120 results on '"San Román, Luis"'
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2. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy
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Halliday, Alison, Bulbulia, Richard, Bonati, Leo H, Peto, Richard, Pan, Hongchao, Potter, John, Henning Eckstein, Hans, Farrell, Barbara, Flather, Marcus, Mansfield, Averil, Mihaylova, Boby, Rahimi, Kazim, Simpson, David, Thomas, Dafydd, Sandercock, Peter, Gray, Richard, Molyneux, Andrew, Shearman, Cliff P, Rothwell, Peter, Belli, Anna, Herrington, Will, Judge, Parminder, Leopold, Peter, Mafham, Marion, Gough, Michael, Cao, Piergiorgio, MacDonald, Sumaira, Bari, Vasha, Berry, Clive, Bradshaw, S, Brudlo, Wojciech, Clarke, Alison, Chester, Johanna, Cox, Robin, Cradduck-Bamford, Andrea, Fathers, Susan, Gaba, Kamran, Gray, Mo, Hayter, Elizabeth, Holliday, Constance, Kurien, Rijo, Lay, Michael, le Conte, Steffi, McManus, Jessica, Madgwick, Zahra, Morris, Dylan, Munday, Andrew, Pickworth, Sandra, Ostasz, Wiktor, Poorthuis, Michiel, Richards, Sue, Teixeira, Louisa, Tochlin, Sergey, Tully, Lynda, Wallis, Carol, Willet, Monique, Young, Alan, Casana, Renato, Malloggi, Chiara, Odero Jr, Andrea, Silani, Vincenzo, Parati, Gianfranco, Malchiodi, Giuseppe, Malferrari, Giovanni, Strozzi, Francesco, Tusini, Nicola, Vecchiati, Enrico, Coppi, Gioacchino, Lauricella, Antonio, Moratto, Roberto, Silingardi, Roberto, Veronesi, Jessica, Zini, Andrea, Ferrero, Emanuele, Ferri, Michelangelo, Gaggiano, Andrea, Labate, Carmelo, Nessi, Franco, Psacharopulo, Daniele, Viazzo, Andrea, Malacrida, Giovanni, Mazzaccaro, Daniela, Meola, Giovanni, Modafferi, Alfredo, Nano, Giovanni, Occhiuto, Maria Teresa, Righini, Paolo, Stegher, Silvia, Chiarandini, Stefano, Griselli, Filippo, Lepidi, Sandro, Pozzi Mucelli, Fabio, Naccarato, Marcello, D'Oria, Mario, Ziani, Barbara, Stella, Andrea, Dieng, Mortalla, Faggioli, Gianluca, Gargiulo, Mauro, Palermo, Sergio, Pini, Rodolfo, Puddu, Giovanni Maria, Vacirca, Andrea, Angiletta, Domenico, Desantis, Claudio, Marinazzo, Davide, Mastrangelo, Giovanni, Regina, Guido, Pulli, Raffaele, Bianchi, Paolo, Cireni, Lea, Coppi, Elisabetta, Pizzirusso, Rocco, Scalise, Filippo, Sorropago, Giovanni, Tolva, Valerio, Caso, Valeria, Cieri, Enrico, DeRango, Paola, Farchioni, Luca, Isernia, Giacomo, Lenti, Massimo, Parlani, Gian Battista, Pupo, Guglielmo, Pula, Grazia, Simonte, Gioele, Verzini, Fabio, Carimati, Federico, Delodovici, Maria Luisa, Fontana, Federico, Piffaretti, Gabriele, Tozzi, Matteo, Civilini, Efrem, Poletto, Giorgio, Reimers, Bernhard, Praquin, Barbara, Ronchey, Sonia, Capoccia, Laura, Mansour, Wassim, Sbarigia, Enrico, Speziale, Francesco, Sirignano, Pasqualino, Toni, Danilo, Galeotti, Roberto, Gasbarro, Vincenzo, Mascoli, Francesco, Rocca, Tiberio, Tsolaki, Elpiniki, Bernardini, Giulia, DeMarco, Ester, Giaquinta, Alessia, Patti, Francesco, Veroux, Massimiliano, Veroux, Pierfrancesco, Virgilio, Carla, Mangialardi, Nicola, Orrico, Matteo, Di Lazzaro, Vincenzo, Montelione, Nunzio, Spinelli, Francesco, Stilo, Francesco, Cernetti, Carlo, Irsara, Sandro, Maccarrone, Giuseppe, Tonello, Diego, Visonà, Adriana, Zalunardo, Beniamino, Chisci, Emiliano, Michelagnoli, Stefano, Troisi, Nicola, Masato, Maela, Dei Negri, Massimo, Pacchioni, Andrea, Saccà, Salvatore, Amatucci, Giovanni, Cannizzaro, Alfredo, Accrocca, Federico, Ambrogi, Cesare, Barbazza, Renzo, Marcucci, Giustino, Siani, Andrea, Bajardi, Guido, Savettieri, Giovanni, Argentieri, Angelo, Corbetta, Riccardo, Odero, Attilio, Quaretti, Pietro, Thyrion, Federico Z, Cappelli, Alessandro, Benevento, Domenico, De Donato, Gianmarco, Mele, Maria Agnese, Palasciano, Giancarlo, Pieragalli, Daniela, Rossi, Alessandro, Setacci, Carlo, Setacci, Francesco, Palombo, Domenico, Perfumo, Maria Cecilia, Martelli, Edoardo, Paolucci, Aldo, Trimarchi, Santi, Grassi, Viviana, Grimaldi, Luigi, La Rosa, Giuliana, Mirabella, Domenico, Scialabba, Matteo, Sichel, Leonildo, D'Angelo, Costantino L, Fadda, Gian Franco, Kasemi, Holta, Marino, Mario, Burzotta, Francesco, Codispoti, Francesco Alberto, Ferrante, Angela, Tinelli, Giovanni, Tshomba, Yamume, Vincenzoni, Claudio, Amis, Deborah, Anderson, Dawn, Catterson, Martin, Clarke, Mike, Davis, Michelle, Dixit, Anand, Dyker, Alexander, Ford, Gary, Jackson, Ralph, Kappadath, Sreevalsan, Lambert, David, Lees, Tim, Louw, Stephen, McCaslin, James, Parr, Noala, Robson, Rebecca, Stansby, Gerard, Wales, Lucy, Wealleans, Vera, Wilson, Lesley, Wyatt, Michael, Baht, Hardeep, Balogun, Ibrahim, Burger, Ilse, Cosier, Tracy, Cowie, Linda, Gunathilagan, Gunaratnam, Hargroves, David, Insall, Robert, Jones, Sally, Rudenko, Hannah, Schumacher, Natasha, Senaratne, Jawaharlal, Thomas, George, Thomson, Audrey, Webb, Tom, Brown, Ellen, Esisi, Bernard, Mehrzad, Ali, MacSweeney, Shane, McConachie, Norman, Southam, Alison, Sunman, Wayne, Abdul-Hamiq, Ahmed, Bryce, Jenny, Chetter, Ian, Ettles, Duncan, Lakshminarayan, Raghuram, Mitchelson, Kim, Rhymes, Christopher, Robinson, Graham, Scott, Paul, Vickers, Alison, Ashleigh, Ray, Butterfield, Stephen, Gamble, Ed, Ghosh, Jonathan, McCollum, Charles N, Welch, Mark, Welsh, Sarah, Wolowczyk, Leszek, Donnelly, Mary, D'Souza, Stephen, Egun, Anselm A, Gregary, Bindu, Joseph, Thomas, Kelly, Christine, Punekar, Shuja, Rahi, M Asad, Raj, Sonia, Seriki, Dare, Thomson, George, Brown, James, Durairajan, Ragunath, Grunwald, Iris, Guyler, Paul, Harman, Paula, Jakeways, Matthew, Khuoge, Christopher, Kundu, Ashish, Loganathan, Thayalini, Menon, Nisha, Prabakaran, Raji O, Sinha, Devesh, Thompson, Vicky, Tysoe, Sharon, Briley, Dennis, Darby, Chris, Hands, Linda, Howard, Dominic, Kuker, Wilhelm, Schulz, Ursula, Teal, Rachel, Barer, David, Brown, Andrew, Crawford, Susan, Dunlop, Paul, Krishnamurthy, Ramesh, Majmudar, Nikhil, Mitchell, Duncan, Myint, Min P, O'Brien, Richard, O'Connell, Janice, Sattar, Naweed, Vetrivel, Shanmugam, Beard, Jonathan, Cleveland, Trevor, Gaines, Peter, Humphreys, John, Jenkins, Alison, King, Craig, Kusuma, Daniel, Lindert, Ralph, Lonsdale, Robbie, Nair, Raj, Nawaz, Shah, Okhuoya, Faith, Turner, Douglas, Venables, Graham, Dorman, Paul, Hughes, Andrea, Jones, Deborah, Mendelow, David, Rodgers, Helen, Raudoniitis, Aidas, Enevoldson, Peter, Nahser, Hans, O'Brien, Imelda, Torella, Francesco, Watling, Dave, White, Richard, Brown, Pauline, Dutta, Dipankar, Emerson, Lorraine, Hilltout, Paula, Kulkarni, Sachin, Morrison, Jackie, Poskitt, Keith, Slim, Fiona, Smith, Sarah, Tyler, Amanda, Waldron, Joanne, Whyman, Mark, Bajoriene, Milda, Baker, Lucy, Colston, Amanda, Eliot-Jones, Bekky, Gramizadeh, Gita, Lewis-Clarke, Catherine, McCafferty, Laura, Oliver, Deborah, Palmer, Debbie, Patil, Abhijeet, Pegler, Suzannah, Ramadurai, Gopi, Roberts, Aisling, Sargent, Tracey, Siddegowda, Shivaprasad, Singh-Ranger, Ravi, Williams, Akintunde, Williams, Lucy, Windebank, Steve, Zuromskis, Tadas, Alwis, Lanka, Angus, Jane, Asokanathan, Asaipillai, Fornolles, Caroline, Hardy, Diana, Hunte, Sophy, Justin, Frances, Phiri, Duke, Mitabouana-Kibou, Marie, Sekaran, Lakshmanan, Sethuraman, Sakthivel, Tate, Margaret L, Akyea-Mensah, Joyce, Ball, Stephen, Chrisopoulou, Angela, Keene, Elizabeth, Phair, Alison, Rogers, Steven, Smyth, John V, Bicknell, Colin, Chataway, Jeremy, Cheshire, Nicholas, Clifton, Andrew, Eley, Caroline, Gibbs, Richard, Hamady, Mohammad, Hazel, Beth, James, Alex, Jenkins, Michael, Khanom, Nyma, Lacey, Austin, Mireskandari, Maz, O'Reilly, Joanna, Pereira, Antony, Sachs, Tina, Wolfe, John, Davey, Philip, Rogers, Gill, Smith, Gemma, Tervit, Gareth, Nichol, Ian, Parry, Andrew, Young, Gavin, Ashley, Simon, Barwell, James, Dix, Francis, Nor, Azlisham