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28 results on '"Sanchez-Antolín, Gloria"'

4. Burnout Among Physicians of Specialties Dedicated to Liver Transplantation.

Author

Sanchez-Antolín, Gloria, Blanco-Fernández, Gerardo, Campos-Varela, Isabel, Ruiz, Patricia, Álamo, José M., Otero, Alejandra, Pascual, Sonia, and Lladó, Laura

Subjects
*MEDICAL personnel, *LIVER transplantation, *SATISFACTION, *PSYCHOLOGICAL burnout, *ANESTHESIOLOGISTS
Abstract

Burnout is increasingly relevant among healthcare professionals. The aim of this study is to describe the prevalence of burnout and other parameters of professional satisfaction among different specialists dedicated to Liver Transplantation (LT) in transplant teams. A working group from the Spanish Society of LT designed a survey with 39 questions evaluating the prevalence of parameters related to professional satisfaction, including burnout. It was distributed among 496 specialists dedicated to liver transplantation in Spanish transplant teams. Responders included surgeons (49%), hepatologists (27%), anesthesiologists (16%), intensivists (4%), and other specialties (4%). Among responders, 78% reported some degree of burnout. Moreover, 46% of responders did not see themselves working in transplantation in 5 years. The rates of burnout and dissatisfaction among anesthesiologists and surgeons were higher than other specialists. The highest levels of dissatisfaction were in economic remuneration and work–life balance. Being younger than 60 years old and non-head of department showed to be risk factors of burnout. In conclusion, the prevalence of burnout among LT physicians in Spain was notably high. Among the various specialties, anesthesiologists and surgeons exhibited the highest dissatisfaction rates. The results of this work may be of interest to healthcare management and planning. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

Author

Chen, Qian, Perales, Celia, Soria, María Eugenia, García-Cehic, Damir, Gregori, Josep, Rodríguez-Frías, Francisco, Buti, María, Crespo, Javier, Calleja, José Luis, Tabernero, David, Vila, Marta, Lázaro, Fernando, Rando-Segura, Ariadna, Nieto-Aponte, Leonardo, Llorens-Revull, Meritxell, Cortese, Maria Francesca, Fernandez-Alonso, Irati, Castellote, José, Niubó, Jordi, Imaz, Arkaitz, Xiol, Xavier, Castells, Lluís, Riveiro-Barciela, Mar, Llaneras, Jordi, Navarro, Jordi, Vargas-Blasco, Víctor, Augustin, Salvador, Conde, Isabel, Rubín, Ángel, Prieto, Martín, Torras, Xavier, Margall, Nuria, Forns, Xavier, Mariño, Zoe, Lens, Sabela, Bonacci, Martin, Pérez-del-Pulgar, Sofía, Londoño, Maria Carlota, García-Buey, María Luisa, Sanz-Cameno, Paloma, Morillas, Rosa, Martró, Elisa, Saludes, Verónica, Masnou-Ridaura, Helena, Salmerón, Javier, Quíles, Rosa, Carrión, José Antonio, Forné, Montserrat, Rosinach, Mercè, Fernández, Inmaculada, García-Samaniego, Javier, Madejón, Antonio, Castillo-Grau, Pilar, López-Núñez, Carme, Ferri, María José, Durández, Rosa, Sáez-Royuela, Federico, Diago, Moisés, Gimeno, Concepción, Medina, Rafael, Buenestado, Juan, Bernet, Albert, Turnes, Juan, Trigo-Daporta, Matilde, Hernández-Guerra, Manuel, Delgado-Blanco, Manuel, Cañizares, Angelina, Arenas, Juan Ignacio, Gomez-Alonso, Maria Juana, Rodríguez, Manuel, Deig, Elisabet, Olivé, Gemma, Río, Oscar del, Cabezas, Joaquín, Quiñones, Ildefonso, Roget, Mercè, Montoliu, Silvia, García-Costa, Juan, Force, Lluís, Blanch, Silvia, Miralbés, Miguel, López-de-Goicoechea, María José, García-Flores, Angels, Saumoy, María, Casanovas, Teresa, Baliellas, Carme, Gilabert, Pau, Martin-Cardona, Albert, Roca, Rosa, Barenys, Mercè, Villaverde, Joana, Salord, Silvia, Camps, Blau, Silvan di Yacovo, María, Ocaña, Imma, Sauleda, Silvia, Bes, Marta, Carbonell, Judit, Vargas-Accarino, Elena, Ruzo, Sofía P., Guerrero-Murillo, Mercedes, Von Massow, Georg, Costafreda, María Isabel, López, Rosa Maria, González-Moreno, Leticia, Real, Yolanda, Acero-Fernández, Doroteo, Viroles, Silvia, Pamplona, Xavier, Cairó, Mireia, Ocete, María Dolores, Macías-Sánchez, José Francisco, Estébanez, Angel, Quer, Joan Carles, Mena-de-Cea, Álvaro, Otero, Alejandra, Castro-Iglesias, Ángeles, Suárez, Francisco, Vázquez, Ángeles, Vieito, David, López-Calvo, Soledad, Vázquez-Rodríguez, Pilar, Martínez-Cerezo, Francisco José, Rodríguez, Raúl, Macenlle, Ramiro, Cachero, Alba, Mereish, Gasshan, Mora-Moruny, Carme, Fábregas, Silvia, Sacristán, Begoña, Albillos, Agustín, Sánchez-Ruano, Juan José, Baluja-Pino, Raquel, Fernández-Fernández, Javier, González-Portela, Carlos, García-Martin, Carmen, Sánchez-Antolín, Gloria, Andrade, Raúl Jesús, Simón, Miguel Angel, Pascasio, Juan Manuel, Romero-Gómez, Manolo, Antonio del-Campo, José, Domingo, Esteban, Esteban, Rafael, Esteban, Juan Ignacio, and Quer, Josep

