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3. Rabies awareness in eight Asian countries

Author

Dodet, Betty, Goswami, Amlan, Gunasekera, Amila, de Guzman, Ferdinand, Jamali, Seemin, Montalban, Cecilia, Purba, Wilfried, Quiambao, Beatriz, Salahuddin, Naseem, Sampath, Gadey, Tang, Qing, Tantawichien, Terapong, Wimalaratne, Omala, and Ziauddin, Ahmad

Published
2008
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4. Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman-Moore strain) manufactured in India

Author

Narayana, Doddabele Hanumanthaiah Ashwath, Madhusudana, Shampur Narayana, Sampath, Gadey, Tripathy, Radhe Madhab, Sudarshan, Mysore Kalappa, Gangaboraiah, Ravish, Haradanahalli Shankaraiah, Satapathy, Durga Madhab, Gowda, Giriyanna, Holla, Ramesh, Ashwin, Belludi Yajman, Padhi, Asutosh, Manjula, Shamanna, and Patel, Pradip Maganlal

Published
2014
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5. A comparative study on the immunogenicity, safety and tolerance of purified duck embryo vaccine (PDEV) manufactured in India (Vaxirab) and Switzerland (Lyssavac-N): A randomized simulated post-exposure study in healthy volunteers

Author

Mahendra, Bangalore Jayakrishnappa, Madhusudana, Shampur Narayan, Ashwathnarayana, Doddabele Hanumanthaiah, Sampath, Gadey, datta, Soma Subhra, Sudarshan, Mysore Kalappa, Venkatesh, Gonibeedu Manjunatah, Muhamuda, Kader, Bilagumba, Gangaboraiah, and Shamanna, Manjula

Published
2007
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10. Immunogenicity and safety study of Indirab: A Vero cell based chromatographically purified human rabies vaccine

Author

Sampath, Gadey, primary, Madhusudana, Shampur Narayan, additional, Sudarshan, Mysore Kalappa, additional, Ashwathnarayana, Doddabele Hanumanthaiah, additional, Mahendra, Bangalore Jayakrishna, additional, Ullas, Thankappan P., additional, Mohan, Krishna, additional, Madhusudhan, Santhosh Kumar, additional, and Ravish, Haradanahalli Shankariah, additional

Published
2010
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11. Safety and immunogenicity study of a new purified chick embryo cell rabies vaccine Vaxirab-N (Pitman-Moore strain) manufactured in India.

Author

Ashwath Narayana, Doddabele Hanumanthaiah, Narayana Madhusudana, Shampur, Sampath, Gadey, Madhab Tripathy, Radhe, Kalappa Sudarshan, Mysore, Gangaboraiah, Shankaraiah Ravish, Haradanahalli, Madhab Satapathy, Durga, Gowda, Giriyanna, Holla, Ramesh, Yajman Ashwin, Belludi, Padhi, Asutosh, Manjula, Shamanna, and Maganlal Patel, Pradip

Published
2014
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12. A comparative study on the safety and immunogenicity of purified duck embryo cell vaccine (PDEV, Vaxirab) with purified chick embryo cell vaccine (PCEC, Rabipur) and purifed vero cell rabies vaccine (PVRV, Verorab)

Author

Ashwathnarayana, Doddabele Hanumantaiah, Madhusudana, Shampur Narayana, Sampath, Gadey, Sathpathy, Durga Madhab, Mankeshwar, Ranjit, Ravish, Haradana Halli Shankariah, Ullas, Padinjaremattathil Thankappan, Behra, Tapas Ranjan, Sudarshan, Mysore Kalappa, Gangaboraiah, and Shamanna, Manjula

Subjects
*MEDICATION safety, *IMMUNOGENETICS, *COMPARATIVE studies, *EMBRYOS, *RABIES vaccines, *CELL culture, *DRUG tolerance, *CLINICAL trials
Abstract

Abstract: Rabies is a fatal but preventable disease. Cell culture vaccines (CCV) and purified duck embryo vaccines (PDEV) are currently recommended by WHO for post-exposure prophylaxis. In India, a PDEV (Vaxirab) is being manufactured and is in use since 2003. In the present study, we have evaluated the safety, immunogenicity and tolerance of this vaccine with two other WHO approved CCVs, viz., purified chick embryo cell vaccine (PCEC, Rabipur) and purified vero cell rabies vaccine (PVRV, Veroroab). This study was an open label, randomized phase IV comparative clinical trial. A total of 152 people bitten by dogs and other animals were recruited from 4 different centres from India. They were randomly assigned to receive one of the vaccines by Essen intramuscular regimen (52 subjects received Vaxirab and 50 each Rabipur and Verorab) and rabies immunoglobulin was also administered in all category III exposures. Their blood samples were collected on day 0 (prior to vaccination), 14, 28, 90 and 180. Side effects if any were monitored. The rabies neutralizing antibody titers in their blood samples were estimated by the rapid fluorescent focus inhibition test (RFFIT). Subjects in all three groups had neutralizing antibody titers by day 14 (>0.5IU/mL) and geometric mean titers (GMT) observed for different vaccines on all days tested did not vary significantly (p >0.5). Side effects observed were minimal and did not vary significantly among the groups. The results of the present study indicate that PDEV (Vaxirab) is as safe, tolerable and immunogenic as both PCEC (Rabipur) and PVRV (Verorab). Thus this vaccine can be a good alternative to WHO approved CCVs for rabies post-exposure prophylaxis. [Copyright &y& Elsevier]

Published
2009
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13. Corrigendum to “A comparative study on the safety and immunogenecity of purified duck embryo cell vaccine (PDEV, VAXIRAB) with purified chick embryo cell vaccine (PCEC, RABIPUR) and purified vero cell rabies vaccine (PVRV, VERORAB)” Vaccine 28 (2010) 148–151

Author

Ashwathnarayana, Doddabele Hanumantaiah, Madhusudana, Shampur Narayana, Sampath, Gadey, Sathpathy, Durga Madhab, Mankeshwar, Ranjit, Ravish, Haradana Halli Shankariah, Ullas, Padinjaremattathil Thankappan, Behra, Tapas Ranjan, Sudarshan, Mysore Kalappa, Gangaboraiah, and Shamanna, Manjula

Published
2010
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