommaso (ORCID:0000-0002-5760-6885), Massetti, Massimo (ORCID:0000-0002-7100-8478), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Antonelli, Massimo (ORCID:0000-0003-3007-1670), and Crea, Filippo (ORCID:0000-0001-9404-8846)

Abstract

Background: Cardiovascular sequelae after COVID-19 are frequent. However, the predictors for their occurrence are still unknown. In this study, we aimed to assess whether myocardial injury during COVID-19 hospitalization is associated to CV sequelae and death after hospital discharge. Methods: In this prospective observational study, consecutive patients who were admitted for COVID-19 in a metropolitan COVID-19 hub in Italy, between March 2021 and January 2022, with a >= 1 assessment of high sensitivity cardiac troponin I (hs-cTnI) were included in the study, if they were alive at hospital discharge. Myocardial injury was defined as elevation hs-cTnI > 99th percentile of the upper reference limit. The incidence of all-cause mortality and major adverse cardiovascular and cerebrovascular events (MACCE, including cardiovascular death, admission for acute or chronic coronary syndrome, hospitalization for heart failure, and stroke/transient ischemic attack) at follow-up were the primary outcomes. Arrhythmias, inflammatory heart diseases, and/or thrombotic disorders were analyzed as well. Results: Among the 701 COVID-19 survivors (mean age 66.4 +/- 14.4 years, 40.2% female), myocardial injury occurred in 75 (10.7%) patients. At a median follow-up of 270 days (IQR 165, 380), all-cause mortality (21.3% vs. 6.1%, p < 0.001), MACCE (25.3% vs. 4.5%, p < 0.001), arrhythmias (9.3% vs. 5.0%, p = 0.034), and inflammatory heart disease (8.0% vs. 1.1%, p < 0.001) were more frequent in patients with myocardial injury compared to those without. At multivariate analysis, myocardial injury (HR 1.95 [95% CI:1.05-3.61]), age (HR 1.09 [95% CI:1.06-1.12]), and chronic kidney disease (HR 2.63 [95% CI:1.33-5.21]) were independent predictors of death. Myocardial injury (HR 3.92 [95% CI:2.07-7.42]), age (HR 1.05 [95% CI:1.02-1.08]), and diabetes (HR 2.35 [95% CI:1.25-4.43]) were independent predictors of MACCE. Conclusion: In COVID-19 survivors, myocardial injury during the hospi

Published
2022

10. Vaccines and Myocardial Injury in Patients Hospitalized for COVID-19 Infection: the CardioCOVID-Gemelli Study.

Author

Montone RA, Rinaldi R, Masciocchi C, Lilli L, Damiani A, La Vecchia G, Iannaccone G, Basile M, Salzillo C, Caffè A, Bonanni A, De Pascale G, Grieco DL, Tanzarella ES, Buonsenso D, Murri R, Fantoni M, Liuzzo G, Sanna T, Richeldi L, Sanguinetti M, Massetti M, Trani C, Tshomba Y, Gasbarrini A, Valentini V, Antonelli M, and Crea F

Abstract

Background: Myocardial injury is prevalent among patients hospitalized for COVID-19. However, the role of COVID-19 vaccines in modifying the risk of myocardial injury is unknown., Objectives: To assess the role of vaccines in modifying the risk of myocardial injury in COVID-19., Methods: We enrolled COVID-19 patients admitted from March 2021 to February 2022 with known vaccination status and ≥1 assessment of hs-cTnI within 30 days from the admission. The primary endpoint was the occurrence of myocardial injury (hs-cTnI levels >99th percentile upper reference limit)., Results: 1019 patients were included (mean age 67.7±14.8 years, 60.8% male, 34.5% vaccinated against COVID-19). Myocardial injury occurred in 145 (14.2%) patients. At multivariate logistic regression analysis, advanced age, chronic kidney disease and hypertension, but not vaccination status, were independent predictors of myocardial injury. In the analysis according to age tertiles distribution, myocardial injury occurred more frequently in the III tertile (≥76 years) compared to other tertiles (I tertile:≤60 years;II tertile:61-75 years) (p<0.001). Moreover, in the III tertile, vaccination was protective against myocardial injury (OR 0.57, CI 95% 0.34-0.94; p=0.03), while a previous history of coronary artery disease was an independent positive predictor. In contrast, in the I tertile, chronic kidney disease (OR 6.94, 95% CI 1.31-36.79, p=0.02) and vaccination (OR 4.44, 95% CI 1.28-15.34, p=0.02) were independent positive predictors of myocardial injury., Conclusions: In patients ≥76 years, COVID-19 vaccines were protective for the occurrence of myocardial injury, while in patients ≤60 years, myocardial injury was associated with previous COVID-19 vaccination. Further studies are warranted to clarify the underlying mechanisms., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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11. Air pollution and plaque healing in acute coronary syndromes.