M, Parry, Chris, Birt, Angela, Davies, Paul, George, Jim, Graham, Anne, Jonker, Leon, Kelsall, Nicci, Potts, Caroline, Wilson, Toni, Crinnion, Jamie, Cuenoud, Larissa, Aleksic, Nikola, Babic, Srdan, Ilijevski, Nenad, Radak, Đorde, Sagic, Dragan, Tanaskovic, Slobodan, Colic, Momcilo, Cvetic, Vladimir, Davidovic, Lazar, Jovanovic, Dejana R, Koncar, Igor, Mutavdžic, Perica, Sladojevic, Miloš, Tomic, Ivan, Debus, Eike S, Grzyska, Ulrich, Otto, Dagmar, Thomalla, Götz, Barlinn, Jessica, Gerber, Johannes, Haase, Kathrin, 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Groden, Christoph, Cöster, Andreas, Engelhardt, Andreas, Ratusinski, Christoph-Maria, Berg, Bengt, Delle, Martin, Formgren, Johan, Gillgren, Peter, Jarl, Lotta, Kall, Torbjörn B, Konrad, Peter, Nyman, Niklas, Skiöldebrand, Claes, Steuer, Johnny, Takolander, Rabbe, Malmstedt, Jonas, Acosta, Stefan, Björses, Katarina, Brandt, Kerstin, Dias, Nuno, Gottsäter, Anders, Holst, Jan, Kristmundsson, Thorarinn, Kühme, Tobias, Kölbel, Tilo, Lindblad, Bengt, Lindh, Mats, Malina, Martin, Ohrlander, Tomas, Resch, Tim, Rönnle, Viola, Sonesson, Björn, Warvsten, Margareta, Zdanowski, Zbigniew, Campbell, Erik, Kjellin, Per, Lindgren, Hans, Nyberg, Johan, Petersen, Björn, Plate, Gunnar, Pärsson, Håkan, Qvarfordt, Peter, Ignatenko, Pavel, Karpenko, Andrey, Starodubtsev, Vladimir, Chernyavsky, Mikhail A, Golovkova, Maria S, Komakha, Boris B, Zherdev, Nikolay N, Belyasnik, Andrey, Chechulov, Pavel, Kandyba, Dmitry, Stepanishchev, Igor, Csobay-Novák, Csaba, Dósa, Edit, Entz, László, Nemes, Balázs, Szeberin, Zoltán, Barzó, Pál, Bodosi, Mihaly, Fákó, Eniko, Fülöp, Béla, Németh, Tamás, Pazdernyik, Szilárd, Skoba, Krisztina, Vörös, Erika, Chatzinikou, Eleni, Giannoukas, Athanasios, Karathanos, Christos, Koutsias, Stylianos, Kouvelos, Georgios, Matsagkas, Miltiadis, Ralli, Styliani, Rountas, Christos, Rousas, Nikolaos, Spanos, Konstantinos, Brountzos, Elias, Kakisis, John D, Lazaris, Andreas, Moulakakis, Konstantinos G, Stefanis, Leonidas, Tsivgoulis, Georgios, Vasdekis, Spyros, Antonopoulos, Constantine N, Bellenis, Ion, Maras, Dimitrios, Polydorou, Antonios, Polydorou, Victoria, Tavernarakis, Antonios, Ioannou, Nikolaos, Terzoudi, Maria, Lazarides, Miltos, Mantatzis, Michalis, Vadikolias, Kostas, Dzieciuchowicz, Lukasz, Gabriel, Marcin, Krasinski, Zbigniew, Oszkinis, Grzegorz, Pukacki, Fryderyk, Slowinski, Maciej, Stanišic, Michal-Goran, Staniszewski, Ryszard, Tomczak, Jolanta, Zielinski, Maciej, Myrcha, Piotr, Rózanski, Dorota, Drelichowski, Stanislaw, Iwanowski, Wojciech, Koncewicz, Katarzyna, Bialek, Pawel, Biejat, Zbigniew, Czepel, Wojciech, Czlonkowska, Anna, Dowzenko, Anatol, Jedrzejewska, Julia, Kobayashi, Adam, Leszczynski, Jerzy, Malek, Andrzej, Polanski, Jerzy, Proczka, Robert, Skorski, Maciej, Szostek, Mieczyslaw, Andziak, Piotr, Dratwicki, Maciej, Gil, Robert, Nowicki, Miroslaw, Pniewski, Jaroslaw, Rzezak, Jaroslaw, Seweryniak, Piotr, Dabek, Pawel, Juszynski, Michal, Madycki, Grzegorz, Pacewski, Bartosz, Raciborski, Witold, Slowinski, Piotr, Staszkiewicz, Walerian, Bombic, Martin, Chlouba, Vladimír, Fiedler, Jirí, Hes, Karel, Koštál, Petr, Sova, Jindrich, Kríž, Zdenek, Prívara, Mojmír, Reif, Michal, Staffa, Robert, Vlachovský, Robert, Vojtíšek, Bohuslav, Hrbác, Tomáš, Kuliha, Martin, Procházka, Václav, Roubec, Martin, Školoudík, David, Netuka, David, Šteklácová, Anna, Beneš III, Vladimír, Buchvald, Pavel, Endrych, Ladislav, Šercl, Miroslav, Campos Jr, Walter, Casella, Ivan B, de Luccia, Nelson, Estenssoro, André E V, Presti, Calógero, Puech-Leão, Pedro, Neves, Celso R B, da Silva, Erasmo S, Sitrângulo Jr, Cid J, Monteiro, José A T, Tinone, Gisela, Bellini Dalio, Marcelo, Joviliano, Edwaldo E, Pontes Neto, Octávio M, Serra Ribeiro, Mauricio, Cras, Patrick, Hendriks, Jeroen M H, Hoppenbrouwers, Mieke, Lauwers, Patrick, Loos, Caroline, Yperzeele, Laetitia, Geenens, Mia, Hemelsoet, Dimitri, van Herzeele, Isabelle, Vermassen, Frank, Astarci, Parla, Hammer, Frank, Lacroix, Valérie, Peeters, André, Verhelst, Robert, Cirelli, Silvana, Dormal, Pol, Grimonprez, Annelies, Lambrecht, Bart, Lerut, Philipe, Thues, Eddy, De Koster, Guy, Desiron, Quentin, Maertens de Noordhout, Alain, Malmendier, Danielle, Massoz, Mireille, Saad, Georges, Bosiers, Marc, Callaert, Joren, Deloose, Koen, Blanco Cañibano, Estrella, García Fresnillo, Beatriz, Guerra Requena, Mercedes, Morata Barrado, Pilar C, Muela Méndez, Miguel, Yusta Izquierdo, Antonio, Aparici Robles, Fernando, Blanes Orti, Paula, García Dominguez, Luis, Martínez López, Rafael, Miralles Hernández, Manuel, Tembl Ferrairo, José I, Chamorro, Ángel, Macho, Juan, Obach, Víctor, Riambau, Vincent, San Román, Luis, Ahlhelm, Frank J, Blackham, Kristine, Engelter, Stefan, Eugster, Thomas, Gensicke, Henrik, Gürke, Lorenz, Lyrer, Philippe, Mariani, Luigi, Maurer, Marina, Mujagic, Edin, Müller, Mandy, Psychogios, Marios, Stierli, Peter, Stippich, Christoph, Traenka, Christopher, Wolff, Thomas, Wagner, Benjamin, Wiegert, Martina M, Clarke, Sandra, Diepers, Michael, Gröchenig, Ernst, Gruber, Philipp, Isaak, Andrej, Kahles, Timo, Marti, Regula, Nedeltchev, Krassen, Remonda, Luca, Tissira, Nadir, Valença Falcão, Martina, de Borst, Gert J, Lo, Rob H, Moll, Frans L, Toorop, Raechel, van der Worp, Bart H, Vonken, Evert J, Kappelle, Jaap L, Jahrome, Ommid, Vos, Floris, Schuiling, Wouter, van Overhagen, Hendrik, Keunen, Rudolf W M, Knippenberg, Bob, Wever, Jan J, Lardenoije, Jan W, Reijnen, Michel, Smeets, Luuk, van Sterkenburg, Steven, Fraedrich, Gustav, Gizewski, Elke, Gruber, Ingrid, Knoflach, Michael, Kiechl, Stefan, Rantner, Barbara, Abdulamit, Timur, Bergeron, Patrice, Padovani, Raymond, Trastour, Jean-Christophe, Cardon, Jean-Marie, Le Gallou-Wittenberg, Anne, Allaire, Eric, Becquemin, Jean-Pierre, Cochennec-Paliwoda, Frédéric, Desgranges, Pascal, Hosseini, Hassan, Kobeiter, Hicham, Marzelle, Jean, Almekhlafi, Mohammed A, Bal, Simerpreet, Barber, Phillip A, Coutts, Shelagh B, Demchuk, Andrew M, Eesa, Muneer, Gillies, Michelle, Goyal, Mayank, Hill, Michael D, Hudon, Mark E, Jambula, Anitha, Kenney, Carol, Klein, Gary, McClelland, Marie, Mitha, Alim, Menon, Bijoy K, Morrish, William F, Peters, Steven, Ryckborst, Karla J, Samis, Greg, Save, Supriya, Smith, Eric E, Stys, Peter, Subramaniam, Suresh, Sutherland, Garnette R, Watson, Tim, Wong, John H, Zimmel, L, Flis, Vojko, Matela, Jože, Miksic, Kazimir, Milotic, Franko, Mrdja, Božidar, Stirn, Barbara, Tetickovic, Erih, Gasparini, Mladen, Grad, Anton, Kompara, Ingrid, Miloševic, Zoren, Palmiste, Veronika, Toomsoo, Toomas, Aidashova, Balzhan, Kospanov, Nursultan, Lyssenko, Roman, Mussagaliev, Daulet, Beyar, Rafi, Hoffman, Aaron, Karram, Tony, Kerner, Arthur, Nikolsky, Eugenia, Nitecki, Samy, Andonova, Silva, Bachvarov, Chavdar, Petrov, Vesko, Cvjetko, Ivan, Vidjak, Vinko, Halužan, Damir, Petrunic, Mladen, Liu, Bao, Liu, Chang-Wei, Bartko, Daniel, Beno, Peter, Rusnák, František, Zelenák, Kamil, Ezura, Masayuki, Inoue, Takashi, Kimura, Naoto, Kondo, Ryushi, Matsumoto, Yasushi, Shimizu, Hiroaki, Endo, Hidenori, Furui, Eisuke, Bakke, Søren, Krohg-Sørensen, Kristen, Nome, Terje, Skjelland, Mona, Tennøe, Bjørn, Albuquerque e Castro, João, Alves, Gonçalo, Bastos Gonçalves, Frederico, de Aragão Morais, José, Garcia, Ana C, Valentim, Hugo, Vasconcelos, Leonor, Belcastro, Fernando, Cura, Fernando, Zaefferer, Patricio, Abd-Allah, Foad, Eldessoki, Mohamed H, Heshmat Kassem, Hussein, Soliman Gharieb, Haytham, Colgan, Mary P, Haider, Syed N, Harbison, Joe, Madhavan, Prakash, Moore, Dermot, Shanik, Gregor, Kazan, Viviane, Nazzal, Munier, and Ramsey-Williams, Vicki
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- 2021
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3. Intraoperative magnetic resonance imaging for cerebral cavernous malformations: When is it maybe worth it?