Published
2020
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9. Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH)

Author

Crespo, Javier, Albillos, Agustín, Buti, María, Calleja, José Luis, Garcia-Samaniego, Javier, Hernández-Guerra, Manuel, Serrano, Trinidad, Turnes, Juan, Acín, Enrique, Berenguer, Juan, Berenguer, Marina, Colom, Joan, Fernández, Inmaculada, Fernández Rodríguez, Conrado, Forns, Xavier, García, Federico, Granados, Rafael, Lazarus, Jeffrey, Molero, Jose María, Molina, Esther, Pérez Escanilla, Fernando, Pineda, Juan A., Rodríguez, Manuel, Romero, Manuel, Roncero, Carlos, Saiz de la Hoya, Pablo, and Sánchez Antolín, Gloria

Published
2019
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10. Eliminación de la hepatitis C. Documento de posicionamiento de la Asociación Española para el Estudio del Hígado (AEEH)

Author

Crespo, Javier, Albillos, Agustín, Buti, María, Calleja, José Luis, García-Samaniego, Javier, Hernández-Guerra, Manuel, Serrano, Trinidad, Turnes, Juan, Acín, Enrique, Berenguer, Juan, Berenguer, Marina, Colom, Joan, Fernández, Inmaculada, Fernández Rodríguez, Conrado, Forns, Xavier, García, Federico, Rafael Granados, Lazarus, Jeffrey V., Molero, Jose María, Molina, Esther, Pérez Escanilla, Fernando, Pineda, Juan A., Rodríguez, Manuel, Romero, Manuel, Roncero, Carlos, Saiz de la Hoya, Pablo, and Sánchez Antolín, Gloria

Published
2019
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11. A retrospective and prospective 12-month observational study of the socioeconomic burden of moderate to severe irritable bowel syndrome with constipation in Spain

Author

Mearin, Fermín, Caballero, Antonio M., Serra, Jordi, Brotons, Carles, Tantiñà, Ana, Fort, Esther, Martínez-Cerezo, Francisco J., Perelló, Antonia, Sánchez-Antolín, Gloria, Rey, Enrique, Angós Musgo, Ramón, Berdier, Ruth, Gómez-Rodríguez, Blas, Clavé, Pere, García-Alonso, Mónica, Torán-Monserrat, Pere, and Tack, Jan

Published
2019
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12. Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation

Author

Pascasio, Juan Manuel, Vinaixa, Carmen, Ferrer, María Teresa, Colmenero, Jordi, Rubin, Angel, Castells, Lluis, Manzano, María Luisa, Lorente, Sara, Testillano, Milagros, Xiol, Xavier, Molina, Esther, González-Diéguez, Luisa, Otón, Elena, Pascual, Sonia, Santos, Begoña, Herrero, José Ignacio, Salcedo, Magdalena, Montero, José Luis, Sánchez-Antolín, Gloria, Narváez, Isidoro, Nogueras, Flor, Giráldez, Álvaro, Prieto, Martín, Forns, Xavier, and Londoño, María-Carlota

Published
2017
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13. Real-World Effectiveness and Safety of Oral Combination Antiviral Therapy for Hepatitis C Virus Genotype 4 Infection

Author

Montoliu, Silvia, Serra, Miguel Angel, Andrade, Raul, Fernandez, Conrado, Fernández Bermejo, Miguel, Simon, Miguel Angel, Bonet, Lucia, de la Vega, Juan, Diago, Moises, Fernández, José Ramón, Sanchez Antolin, Gloria, Crespo, Javier, Calleja, Jose Luis, Fernández, Inmaculada, Sacristan, Begoña, Ruiz-Antorán, Belén, Ampuero, Javier, Hernández-Conde, Marta, García-Samaniego, Javier, Gea, Francisco, Buti, Maria, Cabezas, Joaquin, Lens, Sabela, Morillas, Rosa Maria, Salcines, Jose Ramon, Pascasio, Juan Manuel, Turnes, Juan, Sáez-Royuela, Federico, Arenas, Juan, Rincón, Diego, Prieto, Martin, Jorquera, Francisco, Sanchez Ruano, Juan Jose, Navascués, Carmen A., Molina, Esther, Moya, Adolfo Gallego, and Moreno-Planas, José Maria

