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291 results on '"Sanchez-Perez, Luis A."'

8. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Author

Chongsathidkiet, Pakawat, Jackson, Christina, Koyama, Shohei, Loebel, Franziska, Cui, Xiuyu, Farber, S. Harrison, Woroniecka, Karolina, Elsamadicy, Aladine A., Dechant, Cosette A., Kemeny, Hanna R., Sanchez-Perez, Luis, Cheema, Tooba A., Souders, Nicholas C., Herndon, James E., Coumans, Jean-Valery, Everitt, Jeffrey I., Nahed, Brian V., Sampson, John H., Gunn, Michael D., Martuza, Robert L., Dranoff, Glenn, Curry, William T., and Fecci, Peter E.

Published
2018
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11. Supplementary Figure 7 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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12. Supplementary Data from Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination

Author

Batich, Kristen A., primary, Reap, Elizabeth A., primary, Archer, Gary E., primary, Sanchez-Perez, Luis, primary, Nair, Smita K., primary, Schmittling, Robert J., primary, Norberg, Pam, primary, Xie, Weihua, primary, Herndon, James E., primary, Healy, Patrick, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell, primary, Vlahovic, Gordana, primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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13. Data from Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Author

Reap, Elizabeth A., primary, Suryadevara, Carter M., primary, Batich, Kristen A., primary, Sanchez-Perez, Luis, primary, Archer, Gary E., primary, Schmittling, Robert J., primary, Norberg, Pamela K., primary, Herndon, James E., primary, Healy, Patrick, primary, Congdon, Kendra L., primary, Gedeon, Patrick C., primary, Campbell, Olivia C., primary, Swartz, Adam M., primary, Riccione, Katherine A., primary, Yi, John S., primary, Hossain-Ibrahim, Mohammed K., primary, Saraswathula, Anirudh, primary, Nair, Smita K., primary, Dunn-Pirio, Anastasie M., primary, Broome, Taylor M., primary, Weinhold, Kent J., primary, Desjardins, Annick, primary, Vlahovic, Gordana, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell D., primary, Fecci, Peter E., primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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14. Table S2 from A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Author

Gedeon, Patrick C., primary, Schaller, Teilo H., primary, Chitneni, Satish K., primary, Choi, Bryan D., primary, Kuan, Chien-Tsun, primary, Suryadevara, Carter M., primary, Snyder, David J., primary, Schmittling, Robert J., primary, Szafranski, Scott E., primary, Cui, Xiuyu, primary, Healy, Patrick N., primary, Herndon, James E., primary, McLendon, Roger E., primary, Keir, Stephen T., primary, Archer, Gary E., primary, Reap, Elizabeth A., primary, Sanchez-Perez, Luis, primary, Bigner, Darell D., primary, and Sampson, John H., primary

Published
2023
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15. Table S2 from Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Author

Reap, Elizabeth A., primary, Suryadevara, Carter M., primary, Batich, Kristen A., primary, Sanchez-Perez, Luis, primary, Archer, Gary E., primary, Schmittling, Robert J., primary, Norberg, Pamela K., primary, Herndon, James E., primary, Healy, Patrick, primary, Congdon, Kendra L., primary, Gedeon, Patrick C., primary, Campbell, Olivia C., primary, Swartz, Adam M., primary, Riccione, Katherine A., primary, Yi, John S., primary, Hossain-Ibrahim, Mohammed K., primary, Saraswathula, Anirudh, primary, Nair, Smita K., primary, Dunn-Pirio, Anastasie M., primary, Broome, Taylor M., primary, Weinhold, Kent J., primary, Desjardins, Annick, primary, Vlahovic, Gordana, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell D., primary, Fecci, Peter E., primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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16. Supplementary Figure 5 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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17. Supplementary Figure 4 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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18. Supplementary Figure 1 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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19. Figure S1 from A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Author