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Torné, Ramon, Urra, Xabier, Topczeswki, Thomaz E., Ferrés, Abel, García-García, Sergio, Rodríguez-Hernández, Ana, San Roman, Luís, de Riva, Nicolas, and Enseñat, Joaquim
- Published
- 2021
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4. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
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Berkhemer, Olvert A, Fransen, Puck SS, Beumer, Debbie, van den Berg, Lucie A, Lingsma, Hester F, Yoo, Albert J, Schonewille, Wouter J, Vos, Jan Albert, Nederkoorn, Paul J, Wermer, Marieke JH, van Walderveen, Marianne AA, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, Jaap, Lo, Rob H, van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L.M., van Rooij, Willem Jan J., van den Berg, Jan S.P., van Hasselt, Boudewijn A.A.M., Aerden, Leo A.M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C.J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H.C.M.L., Heijboer, Roel J.J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, Zwenneke, Marquering, Henk A., Sprengers, Marieke E.S., Jenniskens, Sjoerd F.M., Beenen, Ludo F.M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W.E.M., van der Lugt, Aad, van Oostenbrugge, Robert J., Majoie, Charles B.L.M., Dippel, Diederik W.J., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen, Boers, Merel, Santos, Emilie, Borst, Jordi, Jansen, Ivo, Kappelhof, Manon, Lucas, Marit, Geuskens, Ralph, Barros, Renan Sales, Dobbe, Roeland, Csizmadia, Marloes, Hill, MD, Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Ryckborst, KJ, Wright, MR, Kamal, NR, Andersen, L, Randhawa, PA, Stewart, T, Patil, S, Minhas, P, Almekhlafi, M, Mishra, S, Clement, F, Sajobi, T, Shuaib, A, Montanera, WJ, Roy, D, Silver, FL, Jovin, TG, Frei, DF, Sapkota, B, Rempel, JL, Thornton, J, Williams, D, Tampieri, D, Poppe, AY, Dowlatshahi, D, Wong, JH, Mitha, AP, Subramaniam, S, Hull, G, Lowerison, MW, Salluzzi, M, Maxwell, M, Lacusta, S, Drupals, E, Armitage, K, Barber, PA, Smith, EE, Morrish, WF, Coutts, SB, Derdeyn, C, Demaerschalk, B, Yavagal, D, Martin, R, Brant, R, Yu, Y, Willinsky, RA, Weill, A, Kenney, C, Aram, H, Stys, PK, Watson, TW, Klein, G, Pearson, D, Couillard, P, Trivedi, A, Singh, D, Klourfeld, E, Imoukhuede, O, Nikneshan, D, Blayney, S, Reddy, R, Choi, P, Horton, M, Musuka, T, Dubuc, V, Field, TS, Desai, J, Adatia, S, Alseraya, A, Nambiar, V, van Dijk, R, Newcommon, NJ, Schwindt, B, Butcher, KS, Jeerakathil, T, Buck, B, Khan, K, Naik, SS, Emery, DJ, Owen, RJ, Kotylak, TB, Ashforth, RA, Yeo, TA, McNally, D, Siddiqui, M, Saqqur, M, Hussain, D, Kalashyan, H, Manosalva, A, Kate, M, Gioia, L, Hasan, S, Mohammad, A, Muratoglu, M, Cullen, A, Brennan, P, O'Hare, A, Looby, S, Hyland, D, Duff, S, McCusker, M, Hallinan, B, Lee, S, McCormack, J, Moore, A, O'Connor, M, Donegan, C, Brewer, L, Martin, A, Murphy, S, O'Rourke, K, Smyth, S, Kelly, P, Lynch, T, Daly, T, O'Brien, P, O'Driscoll, A, Martin, M, Collins, R, Coughlan, T, McCabe, D, O'Neill, D, Mulroy, M, Lynch, O, Walsh, T, O'Donnell, M, Galvin, T, Harbison, J, McElwaine, P, Mulpeter, K, McLoughlin, C, Reardon, M, Harkin, E, Dolan, E, Watts, M, Cunningham, N, Fallon, C, Gallagher, S, Cotter, P, Crowe, M, Doyle, R, Noone, I, Lapierre, M, Coté, VA, Lanthier, S, Odier, C, Durocher, A, Raymond, J, Daneault, N, Deschaintre, Y, Jankowitz, B, Baxendell, L, Massaro, L, Jackson-Graves, C, Decesare, S, Porter, P, Armbruster, K, Adams, A, Billigan, J, Oakley, J, Ducruet, A, Jadhav, A, Giurgiutiu, D-V, Aghaebrahim, A, Reddy, V, Hammer, M, Starr, M, Totoraitis, V, 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A, Amaro, S, Llull, L, Codas, J, Balasa, M, Navarro, J, Ariño, H, Aceituno, A, Rudilosso, S, Renu, A, Macho, JM, San Roman, L, Blasco, J, López, A, Macías, N, Cardona, P, Quesada, H, Rubio, F, Cano, L, Lara, B, de Miquel, MA, Aja, L, Serena, J, Cobo, E, Albers, Gregory W, Lees, Kennedy R, Arenillas, J, Roberts, R, Al-Ajlan, F, Zimmel, L, Patel, S, Martí-Fàbregas, J, Salvat-Plana, M, Bracard, S, Ducrocq, Xavier, Anxionnat, René, Baillot, Pierre-Alexandre, Barbier, Charlotte, Derelle, Anne-Laure, Lacour, Jean-Christophe, Richard, Sébastien, Samson, Yves, Sourour, Nader, Baronnet-Chauvet, Flore, Clarencon, Frédéric, Crozier, Sophie, Deltour, Sandrine, Di Maria, Federico, Le Bouc, Raphael, Leger, Anne, Mutlu, Gurkan, Rosso, Charlotte, Szatmary, Zoltan, Yger, Marion, Zavanone, Chiara, Bakchine, Serge, Pierot, Laurent, Caucheteux, Nathalie, Estrade, Laurent, Kadziolka, Krzysztof, Leautaud, Alexandre, Renkes, Céline, Serre, Isabelle, Desal, Hubert, Guillon, Benoît, Boutoleau-Bretonniere, Claire, Daumas-Duport, Benjamin, De Gaalon, Solène, Derkinderen, Pascal, Evain, Sarah, Herisson, Fanny, Laplaud, David-Axel, Lebouvier, Thibaud, Lintia-Gaultier, Alina, Pouclet-Courtemanche, Hélène, Rouaud, Tiphaine, Rouaud Jaffrenou, Violaine, Schunck, Aurélia, Sevin-Allouet, Mathieu, Toulgoat, Frederique, Wiertlewski, Sandrine, Gauvrit, Jean-Yves, Ronziere, Thomas, Cahagne, Vincent, Ferre, Jean-Christophe, Pinel, Jean-François, Raoult, Hélène, Mas, Jean-Louis, Meder, Jean-François, Al Najjar-Carpentier, Amen-Adam, Birchenall, Julia, Bodiguel, Eric, Calvet, David, Domigo, Valérie, Godon-Hardy, Sylvie, Guiraud, Vincent, Lamy, Catherine, Majhadi, Loubna, Morin, Ludovic, Naggara, Olivier, Trystram, Denis, Turc, Guillaume, Berge, Jérôme, Sibon, Igor, Menegon, Patrice, Barreau, Xavier, Rouanet, François, Debruxelles, Sabrina, Kazadi, Annabelle, Renou, Pauline, Fleury, Olivier, Pasco-Papon, Anne, Dubas, Frédéric, Caroff, Jildaz, Godard Ducceschi, Sophie, Hamon, Marie-Aurélie, Lecluse, Alderic, Marc, Guillaume, Giroud, Maurice, Ricolfi, Frédéric, Bejot, Yannick, Chavent, Adrien, Gentil, Arnaud, Kazemi, Apolline, Osseby, Guy-Victor, Voguet, Charlotte, Mahagne, Marie-Hélène, Sedat, Jacques, Chau, Yves, Suissa, Laurent, Lachaud, Sylvain, Houdart, Emmanuel, Stapf, Christian, Buffon Porcher, Frédérique, Chabriat, Hugues, Guedin, Pierre, Herve, Dominique, Jouvent, Eric, Mawet, Jérôme, Saint-Maurice, Jean-Pierre, Schneble, Hans-Martin, Nighoghossian, Norbert, Berhoune, Nadia-Nawel, Bouhour, Françoise, Cho, Tae-Hee, Derex, Laurent, Felix, Sandra, Gervais-Bernard, Hélène, Gory, Benjamin, Manera, Luis, Mechtouff, Laura, Ritzenthaler, Thomas, Riva, Roberto, Salaris Silvio, Fabrizio, Tilikete, Caroline, Blanc, Raphael, Obadia, Michaël, Bartolini, Mario Bruno, Gueguen, Antoine, Piotin, Michel, Pistocchi, Silvia, Redjem, Hocine, Drouineau, Jacques, Neau, Jean-Philippe, Godeneche, Gaelle, Lamy, Matthias, Marsac, Emilia, Velasco, Stephane, Clavelou, Pierre, Chabert, Emmanuel, Bourgois, Nathalie, Cornut-Chauvinc, Catherine, Ferrier, Anna, Gabrillargues, Jean, Jean, Betty, Marques, Anna-Raquel, Vitello, Nicolas, Detante, Olivier, Barbieux, Marianne, Boubagra, Kamel, Favre Wiki, Isabelle, Garambois, Katia, Tahon, Florence, Ashok, Vasdev, Coskun, Oguzhan, Rodesch, Georges, Lapergue, Bertrand, Bourdain, Frédéric, Evrard, Serge, Graveleau, Philippe, Decroix, Jean Pierre, Wang, Adrien, Sellal, François, Ahle, Guido, Carelli, Gabriela, Dugay, Marie-Hélène, Gaultier, Claude, Lebedinsky, Ariel Pablo, Lita, Lavinia, Musacchio, Raul Mariano, Renglewicz-Destuynder, Catherine, Tournade, Alain, Vuillemet, Françis, Montoro, Francisco Macian, Mounayer, Charbel, Faugeras, Frederic, Gimenez, Laetitia, Labach, Catherine, Lautrette, Géraldine, Denier, Christian, Saliou, Guillaume, Chassin, Olivier, Dussaule, Claire, Melki, Elsa, Ozanne, Augustin, Puccinelli, Francesco, Sachet, Marina, Sarov, Mariana, Bonneville, Jean-François, Moulin, Thierry, Biondi, Alessandra, De Bustos 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Joanna, Molyneux, Andy, Robinson, Thompson, Lewis, Steff, Norrie, John, Robertson, Fergus, Perry, Richard, Dixit, Anand, Cloud, Geoffrey, Clifton, Andrew, Madigan, Jeremy, Roffe, Christine, Nayak, Sanjeev, Lobotesis, Kyriakos, Smith, Craig, Herwadkar, Amit, Kandasamy, Naga, Goddard, Tony, Bamford, John, Subramanian, Ganesh, Lenthall, Rob, Littleton, Edward, Lamin, Sal, Storey, Kelley, Ghatala, Rita, Banaras, Azra, Aeron-Thomas, John, Hazel, Bath, Maguire, Holly, Veraque, Emelda, Harrison, Louise, Keshvara, Rekha, Cunningham, James, Campbell, Bruce C V, Majoie, Charles B L M, Menon, Bijoy K, van Zwam, Wim H, van Oostenbrugge, Robert J, Demchuk, Andrew M, Guillemin, Francis, Dávalos, Antoni, Butcher, Kenneth S, Cherifi, Aboubaker, Marquering, Henk A, Macho Fernández, Juan M, Oppenheim, Catherine, Roos, Yvo B W E M, Shankar, Jai, Lingsma, Hester, Hernández-Pérez, María, Bharatha, Aditya, Levy, Elad I, Soudant, Marc, Aja, Lucia, Krings, Timo, Tisserand, Marie, San Román, Luis, Tomasello, Alejandro, Brown, Scott, Liebeskind, David S, Bracard, Serge, Dippel, Diederik W J, Jovin, Tudor G, and Hill, Michael D
- Published
- 2019
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5. Evaluation of white matter hypodensities on computed tomography in stroke patients using the Fazekas score
- Author
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Rudilosso, Salvatore, San Román, Luis, Blasco, Jordi, Hernández-Pérez, María, Urra, Xabier, and Chamorro, Ángel
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- 2017