Published
2017
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18. Impact of Cytomegalovirus Infection on Severe Hepatitis C Recurrence in Patients Undergoing Liver Transplantation

Author

Caston, Juan Jose, primary, Castells, Luis, additional, Varo, Evaristo, additional, Gomez, Miguel Angel, additional, de la Mata, Manuel, additional, Campos-Varela, Isabel, additional, Lumbreras, Carlos, additional, Gonzalez-Dieguez, Luisa, additional, Fabregat, Joan, additional, Herrero, Ignacio, additional, Salcedo, Magdalena, additional, Sanchez-Antolín, Gloria, additional, and Torre-Cisneros, Julian, additional

Published
2016
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28. Increased Th1, Th17 and pro-fibrotic responses in hepatitis C-infected patients are down-regulated after 12 weeks of treatment with pegylated interferon plus ribavirin.

Author

Jimenez-Sousa MA, Almansa R, de la Fuente C, Caro-Paton A, Ruiz L, Sanchez-Antolín G, Gonzalez JM, Aller R, Alcaide N, Largo P, Resino S, de Lejarazu RO, and Bermejo-Martin JF

Subjects
Antiviral Agents administration & dosage, Case-Control Studies, Chemokines blood, Cytokines blood, Drug Therapy, Combination, Fibrosis, Hepatitis C immunology, Hepatitis C pathology, Humans, Interferon alpha-2, Interferon-alpha administration & dosage, Polyethylene Glycols administration & dosage, Recombinant Proteins, Ribavirin administration & dosage, Viral Load, Antiviral Agents therapeutic use, Down-Regulation, Hepatitis C drug therapy, Interferon-alpha therapeutic use, Polyethylene Glycols therapeutic use, Ribavirin therapeutic use, T-Lymphocytes, Helper-Inducer immunology
Abstract

Hepatitis C virus causes significant morbidity and mortality worldwide. The infection induces up-regulation of cytokine and chemokines commonly linked to the development of cellular and pro-inflammatory antiviral responses. The current standard in hepatitis C treatment consists of combination regimens of pegylated interferon-alpha plus ribavirin. The impact of combined treatment in the host immune response is still poorly understood. In the present study, we profiled 27 cytokines, chemokines and growth factors involved in the innate and adaptive responses to the virus in the serum of 27 hepatitis C virus-infected patients, before and after 12 weeks of combined treatment, and compared them to 10 healthy controls. Hepatitis C virus infection induced not only the secretion of chemokines and cytokines participating in Th1 responses (MIP-1 alpha, IP-10, TNF-alpha, IL-12p70, IL-2), but also cytokines involved in the development of Th17 responses (IL-6, IL-8, IL-9 and IL-17) and two pro-fibrotic factors (FGF-b, VEGF). The most important increases included MIP-1 alpha (4.7-fold increase compared to the control group), TNF-alpha (3.0-fold), FGF-b (3.4-fold), VEGF (3.5-fold), IP-10 (3.6-fold), IL-17 (107.0-fold), IL-9 (7.5-fold), IL-12p70 (7.0-fold), IL-2 (5.6-fold) and IL-7 (5.6-fold). Combined treatment with pegylated interferon-alpha plus ribavirin down-modulated the secretion of key Th1 and Th17 pro-inflammatory mediators, and pro-fibrotic growth factors as early as 12 weeks after treatment initiation. MIP-1 alpha, FGF-b, IL-17 decreased in a more dramatic manner in the group of responder patients than in the group of non-responders (fold-change in cEVR; fold-change in NcEVR): MIP-1 alpha (4.72;1.71), FGF-b (4.54;1.21), IL-17 (107.1;1.8). Correlation studies demonstrated that the decreases in the levels of these mediators were significantly associated with each other, pointing to a coordinated effect of the treatment on their secretion (r coefficient; p value): [ FGF-b versus IL-17 (0.90; 0.00), IL-17 versus VEGF (0.88; 0.00), MIP-1 alpha versus IL-17 (0.84;0.00), FGF-b versus MIP-1 alpha (0.96;0.00), FGF-b versus IL-12p70 (0.90; 0.00), VEGF versus IL-12p70 (0.89; 0.00)]. Th17 immunity has been previously associated with autoimmune diseases and asthma, but this is the first work reporting a role for this profile in viral hepatitis. These results provide an opportunity to evaluate the impact of the treatment with Peg-INF-alpha and RBV on the prevention of immune-driven tissue damage in infected patients.

Published
2010
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