9 results on '"Samarjit S. Ghuman"'
Search Results
2. Correlation of epicardial fat quantification with severity of coronary artery disease: A study in Indian population
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Rishabh Khurana, Anurag Yadav, T.B.S. Buxi, J.P.S. Sawhney, Kishan Singh Rawat, and Samarjit S. Ghuman
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Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: We studied the correlation of quantified epicardial fat with severity of coronary artery disease in patients [suspected cases of coronary artery disease (CAD)] referred for computed tomography (CT) coronary angiography and established cutoffs for epicardial fat volume (EFV) for the presence of CAD and obstructive CAD. Methods: A prospective cum retrospective cross-sectional observational study was carried out on 950 Indian subjects (suspected cases of CAD) who were referred for coronary CT in the year 2013–2016. EFV was quantified using semiautomatic technique on multidetector coronary CT angiography. The presence of atherosclerotic plaques and degree of stenosis was assessed on coronary CT angiography scans. The correlation between quantified EFV and degree of stenosis was assessed. Multivariate analysis was also performed. Results: A higher quantity of epicardial fat is found in patients with increasing severity of coronary artery stenosis. The EFV cutoff for the presence of CAD and obstructive CAD are 49.75 and 67.69 mL with area under the curve, sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of 0.68, 81%, 45.9%,58.24%, 72.2%, and 62.84% and 0.709, 64.9%, 66.4%, 35.84%, 86.55%, and 66%, respectively. EFV correlates with age, weight, and body mass index (BMI). Multivariate analysis revealed EFV to be an independent risk factor for the presence of CAD. Conclusions: Higher quantities of EFV are found in patients with greater degree of coronary artery stenosis. EFV correlates with age, weight, and BMI. EFV is an independent risk factor for CAD. Keywords: Epicardial fat, Epicardial fat volume, Epicardial fat quantification, Regional thoracic fat depots
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- 2018
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3. Imaging of Kaposi sarcoma in a transplanted liver: A rare case report
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Saumya Gupta, Samarjit S. Ghuman, T.B.S. Buxi, Hariprasad Sudarsan, Sankalp Sethi, Ajit K. Yadav, Anurag Yadav, Kishan S. Rawat, Naimish Mehta, and Seema Rao
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Kaposi sarcoma ,Liver transplant ,Immunotherapy ,Lymphoproliferative disease ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
In post-transplant patients, de novo malignancies such as post-transplant lymphoproliferative disease (PTLD), lung carcinoma, renal cell carcinoma, cutaneous malignancies, and Kaposi sarcoma are now seen. The immunotherapy used to prevent graft failure indirectly increases their risk. We present a rare case of visceral Kaposi sarcoma in a patient with orthotopic liver transplant.
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- 2015
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4. Non-traditional tools for predicting coronary artery disease
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RISHABH KHURANA, ANURAG YADAV, T.B.S. BUXI, KISHAN SINGH RAWAT, and SAMARJIT S. GHUMAN
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General Medicine - Abstract
Background The traditional coronary calcium score (CCS) is a time-tested tool for the evaluation of coronary atherosclerosis and predictor of future cardiovascular events. Non-traditional tools can also have a value in predicting and detecting subclinical coronary artery disease (CAD). Methods We studied the role of CCS, the traditional CAD risk predictor, and the less-recognized, non-traditional risk factors, i.e. epicardial fat volume (EFV) and thoracic extracoronary calcium (ECC), to assess the degree of subclinical CAD. In this cross-sectional observational study, we included 950 Indian patients (suspected to have CAD). Coronary computed tomography angiography was performed. Estimation of CCS, EFV and thoracic ECC was done. Results A CCS of 0 was seen in 583 patients (61.4%). Of these, 492 patients had normal coronary angiogram but 91 patients had CAD. The median values of EFV were statistically significantly higher in the ‘CAD present and CCS 0’ group compared to the ‘CAD absent and CCS 0’ group (p Conclusion The combined use of traditional CCS along with non-traditional EFV may guide us in better profiling cardiovascular risk and supplement the various traditional cardiovascular risk factors/scores.
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- 2023
5. The Abernethy malformation-myriad imaging manifestations of a single entity
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Samarjit S Ghuman, Saumya Gupta, T B S Buxi, Kishan S Rawat, Anurag Yadav, Naimish Mehta, and Seema Sud
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abernethy malformation ,congenital extrahepatic portosystemic shunts ,portosystemic shunts ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abernethy malformation, also known as congenital extrahepatic portosystemic shunts (CEPS) is a rare clinical entity and manifests with different clinical symptoms. CEPS are abnormalities of vascular development where there is shunting of portal blood into the systemic venous system. Multidetector computed tomography (MDCT) is a fast and effective modality for evaluation of CEPS. CT displays all the information desired by the surgeon as well as the clinician including the anatomy of the splenic and superior mesenteric veins, size and site of the shunt, presence or absence of the portal vein radicles, and helps to plan the therapy and even the follow-up of these patients. Contrast-enhanced magnetic resonance imaging (MRI) has also emerged as a promising tool for the evaluation of liver lesions associated with the malformation. The Radiologist should be aware of the various imaging appearances of this entity including its complications. In this article, we describe the imaging appearances of CEPS, their complications, and their imaging appearances on CT and MRI. We have also described various associated anomalies.