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6. Comparison of Three Scores of Collateral Status for Their Association With Clinical Outcome
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Gensicke, Henrik, Al-Ajlan, Fahad, Fladt, Joachim, Campbell, Bruce C.V., Majoie, Charles B.L.M., Bracard, Serge, Hill, Michael D., Muir, Keith W., Demchuk, Andrew, San Román, Luis, van der Lugt, Aad, Liebeskind, David S., Brown, Scott, White, Philip M., Guillemin, Francis, Dávalos, Antoni, Jovin, Tudor G., Saver, Jeffrey L., Dippel, Diederik W.J., Goyal, Mayank, Mitchell, Peter J., Menon, Bijoy K., Radiology & Nuclear Medicine, Neurology, Radiology and Nuclear Medicine, ACS - Microcirculation, Amsterdam Neuroscience - Neurovascular Disorders, ACS - Atherosclerosis & ischemic syndromes, and Radiology and nuclear medicine
- Subjects
Advanced and Specialized Nursing ,Computed Tomography Angiography ,association ,Collateral Circulation ,Triacetoneamine-N-Oxyl ,patients ,Brain Ischemia ,Cerebral Angiography ,Stroke ,Treatment Outcome ,thrombectomy ,ischemic stroke ,Humans ,angiography ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
Background: Leptomeningeal collateral status on baseline computed tomographic angiography (CTA) is associated with clinical outcome after acute ischemic stroke treatment. However, assessment of collateral status is not uniform. To compare 3 different CTA collateral scores (CS) and imaging techniques about their association with clinical outcome. Methods: Pooled analysis of patient-level data from the Highly Effective Reperfusion Using Multiple Endovascular Devices collaboration. Patients with large vessel occlusion from 7 randomized controlled trials that compared endovascular thrombectomy with standard medical care were included. Three different CS (Tan CS, regional CS [rCS], and regional Alberta Stroke Program Early CT Score CS) and 2 imaging techniques (single-phase [sCTA] and multiphase/dynamic CTA) were evaluated. Functional independence (modified Rankin Scale score 0–2) at 3 months poststroke was the primary outcome. Furthermore, we assessed the effect of sCTA image acquisition time on collateral status assessment using an adjusted ordinal logistic regression model to obtain predicted values for the trichotomized rCS. Results: Among 1147 pooled patients, 948 (82.7%) had sCTA and 199 (17.3%) multiphase/dynamic CTA as baseline angiography. With all 3 collateral scales, better CSs were associated with better 3-month functional outcome. With sCTA images, the rCS (area under the curve [AUC] 0.63) and regional Alberta Stroke Program Early CT Score CS (AUC 0.62) better predicted functional outcome than the Tan CS (AUC 0.60, respectively; P P =0.02). With multiphase/dynamic CTA images, all collateral scales performed similarly in predicting functional outcome (rCS [AUC 0.61]; regional Alberta Stroke Program Early CT Score CS [AUC 0.61] versus Tan CS [AUC 0.61], respectively; P =0.93 and P =0.91). Overall, no endovascular thrombectomy treatment effect modification by collateral status (rCS) was demonstrated ( P =0.41). sCTA timing independently influenced CS assessment. On earlier timed sCTA, the predicted proportions of scans with poor collaterals was higher and vice versa. Conclusions: In this data set of highly selected patients with stroke, using a regional CS on sCTA likely allows for the most accurate prediction of functional outcome while on time-resolved CTA, the type of CS did not matter. Patients across all collateral grades benefit from endovascular thrombectomy. sCTA timing independently influenced CS assessment.
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- 2022
7. Impact of Balloon Guide Catheters in Elderly Patients Treated with Mechanical Thrombectomy: Insights from the ROSSETTI Registry.
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Terceño, Mikel, Bashir, Saima, Puig, Josep, Daunis-I-Estadella, Josep, Murias, Eduardo, María Jiménez, Jose, González Díaz, Eva, Fondevila Monso, Jon, Bravo-Rey, Isabel, Romero, Veredas, Werner, Mariano, López-Rueda, Antonio, San Román, Luis, Blasco Anadaluz, Jordi, Doncel-Moriano, Antonio, Rosati, Santiago, Pérez-García, Carlos, Remollo, Sebastian, Rodríguez Caamaño, Isabel, and Aixut, Sonia
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- 2023
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8. A Novel and Freely Available Interactive 3d Model of the Internal Carotid Artery
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Valera-Melé, Marc, Puigdellívol-Sánchez, Anna, Mavar-Haramija, Marija, Juanes-Méndez, Juan A., San-Román, Luis, de Notaris, Matteo, and Prats-Galino, Alberto
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- 2018
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9. Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke
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Almekhlafi, Mohammed, Goyal, Mayank, Dippel, Diederik, Majoie, Charles, Campbell, Bruce, Muir, Keith, Demchuk, Andrew, Bracard, Serge, Guillemin, Francis, Jovin, Tudor, Mitchell, Peter, White, Philip, Hill, Michael, Brown, Scott, Saver, Jeffrey, Berkhemer, Olvert, Fransen, Puck, Beumer, Debbie, Van Den Berg, Lucie, Lingsma, Hester, Yoo, Albert, Schonewille, Wouter, Vos, Jan, Nederkoorn, Paul, Wermer, Marieke, Van Walderveen, Marianne, Staals, Julie, Hofmeijer, Jeannette, Van Oostayen, Jacques, Lycklama À Nijeholt, Geert, Boiten, Jelis, Brouwer, Patrick, Emmer, Bart, De Bruijn, Sebastiaan, Van Dijk, Lukas, Kappelle, L, Lo, Rob, Van Dijk, Ewoud, de Vries, Joost, De Kort, Paul, Van Rooij, Willem, Van Den Berg, Jan, Van Hasselt, Boudewijn, Aerden, Leo, Dallinga, René, Visser, Marieke, Bot, Joseph, Vroomen, Patrick, Eshghi, Omid, Schreuder, Tobien, Heijboer, Roel, Keizer, Koos, Tielbeek, Alexander, Den Hertog, Heleen, Gerrits, Dick, Van Den Berg-Vos, Renske, Karas, Giorgos, Steyerberg, Ewout, Flach, H, Marquering, Henk, Sprengers, Marieke, Jenniskens, Sjoerd, Beenen, Ludo, Van Den Berg, René, Koudstaal, Peter, Van Zwam, Wim, Roos, Yvo, van der Lugt, Aad, Van Oostenbrugge, Robert, Menon, Bijoy, Eesa, Muneer, Rempel, Jeremy, Thornton, John, Roy, Daniel, Willinsky, Robert, Sapkota, Biggya, Dowlatshahi, Dar, Frei, Donald, Kamal, Noreen, Montanera, Walter, Poppe, Alexandre, Ryckborst, Karla, Silver, Frank, Shuaib, Ashfaq, Tampieri, Donatella, Williams, David, Bang, Oh, Baxter, Blaise, Burns, Paul, Choe, Hana, Heo, Ji-Hoe, Holmstedt, Christine, Jankowitz, Brian, KELLY, Michael, Linares, Guillermo, Mandzia, Jennifer, Shankar, Jai, Sohn, Sung-Il, Swartz, Richard, Coutts, Shelagh, Smith, Eric, Morrish, William, Weill, Alain, Subramaniam, Suresh, Mitha, Alim, Wong, John, Lowerison, Mark, Sajobi, Tolulope, Bonafe, Alain, Diener, Hans, Levy, Elad, Pereira, Vitor, Albers, Gregory, Cognard, Christophe, Cohen, David, Hacke, Werner, Jansen, Olav, Mattle, Heinrich, Nogueira, Raul, Siddiqui, Adnan, Yavagal, Dileep, Devlin, Thomas, Lopes, Demetrius, Reddy, Vivek, du Mesnil de Rochemont, Richard, Singer, Oliver, Jahan, Reza, Kleinig, Timothy, Dewey, Helen, Churilov, Leonid, Yassi, Nawaf, Yan, Bernard, Dowling, Richard, Parsons, Mark, Oxley, Thomas, Wu, Teddy, Brooks, Mark, Simpson, Marion, Miteff, Ferdinand, Levi, Christopher, Krause, Martin, Harrington, Timothy, Faulder, Kenneth, Steinfort, Brendan, Priglinger, Miriam, Ang, Timothy, Scroop, Rebecca, Barber, Philip, McGuinness, Ben, Wijeratne, Tissa, Phan, Thanh, Chong, Winston, Chandra, Ronil, Bladin, Christopher, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Ma, Henry, Desmond, Patricia, Donnan, Geoffrey, Davis, Stephen, Chamorro, Angel, Cobo, Erik, De Miquel, María, Molina, Carlos, Rovira, Alex, San Román, Luis, Serena, Joaquín, Abilleira, Sonia, Ribó, Marc, Millán, Mònica, Urra, Xabier, Cardona, Pere, López-Cancio, Elena, Tomasello, Alejandro, Castaño, Carlos, Blasco, Jordi, Aja, Lucía, Dorado, Laura, Quesada, Helena, Rubiera, Marta, Hernandez-Pérez, María, von Kummer, Rüdiger, Gallofré, Miquel, Dávalos, Antoni, Ford, Gary, Messow, Claudia-Martina, Ford, Ian, Murray, Alicia, Clifton, Andrew, Brown, Martin, Madigan, Jeremy, Lenthall, Rob, Robertson, Fergus, Dixit, Anand, Cloud, Geoffrey, Wardlaw, Joanna, Freeman, Janet, Ducrocq, Xavier, Mas, Jean, Soudant, Marc, Oppenheim, Catherine, Moulin, Thierry, University of Calgary, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Radiology and Nuclear Medicine [Amsterdam], VU University Medical Center [Amsterdam], University of Melbourne, University of Glasgow, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), The Royal Melbourne Hospital, Newcastle University [Newcastle], Altair Development, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), and University of California-University of California
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[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known. OBJECTIVE To assess the lifetime outcomes associated with speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO). DATA SOURCES PubMed was searched for randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time, and for which a peer-reviewed, complete primary results article was published by August 1, 2020.
