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In response to urgent calls for teaching that is culturally affirming, scholars have developed a myriad of images of culturally sustaining (and related) pedagogies (CSPs). However, for maths teachers, CSPs remain elusive, in part because these images are typically content-neutral and their applicability to practice opaque. In this paper, I synthesize research to help conceptualize and clarify what CSPs may look like specifically in mathematics classrooms. I offer a framework for CSPs in mathematics comprised of four dimensions: (1) anti-assimilationism, (2) strengths-based teaching, (3) power and justice, and (4) affirming identities.

It is estimated that up to 60% of people living with dementia go missing at least once during the course of their disease. Databases on missing incidents involving people living with dementia are managed in silos with minimal or incomplete data. A national strategy for the collection of data on missing incidents of people living with dementia would optimize time and resources spent on police and search and rescue and enhance chances of saving lives of those who go missing. Such a strategy would be a first step toward developing strategies to prevent future missing person incidents among this population. The objectives of this manuscript are to: (1) describe the issues and challenges related to the lack of integrated data on people living with dementia at risk of going missing, and (2) propose directions to create a national database.

Background Although information and communication technologies (ICT) are becoming more common among health care providers, there is little evidence on how ICT can support health care aides. Health care aides, also known as personal care workers, are unlicensed service providers who encompass the second largest workforce, next to nurses, that provide care to older adults in Canada. Objective The purpose of this literature review is to examine the range and extent of barriers and benefits of ICT used by health care workers to manage and coordinate the care-delivery workflow for their clients. Methods We conducted a literature review to examine the range and extent of ICT used by health care aides to manage and coordinate their care delivery, workflow, and activities. We identified 8,958 studies of which 40 were included for descriptive analyses. Results We distinguished the following five different purposes for the use and implementation of ICT by health care aides: (1) improve everyday work, (2) access electronic health records for home care, (3) facilitate client assessment and care planning, (4) enhance communication, and (5) provide care remotely. We identified 128 barriers and 130 benefits related to adopting ICT. Most of the barriers referred to incomplete hardware and software features, time-consuming ICT adoption, heavy or increased workloads, perceived lack of usefulness of ICT, cost or budget restrictions, security and privacy concerns, and lack of integration with technologies. The benefits for health care aides' adoption of ICT were improvements in communication, support to workflows and processes, improvements in resource planning and health care aides' services, and improvements in access to information and documentation. Conclusion Health care aides are an essential part of the health care system. They provide one-on-one care to their clients in everyday tasks. Despite the scarce information related to health care aides, we identified many benefits of ICT adoption.

Gastric cancer significantly contributes to cancer mortality globally. Gastric intestinal metaplasia (GIM) is a stage in the Correa cascade and a premalignant lesion of gastric cancer. The natural history of GIM formation and progression over time is not fully understood. Currently, there are no clear guidelines on GIM surveillance or management in the United States.To investigate factors associated with GIM development over time in African American-predominant study population.This is a retrospective longitudinal study in a single tertiary hospital in Washington DC. We retrieved upper esophagogastroduodenoscopies (EGDs) with gastric biopsies from the pathology department database from January 2015 to December 2020. Patients included in the study had undergone two or more EGDs with gastric biopsy. Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD. Exclusion criteria consisted of patients age18, pregnancy, previous diagnosis of gastric cancer, and missing data including pathology results or endoscopy reports. The study population was divided into two groups based on GIM status. Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics, EGD findings, andOf 2375 patients who had at least 1 EGD with gastric biopsy, 579 patients were included in the study. 138 patients developed GIM during the study follow-up period of 1087 d on average, compared to 857 d in patients without GIM (An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation. The effect of