Gedeon, Patrick C., primary, Schaller, Teilo H., primary, Chitneni, Satish K., primary, Choi, Bryan D., primary, Kuan, Chien-Tsun, primary, Suryadevara, Carter M., primary, Snyder, David J., primary, Schmittling, Robert J., primary, Szafranski, Scott E., primary, Cui, Xiuyu, primary, Healy, Patrick N., primary, Herndon, James E., primary, McLendon, Roger E., primary, Keir, Stephen T., primary, Archer, Gary E., primary, Reap, Elizabeth A., primary, Sanchez-Perez, Luis, primary, Bigner, Darell D., primary, and Sampson, John H., primary

Published
2023
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20. Supplementary Figure 2 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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21. Figure S2 from Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Author

Reap, Elizabeth A., primary, Suryadevara, Carter M., primary, Batich, Kristen A., primary, Sanchez-Perez, Luis, primary, Archer, Gary E., primary, Schmittling, Robert J., primary, Norberg, Pamela K., primary, Herndon, James E., primary, Healy, Patrick, primary, Congdon, Kendra L., primary, Gedeon, Patrick C., primary, Campbell, Olivia C., primary, Swartz, Adam M., primary, Riccione, Katherine A., primary, Yi, John S., primary, Hossain-Ibrahim, Mohammed K., primary, Saraswathula, Anirudh, primary, Nair, Smita K., primary, Dunn-Pirio, Anastasie M., primary, Broome, Taylor M., primary, Weinhold, Kent J., primary, Desjardins, Annick, primary, Vlahovic, Gordana, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell D., primary, Fecci, Peter E., primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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22. Supplementary Figure 6 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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23. Supplementary Table 1 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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24. Supplementary Figure 3 from T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Author

Woroniecka, Karolina, primary, Chongsathidkiet, Pakawat, primary, Rhodin, Kristen, primary, Kemeny, Hanna, primary, Dechant, Cosette, primary, Farber, S. Harrison, primary, Elsamadicy, Aladine A., primary, Cui, Xiuyu, primary, Koyama, Shohei, primary, Jackson, Christina, primary, Hansen, Landon J., primary, Johanns, Tanner M., primary, Sanchez-Perez, Luis, primary, Chandramohan, Vidyalakshmi, primary, Yu, Yen-Rei Andrea, primary, Bigner, Darell D., primary, Giles, Amber, primary, Healy, Patrick, primary, Dranoff, Glenn, primary, Weinhold, Kent J., primary, Dunn, Gavin P., primary, and Fecci, Peter E., primary

Published
2023
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25. Data from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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26. Supplementary Figure 4 from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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27. Supplementary Figure 3 from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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28. Supplementary Figure 5 from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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29. Supplementary Figure 1 from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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30. Supplementary Figure 2 from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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31. Supplementary Figure 6 from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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32. Supplementary Figure 7 from Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Author

Kerkar, Sid P., primary, Muranski, Pawel, primary, Kaiser, Andrew, primary, Boni, Andrea, primary, Sanchez-Perez, Luis, primary, Yu, Zhiya, primary, Palmer, Douglas C., primary, Reger, Robert N., primary, Borman, Zachary A., primary, Zhang, Ling, primary, Morgan, Richard A., primary, Gattinoni, Luca, primary, Rosenberg, Steven A., primary, Trinchieri, Giorgio, primary, and Restifo, Nicholas P., primary

Published
2023
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36. Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models

Author

Parker, Scott, primary, McDowall, Charlotte, additional, Sanchez-Perez, Luis, additional, Osorio, Cristina, additional, Duncker, Patrick C., additional, Briley, Aaron, additional, Swartz, Adam M., additional, Herndon, James E., additional, Yu, Yen-Rei A., additional, McLendon, Roger E., additional, Tedder, Thomas F., additional, Desjardins, Annick, additional, Ashley, David M., additional, Gunn, Michael Dee, additional, Enterline, David S., additional, Knorr, David A., additional, Pastan, Ira H., additional, Nair, Smita K., additional, Bigner, Darell D., additional, and Chandramohan, Vidyalakshmi, additional

Published
2023
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42. A Modification of the Lernmatrix for Real Valued Data Processing

Author

Carbajal-Hernández, José Juan, Sánchez-Fernández, Luis P., Sánchez-Pérez, Luis A., Carrasco-Ochoa, Jesús Ariel, Martínez-Trinidad, José Francisco, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Alvarez, Luis, editor, Mejail, Marta, editor, Gomez, Luis, editor, and Jacobo, Julio, editor

Published
2012
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44. Reproducibility of outcomes in sequential trials using CMV-targeted dendritic cell vaccination for glioblastoma.