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- 2021
10. Combined Approach to Stroke Thrombectomy Using a Novel Short Flexible Aspiration Catheter with a Stent Retriever
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Remollo, Sebastian, primary, Terceño, Mikel, additional, Werner, Mariano, additional, Castaño, Carlos, additional, Hernández-Pérez, María, additional, Blasco, Jordi, additional, San Román, Luis, additional, Daunis-i-Estadella, Pepus, additional, Thió-Henestrosa, Santiago, additional, Cuba, Víctor, additional, Gimeno, Alfredo, additional, and Puig, Josep, additional
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- 2021
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11. Combined Approach to Stroke Thrombectomy Using a Novel Short Flexible Aspiration Catheter with a Stent Retriever
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Remollo Friedemann, Sebastian, Terceño Izaga, Mikel, Werner, Mariano, Castaño, Carlos, Hernández Pérez, María, Blasco, Jordi, San Román, Luis, Daunis-i-Estadella, Pepus, Thió i Fernández de Henestrosa, Santiago, Cuba, Víctor, Gimeno, Alfredo, and Puig, Josep
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Neurocirurgia ,Isquèmia cerebral ,Cerebral embolism and thrombosis ,Catheters ,Catèters ,Embòlia i trombosi cerebral ,cardiovascular diseases ,Cerebral ischemia ,Nervous system--Surgery - Abstract
Background Large-bore aspiration catheters enabling greater flow rates and suction force for mechanical thrombectomy might improve outcomes in patients with stroke secondary to large-vessel occlusion. Complete or near-complete reperfusion after a single thrombectomy pass (first-pass effect) is associated with improved clinical outcomes. We assessed the efficacy and safety of novel MIVI Q™ aspiration catheters in combination with stent-retriever devices. Methods We retrospectively analyzed demographics, procedure characteristics, and clinical data from consecutive patients with acute anterior large-vessel occlusion treated with a combined approach using MIVI Q™ aspiration catheters and stent retrievers. Reperfusion was defined according to the modified thrombolysis in cerebral infarction (mTICI) score. Clinical outcomes were measured by the National Institute of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS) scores. Results We included 52 patients (median age, 75 y IQR: 64–83); 31 (59.6%) women; 14 (26.9%) with terminal internal carotid artery occlusions, 26 (50%) middle cerebral artery (MCA) segment M1 occlusions, and 12 (23.1%) MCA segment M2 occlusions; median NIHSS score at admission was 19 (IQR: 13–22). After the first pass, 25 (48%) patients had mTICI ≥ 2c. At the end of the procedure, 47 (90.4%) had mTICI ≥ 2b and 35 (67.3%) had mTICI ≥ 2c. No serious device-related adverse events were observed. Symptomatic intracranial hemorrhage developed in 1 patient. Mean NIHSS score was 13 at 24 h and 5 at discharge. At 90 days, 24 (46.2%) patients were functionally independent (mRS 0–2). Conclusion This preliminary study found good efficacy and safety for MIVI Q™ aspiration catheters used in combination with stent-retriever devices
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- 2021
12. Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat
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Morán, Asunción, Ortiz de Urbina, Ana-Vega, Martín, Maria-Luisa, García, Mónica, Rodriguez-Barbero, Alicia, Dorado, Fernando, and San Román, Luis
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- 2008
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13. Medical and Endovascular Treatment of Patients with Large Vessel Occlusion Presenting with Mild Symptoms: An Observational Multicenter Study
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Urra, Xabier, San Román, Luis, Gil, Francisco, Millán, Mónica, Cánovas, David, Roquer, Jaume, Cardona, Pere, Ribó, Marc, Martí-Fàbregas, Joan, Abilleira, Sònia, and Chamorro, Ángel
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- 2014
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14. Focal myositis of the thigh: unusual MR pattern
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Llauger, Jaume, Bagué, Sílvia, Palmer, Jaume, Matías-Guiu, Xavier, San Román, Luis, and Doncel, Antonio
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- 2002
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15. Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke: The CHOICE Randomized Clinical Trial.
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Renú, Arturo, Millán, Mónica, San Román, Luis, Blasco, Jordi, Martí-Fàbregas, Joan, Terceño, Mikel, Amaro, Sergio, Serena, Joaquín, Urra, Xabier, Laredo, Carlos, Barranco, Roger, Camps-Renom, Pol, Zarco, Federico, Oleaga, Laura, Cardona, Pere, Castaño, Carlos, Macho, Juan, Cuadrado-Godía, Elisa, Vivas, Elio, and López-Rueda, Antonio
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ALTEPLASE ,STROKE ,ANGIOGRAPHY ,CLINICAL trials ,HEMORRHAGE - Abstract
Importance: It is estimated that only 27% of patients with acute ischemic stroke and large vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are disability free at 90 days. An incomplete microcirculatory reperfusion might contribute to these suboptimal clinical benefits.Objective: To investigate whether treatment with adjunct intra-arterial alteplase after thrombectomy improves outcomes following reperfusion.Design, Setting, and Participants: Phase 2b randomized, double-blind, placebo-controlled trial performed from December 2018 through May 2021 in 7 stroke centers in Catalonia, Spain. The study included 121 patients with large vessel occlusion acute ischemic stroke treated with thrombectomy within 24 hours after stroke onset and with an expanded Treatment in Cerebral Ischemia angiographic score of 2b50 to 3.Interventions: Participants were randomized to receive intra-arterial alteplase (0.225 mg/kg; maximum dose, 22.5 mg) infused over 15 to 30 minutes (n = 61) or placebo (n = 52).Main Outcomes and Measures: The primary outcome was the difference in proportion of patients achieving a score of 0 or 1 on the 90-day modified Rankin Scale (range, 0 [no symptoms] to 6 [death]) in all patients treated as randomized. Safety outcomes included rate of symptomatic intracranial hemorrhage and death.Results: The study was terminated early for inability to maintain placebo availability and enrollment rate because of the COVID-19 pandemic. Of 1825 patients with acute ischemic stroke treated with thrombectomy at the 7 study sites, 748 (41%) patients fulfilled the angiographic criteria, 121 (7%) patients were randomized (mean age, 70.6 [SD, 13.7] years; 57 women [47%]), and 113 (6%) were treated as randomized. The proportion of participants with a modified Rankin Scale score of 0 or 1 at 90 days was 59.0% (36/61) with alteplase and 40.4% (21/52) with placebo (adjusted risk difference, 18.4%; 95% CI, 0.3%-36.4%; P = .047). The proportion of patients with symptomatic intracranial hemorrhage within 24 hours was 0% with alteplase and 3.8% with placebo (risk difference, -3.8%; 95% CI, -13.2% to 2.5%). Ninety-day mortality was 8% with alteplase and 15% with placebo (risk difference, -7.2%; 95% CI, -19.2% to 4.8%).Conclusions and Relevance: Among patients with large vessel occlusion acute ischemic stroke and successful reperfusion following thrombectomy, the use of adjunct intra-arterial alteplase compared with placebo resulted in a greater likelihood of excellent neurological outcome at 90 days. However, because of study limitations, these findings should be interpreted as preliminary and require replication.Trial Registration: ClinicalTrials.gov Identifier: NCT03876119; EudraCT Number: 2018-002195-40. [ABSTRACT FROM AUTHOR]- Published
- 2022
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16. Single-Center Experience of Cerebral Artery Thrombectomy Using the TREVO Device in 60 Patients With Acute Ischemic Stroke
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San Román, Luis, Obach, Victor, Blasco, Jordi, Macho, Juan, Lopez, Antonio, Urra, Xabier, Tomasello, Alejandro, Cervera, Alvaro, Amaro, Sergio, Perandreu, Joan, Branera, Jordi, Capurro, Sebastián, Oleaga, Laura, and Chamorro, Angel
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- 2012
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17. DIABETES-INDUCED CHANGES IN 5-HYDROXYTRYPTAMINE MODULATION OF VAGALLY INDUCED BRADYCARDIA IN RAT HEART
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García, Mónica, Morán, Asunción, Martín, M Luisa, Ortizde Urbina, A Vega, and San Román, Luis
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- 2007
18. Frequency and Predictors of Symptomatic Intracerebral Hemorrhage in Patients with Ischemic Stroke Treated with Recombinant Tissue Plasminogen Activator outside Clinical Trials
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Martí-Fàbregas, Joan, Bravo, Yolanda, Cocho, Dolores, Martí-Vilalta, Josep-Lluis, Díaz-Manera, Jordi, San Román, Luis, Puig, Mireia, Blanco, Miguel, Castellanos, Mar, Millán, Mónica, Roquer, Jaume, Obach, Víctor, and Maestre, José
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- 2007
19. Amlodipine decreases fibrosis and cardiac hypertrophy in spontaneously hypertensive rats: persistent effects after withdrawal
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Sevilla, María A, Voces, Felipe, Carrón, Rosalía, Guerrero, Estela I, Ardanaz, Noelia, San Román, Luis, Arévalo, Miguel A, and Montero, María J
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- 2004
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20. Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data
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Campbell, Bruce C V, primary, Majoie, Charles B L M, additional, Albers, Gregory W, additional, Menon, Bijoy K, additional, Yassi, Nawaf, additional, Sharma, Gagan, additional, van Zwam, Wim H, additional, van Oostenbrugge, Robert J, additional, Demchuk, Andrew M, additional, Guillemin, Francis, additional, White, Philip, additional, Dávalos, Antoni, additional, van der Lugt, Aad, additional, Butcher, Kenneth S, additional, Cherifi, Aboubaker, additional, Marquering, Henk A, additional, Cloud, Geoffrey, additional, Macho Fernández, Juan M, additional, Madigan, Jeremy, additional, Oppenheim, Catherine, additional, Donnan, Geoffrey A, additional, Roos, Yvo B W E M, additional, Shankar, Jai, additional, Lingsma, Hester, additional, Bonafé, Alain, additional, Raoult, Hélène, additional, Hernández-Pérez, María, additional, Bharatha, Aditya, additional, Jahan, Reza, additional, Jansen, Olav, additional, Richard, Sébastien, additional, Levy, Elad I, additional, Berkhemer, Olvert A, additional, Soudant, Marc, additional, Aja, Lucia, additional, Davis, Stephen M, additional, Krings, Timo, additional, Tisserand, Marie, additional, San Román, Luis, additional, Tomasello, Alejandro, additional, Beumer, Debbie, additional, Brown, Scott, additional, Liebeskind, David S, additional, Bracard, Serge, additional, Muir, Keith W, additional, Dippel, Diederik W J, additional, Goyal, Mayank, additional, Saver, Jeffrey L, additional, Jovin, Tudor G, additional, Hill, Michael D, additional, Mitchell, Peter J, additional, Fransen, Puck SS, additional, van den Berg, Lucie A, additional, Lingsma, Hester F, additional, Yoo, Albert J, additional, Schonewille, Wouter J, additional, Vos, Jan Albert, additional, Nederkoorn, Paul J, additional, Wermer, Marieke JH, additional, van Walderveen, Marianne AA, additional, Staals, Julie, additional, Hofmeijer, Jeannette, additional, van Oostayen, Jacques A., additional, Lycklama à Nijeholt, Geert J., additional, Boiten, Jelis, additional, Brouwer, Patrick A., additional, Emmer, Bart J., additional, de Bruijn, Sebastiaan F., additional, van Dijk, Lukas C., additional, Kappelle, Jaap, additional, Lo, Rob H, additional, van Dijk, Ewoud J., additional, de Vries, Joost, additional, de Kort, Paul L.M., additional, van Rooij, Willem Jan J., additional, van den Berg, Jan S.P., additional, van Hasselt, Boudewijn A.A.M., additional, Aerden, Leo A.M., additional, Dallinga, René J., additional, Visser, Marieke C., additional, Bot, Joseph C.J., additional, Vroomen, Patrick C., additional, Eshghi, Omid, additional, Schreuder, Tobien H.C.M.L., additional, Heijboer, Roel J.J., additional, Keizer, Koos, additional, Tielbeek, Alexander V., additional, den Hertog, Heleen M., additional, Gerrits, Dick G., additional, van den Berg-Vos, Renske M., additional, Karas, Giorgos B., additional, Steyerberg, Ewout W., additional, Flach, Zwenneke, additional, Marquering, Henk A., additional, Sprengers, Marieke E.S., additional, Jenniskens, Sjoerd