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- 2016
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6. Caudate Lobe Liver Abscess: Laparoscopic Drainage the best approach
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Samarjit S Ghuman, Ushast Dhir, Suresh Singhvi, and Saumitr Rawat
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medicine.medical_specialty ,Hepatology ,business.industry ,Gastroenterology ,medicine ,Caudate lobe ,Drainage ,business ,medicine.disease ,Surgery ,Liver abscess - Published
- 2019
7. Effect of prostaglandin on cell membrane permeability and hepatic high-energy stores following hemorrhagic shock
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Benjamin F. Rush, George Dikdan, Paul J. Loverme, Samarjit S. Ghuman, George W. Machiedo, and Thomas Kraven
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Male ,Purine ,medicine.medical_specialty ,Cell Membrane Permeability ,Phosphocreatine ,medicine.medical_treatment ,Prostaglandin ,Shock, Hemorrhagic ,Biology ,Placebo ,Creatine ,Phosphates ,chemistry.chemical_compound ,Adenosine Triphosphate ,Internal medicine ,medicine ,Animals ,Prostaglandin E1 ,Saline ,Prostaglandins E ,Rats, Inbred Strains ,Rats ,Endocrinology ,Liver ,chemistry ,Biochemistry ,Shock (circulatory) ,Lactates ,Surgery ,medicine.symptom ,Intracellular - Abstract
Infusion of prostaglandin E1 is known to exert a beneficial effect in hemorrhagic shock. It is also known that hemorrhagic shock lowers hepatic stores of high-energy phosphates and that restoration of hepatic ATP is associated with improved organ function and survival. The present study was undertaken to evaluate the effect of infusion of exogenous prostaglandin E1 on (1) hepatic ATP levels and (2) restoration of hepatic ATP-dependent intracellular function. Rats were subjected to hemorrhagic shock, resuscitated, and then treated with either prostaglandin E1 or a saline placebo. Ten minutes after the completion of treatment, hepatic ATP levels were significantly higher in prostaglandin-treated animals (1.37 ± 0.43 μmol/g) than in animals receiving the placebo (0.70 ± 0.11 μmol/g). Creatine phosphate levels were also higher in the prostaglandin-treated group (1.59 ± 0.16 μmol/g) than in the placebo-treated group (0.89 ± 0.14 μmol/g). Lactate production ratios, an index of ATP-dependent membrane function, were near the theoretical normal of 100% in unshocked, untreated animals (95 ± 10%). They were significantly reduced (57 ± 10%) in animals receiving only placebo, but were not significantly different from unshocked animals in those receiving prostaglandin E1 following shock (91 ± 10%). It is concluded that prostaglandin infusion improves both hepatic high-energy phosphate levels and ATP-dependent intracellular function following hemorrhagic shock. This might be due to replenishing the purine base, selectively increasing hepatic blood flow, or both.
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- 1982
8. Percutaneous Recanalization of Anastomotic Portal Vein in a Pediatric Patient After Liver Transplant Without Any Recognizable Portal Vein Remnant on Imaging.
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Gupta A, Gangwani G, Mehta N, Wadhwa N, Ghuman S, and Yadav A
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- Anastomosis, Surgical, Angiography, Digital Subtraction, Biliary Atresia diagnostic imaging, Female, Humans, Infant, Liver Cirrhosis diagnostic imaging, Phlebography, Portal Vein diagnostic imaging, Portal Vein physiopathology, Stents, Treatment Outcome, Vascular Patency, Venous Thrombosis diagnostic imaging, Venous Thrombosis etiology, Venous Thrombosis physiopathology, Biliary Atresia surgery, Endovascular Procedures instrumentation, Liver Cirrhosis surgery, Liver Transplantation adverse effects, Portal Vein surgery, Venous Thrombosis therapy
- Abstract
In patients with complete portal vein thrombosis, the main portal vein is obstructed, resulting in development of hepatopetal collateral vessels. In cases of complete portal vein thrombosis, interventional procedures are challenging, with the greatest difficulty in the form of passing the guide wire across the level of obstruction. A recognizable main portal vein remnant has been deemed as a mandatory criterion in previous reports. Here, we report a case of cavernous trans-formation of the portal vein in a pediatric patient after liver transplant who had no obvious detectable portal vein remnant on radiologic imaging. Using digital subtraction angiography, we were successful in passing a guide wire through the level of obstruction and placing a stent, thus causing successful recanalization of the occluded segment.
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- 2020
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9. Living donor intestinal transplant using a standardized technique: first report from India.
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Kumaran V, Mehta NN, Varma V, Pandey S, Rao PS, Nath B, Mallya A, Bansal N, Ghuman S, Bhalla S, and Nundy S
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- Adult, Gangrene etiology, Gangrene surgery, Humans, India, Intestine, Small pathology, Male, Parenteral Nutrition, Thrombosis complications, Treatment Outcome, Intestine, Small transplantation, Living Donors, Mesenteric Artery, Superior surgery
- Abstract
Aim: We describe the first living donor intestinal transplant (LDIT) in India and discuss the indications and problems of this complex procedure., Methods: A 43-year-old male patient required massive bowel resection for gangrene due to thrombosis of the superior mesenteric artery. He was maintained on parenteral nutrition but developed cholestasis and well as repeated catheter related infections with progressive loss of venous access due to thrombosis of central veins. A LDIT was performed using 200 cm of small intestine from the patient's son. The graft was based on the continuation of the superior mesenteric vessels beyond the ileocolic branch. The artery was anastomosed directly to the aorta and the vein to the venacava., Results: The graft functioned well and he was weaned off parenteral nutrition. However, he later developed complications (wound dehiscence and enterocutaneous fistula) and developed sepsis. He succumbed to sepsis with a functioning graft 6 weeks after the transplant. The donor recovered uneventfully and was discharged on the 4th postoperative day., Conclusions: LDIT can be life saving in patients with intestinal failure and failure of parenteral nutrition. There is a need to introduce this modality in India. In a setting of scarcity of deceased donor organs the living donor option has advantages.
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- 2012
- Full Text
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