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350 results on '"Salzmann, Gian M."'

8. Response of Articular Cartilage to Hyperosmolar Stress: Report of an Ex Vivo Injury Model.

Author

Unterguggenberger, Clemens, Jahangir, Shahrbanoo, Salzmann, Gian M., Stoddart, Martin J., Grad, Sibylle, Schmal, Hagen, and Kubosch, Eva Johanna

Subjects
ARTICULAR cartilage, PHYSIOLOGIC salines, ARTHROSCOPY, DESCRIPTIVE statistics, OSMOTIC pressure, GENE expression, CARTILAGE cells, ANIMAL experimentation, CELL death, CELL survival, CONFIDENCE intervals
Abstract

Background: Physiological 0.9% saline is commonly used as an irrigation fluid in modern arthroscopy. There is a growing body of evidence that a hyperosmolar saline solution has chondroprotective effects, especially if iatrogenic injury occurs. Purpose: To (1) corroborate the superiority of a hyperosmolar saline solution regarding chondrocyte survival after mechanical injury and (2) observe the modulatory response of articular cartilage to osmotic stress and injury. Study Design: Controlled laboratory study. Methods: Osteochondral explants were isolated from bovine stifle joints and exposed to either 0.9% saline (308 mOsm) or hyperosmolar saline (600 mOsm) and then damaged with a sharp dermatome blade to attain a confined full-thickness cartilage injury site, incubated in the same fluids for another 3 hours, and transferred to chondropermissive medium for further culture for 1 week. Chondrocyte survival was assessed by confocal imaging, while the cellular response was evaluated over 1 week by relative gene expression for apoptotic and inflammatory markers and mediator release into the medium. Results: The full-thickness cartilage cut resulted in a confined zone of cell death that mainly affected superficial zone chondrocytes. Injured samples that were exposed to hyperosmolar saline showed less expansion of cell death in both the axial (P <.007) and the coronal (P <.004) plane. There was no progression of cell death during the following week of culture. Histological assessment revealed an intact cartilage matrix and normal chondrocyte morphology. Inflammatory and proapoptotic genes were upregulated on the first days postexposure with a notable downregulation toward day 7. Mediator release into the medium was concentrated on day 3. Conclusion: This in vitro cartilage injury model provides further evidence for the chondroprotective effect of a hyperosmolar saline irrigation fluid, as well as novel data on the capability of articular cartilage to quickly regain joint homeostasis after osmotic stress and injury. Clinical Relevance: Raising the osmolarity of an irrigating solution may be a simple and safe strategy to protect articular cartilage during arthroscopic surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Vergleich der Knorpelchipsplastik mit der Autologen Chondrozytentransplantation im in-vitro Inflammationsmodell

Author

Ossendorff, Robert, Grede, Lisa, Schnell, Sophie, Wirtz, Dieter C., Salzmann, Gian M., and Schildberg, Frank A.

Subjects
Minced Cartilage, Medicine and health, Knorpelrgeneration, Arthrose, Knorpelchipsplastik, ACT, MCI
Abstract

Fragestellung: Symptomatische fokale Knorpelschäden können je nach Größe und Begleitpathologie mit den etablierten operativen knorpelregenerativen Verfahren behandelt werden. Als neues operatives Verfahren der Knorpelregeneration rückt zunehmend die Knorpelchipsplastik (MCI) [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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33. The influence of the stable expression of BMP2 in fibrin clots on the remodelling and repair of osteochondral defects

Author

Vogt, Stephan, Wexel, Gabriele, Tischer, Thomas, Schillinger, Ulrike, Ueblacker, Peter, Wagner, Bettina, Hensler, Daniel, Wilisch, Jonas, Geis, Christopher, Wübbenhorst, Daniela, Aigner, Joachim, Gerg, Michael, Krüger, Achim, Salzmann, Gian M., Martinek, Vladimir, Anton, Martina, Plank, Christian, Imhoff, Andreas B., and Gansbacher, Bernd

Published
2009
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40. Arthroscopically assisted 2-bundle anatomical reduction of acute acromioclavicular joint separations

Author

Salzmann, Gian M., Walz, Lars, Buchmann, Stefan, Glabgly, Prapagorn, Venjakob, Arne, and Imhoff, Andreas B.

Subjects
Acromioclavicular joint -- Injuries, Shoulder surgery -- Methods, Shoulder surgery -- Patient outcomes, Shoulder surgery -- Research, Arthroscopy -- Research, Arthroscopy -- Usage, Shoulder joint -- Dislocation, Shoulder joint -- Care and treatment, Shoulder joint -- Patient outcomes, Shoulder joint -- Research, Joints -- Endoscopic surgery, Joints -- Research, Joints -- Usage, Health, Sports and fitness
Published
2010

47. The coracoidal insertion of the coracoclavicular ligaments: an anatomic study

Author

Salzmann, Gian M., Paul, Jochen, Sandmann, Gunther H., Imhoff, Andreas B., and Schottle, Philip B.

Subjects
Shoulder joint -- Physiological aspects, Shoulder joint -- Research, Shoulder surgery -- Methods, Shoulder surgery -- Patient outcomes, Shoulder surgery -- Research, Shoulder joint -- Dislocation, Shoulder joint -- Care and treatment, Health, Sports and fitness
Published
2008

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