F.M., additional, Beenen, Ludo F.M., additional, van den Berg, René, additional, Koudstaal, Peter J., additional, van Zwam, Wim H., additional, Roos, Yvo B.W.E.M., additional, van Oostenbrugge, Robert J., additional, Majoie, Charles B.L.M., additional, Dippel, Diederik W.J., additional, Brown, Martin M., additional, Liebig, Thomas, additional, Stijnen, Theo, additional, Andersson, Tommy, additional, Mattle, Heinrich, additional, Wahlgren, Nils, additional, van der Heijden, Esther, additional, Ghannouti, Naziha, additional, Fleitour, Nadine, additional, Hooijenga, Imke, additional, Puppels, Corina, additional, Pellikaan, Wilma, additional, Geerling, Annet, additional, Lindl-Velema, Annemieke, additional, van Vemde, Gina, additional, de Ridder, Ans, additional, Greebe, Paut, additional, de Bont-Stikkelbroeck, José, additional, de Meris, Joke, additional, Janssen, Kirsten, additional, Struijk, Willy, additional, Licher, Silvan, additional, Boodt, Nikki, additional, Ros, Adriaan, additional, Venema, Esmee, additional, Slokkers, Ilse, additional, Ganpat, Raymie-Jayce, additional, Mulder, Maxim, additional, Saiedie, Nawid, additional, Heshmatollah, Alis, additional, Schipperen, Stefanie, additional, Vinken, Stefan, additional, van Boxtel, Tiemen, additional, Koets, Jeroen, additional, Boers, Merel, additional, Santos, Emilie, additional, Borst, Jordi, additional, Jansen, Ivo, additional, Kappelhof, Manon, additional, Lucas, Marit, additional, Geuskens, Ralph, additional, Barros, Renan Sales, additional, Dobbe, Roeland, additional, Csizmadia, Marloes, additional, Hill, MD, additional, Goyal, M, additional, Demchuk, AM, additional, Menon, BK, additional, Eesa, M, additional, Ryckborst, KJ, additional, Wright, MR, additional, Kamal, NR, additional, Andersen, L, additional, Randhawa, PA, additional, Stewart, T, additional, Patil, S, additional, Minhas, P, additional, Almekhlafi, M, additional, Mishra, S, additional, Clement, F, additional, Sajobi, T, additional, Shuaib, A, additional, Montanera, WJ, additional, Roy, D, additional, Silver, FL, additional, Jovin, TG, additional, Frei, DF, additional, Sapkota, B, additional, Rempel, JL, additional, Thornton, J, additional, Williams, D, additional, Tampieri, D, additional, Poppe, AY, additional, Dowlatshahi, D, additional, Wong, JH, additional, Mitha, AP, additional, Subramaniam, S, additional, Hull, G, additional, Lowerison, MW, additional, Salluzzi, M, additional, Maxwell, M, additional, Lacusta, S, additional, Drupals, E, additional, Armitage, K, additional, Barber, PA, additional, Smith, EE, additional, Morrish, WF, additional, Coutts, SB, additional, Derdeyn, C, additional, Demaerschalk, B, additional, Yavagal, D, additional, Martin, R, additional, Brant, R, additional, Yu, Y, additional, Willinsky, RA, additional, Weill, A, additional, Kenney, C, additional, Aram, H, additional, Stys, PK, additional, Watson, TW, additional, Klein, G, additional, Pearson, D, additional, Couillard, P, additional, Trivedi, A, additional, Singh, D, additional, Klourfeld, E, additional, Imoukhuede, O, additional, Nikneshan, D, additional, Blayney, S, additional, Reddy, R, additional, Choi, P, additional, Horton, M, additional, Musuka, T, additional, Dubuc, V, additional, Field, TS, additional, Desai, J, additional, Adatia, S, additional, Alseraya, A, additional, Nambiar, V, additional, van Dijk, R, additional, Newcommon, NJ, additional, Schwindt, B, additional, Butcher, KS, additional, Jeerakathil, T, additional, Buck, B, additional, Khan, K, additional, Naik, SS, additional, Emery, DJ, additional, Owen, RJ, additional, Kotylak, TB, additional, Ashforth, RA, additional, Yeo, TA, additional, McNally, D, additional, Siddiqui, M, additional, Saqqur, M, additional, Hussain, D, additional, Kalashyan, H, additional, Manosalva, A, additional, Kate, M, additional, Gioia, L, additional, Hasan, S, additional, Mohammad, A, additional, Muratoglu, M, additional, Cullen, A, additional, Brennan, P, additional, O'Hare, A, additional, Looby, S, additional, Hyland, D, additional, Duff, S, additional, McCusker, M, additional, Hallinan, B, additional, Lee, S, additional, McCormack, J, additional, Moore, A, additional, O'Connor, M, additional, Donegan, C, additional, Brewer, L, additional, Martin, A, additional, Murphy, S, additional, O'Rourke, K, additional, Smyth, S, additional, Kelly, P, additional, Lynch, T, additional, Daly, T, additional, O'Brien, P, additional, O'Driscoll, A, additional, Martin, M, additional, Collins, R, additional, Coughlan, T, additional, McCabe, D, additional, O'Neill, D, additional, Mulroy, M, additional, Lynch, O, additional, Walsh, T, additional, O'Donnell, M, additional, Galvin, T, additional, Harbison, J, additional, McElwaine, P, additional, Mulpeter, K, additional, McLoughlin, C, additional, Reardon, M, additional, Harkin, E, additional, Dolan, E, additional, Watts, M, additional, Cunningham, N, additional, Fallon, C, additional, Gallagher, S, additional, Cotter, P, additional, Crowe, M, additional, Doyle, R, additional, Noone, I, additional, Lapierre, M, additional, Coté, VA, additional, Lanthier, S, additional, Odier, C, additional, Durocher, A, additional, Raymond, J, additional, Daneault, N, additional, Deschaintre, Y, additional, Jankowitz, B, additional, Baxendell, L, additional, Massaro, L, additional, Jackson-Graves, C, additional, Decesare, S, additional, Porter, P, additional, Armbruster, K, additional, Adams, A, additional, Billigan, J, additional, Oakley, J, additional, Ducruet, A, additional, Jadhav, A, additional, Giurgiutiu, D-V, additional, Aghaebrahim, A, additional, Reddy, V, additional, Hammer, M, additional, Starr, M, additional, Totoraitis, V, additional, Wechsler, L, additional, Streib, S, additional, Rangaraju, S, additional, Campbell, D, additional, Rocha, M, additional, Gulati, D, additional, Krings, T, additional, Kalman, L, additional, Cayley, A, additional, Williams, J, additional, Wiegner, R, 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additional, Cortes, M, additional, Lum, C, additional, Shamloul, R, additional, Robert, S, additional, Stotts, G, additional, Shamy, M, additional, Steffenhagen, N, additional, Blacquiere, D, additional, Hogan, M, additional, AlHazzaa, M, additional, Basir, G, additional, Lesiuk, H, additional, Iancu, D, additional, Santos, M, additional, Choe, H, additional, Weisman, DC, additional, Jonczak, K, additional, Blue-Schaller, A, additional, Shah, Q, additional, MacKenzie, L, additional, Klein, B, additional, Kulandaivel, K, additional, Kozak, O, additional, Gzesh, DJ, additional, Harris, LJ, additional, Khoury, JS, additional, Mandzia, J, additional, Pelz, D, additional, Crann, S, additional, Fleming, L, additional, Hesser, K, additional, Beauchamp, B, additional, Amato-Marzialli, B, additional, Boulton, M, additional, Lopez- Ojeda, P, additional, Sharma, M, additional, Lownie, S, additional, Chan, R, additional, Swartz, R, additional, Howard, P, additional, Golob, D, additional, 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- 2019
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21. Anomalías congénitas de las arterias coronarias del adulto descritas en 31 años de estudios coronariográficos en el Principado de Asturias: principales características angiográficas y clínicas
- Author
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Barriales Villa, Roberto, López Muñiz, Alfonso, Hernández, Luis C., San Román, Luis, de la Hera, Jesús M., Morís, César, Barriales Álvarez, Vicente, Testa, Ana, Sanmartín, Juan C., and Cortina, Arturo
- Published
- 2001
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22. eTICI reperfusion: defining success in endovascular stroke therapy
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Liebeskind, David S, primary, Bracard, Serge, additional, Guillemin, Francis, additional, Jahan, Reza, additional, Jovin, Tudor G, additional, Majoie, Charles BLM, additional, Mitchell, Peter J, additional, van der Lugt, Aad, additional, Menon, Bijoy K, additional, San Román, Luis, additional, Campbell, Bruce CV, additional, Muir, Keith W, additional, Hill, Michael D, additional, Dippel, Diederik WJ, additional, Saver, Jeffrey L, additional, Demchuk, Andrew M, additional, Dávalos, Antoni, additional, White, Philip, additional, Brown, Scott, additional, and Goyal, Mayank, additional
- Published
- 2018
- Full Text
- View/download PDF
23. Edificio multifamiliar 'La Mar' en el distrito de Miraflores
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Silva San Román, Luis Alberto and Díaz Imiela-Gentimur, Luis
- Subjects
Viviendas--Lima--Perú ,Industria de la construcción--Viviendas--Perú ,purl.org/pe-repo/ocde/ford#5.02.04 [https] - Abstract
La presente tesis se basa en el estudio del análisis de la oportunidad que se presenta para la compra de un terreno de 779.00 m2, dentro del distrito de Miraflores, y la posibilidad de desarrollar un proyecto de mediana escala, el terreno cuenta con características tales como buena ubicación, cuenta con certificado de parámetros urbanísticos y edificatorios con el reglamento antiguo(lo cual permite diseñar departamentos de menor área que los del reglamento actual), cuenta con vías de acceso, está en una zona urbana, y cuenta con las factibilidades de servicio. Del análisis de la situación realizado se concluye que en Lima, se registra una importante demanda habitacional, proveniente sobre todo de los segmentos socioeconómicos B y C; es decir los que encajarían correctamente en los programas habitacionales promocionados por el estado. Nuestro mercado meta es el grupo de hogares pertenecientes a los NSE B y C con intención de adquirir una vivienda, cuya motivación de compra es la de contar con casa propia. Los elementos diferenciadores de nuestro producto es el producto en sí; un edificio cerrado, que bridad seguridad y exclusividad a las familias, gran área verde interior, departamentos bien distribuidos, y zona de estacionamientos, además de salir a la venta con un costo por m2 inferior al de la competencia. Cumpliendo con lo establecido en el plan de marketing, el flujo de los egresos depende directamente de los ingresos que se den por las ventas, caso contrario el proyecto tendría que tirar de línea, lo que generaría sobrecostos financieros y una disminución en la utilidad. De la evaluación económica y financiera del proyecto se puede determinar que el proyecto es rentable, esto debido que al finalizar el proyecto este dejara una utilidad antes de impuestos de U$ 722,397. Tesis
- Published
- 2015
24. eTICI reperfusion: defining success in endovascular stroke therapy
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Liebeskind, David S, Bracard, Serge, Guillemin, Francis, Jahan, Reza, Jovin, Tudor G, Majoie, Charles BLM, Mitchell, Peter J, van der Lugt, Aad, Menon, Bijoy K, San Román, Luis, Campbell, Bruce CV, Muir, Keith W, Hill, Michael D, Dippel, Diederik WJ, Saver, Jeffrey L, Demchuk, Andrew M, Dávalos, Antoni, White, Philip, Brown, Scott, and Goyal, Mayank
- Abstract
BackgroundRevascularization after endovascular therapy for acute ischemic stroke is measured by the Thrombolysis In Cerebral Infarction (TICI) scale, yet variability exists in scale definitions. We examined the degree of reperfusion with the expanded TICI (eTICI) scale and association with outcomes in the HERMES collaboration of recent endovascular trials.MethodsThe HERMES Imaging Core, blind to all other data, evaluated angiography after endovascular therapy in HERMES. A battery of TICI scores (mTICI, TICI, TICI2C) was used to define reperfusion of the initial target occlusion defined by non-invasive imaging and conventional angiography.ResultsAngiography of 801 subjects was available, including 797 defined by non-invasive imaging (154 internal carotid artery (ICA), 583 M1, 60 M2) and 748 by conventional angiography (195 ICA, 459 M1, 94 M2). Among 729 subjects in whom the reperfusion grade could be established, using eTICI (3=100%, 2C=90–99%, 2b67=67–89%, 2b50=50–66%) of the conventional angiography target occlusion, there were 63 eTICI 3 (9%), 166 eTICI 2c (23%), 218 eTICI 2b67 (30%), 103 eTICI 2b50 (14%), 100 eTICI 2a (14%), 19 eTICI 1 (3%), and 60 eTICI 0 (8%). Modified Rankin Scale shift analyses from baseline to 90 days showed that increasing TICI grades were linked with better outcomes, with significant distinctions between TICI 0/1 versus 2a (p=0.028), 2a versus 2b50 (p=0.017), and 2b50 versus 2b67 (p=0.014).ConclusionsThe benefit of endovascular therapy in HERMES was strongly associated with increasing degrees of reperfusion defined by eTICI. The eTICI metric identified meaningful distinctions in clinical outcomes and may be used in future studies and routine practice.