Global plastic production reached 368 million tonnes in 2019 (Plastics Europe, 2020), with the greatest demand being for packaging. Plastic waste management in many countries is mismanaged, with ~25% of post-consumer waste globally sent to landfill in 2018, this increases the likelihood of plastic ending up in the environment, raising concerns about the impact of plastic pollution on the environment. Microplastics (particles Microplastics are present in all environmental compartments, but research to date has focused on marine systems, leaving a substantial knowledge gap in understanding how microplastics behave in and impact other environments, especially terrestrial ones. Terrestrial soils provide key ecosystem services (e.g. food provision and climate regulation), however these services are threatened by soil pollution including from microplastics. Soils act as a sink for microplastics, which typically enter the soil through their widespread use in agriculture. Common entry pathways include the application of microplastic containing sewage sludge as fertiliser, and the direct application of microplastics via the polymer encapsulation of pesticides and seeds. Whilst the impacts of microplastics are not fully known, it is possible that they will compromise soil health and functions.We urgently need to understand how microplastics of different compositions and sources affect soil ecosystems, but research progress is hindered due to the lack of standardised protocols for the identification, extraction, and analysis of microplastics in the complex soil environment. Soil is high in organic matter, meaning protocols devised for aquatic samples are not feasible because more aggressive digestion steps are required to remove soil organics.This poster looks at the extraction and analysis of microplastics from soil samples, following a generalised framework of sieving, density separation, organic digestion, and analysis. It outlines the effectiveness of each step in the soil matrix and its applicability for both biodegradable and non-biodegradable microplastics. It compares the effect of commonly used digestion solutions (e.g. Fenton’s reagent, hydrogen peroxide) on the polymers, by using Raman spectroscopy to characterise the plastics before and after treatment, and thus to assess chemical changes arising from the sample processing. Based on these results an optimal workflow is defined as the basis for evaluating the biodegradation of microplastics in soil.

In response to the COVID-19 pandemic, elite sport leagues implemented hubs, or ‘bubbles’, which restricted athletes’ movements and social interactions in order to minimise the risk of athlete infection and allow competitions to continue. This was a new way of working and living for elite athletes and there was a dearth of literature on this topic. The main objective of the study was to investigate the impacts of the hub model on athletes over time, and what job demands and resources existed for athletes through the application of Demerouti et al. (2001) Job Demands-Resources Model. Multiple sequential semi-structured interviews were conducted with Women’s National Basketball League (WNBL) athletes during the 2020 season, which was held entirely in a hub in North Queensland, Australia. The key job demands in an elite sport hub identified were the volume of work, simultaneous overload and underload, and nature of work in the hub. The key resources that emerged include recovery services, control and player agency, and constructive social relations. Despite the presence of job resources, which work to counteract, or buffer job demands in order to reduce work stress and improve motivation, they were found to be insufficient for athletes and inequitably distributed between clubs. The intensity of the hub model also amplified demands present in all WNBL seasons. This research is therefore useful for planning of future elite sport leagues to improve the type and amount of resources available to athletes, thereby improving athlete wellbeing and performance both within and outside a hub model.

Sport official's experience of abuse in their role is well documented, but the additional gendered barriers that women officials face are not. This study used Concept Mapping to explore the most important and frequent barriers that women referees and officials in Australian basketball face. Results were analyzed according to the Socio-Ecological Framework with a feminist lens, which demonstrated the complexity and interconnectedness of barriers between different levels. While participants were not specifically asked about gendered experiences, the results indicated that barriers were overwhelmingly gendered at every level, including discriminatory resourcing, lack of senior women, and concerningly, incidents of sexual harassment. This research sheds new light on the experience of women officials and the organizational and societal barriers that limit their careers and make their workplace unsafe. Finally, it discusses where the locus of responsibility lies in addressing these issues for women sport officials, placing emphasis on the role of organizations.

