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Antibiotics are chemical compounds elaborated by a micro-organism or produced by synthesis and whose specific activity manifests itself in doses on the micro-organisms. They are commonly used in the management of infectious pathologies in ENT and Cervico-Facial Surgery. This study aims to evaluate the use of antibiotics in the therapeutic arsenal in the ENT-CCF department of the Sikasso hospital. This is a 4-month prospective study from November 1, 2016 to February 28, 2017 on the prescription of antibiotics in the ENT department of Sikasso hospital. Four hundred (400) patients were included in this study. The following variables were collected: gender, age, occupation, reason for consultation, history, prescription and evolution. During the study period 400 patients were retained. Among which 293 benefited from a prescription of antibiotics that is 73.25% of the cases and (107 cases) 26.75% without antibiotics. The female sex was predominant with 57% of cases, i.e. a sex ratio of 1.32. More than half of the work force were made up of learners and preschoolers. The reasons for consultation were dominated by otalgia with 35.8% followed by odynophagia in 15% of cases. 76.75% of our patients had no history. The prevalence of antibiotic therapy was 73.25%, including 49.83% amoxi+clavulanic acid, 10.92% cephalosporin, 10.60% macrolides, 3.75% sulfonamides, 1.70% amoxicillin and ear drops in 23.2% of cases. Apart from antibiotic therapy, antihistamines were the most prescribed with 32.75% followed by nasal corticosteroids in 23.36% of cases. Non-steroidal anti- inflammatory drugs were associated with the antibiotic in 33.78%, followed by the analgesic-nasal corticosteroid- antihistamine combination in 15.35% of cases. The evolution was favorable in 83.62% of cases, unfavorable in 10.92% of cases and 5.46% of patients did not show up for the check-up appointment on the 7th day. It was a prospective study of four (04) months on the place of antibiotic therapy ......