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- 2019
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25. Automated segmentation of cerebral vasculature with aneurysms in 3DRA and TOF-MRA using geodesic active regions: An evaluation study
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Bogunovic, Hrvoje, Pozo Soler, José Ma. (José María), Villa-Uriol, Maria-Cruz, Majoie, Charles B. L. M., van den Berg, Rene, Gratama van Andel, Hugo A. F., Macho, Juan M., Blasco, Jordi, San Román, Luis, Frangi Caregnato, Alejandro, ACS - Amsterdam Cardiovascular Sciences, ANS - Amsterdam Neuroscience, Radiology and Nuclear Medicine, and Universitat Pompeu Fabra
- Subjects
Quantitative evaluation ,Cerebral angiography ,Geodesic active regions ,Aneurismes cerebrals ,Cerebral aneurysms ,Vessel segmentation ,Angiografia - Tècniques digitals - Abstract
Purpose: To evaluate the suitability of an improved version of an automatic segmentation method based on geodesic active regions (GAR) for segmenting cerebral vasculature with aneurysms from 3D X-ray reconstruc-/ntion angiography (3DRA) and time of °ight magnetic resonance angiography (TOF-MRA) images available in the clinical routine./nMethods: Three aspects of the GAR method have been improved: execution time, robustness to variability in imaging protocols and robustness to variability in image spatial resolutions. The improved GAR was retrospectively evaluated on images from patients containing intracranial aneurysms in the area of the Circle of Willis and imaged with two modalities: 3DRA and TOF-MRA. Images were obtained from two clinical centers, each using di®erent imaging equipment. Evaluation included qualitative and quantitative analyses of/nthe segmentation results on 20 images from 10 patients. The gold standard was built from 660 cross-sections (33 per image) of vessels and aneurysms, manually measured by interventional neuroradiologists. GAR has also been compared to an interactive segmentation method: iso-intensity surface extraction (ISE). In addition, since patients had been imaged with the two modalities, we performed an inter-modality agreement analysis with respect to both the manual measurements and each of the two segmentation methods. Results: Both GAR and ISE di®ered from the gold standard within acceptable limits compared to the imaging resolution. GAR (ISE, respectively) had an average accuracy of 0.20 (0.24) mm for 3DRA and 0.27 (0.30) mm for TOF-MRA, and had a repeatability of 0.05 (0.20) mm. Compared to ISE, GAR had a lower qualitative error in the vessel region and a lower quantitative error in the aneurysm region. The repeatability/nof GAR was superior to manual measurements and ISE. The inter-modality agreement was similar between GAR and the manual measurements. Conclusions: The improved GAR method outperformed ISE qualitatively as well as quantitatively and is suitable for segmenting 3DRA and TOF-MRA images from clinical routine. The authors would like to acknowledge J. Schneiders for providing part of the TOF-MRA imaging data. The authors would like to thank also A. G. Radaelli, M. Nieber, and X. Planes for the help in implementing some of the methods. This work was partially supported by the @neurIST Integrated Project (co-financed by the European Commission through Contract No. IST-027703), the CDTI CENIT-CDTEAM grant funded by the Spanish Ministry of Science and Innovation (MICINN-CDTI), the AGAUR-FI fellowship from Generalitat de Catalunya, and Philips Healthcare (Best, The Netherlands).
- Published
- 2011
26. Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke
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Jovin, Tudor G., primary, Chamorro, Angel, additional, Cobo, Erik, additional, de Miquel, María A., additional, Molina, Carlos A., additional, Rovira, Alex, additional, San Román, Luis, additional, Serena, Joaquín, additional, Abilleira, Sonia, additional, Ribó, Marc, additional, Millán, Mònica, additional, Urra, Xabier, additional, Cardona, Pere, additional, López-Cancio, Elena, additional, Tomasello, Alejandro, additional, Castaño, Carlos, additional, Blasco, Jordi, additional, Aja, Lucía, additional, Dorado, Laura, additional, Quesada, Helena, additional, Rubiera, Marta, additional, Hernandez-Pérez, María, additional, Goyal, Mayank, additional, Demchuk, Andrew M., additional, von Kummer, Rüdiger, additional, Gallofré, Miquel, additional, and Dávalos, Antoni, additional
- Published
- 2015
- Full Text
- View/download PDF
27. Mechanisms of relaxation induced by flavonoid ayanin in isolated aorta rings from Wistar rats
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Carrón, Rosalía, Sanz, Eva, Puebla, Pilar, Martín, María Luisa, San Román, Luis, and Guerrero, Mario Francisco
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Flavonoids ,Endothelium-dependent relaxing factors ,Ayanina ,Factores relajantes endotelio-dependientes ,Ayanin ,Croton ,Flavonoides ,Aorta - Abstract
Introduction: This study shows the relaxant effect induced by ayanin in aorta rings from Wistar rats linked to nitric oxide/cyclic-GMP pathway. This flavonoid is the prevalent compound obtained from Croton schiedeanus Schlecht (Euphorbiaceae), specie used in Colombian folk medicine for the treatment of arterial hypertension. Objectives: To identify possible action mechanisms of vascular relaxation induced by ayanin (quercetin 3,4',7-trimethyl ether). Methodology: Isolated aorta rings from Wistar rats obtained at the Animal House of the University of Salamanca were contracted with KCl (80 mM) or phenylephrine (PE, 10-6 M) and exposed to ayanin (10-6-10-4M). Then, the effect of ayanin was assessed in deendothelized rings contracted with PE and in intact rings contracted with PE previously incubated with: ODQ (10-6 M), L-NAME (10-4 M), L-NAME plus D- and L-arginine (10-4 M), indomethacin (5x10-6 M), dipyridamole (3x10-7 M), glibenclamide (10-6 M), propranolol (10-6 M), verapamil (10-7 M) or atropine (3x10-5 M). In addition, the relaxant effect of acetylcholine (Ach, 10-8-3x10-4 M), and sodium nitroprusside (SNP, 10-9-3x10-5 M) was assessed in the presence and absence of ayanin (10-6 M). Results: Ayanin induced a greater concentration-dependent relaxation in vessels contracted with phenylephrine (pEC50: 5.84±0.05), an effect significantly reduced by deendothelization and by both ODQ and L-NAME. L-arginine was able to reverse the effect of L-NAME. Indomethacin weakly inhibited ayanin response. Dipyridamole, glibenclamide, propranolol, verapamil, and atropine did not affect ayanin relaxation. Ayanin did not have any effect on the relaxation elicited by acetylcholine (ACh), while weakly decreasing the relaxation induced by sodium nitroprusside (SNP). Conclusion: Ayanin induces endothelium-dependent relaxation in the rat aorta mainly related to nitric oxide/cGMP pathway, according to the response observed in the presence of L-NAME, L-arginine and ODQ. Introdución: Este estudio muestra el efecto vasodilatador inducido por ayanina en anillos de aorta de ratas Wistar vinculado con la vía óxido nítrico/GMP-cíclico. Este flavonoide es el compuesto mayoritario aislado de Croton schiedeanus Schlecht (Euphorbiaceae), especie utilizada en la medicina popular colombiana para el tratamiento de la hipertensión arterial. Objetivos: Identificar los posibles mecanismos vasodilatadores inducidos por la ayanina (quercetin 3,4',7-trimetileter). Metodología: Se adicionó ayanina (10-6 - 10-4 M) a anillos aislados de aorta procedentes de ratas Wistar contraídos con KCl (80 mM) o fenilefrina (10-6M). Luego se evaluó el efecto de la ayanina en anillos sin endotelio contraídos con fenilefrina y en anillos íntegros, contraídos con fenilefrina, previamente incubados con: ODQ (10-6 M), L-NAME (10-4 M), L-NAME más L- o D-arginina (10-4 M), indometacina (5x10-6 M), dipiridamol (3x10-7 M), glibenclamida (10-6 M), propranolol (10-6 M), verapamilo (10-7 M) o atropina (3x10-5 M). Además se examinó la relajación inducida por acetilcolina (Ach, 10-8-3x10-4 M) y nitroprusiato de sodio (SNP, 10-9-3x10-5 M) en presencia y ausencia de ayanina (10-6 M). Resultados: La ayanina produjo una mayor relajación en los anillos contraídos con fenilefrina (pEC50: 5.84±0.05), efecto que se redujo en anillos sin endotelio o en anillos íntegros preincubados con ODQ y L-NAME. L-arginina fue capaz de revertir la respuesta inducida por L-NAME. La indometacina inhibió discretamente la relajación generada por la ayanina. El dipyridamol, la glibenclamida, el propranolol, el verapamilo y la atropina no modificaron el efecto de la ayanina. La ayanina no afectó la relajación inducida por la acetilcolina y débilmente disminuyó la inducida por el nitroprusiato de sodio. Conclusión: La ayanina induce una relajación dependiente del endotelio en la aorta de rata, efecto vinculado principalmente con la vía de óxido nítrico/GMP cíclico, de acuerdo con la respuesta observada en presencia de L-NAME, ODQ y L-arginina.
- Published
- 2010
28. The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats
- Author
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García-Pedraza, José Ángel, primary, García, Mónica, additional, Martín, María Luisa, additional, San Román, Luis, additional, and Morán, Asunción, additional
- Published
- 2014
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29. Peripheral 5-HT1D and 5-HT7 serotonergic receptors modulate sympathetic neurotransmission in chronic sarpogrelate treated rats
- Author
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García-Pedraza, José Ángel, primary, García, Mónica, additional, Martín, María Luisa, additional, Gómez-Escudero, Jesús, additional, Rodríguez-Barbero, Alicia, additional, San Román, Luis, additional, and Morán, Asunción, additional
- Published
- 2013
- Full Text
- View/download PDF
30. Abstract TP7: The Healthy Octogenarian Profile (HOPE): A Simple Indicator of Elderly Stroke Patients that may Benefit from Endovascular Intervention
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Urra, Xabier, primary, San Román, Luis, additional, and Jovin, Tudor G, additional
- Published
- 2013
- Full Text
- View/download PDF
31. Square alopecia: A new type of transient alopecia of the scalp following fluoroscopically endovascular embolization
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Podlipnik, Sebastian, primary, Giavedoni, Priscila, additional, San-Román, Luis, additional, and Ferrando, Juan, additional
- Published
- 2013
- Full Text
- View/download PDF
32. The Heidelberg Bleeding Classification: Classification of Bleeding Events After Ischemic Stroke and Reperfusion Therapy.