Author

Sampson, John H., primary, Batich, Kristen A, additional, Mitchell, Duane Anthony, additional, Herndon, James Emmett, additional, Broadwater, Gloria, additional, Healy, Patrick, additional, Sanchez-Perez, Luis, additional, Nair, Smita, additional, Congdon, Kendra, additional, Norberg, Pamela, additional, Weinhold, Kent J., additional, Archer, Gerald E., additional, Reap, Elizabeth A., additional, Xie, Weihua, additional, McLendon, Roger E., additional, Reardon, David A., additional, Vredenburgh, James J., additional, Friedman, Henry S., additional, Bigner, Darell, additional, and Friedman, Allan H., additional

Published
2022
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48. Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice

Author

Evgin, Laura, primary, Kottke, Tim, additional, Tonne, Jason, additional, Thompson, Jill, additional, Huff, Amanda L., additional, van Vloten, Jacob, additional, Moore, Madelyn, additional, Michael, Josefine, additional, Driscoll, Christopher, additional, Pulido, Jose, additional, Swanson, Eric, additional, Kennedy, Richard, additional, Coffey, Matt, additional, Loghmani, Houra, additional, Sanchez-Perez, Luis, additional, Olivier, Gloria, additional, Harrington, Kevin, additional, Pandha, Hardev, additional, Melcher, Alan, additional, Diaz, Rosa Maria, additional, and Vile, Richard G., additional

Published
2022
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50. Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

Author

Mitchell, Duane A., Batich, Kristen A., Gunn, Michael D., Huang, Min-Nung, Sanchez-Perez, Luis, Nair, Smita K., Congdon, Kendra L., Reap, Elizabeth A., Archer, Gary E., Desjardins, Annick, Friedman, Allan H., Friedman, Henry S., Herndon II, James E., Coan, April, McLendon, Roger E., Reardon, David A., Vredenburgh, James J., Bigner, Darell D., and Sampson, John H.

Subjects
Medical research, Medicine, Experimental, Dendritic cells -- Physiological aspects, Vaccines -- Research, Glioblastoma multiforme -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes to induce immune responses (1). As such, autologous DCs generated ex vivo have been pulsed with tumour antigens and injected back into patients as immunotherapy. While DC vaccines have shown limited promise in the treatment of patients with advanced cancers (2-4) including glioblastoma (5-7), the factors dictating DC vaccine efficacy remain poorly understood. Here we show that pre-conditioning the vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and efficacy of tumour-antigen-specific DCs. To assess the effect of vaccine site pre-conditioning in humans, we randomized patients with glioblastoma to pre-conditioning with either mature DCs (8) or Td unilaterally before bilateral vaccination with DCs pulsed with Cytomegalovirus phosphoprotein 65 (pp65) RNA. We and other laboratories have shown that pp65 is expressed in more than 90% of glioblastoma specimens but not in surrounding normal brain (9-12), providing an unparalleled opportunity to subvert this viral protein as a tumour-specific target. Patients given Td had enhanced DC migration bilaterally and significantly improved survival. In mice, Td pre-conditioning also enhanced bilateral DC migration and suppressed tumour growth in a manner dependent on the chemokine CCL3. Our clinical studies and corroborating investigations in mice suggest that pre-conditioning with a potent recall antigen may represent a viable strategy to improve anti-tumour immunotherapy., To evaluate the influence of vaccine site pre-conditioning on DC migration clinically, we conducted a randomized and blinded clinical trial in newly diagnosed glioblastoma (GBM) (Extended Data Fig. 1). A [...]

Published
2015

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