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3 results on '"Sandeep Kansara"'

1. A Study of Erectile Dysfunction in Male Diabetes Patients and its Correlation with Platelet-Lymphocyte Ratio

Author

Mahesh Dave, Sahil Kharbanda, Sandeep Kansara, Manasvin Sareen, Yash Shah, Ravi Manglani, Ramgopal Saini, Nagaraj T, Mahesh Dave, Sahil Kharbanda, Sandeep Kansara, Manasvin Sareen, Yash Shah, Ravi Manglani, Ramgopal Saini, and Nagaraj T

Abstract

Introduction: Erectile dysfunction (ED) constitutes a large burden on society given its high prevalence and impact on quality of life. Diabetes is a common cause of organic ED. Prevalence of ED in diabetes ranges from 35% to 85% depending on the study, versus 26% in general population. Platelet-lymphocyte ratio (PLR) has been detected as an important marker for inflammation. Some studies have identified its role in ED but more research is needed. Material and methods: It was a hospital-based prospective observational study. According to International Index of Erectile Function (IIEF)-5 questionnaire, patients were divided into 4 categories: mild ED with score 17 to 21, mild-to-moderate ED with score 12 to 16, moderate ED with score 8 to 11 and severe ED with score 1 to 7. Presence of ED and its severity was correlated with age, residence, duration of diabetes, glycemic status, lipid profile, PLR, complications, body mass index (BMI), etc. Results: Prevalence of ED in male diabetes patients was found to be 72.4%. Among 110 cases with ED, 8 had mild ED (7.2%), 27 had mild-to-moderate (24.5%), 27 had moderate ED (24.5%) and 48 had severe ED (43.6%). Prevalence of ED was found to be proportional to age. Majority of cases in ED group were those with long-standing diabetes. Correlation of ED with complication of diabetes, like nephropathy and retinopathy, was significant, whereas it was not significant with neuropathy. Significant correlation of ED was found with BMI and PLR. Conclusion: ED prevalence was high among the diabetes patients and it increased with age and duration of the disease. Presence of diabetic complications was significantly associated with ED. BMI was significantly associated with development of ED. PLR was significantly higher in ED group and closely related to severity of ED.

Published
2022

2. A study of prevalence of autoantibodies in lean or underweight diabetic subjects in Southern Rajasthan

Author

Sandeep Kansara, Akhlaq Hasan, and Shuchi Goyal

Subjects
General Engineering
Abstract

Background: The prevalence of diabetes mellitus (DM) is increasing day by day. Changing life style and unhealthy eating habits are major contributor to this pandemic, however certain individuals develop diabetes despite enough physical activity and low to normal body weight, even in absence of family history. The current study aimed to assess the autoantibody profile of these underweight/lean diabetic subjects, in order to better understand their aetiology.Methods: This cross sectional, observational study was carried out in endocrinology OPD and ward of RNT Medical College, Udaipur, Rajasthan (India). The study included consecutive 207 lean/underweight diabetic subjects, on insulin or oral antidiabetic drugs (OAD), with or without history of ketosis and negative family history of diabetes. After detailed history and anthropometric examination, subjects were screened for presence of autoantibodies to GAD, TPO and IgA tTG.Results: 9 subjects were excluded from analysis (7 pancreatic calcification, 2 incomplete data). Out of 198 subjects, 153 (77.3%) subjects tested positive for GAD antibodies, while Anti TPO and IgA anti tTG antibodies were positive in 50 (25.3%) and 6 (3.0%) subjects, respectively. 39 (19.69%) subjects tested positive for both anti GAD and anti TPO antibodies and only 1(0.505%) subject had all the 3 antibodies present. Of the total study population, 158 (79.8%) subjects were on insulin, while 13 (6.6%) subjects received OAD, and 27 (13.6%) subjects both insulin and OAD.Conclusions: Lean/underweight diabetic subjects with negative family history of diabetes should be screened for presence of autoimmune markers for type 1 diabetes mellitus, irrespective of their treatment.

Published
2022
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3. Prediction of gestational diabetes mellitus at 24 to 28 weeks of gestation by using first-trimester insulin sensitivity indices in Asian Indian subjects

Author

Emmy Grewal, Alka Kriplani, Nandita Gupta, Garima Kachhawa, Nutan Aggarwal, Ariachery C. Ammini, Rajesh Khadgawat, and Sandeep Kansara

Subjects
Adult, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, India, Endocrinology, Insulin resistance, Asian People, Predictive Value of Tests, Pregnancy, Internal medicine, Hyperinsulinism, medicine, Hyperinsulinemia, Homeostasis, Humans, Insulin, Prospective Studies, business.industry, Quantitative insulin sensitivity check index, Age Factors, nutritional and metabolic diseases, Insulin sensitivity, Glucose Tolerance Test, medicine.disease, Gestational diabetes, Diabetes, Gestational, Pregnancy Trimester, First, Sample Size, Gestation, Female, Insulin Resistance, business, Algorithms
Abstract

The aim of the present study was to predict the development of gestational diabetes mellitus (GDM) after 24 weeks of gestation by using first-trimester insulin indices. A total of 298 nondiabetic pregnant women underwent 3-hour oral glucose tolerance test (OGTT) in the first trimester of pregnancy. The normoglycemic women underwent second OGTT between 24 and 28 weeks. Insulin sensitivity and resistance indices were calculated by using the Matsuda index (composite insulin sensitivity from OGTT), quantitative insulin sensitivity check index, and homeostasis model assessment for insulin resistance and sensitivity by using the results of the first-trimester OGTT. These indices were compared between subjects who were diagnosed as having GDM and subjects with normal glucose tolerance in the second OGTT. The overall prevalence of GDM was 15.49% (24 in the first trimester and 16 between 24 and 28 weeks). First-trimester fasting plasma insulin greater than 7.45 μU/mL was able to predict GDM with sensitivity and specificity of 80% and 57.4%, respectively. The negative predictive value for this parameter was 0.97. Values of first-trimester composite insulin sensitivity from OGTT less than 5.5 had sensitivity and specificity of 71.4% and 62.5% for the prediction of GDM. First-trimester hyperinsulinemia preceded the onset of hyperglycemia between 24 and 28 weeks of gestation and would predict the development of GDM with limited sensitivity and specificity.

Published
2011

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