- Author
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von Kummer, Rüdiger, Broderick, Joseph P., Campbell, Bruce C. V., Demchuk, Andrew, Goyal, Mayank, Hill, Michael D., Treurniet, Kilian M., Majoie, Charles B. L. M., Marquering, Henk A., Mazya, Michael V., San Román, Luis, Saver, Jeffrey L., Strbian, Daniel, Whiteley, William, Hacke, Werner, and Román, Luis San
- Published
- 2015
- Full Text
- View/download PDF
33. Automated segmentation of cerebral vasculature with aneurysms in 3DRA and TOF-MRA using geodesic active regions: An evaluation study
- Author
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Bogunović, Hrvoje, primary, Pozo, José María, additional, Villa-Uriol, María Cruz, additional, Majoie, Charles B. L. M., additional, van den Berg, Rene, additional, Gratama van Andel, Hugo A. F., additional, Macho, Juan M., additional, Blasco, Jordi, additional, San Román, Luis, additional, and Frangi, Alejandro F., additional
- Published
- 2010
- Full Text
- View/download PDF
34. Peripheral 5-HT1Aand 5-HT7Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats
- Author
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Restrepo, Beatriz, primary, Martín, María Luisa, additional, San Román, Luis, additional, and Morán, Asunción, additional
- Published
- 2010
- Full Text
- View/download PDF
35. Medical and Endovascular Treatment of Patients with Large Vessel Occlusion Presenting with Mild Symptoms: An Observational Multicenter Study.
- Author
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Urra, Xabier, San Román, Luis, Gil, Francisco, Millán, Mónica, Cánovas, David, Roquer, Jaume, Cardona, Pere, Ribó, Marc, Martí-Fàbregas, Joan, abilleira, Sònia, and Chamorro, Ángel
- Subjects
- *
STROKE patients , *ARTERIAL occlusions , *ARTERIAL diseases , *THROMBOLYTIC therapy , *TREATMENT of reperfusion injuries , *CEREBROVASCULAR disease - Abstract
Background: A significant proportion of stroke patients presenting with mild symptoms does not have a successful recovery, especially when a large vessel is occluded. IV thrombolysis is safe and may benefit patients presenting with mild symptoms. In this study, we tested whether endovascular therapy (ET) is superior to medical therapy in these patients. Methods: Observational, prospectively collected, multicenter study of 78 consecutive patients admitted from 2009 to 2012 within 6 h of stroke, with NIHSS ≤5 at presentation or during initial diagnostic work-up and large vessel occlusion. Data for patients undergoing ET and/or IV thrombolysis were taken from the SONIIA registry of reperfusion therapies in Catalonia, or from our local stroke registry if no reperfusion therapy was delivered. We compared risk factors, clinical course, collateral circulation, revascularization rates, hemorrhagic complications, infarct volume, and the functional outcome at 3 months of patients treated with ET and those not receiving ET. Ordinal regression was used to assess the independent effect of ET on functional outcome. Results: Baseline characteristics were similar for ET (n = 34) and medically (n = 44) treated patients, except for older age in the latter. The occlusions were located in the terminal internal carotid artery (1%), M1 segment of the middle cerebral artery (33%), M2 segment (30%), posterior circulation (31%), and 5% of the patients had tandem lesions, with no significant differences between groups. Most patients in both treatment groups had good collateral flow. The rate of successful revascularization (91.2 vs. 63.4%; p = 0.006) and the risk of symptomatic intracranial hemorrhage (11.8 vs. 0%; p = 0.033) were higher in the ET group. The NIHSS scores were similar at hospital arrival, after initial neuroimaging, and at 24 h in both treatment groups and there were no significant differences in the infarct volume in a follow-up MRI. At 3 months, 35.9% of the patients had some disability. The functional outcome was similar in both treatment groups in univariate analysis and also in models adjusted for age and initial NIHSS or for variables associated to functional outcome on univariate comparison. Conversely, IV thrombolysis was associated with significantly greater chances of full recovery after adjusting for baseline differences (OR 3.70, p = 0.015). Conclusions: One third of stroke patients with mild symptoms and large vessel occlusions do not have a successful recovery. ET is effective to recanalize the occluded vessel but increases the risk of serious bleeding significantly without improving the functional outcome, and is therefore not justified routinely in these patients. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2015
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36. Frequency and Predictors of Symptomatic Intracerebral Hemorrhage in Patients with Ischemic Stroke Treated with Recombinant Tissue Plasminogen Activator outside Clinical Trials
- Author
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Martí-Fàbregas, Joan, primary, Bravo, Yolanda, additional, Cocho, Dolores, additional, Martí-Vilalta, Josep-Lluis, additional, Díaz-Manera, Jordi, additional, San Román, Luis, additional, Puig, Mireia, additional, Blanco, Miguel, additional, Castellanos, Mar, additional, Millán, Mónica, additional, Roquer, Jaume, additional, Obach, Víctor, additional, and Maestre, José, additional
- Published
- 2006
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- View/download PDF
37. The nitric oxide synthesis/pathway mediates the inhibitory serotoninergic responses of the pressor effect elicited by sympathetic stimulation in diabetic pithed rats
- Author
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García, Mónica, primary, Morán, Asunción, additional, Luisa Martín, María, additional, Barthelmebs, Mariette, additional, and San Román, Luis, additional
- Published
- 2006
- Full Text
- View/download PDF
38. Mesenteric vasoconstrictor response to 5-hydroxytryptamine in the in situ blood autoperfused rat mesentery: involvement of 5-HT2B and/or 5-HT2C receptor activation
- Author
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Fernández, Ma del Mar, primary, Morán, Asunción, additional, Martı́n, Ma Luisa, additional, and San Román, Luis, additional
- Published
- 2000
- Full Text
- View/download PDF
39. Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7 H -oxazolo[3,2- a ]pyridinedicarboxylate enantiomers
- Author
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Martı́n, Elena, primary, Morán, Asunción, additional, Martı́n, Ma Luisa, additional, San Román, Luis, additional, Puebla, Pilar, additional, Medarde, Manuel, additional, Caballero, Esther, additional, and San Feliciano, Arturo, additional
- Published
- 2000
- Full Text
- View/download PDF
40. Renal vasoconstrictor response to 5-hydroxytryptamine in the in situ autoperfused rat kidney: involvement of angiotensin II and the 5-HT2 receptor activation
- Author
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Morán, Asunción, primary, Velasco, Cristina, additional, Martı́n, Maria-Luisa, additional, and San Román, Luis, additional
- Published
- 1997
- Full Text
- View/download PDF
41. Pharmacological characterization of 5-HT receptors in parasympathetic innervation of rat heart
- Author
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Morán, Asunción, primary, Velasco, Cristina, additional, Martín, Maria-Luisa, additional, and San Román, Luis, additional
- Published
- 1994
- Full Text
- View/download PDF
42. Peripheral 5-HT1A and 5-HT7 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats.
- Author
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Restrepo, Beatriz, Martín, María Luisa, San Román, Luis, and Morán, Asunción
- Abstract
We analyzed the modulation of serotonin on the bradycardia induced in vivo by vagal electrical stimulation in alloxan-induced long-term diabetic rats. Bolus intravenous administration of serotonin had a dual effect on the bradycardia induced either by vagal stimulation or exogenous Ach, increasing it at low doses and decreasing it at high doses of 5-hydroxytryptamine (5-HT), effect reproduced by 5-carboxamidotryptamine maleate (5-CT), a 5-HT
1/7 agonist. The enhancement of the bradycardia at low doses of 5-CT was reproduced by 5-HT1A agonist 8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) and abolished by WAY-100,635, 5-HT1A antagonist. Pretreatment with 5-HT1 antagonist methiothepin blocked the stimulatory and inhibitory effect of 5-CT, whereas pimozide, 5-HT7 antagonist, only abolished 5-CT inhibitory action. In conclusion, long-term diabetes elicits changes in the subtype of the 5-HT receptor involved in modulation of vagally induced bradycardia. Activation of the 5- HT1A receptors induces enhancement, whereas attenuation is due to 5-HT7 receptor activation. This 5-HT dual effect occurs at pre- and postjunctional levels. [ABSTRACT FROM AUTHOR]- Published
- 2010
- Full Text
- View/download PDF
43. MR-14134, a New Benzothiazepine with Central Hypotensive Action.
- Author
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Prieto, Pilar, Carrón, Rosalia, Montero, Maria José, Morán, Asuncion, and San Román, Luis
- Published
- 1995
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44. Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers
- Author
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Martı́n, Elena, Morán, Asunción, Martı́n, Ma Luisa, San Román, Luis, Puebla, Pilar, Medarde, Manuel, Caballero, Esther, and San Feliciano, Arturo
- Published
- 2000
- Full Text
- View/download PDF
45. Virtual Model of the Internal Carotid Artery Classifications
- Author
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Valera, Marc, Mavar Haramija, Marija, Puigdellívol Sánchez, Anna, Juanes Méndez, Juan Antonio, San Román, Luis, Notaris, Matteo de, and Prats Galino, Alberto
- Subjects
Skull base ,Base del crani ,Human anatomy ,Anatomia humana ,Three-dimensional display systems ,Visualització tridimensional - Abstract
Interactive model developed from 3D reconstructions of human magnetic resonance (MR) images
46. Mechanisms of relaxation induced by flavonoid ayanin in isolated aorta rings from Wistar rats
- Author
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Carrón, Rosalía, primary, Sanz, Eva, primary, Puebla, Pilar, primary, Martín, María Luisa, primary, San Román, Luis, primary, and Guerrero, Mario Francisco, primary
- Published
- 1969
- Full Text
- View/download PDF
47. Abstract 31: The Association Between Baseline Ischemic Core Volume and Benefit of Endovascular Thrombectomy in Pooled Data from Six Randomized Trials.
- Author
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Campbell, Bruce C, Majoie, Charles B, Menon, Bijoy K, Goyal, Mayank, Dippel, Diederik W, Demchuk, Andrew, Dávalos, Antoni, Liebeskind, David S, Brown, Scott, Sharma, Gagan, van der Lugt, Aad, San Román, Luis, Muir, Keith W, White, Philip, Saver, Jeffrey L, Jovin, Tudor G, Hill, Michael D, and Mitchell, Peter J
- Published
- 2017
- Full Text
- View/download PDF
48. Abstract 176: HERMES: Collaterals at Angiography Guide Clinical Outcomes.
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Liebeskind, David S, Jovin, Tudor G, Majoie, Charles B, Mitchell, Peter J, San Román, Luis, Campbell, Bruce C, van Zwam, Wim H, Menon, Bijoy K, Saver, Jeffrey L, White, Philip, Hill, Michael D, Muir, Keith W, Demchuk, Andrew, Dippel, Diederik W, Dávalos, Antoni, Brown, Scott, and Goyal, Mayank
- Published
- 2017
- Full Text
- View/download PDF
49. Abstract 128: TICI Reperfusion in HERMES: Success in Endovascular Stroke Therapy.
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Liebeskind, David S, Jovin, Tudor G, Majoie, Charles B, Mitchell, Peter J, van der Lugt, Aad, Menon, Bijoy K, San Román, Luis, Campbell, Bruce C, Muir, Keith W, Hill, Michael D, Dippel, Diederik W, Saver, Jeffrey L, Demchuk, Andrew, Dávalos, Antoni, White, Philip, Brown, Scott, and Goyal, Mayank
- Published
- 2017
- Full Text
- View/download PDF
50. Abstract TP7.
- Author
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Urra, Xabier, San Román, Luis, and Jovin, Tudor G
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- 2013
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