The 63F early puff in the larval salivary gland polytene chromosomes contains the divergently transcribed E63-1 and E63-2 ecdysone-inducible genes. E63-1 encodes a member of the EF-hand family of Ca2+-binding proteins, while E63-2 has no apparent open reading frame. To understand the functions of the E63 genes, we have determined the temporal and spatial patterns of E63-1 protein expression, as well as undertaken a genetic analysis of the 63F puff. We show that E63-1 is expressed in many embryonic and larval tissues, but the third-instar larval salivary gland is the only tissue where increases in protein levels correlate with increases in ecdysone titer. Furthermore, the subcellular distribution of E63-1 protein changes dynamically in the salivary glands at the onset of metamorphosis. E63-1 and E63-2 null mutations, however, have no effect on development or fertility. We have characterized 40 kb of the 63F region, defined as the interval between Ubi-p and E63-2, and have identified three lethal complementation groups that correspond to the dSc-2, ida, and mge genes. We show that mge mutations lead to first-instar larval lethality and that Mge protein is similar to the Tom22 mitochondrial import proteins of fungi, suggesting that it has a role in mitochondrial function.

Crop protection products (CPPs) are subject to strict regulatory evaluation, including laboratory and field trials, prior to approval for commercial use. Laboratory tests lack environmental realism, while field trials are difficult to control. Addition of environmental complexity to laboratory systems is therefore desirable to mimic a field environment more effectively. We investigated the effect of non-UV light on the degradation of eight CPPs (chlorotoluron, prometryn, cinosulfuron, imidacloprid, lufenuron, propiconazole, fludioxonil, and benzovindiflupyr) by addition of non-UV light to standard OECD 307 guidelines. Time taken for 50% degradation of benzovindiflupyr was halved from 373 to 183 days with the inclusion of light. Similarly, time taken for 90% degradation of chlorotoluron decreased from 79 to 35 days under light conditions. Significant reductions in extractable parent compound occurred under light conditions for prometryn (4%), imidacloprid (8%), and fludioxonil (24%) compared to dark controls. However, a significantly slower rate of cinosulfuron (14%) transformation was observed under light compared to dark conditions. Under light conditions, nonextractable residues were significantly higher for seven of the CPPs. Soil biological and chemical analyses suggest that light stimulates phototroph growth, which may directly and/or indirectly impact CPP degradation rates. The results of this study strongly suggest that light is an important parameter affecting CPP degradation, and inclusion of light into regulatory studies may enhance their environmental realism.

Background It has long been known that fatigue and breathlessness for patients with a life limiting illness is prevalent and is frequently rated as having a greater impact on quality of life than pain (Hoekstra et al 2007). It has also been shown that often it is not addressed adequately, (Coakley et al 2002). Patients believe that the symptoms are an inevitable part of their disease and patient, carers and some health professionals misguidedly use rest as a coping strategy. In 2007, in order to address these issues in a group setting, the first Fatigue and Breathlessness course commenced at St Peter9s Hospice, Bristol. Topics covered on the course are fatigue, breathlessness, benefits of exercise, energy conservation, sleep, anxiety management and nutrition. Patients themselves set goals, and are encouraged to practise what they have learnt in the group at home. One of the biggest challenges has been how to measure the effectiveness of the programme. As highlighted by Pearson et al (2007) ‘this poses significant problems in palliative care due to the declining function of clients that confounds the apparent effectiveness of the intervention’. An assessment tool has now been introduced which asks patients to measure their symptoms using a visual analogue scale (VAS), alongside a questionnaire which gives a qualitative assessment of abilities and focuses on goal achievement. Aim To measure the effectiveness of the course using pre and post VAS scores and qualitative assessment tools such as goal setting and questionnaires. Conclusion Goal setting and patient feedback proved to be the most effective tools in providing measurable and meaningful outcomes. This demonstrated a high patient satisfaction rate and improvement in quality of life. We can now provide evidence for the effectiveness of the course in a palliative setting.