Author

Russo M, Rinaldi R, Camilli M, Bonanni A, Caffè A, Basile M, Salzillo C, Colucci M, Torre I, Sanna T, Liuzzo G, Burzotta F, Trani C, Niccoli G, Crea F, and Montone RA

Subjects
Humans, Acute Coronary Syndrome, Plaque, Atherosclerotic, Coronary Artery Disease, Air Pollution adverse effects, Coronary Thrombosis
Abstract

Competing Interests: Conflict of interest: The authors declare that there is no conflict of interest.

Published
2023
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12. Myocardial Injury Portends a Higher Risk of Mortality and Long-Term Cardiovascular Sequelae after Hospital Discharge in COVID-19 Survivors.

Author

Rinaldi R, Basile M, Salzillo C, Grieco DL, Caffè A, Masciocchi C, Lilli L, Damiani A, La Vecchia G, Iannaccone G, Bonanni A, De Pascale G, Murri R, Fantoni M, Liuzzo G, Sanna T, Massetti M, Gasbarrini A, Valentini V, Antonelli M, Crea F, Montone RA, and On Behalf Of The Gemelli Against Covid Group

Abstract

Background: Cardiovascular sequelae after COVID-19 are frequent. However, the predictors for their occurrence are still unknown. In this study, we aimed to assess whether myocardial injury during COVID-19 hospitalization is associated to CV sequelae and death after hospital discharge. Methods: In this prospective observational study, consecutive patients who were admitted for COVID-19 in a metropolitan COVID-19 hub in Italy, between March 2021 and January 2022, with a ≥ 1 assessment of high sensitivity cardiac troponin I (hs-cTnI) were included in the study, if they were alive at hospital discharge. Myocardial injury was defined as elevation hs-cTnI > 99th percentile of the upper reference limit. The incidence of all-cause mortality and major adverse cardiovascular and cerebrovascular events (MACCE, including cardiovascular death, admission for acute or chronic coronary syndrome, hospitalization for heart failure, and stroke/transient ischemic attack) at follow-up were the primary outcomes. Arrhythmias, inflammatory heart diseases, and/or thrombotic disorders were analyzed as well. Results: Among the 701 COVID-19 survivors (mean age 66.4 ± 14.4 years, 40.2% female), myocardial injury occurred in 75 (10.7%) patients. At a median follow-up of 270 days (IQR 165, 380), all-cause mortality (21.3% vs. 6.1%, p < 0.001), MACCE (25.3% vs. 4.5%, p < 0.001), arrhythmias (9.3% vs. 5.0%, p = 0.034), and inflammatory heart disease (8.0% vs. 1.1%, p < 0.001) were more frequent in patients with myocardial injury compared to those without. At multivariate analysis, myocardial injury (HR 1.95 [95% CI:1.05−3.61]), age (HR 1.09 [95% CI:1.06−1.12]), and chronic kidney disease (HR 2.63 [95% CI:1.33−5.21]) were independent predictors of death. Myocardial injury (HR 3.92 [95% CI:2.07−7.42]), age (HR 1.05 [95% CI:1.02−1.08]), and diabetes (HR 2.35 [95% CI:1.25−4.43]) were independent predictors of MACCE. Conclusion: In COVID-19 survivors, myocardial injury during the hospital stay portends a higher risk of mortality and cardiovascular sequelae and could be considered for the risk stratification of COVID-19 sequelae in patients who are successfully discharged.

Published
2022
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