Search

Objective: To identify the prevalence and predictors of metabolic syndrome using NCEP ATP III guidelines in patients with CAD who underwent angiography at Karachi Institute of Heart Disease (KIHD). Methodology: This cross-sectional study was conducted at the Department of Cardiology; Karachi Institute of Heart Disease from 1st March to 31st December 2016. Patients with confirmed diagnosis of CAD after satisfying the inclusion and exclusion criteria were recruited in this study through non-probability consecutive sampling technique. Data was collected on demographics (i.e. age, gender, and ethnicity) and co-morbidities (i.e. diabetes and hypertension). Metabolic syndrome in patients with CAD was assessed according to the 2011 NCEP ATP III guidelines. Moreover, severity of CAD in patients was also recorded as well as systolic and diastolic blood pressure and biochemical parameters. The data was analysed using SPSS version 21. Objective: To identify the prevalence and predictors of metabolic syndrome using NCEP ATP III guidelines in patients with CAD who underwent angiography at Karachi Institute of Heart Disease (KIHD). Methodology: This cross-sectional study was conducted at the Department of Cardiology; Karachi Institute of Heart Disease from 1st March to 31st December 2016. Patients with confirmed diagnosis of CAD after satisfying the inclusion and exclusion criteria were recruited in this study through non-probability consecutive sampling technique. Data was collected on demographics (i.e. age, gender, and ethnicity) and co-morbidities (i.e. diabetes and hypertension). Metabolic syndrome in patients with CAD was assessed according to the 2011 NCEP ATP III guidelines. Moreover, severity of CAD in patients was also recorded as well as systolic and diastolic blood pressure and biochemical parameters. The data was analysed using SPSS version 21. Results: Among 400 participants, majority (60%) of the participants with CAD were diagnosed with metabolic syndrome. Significantly greater proportion of females (51.2% vs. 21.9%; p = 0.001) were diagnosed with metabolic syndrome. The mean weight, height, BMI and waist circumference was significantly higher in CAD patients diagnosed with metabolic syndrome. Significant difference was not observed in severity of CAD between patients with and without metabolic syndrome. Conclusion: The study highlighted a higher prevalence of metabolic syndrome evaluated using the 2011 NCEP ATP III guidelines among patients with CAD. [ABSTRACT FROM AUTHOR]

Objective: To determine the association between serum 25 hydroxyvitamin D levels and percent breast density among asymptomatic premenopausal women., Methods: Hundred asymptomatic, pre-menopausal women who visited the General Surgery Breast Clinic, Patel Hospital, Karachi, Pakistan between 3rd March and 10th November, 2015 were included in this study. The serum 25 (OH)D and calcium levels were measured and mammographic density (MD) was assessed using automated volumetric breast density software, Volpara Research (algorithm version 1.5.1, Volpara solutions Ltd, Wellington, NZ) on the same day. The volumetric breast density (VBD) was categorized as; VG1: 0% - 4.5 %; VG2: 4.6% - 7.5%; VG3: 7.6% - 15.5% and VG4 >15.5%. Mean serum 25(OH)D and calcium levels were compared across the four volumetric breast density categories. The percent volumetric density was also correlated with anthropometric measurements and other related variables., Results: No significant difference was found in mean serum 25 (OH)D level across the four groups (15.87 Vs. 12.40 Vs. 8.99 Vs. 9.68; p-value = 0.106). The percent VBD were found significantly negatively correlated with age (r = - 0.365; p-value = 0.001), weight (r = - 0.575; p-value = 0.001), height (r = - 0.197; p-value = 0.049), and BMI (r = - 0.519; p-value = 0.001). The serum Vitamin D, and calcium levels were not found significantly correlated with percent VBD (p-value > 0.05)., Conclusion: No significant association exists between serum 25(OH)D level and breast density., Competing Interests: Declaration of interest: None.