Introduction New drugs have significantly improved the outcome of MM patients (pts) increasing both progression free survival (PFS) and overall survival (OS). Among new drugs lenalidomide (LEN) due to its oral availability and favourable toxicity profile is an attractive option both as an induction and as a maintenance treatment, with different studies demonstrating its effectiveness. Long term therapy with LEN, however, has been associated with an increased risk of developing SPMs. Aims We are conducting a large phase III study to evaluate the use of LEN as induction and/or as maintenance therapy. The primary end points of the study are OS and PFS. Secondary end points are response and toxicity. Methods Pts are treated following an intensive or a non intensive pathway based on their eligibility for high dose Melphalan (HDM) and stem cell transplantation (ASCT) and are randomised to receive induction therapy with cyclophosphamide and dexamethasone combined with either LEN (CRD) or thalidomide (CTD). Pts failing to achieve an optimal response are randomised to receive additional therapy with cyclophosphamide, dexamethasone and bortezomib (CVD) or no extra therapy. Pts with minimal or no response will automatically receive further therapy with CVD. A randomisation between LEN maintenance and no maintenance is also performed. Data on the occurrence of SPMs are being routinely collected as part of safety assessment during all protocol phases and follow up. Analyses were performed on treatment actually received. Results As per cut off of the 23rd July, 2371 pts have undergone the induction randomisation, of which 2368 are eligible for the safety analysis; 794 pts entered maintenance randomisation. The median follow up is 1.36 years from initiation of the study and 1.06 years from maintenance randomisation. Localised skin cancer other than melanoma were considered as non-invasive SPMs. At the time of the present analysis 17 SPMs have been reported with a cumulative incidence rate of 0.7% (cumulative rate of 0.6% for invasive SPMs and 0.1% for non-invasive SPMs); four additional patients, reported as having a SPM, were excluded, after central review of the data, either due to a previous history of malignancy or because of the evidence of a pre-existing tumour other than MM at the time of study entry. The median age at the time of SPMs development is 72 years (range 61-92), and the median time from trial entry to development of SPMs is 11 months (range 2.1-27.0). The most common SPMs reported were squamous cell carcinoma (4 pts, 2 invasive and 2 non invasive), breast cancer (3 pts), colon cancer (2 pts) and prostate cancer (2 pts). No haematological SPM has so far been reported. One patient, treated according to the intensive arm with LEN both as induction and maintenance, was reported as having a suspect myelodysplasia (MDS) due to anaemia and thrombocytopenia 2.7 months after entering the maintenance randomisation. No clear histological sign of MDS was found and the values improved after stopping maintenance treatment; these data fit with treatment related toxicity and not with the development of a MDS, and the patient was excluded from this analysis. Ten out of 17 SPMs developed during maintenance treatment or follow up phase, with 7 patients having received LEN maintenance. Median time from maintenance randomisation to SPMs development is 7 months (range 2-20.6 months). The remaining 7 were diagnosed during or immediately after induction. About half of the patients (8/17) were randomised to receive LEN induction; 3 patients received LEN both as induction and as maintenance. Interestingly only one of those 3 pts had been treated according to the intensive arm. With a median follow up of 1.36 years the estimated incidence rate at 1 and 2 years are 0.70% (95% CI .40-1.22)and 1.17% (95% CI .70-1.96) respectively (Figure 1). Conclusions Our data do not confirm previous findings of an excess risk of SPMs in association with the use of LEN and HDM in presenting patients, with 12/17 pts developing SPMs treated on the non intensive pathway that does not contain HDM. Most importantly only 0.4% of the patients enrolled within the intensive pathway developed a SPM, with only 2 of them receiving LEN maintenance. Longer follow up will help to further elucidate the risk of LEN associated SPMs. On behalf of the NCRI Haemato-Oncology subgroup Disclosures: Brioli: Celgene: Honoraria. Off Label Use: The presentation include the use of Lenalidomide as induction and as maintenance treatment for newly diagnosed multiple myeloma patients. Cook:Janssen: Honoraria, Research Funding, Speakers Bureau. Cavo:Celgene: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Janssen: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Millenium: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Onyx: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Bristol-Meyer Squibb: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees. Morgan:Celgene: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Millenium: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Novartis: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Merck: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees; Johnson and Johnson: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees.